{"product_id":"fragment-based-drug-design-tools-practical-approaches-and-examples-hardback-9780123812742","title":"Fragment Based Drug Design; Tools, Practical Approaches, and Examples (Hardback) 9780123812742","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eFragment Based Drug Design\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eTools, Practical Approaches, and Examples\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003e\u003cp\u003e\u003ci\u003eThis\u003c\/i\u003e Methods in Enzymology \u003ci\u003evolume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens.\u003c\/i\u003e \u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eLawrence C. Kuo (Volume editor)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123812742, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 21 April 2011\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e645 pages\u003cbr\u003e22.9 x 15.1 x 3.5 cm, 1.19 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eThere are numerous excellent reviews on fragment-based drug discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This \u003ci\u003eMethods in Enzymology\u003c\/i\u003e volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. Also elaborated by experienced researchers in FBDD are sample preparations of fragments, proteins, and GPCR as well as examples of how to generate leads from hits.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePart I. Tools \u003c\/p\u003e \u003cp\u003e1. Designing a Diverse High Quality Library for Crystallography Based FBDD Screening  Brett A. Tounge, Michael H. Parker \u003c\/p\u003e \u003cp\u003e2. Preparation of Protein Samples for NMR Structure, Function, and Small-Molecule Screening Studies  Thomas B. Acton, Rong Xiao, James Aramini, William A. Buchwald, Colleen Ciccosanti, Ken Conover, Keith Hamilton, Yuanpeng Janet Huang, Haleema Janjua, Paolo Rossi, Seema Sharma, G.V.T.Swapna, Huang Wang, Li Zhao, Gaetano T. Montelione \u003c\/p\u003e \u003cp\u003e3. Key Factors for Successful Generation of Protein-Fragment Structures: Requirements on Protein, Crystals, and Technology  Anja Jestel, Stefan Steinbacher \u003c\/p\u003e \u003cp\u003e4. Automated Crystal Amplification and Compound Dispensation for FBDD Analysis  Francis A. Lewandowski, Brett A. Tounge, Cynthia M. Milligan \u003c\/p\u003e \u003cp\u003e5. Hardware and Protocols for Rapid Fragment Based Structure Determination  Richard S. Alexander, John C. Spurlino \u003c\/p\u003e \u003cp\u003e6. Using Computational Techniques in Fragment-Based Drug Discovery  Renee L. DesJarlais \u003c\/p\u003e \u003cp\u003e7. Computational Approaches to De Novo Discovery of Fragment Binding for Unprecedented Protein States  Zenon D. Konteatis, Jinming Zou, Anthony E. Klon, Siavash Meshkat \u003c\/p\u003e \u003cp\u003ePart II. Practical Approaches \u003c\/p\u003e \u003cp\u003e8. How to Avoid Rediscovering the Known  Lawrence C. Kuo \u003c\/p\u003e \u003cp\u003e9. From Experimental Design to Data Analysis: A Comprehensive Walk-Through of Fragment Identification Using Surface Plasmon Resonance  Anthony M. Giannetti \u003c\/p\u003e \u003cp\u003e10. Practical Aspects of NMR Based Fragment Screening  Christopher Lepre \u003c\/p\u003e \u003cp\u003e11. Fluorescent Protein Thermal Shifts to Identify Low Molecular Weight Fragments  James K. Kranz, Matthew J. Todd \u003c\/p\u003e \u003cp\u003e12. A HTS Reporter Displacement Assay for Fragment Screening and Fragment Evolution Towards Leads with Optimized Binding Affinity, Binding Kinetics, and Kinetic Selectivity  Lars Neumann \u003c\/p\u003e \u003cp\u003e13. Fragment Screening of Stabilized G-Protein Coupled Receptors Using Biophysical Methods  Miles Congreve, Fiona H. Marshall, David Myszka, Gregg Siegal \u003c\/p\u003e \u003cp\u003e14. Predicting the Success of a Fragment Screening by X-Ray Crystallography  Douglas Davies, Lance Stewart \u003c\/p\u003e \u003cp\u003e15. Fragment Screening Purely with Protein Crystallography  John C. Spurlino \u003c\/p\u003e \u003cp\u003e16. Structure Density Relationship Based FBDD  Marta C. Abad, Xuqing Zhang, Alan C. Gibbs \u003c\/p\u003e \u003cp\u003ePart III. Lead Generation Examples \u003c\/p\u003e \u003cp\u003e17. Lead Generation and Examples – Opinions Regarding How to Follow Up Hits  Masaya Orita, Kazuki Ohno, Masaichi Warizaya, Yasushi Amano, Tatsuya Niimi \u003c\/p\u003e \u003cp\u003e18. High Throughput Thermodynamics for Selection of Fragment Hits and Guidance of Fragment Evolution  Lars Neumann \u003c\/p\u003e \u003cp\u003e19. Medicinal Chemistry Inspired Fragment Based Drug Discovery  James C. Lanter, Xuqing Zhang, Zhihua Sui \u003c\/p\u003e \u003cp\u003e20. Experiences in Fragment-Based Lead Discovery  Roderick E. Hubbard, James B. Murray \u003c\/p\u003e \u003cp\u003e21. Advancing Fragment Binders to Lead Like Compounds Using Ligand and Protein Based NMR Spectroscopy  Till Maurer \u003c\/p\u003e \u003cp\u003e22. Effective Progression of NMR-Directed Fragment Hits  Hugh Eaton, Daniel Wyss \u003c\/p\u003e \u003cp\u003e23. Fragment Screening of Infectious Disease Targets in a Structural Genomics Environment  Douglas Davies, Lance Stewart\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biochemistry [\u003ca title=\"See our other books on Biochemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemistry%20%5BPSB%5D%22\"\u003ePSB\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649312674072,"sku":"9780123812742","price":137.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123812742_ae4385d2-5b9d-4663-9ea6-6944ef236ec3.jpg?v=1695014007","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/fragment-based-drug-design-tools-practical-approaches-and-examples-hardback-9780123812742","provider":"Freshly Printed Books","version":"1.0","type":"link"}