{"product_id":"evaluation-of-drug-candidates-for-preclinical-development-pharmacokinetics-metabolism-pharmaceutics-and-toxicology-hardback-9780470044919","title":"Evaluation of Drug Candidates for Preclinical Development; Pharmacokinetics, Metabolism, Pharmaceutics, and Toxicology (Hardback) 9780470044919","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eEvaluation of Drug Candidates for Preclinical Development\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003ePharmacokinetics, Metabolism, Pharmaceutics, and Toxicology\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eChao Han (Edited by), C Han (Author), Charles B. Davis (Edited by), Binghe Wang (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470044919, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 28 January 2010\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e304 pages\u003cbr\u003e24.1 x 16 x 2.1 cm, 0.562 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"This is a useful reference source for those new to, or aspiring to join the pharmaceutical industry, for academics, and for students of pharmacy and pharmaceutical sciences.\" (Chromatographia, 1 December 2010)\u003cbr\u003e\u003cbr\u003e\"In conclusion, the book brings the areas of ADME, toxicology and pharmaceutical science together to describe the approaches used to select safe compounds with the required pharmacokinetic and physiochemical properties for progressing into clinical development\". (British Toxicology Society, Winter 2010)\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eEmphasizes the integration of major areas of drug discovery and their importance in candidate evaluation\u003c\/p\u003e \u003cp\u003eIt is believed that selecting the \"right\" drug candidate for development is the key to success. In the last decade, pharmaceutical R\u0026amp;D departments have integrated pharmacokinetics and drug metabolism, pharmaceutics, and toxicology into early drug discovery to improve the assessment of potential drug compounds. Now, Evaluation of Drug Candidates for Preclinical Development provides a complete view and understanding of why absorption-distribution-metabolism-excretion-toxicology (ADMET) plays a pivotal role in drug discovery and development.\u003c\/p\u003e \u003cp\u003eEncompassing the three major interrelated areas in which optimization and evaluation of drug developability is most critical—pharmacokinetics and drug metabolism, pharmaceutics, and safety assessment—this unique resource encourages integrated thinking in drug discovery. The contributors to this volume:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eCover drug transporters, cytochrome P-450 and drug-drug interactions, plasma protein binding, stability, drug formulation, preclinical safety assessment, toxicology, and toxicokinetics\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eAddress developability issues that challenge pharma companies, moving beyond isolated experimental results\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eReveal connections between the key scientific areas that are critical for successful drug discovery and development\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eInspire forward-thinking strategies and decision-making processes in preclinical evaluation to maximize the potential of drug candidates to progress through development efficiently and meet the increasing demands of the marketplace\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eEvaluation of Drug Candidates for Preclinical Development serves as an introductory reference for those new to the pharmaceutical industry and drug discovery in particular. It is especially well suited for scientists and management teams in small- to mid-sized pharmaceutical companies, as well as academic researchers and graduate students concerned with the practical aspects related to the evaluation of drug developability.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePREFACE.  \u003cp\u003eCONTRIBUTORS.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1. INTRODUCTION\u003c\/b\u003e \u003ci\u003e(Charles B. Davis).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. PHARMACOKINETICS IN PRECLINICAL DRUG DEVELOPMENT: AN OVERVIEW\u003c\/b\u003e \u003ci\u003e(Dion Brocks).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. THE ROLE OF MEMBRANE TRANSPORTERS IN DRUG DISPOSITION\u003c\/b\u003e \u003ci\u003e(Fanfan Zhou, Peng Duan, and Guofeng You).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. CYTOCHROME P450: STRUCTURE, FUNCTION, AND APPLICATION IN DRUG DISCOVERY AND DEVELOPMENT\u003c\/b\u003e \u003ci\u003e(Ramesh B. Bambal and Stephen E. Clarke).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. THE ROLE OF DRUG METABOLISM AND METABOLITE IDENTIFICATION IN DRUG DISCOVERY\u003c\/b\u003e \u003ci\u003e(Xiangming Guan).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. PROTEIN BINDING IN DRUG DISCOVERY AND DEVELOPMENT\u003c\/b\u003e \u003ci\u003e(Vikram Ramanathan and Nimish Vachharajani).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7. PREDICTION OF THE PHARMACOKINETICS IN HUMANS\u003c\/b\u003e \u003ci\u003e(Chao Han and Ramesh Bambal).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. PHARMACEUTICS DEVELOPABILITY ASSESSMENT\u003c\/b\u003e \u003ci\u003e(Lian Huang, Jinquan Dong, and Shyam Karki).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9. SAFETY ASSESSMENT IN DRUG DISCOVERY\u003c\/b\u003e \u003ci\u003e(Vito G. Sasseville, William R. Foster, and Bruce D. Car).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10. ASSESSMENT OF STRATEGIES UTILIZED TO MINIMIZE THE POTENTIAL FOR INDUCTION OF ACQUIRED LONG QT SYNDROME AND TORSADE DE POINTES\u003c\/b\u003e \u003ci\u003e(Khuram W. Chaudhary and Barry S. Brown).\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eINDEX.\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52256831635736,"sku":"9780470044919","price":98.59,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470044919.jpg?v=1781275192","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/evaluation-of-drug-candidates-for-preclinical-development-pharmacokinetics-metabolism-pharmaceutics-and-toxicology-hardback-9780470044919","provider":"Freshly Printed Books","version":"1.0","type":"link"}