{"product_id":"essential-pharmacology-how-drugs-alter-signaling-pathways-in-the-body-paperback-softback-9781394347858","title":"Essential Pharmacology; How Drugs Alter Signaling Pathways in the Body (Paperback \/ softback) 9781394347858","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eEssential Pharmacology\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eHow Drugs Alter Signaling Pathways in the Body\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eCarl E. Creutz (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781394347858, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 11 March 2026\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e128 pages\u003cbr\u003e22.6 x 15.2 x 1.5 cm, 0.204 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eMaster how drugs modulate the body’s signaling pathways\u003c\/b\u003e \u003c\/p\u003e\n\u003cp\u003eMost medicines work not by creating new physiological processes, but by modulating the body's existing signaling systems, the internal language of hormones, neurotransmitters, and cellular messengers. \u003ci\u003eEssential Pharmacology\u003c\/i\u003e illuminates this central concept while providing accessible yet rigorous mathematical foundations for understanding quantitative pharmacology. \u003c\/p\u003e\n\u003cp\u003eWritten by Carl E. Creutz, Harrison Professor of Medical Teaching in Pharmacology, Emeritus at the University of Virginia, this text guides students through drug absorption, distribution, and biotransformation; clinical pharmacokinetics with practical dosing models; and comprehensive pharmacodynamics including receptor theory, competitive antagonism, and partial agonists. The book explores G-protein coupled receptors, second messenger cascades, and signaling networks that drugs target. By emphasizing general principles, it complements specialized texts in clinical therapeutics, veterinary medicine, toxicology, antimicrobial therapy, and nursing practice. \u003c\/p\u003e\n\u003cp\u003eReaders will find: \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eQuantitative pharmacology presented with mathematical rigor yet accessible to students with undergraduate science and mathematics training\u003c\/li\u003e\n\u003cli\u003eComplete drug-receptor interaction models covering competitive antagonists, partial agonists, allosteric mechanisms, and spare receptor theory\u003c\/li\u003e\n\u003cli\u003eClinical pharmacokinetics with single-dose and steady-state models enabling rational drug dosing and therapeutic monitoring\u003c\/li\u003e\n\u003cli\u003eDetailed receptor-effector mechanisms including G-protein signaling, second messengers, and the networks controlling physiological responses\u003c\/li\u003e\n\u003cli\u003eFocus on the unifying principle that modern pharmacology modulates endogenous signaling rather than creating novel body processes\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003eEssential Pharmacology\u003c\/i\u003e serves medical, nursing, pharmacy, and other health professional students building theoretical foundations in pharmacology. It equally benefits biomedical researchers, pharmaceutical scientists, and public policy professionals seeking to understand drug development principles and therapeutic limitations.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eAbout the Author viii\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 1: Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 2: Definition and Scope of Pharmacology 3\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 3: Movement of Drugs to and from Sites of Action 5\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Physicochemical Factors in the Transfer of Drugs Across Membranes 6\u003c\/p\u003e \u003cp\u003e3.2 Active, Carrier- Mediated Transport 7\u003c\/p\u003e \u003cp\u003e3.3 Weak Electrolytes and Influence of pH 7\u003c\/p\u003e \u003cp\u003e3.4 Absorption of Drugs 13\u003c\/p\u003e \u003cp\u003e3.5 Bioavailability and Bioequivalence 15\u003c\/p\u003e \u003cp\u003e3.6 Distribution of Drugs 15\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 4: Biotransformation of Drugs 19\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Consequences of Drug Metabolism 20\u003c\/p\u003e \u003cp\u003e4.2 Enzymatic Biotransformation Reactions 20\u003c\/p\u003e \u003cp\u003e4.3 Metabolizing Systems in the Smooth Endoplasmic Reticulum (“Microsomal” Fraction of Cell Homogenates) 21\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 5: Excretion of Drugs 26\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 6: Clinical Pharmacokinetics 28\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 28\u003c\/p\u003e \u003cp\u003e6.2 Pharmacokinetic Parameters and Variables 29\u003c\/p\u003e \u003cp\u003e6.3 A Simple Pharmacokinetic Model 35\u003c\/p\u003e \u003cp\u003e6.3.1 Consider if D.R. = 0 38\u003c\/p\u003e \u003cp\u003e6.3.2 Consider if C 0 = 0 40\u003c\/p\u003e \u003cp\u003e6.3.3 The Steady State 42\u003c\/p\u003e \u003cp\u003e6.3.4 Additional Examples of the Linear Pharmacokinetic Model 43\u003c\/p\u003e \u003cp\u003e6.4 A “Dose- Dependent” (or “Non- Linear”) Pharmacokinetic Model 47\u003c\/p\u003e \u003cp\u003e6.5 Intermittent Oral Dosing 52\u003c\/p\u003e \u003cp\u003e6.6 Pharmacokinetics of Single Doses 54\u003c\/p\u003e \u003cp\u003e6.7 Recapitulation of Equations (These are the “Need- to- Know” Equations for Pharmacokinetics) 55\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 7: Pharmacodynamics I: Determining Effects in Intact Organisms; Dose- Response Relationships in Patients 56\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Graded Responses: Plots of Dose (Dosage) Versus Intensity of Effect 56\u003c\/p\u003e \u003cp\u003e7.2 Therapeutic Index and Therapeutic Window 58\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 8: Pharmacodynamics II: Determining Sites and Mechanisms of Action of Drugs 60\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 60\u003c\/p\u003e \u003cp\u003e8.2 Specificity of Drugs 62\u003c\/p\u003e \u003cp\u003e8.3 Nature of Drug Receptors: Molecules that Combine with the Drug and Mediate its Actions 63\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 9: Pharmacodynamics III: Quantitative Analysis of Drug–Receptor Interactions 64\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 The “Simple Occupancy Model” 65\u003c\/p\u003e \u003cp\u003e9.2 “Competitive” or “Surmountable” Antagonists 68\u003c\/p\u003e \u003cp\u003e9.3 “Noncompetitive” or “Insurmountable” Antagonists 71\u003c\/p\u003e \u003cp\u003e9.4 Irreversible Antagonists 73\u003c\/p\u003e \u003cp\u003e9.5 Partial Agonists 73\u003c\/p\u003e \u003cp\u003e9.6 The Allosteric Model for Drug–Receptor Interaction 77\u003c\/p\u003e \u003cp\u003e9.7 “Spare Receptors” 81\u003c\/p\u003e \u003cp\u003eContents vii\u003c\/p\u003e \u003cp\u003e9.7.1 Behavior of Noncompetitive Antagonists When Spare Receptors Are Present 84\u003c\/p\u003e \u003cp\u003e9.8 Displacement of the Activation Curve to the Right of the Binding Curve: Fractional Occupancy Threshold 86\u003c\/p\u003e \u003cp\u003e9.9 Review: The Use of the Dose–Response Curve to Characterize Drugs and Receptors 87\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 10: Biological Receptor- Effector Mechanisms 90\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Receptor Identification and Classification 90\u003c\/p\u003e \u003cp\u003e10.2 Location of Receptors 92\u003c\/p\u003e \u003cp\u003e10.3 Second Messengers: The Intracellular Language 92\u003c\/p\u003e \u003cp\u003e10.4 Signaling Networks of Protein Kinases and Transcription Factors 93\u003c\/p\u003e \u003cp\u003e10.5 Importance of Second Messengers in Pharmacology 94\u003c\/p\u003e \u003cp\u003e10.6 Receptor Structure and Proximal Effector Systems 94\u003c\/p\u003e \u003cp\u003e10.7 G- Protein Coupled Receptors 96\u003c\/p\u003e \u003cp\u003e10.8 The G- Protein Activation Cycle 96\u003c\/p\u003e \u003cp\u003e10.9 The G- Proteins Provide Amplification, Diffusion, and Integration of Signals 99\u003c\/p\u003e \u003cp\u003e10.10 Signaling Homeostasis and Receptor Metabolism 100\u003c\/p\u003e \u003cp\u003e10.11 Diseases Resulting From Receptor Malfunction 102\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 11: Testing and Evaluation of New Drugs 103\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eChapter 12: Further Study in Pharmacology 105\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eIndex 107\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Other branches of medicine [\u003ca title=\"See our other books on Other branches of medicine\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Other%20branches%20of%20medicine%20%5BMM%5D%22\"\u003eMM\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52433819566360,"sku":"9781394347858","price":39.29,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9781394347858.jpg?v=1784853957","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/essential-pharmacology-how-drugs-alter-signaling-pathways-in-the-body-paperback-softback-9781394347858","provider":"Freshly Printed Books","version":"1.0","type":"link"}