{"product_id":"epigenetics-of-aging-and-longevity-translational-epigenetics-vol-4-hardback-9780128110607","title":"Epigenetics of Aging and Longevity; Translational Epigenetics vol 4 (Hardback) 9780128110607","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eEpigenetics of Aging and Longevity\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eTranslational Epigenetics vol 4\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003e\u003cp\u003eExamines the role of epigenetic mechanisms in aging and longevity, with an emphasis on therapeutic interventions to extend human lifespan and treat diseases\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eAlexey Moskalev (Edited by), Alexander Vaiserman (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780128110607, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 13 November 2017\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e544 pages\u003cbr\u003e23.4 x 19 x 3.1 cm, 1.31 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eEpigenetics of Aging and Longevity\u003c\/i\u003e provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. \u003c\/p\u003e  \u003cp\u003eThis book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eSection I: Epigenetic Mechanisms in Aging\u003c\/b\u003e 1. Aging epigenetics: changes and challenges 2. Defective DNA methylation\/demethylation processes define aging-dependent methylation patterns 3. S-adenosylmethionine Metabolism and Aging 4. The Epigenetic Clock and Ageing 5. The Epigenetic Regulation of Telomere Maintenance in Aging 6. Living Long and Ageing Well: Are Lifestyle factors the Epigenetic link in the Longevity Phenotype? 7. Epigenetic Biomarkers for Biological Age 8. The Role of Non-Coding RNAs in Genome Stability and Aging 9. Intra-tissue DNA methylation heterogeneity in aging\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II. Early-life Epigenetic Programming of Aging Trajectories\u003c\/b\u003e 10. Early Life Nutrition, Epigenetics and Altered Energy Balance Later in Life 11. Early Nutrition, Epigenetics and Human Health 12. Biological Embedding of Psychosocial Stress over the Life Course 13. Epigenetics of longevity in social insects\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III. Epigenetics of Aging-Associated Diseases\u003c\/b\u003e 14. Drosophila melanogaster as a Model for Studying the Epigenetic Basis of Aging 15. Histone modification changes during aging: Cause or Consequence? - What we have learned about epigenetic regulation of aging from model organisms 16. Epigenetics of brain\/cognitive aging 17. The role of epigenetic modifications in cardiometabolic diseases 18. Epigenetic mechanisms in osteoporosis 19. Epigenetics of Skeletal Muscle Aging\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IV. Epigenome-targeted Therapies in Gerocscience\u003c\/b\u003e 20. Healthy Aging and Epigenetic Drugs for Diabetes and Obesity: A Novel Perspective 21. Epigenetic Drugs for Cancer and Precision Medicine 22. Epigenetic Drug Discovery for Alzheimer’s Disease\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection V. Conclusions and Perspectives\u003c\/b\u003e 23. Epigenetics of aging and longevity: challenges and future directions\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Cellular biology [\u003ca title=\"See our other books on Cellular biology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Cellular%20biology%20%5Bcytology%5D%20%5BPSF%5D%22\"\u003ecytology PSF\u003c\/a\u003e], Genetics [\u003ca title=\"See our other books on Genetics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Genetics%20%5Bnon-medical%5D%20%5BPSAK%5D%22\"\u003enon-medical PSAK\u003c\/a\u003e], Medicine: general issues [\u003ca title=\"See our other books on Medicine: general issues\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Medicine:%20general%20issues%20%5BMB%5D%22\"\u003eMB\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649766674712,"sku":"9780128110607","price":103.75,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780128110607.jpg?v=1694103372","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/epigenetics-of-aging-and-longevity-translational-epigenetics-vol-4-hardback-9780128110607","provider":"Freshly Printed Books","version":"1.0","type":"link"}