{"product_id":"enzyme-inhibition-in-drug-discovery-and-development-the-good-and-the-bad-hardback-9780470281741","title":"Enzyme Inhibition in Drug Discovery and Development; The Good and the Bad (Hardback) 9780470281741","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eEnzyme Inhibition in Drug Discovery and Development\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eThe Good and the Bad\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eChuang Lu (Edited by), C Lu (Author), Albert P. Li (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470281741, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 26 January 2010\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e876 pages\u003cbr\u003e24.3 x 16.3 x 4.4 cm, 1.311 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"The description of each topic is clear, well organized and informative, making the book a useful or even essential high-level handbook.\" (\u003ci\u003eChemMedChem,\u003c\/i\u003e November 2010)\u003cbr\u003e \u003cbr\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThe science and applied approaches of enzyme inhibition in drug discovery and development  \u003cp\u003eOffering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, \u003ci\u003eEnzyme Inhibition in Drug Discovery and Development\u003c\/i\u003e examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development.\u003c\/p\u003e \u003cp\u003eWith chapters written by over fifty leading experts in their fields, \u003ci\u003eEnzyme Inhibition in Drug Discovery and Development\u003c\/i\u003e fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the \"good\" inhibitions—desirable pharmacological effects—and \"bad\" inhibitions—drug–drug interactions and toxicity. The book discusses:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eThe drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug–drug interactions\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eThe inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eThrough this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePREFACE.  \u003cp\u003eCONTRIBUTORS.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I. DRUG DISCOVERY APPROACHES AND TECHNOLOGIES.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1. The Drug Discovery Process (\u003ci\u003eGerald T. Miwa\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2. Medicinal Chemistry of the Optimization of Enzyme Inhibitors (\u003ci\u003eGeraldine Harriman, Amy Elder, and Indranath Ghosh\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3. Bioanalytical Technologies in Drug Discovery (\u003ci\u003eJing-Tao Wu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4. Safety Biomarkers in Drug Development: Emerging Trends and Implications (\u003ci\u003eEric R. Fedyk\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e5. The Role of Drug Metabolism in Drug Discovery (\u003ci\u003eTonika Bohnert and Liang-Shang Gan\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6. Applied Pharmacokinetics in Drug Discovery and Development (\u003ci\u003eHua Yang, Xingrong Liu, Anjaneya Chimalakonda, Zheng Lu, Cuiping Chen, Frank Lee, and Wen Chyi Shyu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II. INHIBITION OF THE DRUG METABOLIZING ENZYMES—THE UNDESIRABLE INHIBITION.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7. Enzyme Inhibition and Inactivation: Cytochrome P450 Enzymes (\u003ci\u003eR. Scott Obach\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e8. Cytochrome P450 Induction (\u003ci\u003eEdward L. LeCluyse, Michael W. Sinz, Nicola Hewitt, Stephen S. Ferguson, and Jasminder Sahi\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e9. Inhibition of Drug-Metabolizing Enzymes in Gastrointestinal Tract and Its Influence on the Drug–Drug Interaction Prediction (\u003ci\u003eAleksandra Galetin and J. Brian Houston\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e10. Enzyme Inhibition in Various \u003ci\u003eIn Vitro\u003c\/i\u003e Systems (\u003ci\u003ePing Zhou\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e11. Cytochrome P450 Degradation and Its Clinical Relevance (\u003ci\u003eMingxiang Liao, Ping Kang, Bernard P. Murray, and Maria Almira Correia\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e12. Complexities of Working with UDP-Glucuronosyltransferases (UGTs): Focus on Enzyme Inhibition (\u003ci\u003eMichael B. Fisher\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e13. Evaluation of Inhibitors of Drug Metabolism in Human Hepatocytes (\u003ci\u003eAlbert P. Li and Chuang Lu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e14. Grapefruit Juice and Its Constituents as New Esterase Inhibitors (\u003ci\u003eSuresh K. Balani\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e15. Transporter–Xenobiotic Interactions: An Important Aspect of Drug Development Studies (\u003ci\u003eGang Luo, Richard Ridgewell, and Thomas Guenthner\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e16. Polymorphisms of Drug Transporters and Their Clinical Implications (\u003ci\u003eCindy Q. Xia and Johnny J. Yang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e17. Clinical Drug Interactions Due to Metabolic Inhibition: Prediction, Assessment, and Interpretation (\u003ci\u003eLisa L. von Moltke and David J. Greenblatt\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e18. Predicting Interindividual Variability of Metabolic Drug–Drug Interactions: Identifying the Causes and Accounting for Them Using Systems Approach (\u003ci\u003eAmin Rostami-Hodjegan\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III. INHIBITION OF THE DRUG TARGET ENZYMES—THE DESIRABLE INHIBITION.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e19. NF-κB: Mechanism, Tumor Biology, and Inhibitors (\u003ci\u003eLenny Dang\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e20. G-Protein-Coupled Receptors as Drug Targets (\u003ci\u003eWenyan Miao and Lijun Wu\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e21. Pharmacological Modulation of Ion Channels for the Treatment of Chronic Pain (\u003ci\u003eYi Liu and Ning Qin\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e22. Targeting the mTOR Pathway for Tumor Therapeutics (\u003ci\u003eWei Chen\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e23. HIV-1 Protease Inhibitors as Antiretroviral Agents (\u003ci\u003eSergei V. Gulnik, Elena Afonina, and Michael Eissenstat\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eINDEX.\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52276159971608,"sku":"9780470281741","price":137.77,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470281741.jpg?v=1781364626","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/enzyme-inhibition-in-drug-discovery-and-development-the-good-and-the-bad-hardback-9780470281741","provider":"Freshly Printed Books","version":"1.0","type":"link"}