{"product_id":"engineering-polymer-systems-for-improved-drug-delivery-hardback-9781118098479","title":"Engineering Polymer Systems for Improved Drug Delivery (Hardback) 9781118098479","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eEngineering Polymer Systems for Improved Drug Delivery\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eRebecca A. Bader (Author), David A. Putnam (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781118098479, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 11 February 2014\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e496 pages\u003cbr\u003e24.2 x 16.4 x 2.8 cm, 0.78 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePolymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, \u003ci\u003eEngineering Polymer Systems for Improved Drug Delivery\u003c\/i\u003e explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eForeword xi\u003c\/p\u003e \u003cp\u003ePreface xiii\u003c\/p\u003e \u003cp\u003eContributors xv\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Introduction 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Fundamentals of Drug Delivery 3\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eRebecca A. Bader\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction: History and Future of Drug Delivery 3\u003c\/p\u003e \u003cp\u003e1.2 Terminology 5\u003c\/p\u003e \u003cp\u003e1.3 Basic Pharmacokinetics 8\u003c\/p\u003e \u003cp\u003e1.4 Basic Pharmacodynamics 12\u003c\/p\u003e \u003cp\u003e1.5 Mass Transfer 13\u003c\/p\u003e \u003cp\u003e1.6 Key Points 23\u003c\/p\u003e \u003cp\u003e1.7 Homework Problems 23\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Challenges of Drug Delivery 29\u003cbr\u003e \u003c\/b\u003e\u003ci\u003ePatricia R. Wardwell and Rebecca A. Bader\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 29\u003c\/p\u003e \u003cp\u003e2.2 History and Challenges of Drug Delivery 30\u003c\/p\u003e \u003cp\u003e2.3 Physical Barriers 31\u003c\/p\u003e \u003cp\u003e2.4 Metabolic and Chemical Concerns 39\u003c\/p\u003e \u003cp\u003e2.5 Physical Properties of Therapeutics 42\u003c\/p\u003e \u003cp\u003e2.6 Polymer Carriers as a Solution to Challenges 45\u003c\/p\u003e \u003cp\u003e2.7 Key Points 50\u003c\/p\u003e \u003cp\u003e2.8 Homework Problems 50\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Injectable Polymeric Drug Delivery Systems 55\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Polymer–drug Conjugates 57\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eCristina Fante and Francesca Greco\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 57\u003c\/p\u003e \u003cp\u003e3.2 Historical Perspective 58\u003c\/p\u003e \u003cp\u003e3.3 Polymer–Drug Conjugates: Biological Rationale 59\u003c\/p\u003e \u003cp\u003e3.4 Structural Features of Polymer–Drug Conjugates 62\u003c\/p\u003e \u003cp\u003e3.5 Making a Polymer–Drug Conjugate 68\u003c\/p\u003e \u003cp\u003e3.6 Current Challenges and Future Perspectives 71\u003c\/p\u003e \u003cp\u003e3.7 Key Points 75\u003c\/p\u003e \u003cp\u003e3.8 Worked Example 76\u003c\/p\u003e \u003cp\u003e3.9 Homework Problems 76\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Polymeric Microparticles 85\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eNoelle K. Comolli and Colleen E. Clark\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 85\u003c\/p\u003e \u003cp\u003e4.2 The Rationale for Microparticles 86\u003c\/p\u003e \u003cp\u003e4.3 Defining the Design Criteria 87\u003c\/p\u003e \u003cp\u003e4.4 Polymer Selection 89\u003c\/p\u003e \u003cp\u003e4.5 Microparticle Synthesis 91\u003c\/p\u003e \u003cp\u003e4.6 Microparticle Characterization Methods 96\u003c\/p\u003e \u003cp\u003e4.7 Drug Release from Microparticles 100\u003c\/p\u003e \u003cp\u003e4.8 Microparticle Design Examples 108\u003c\/p\u003e \u003cp\u003e4.9 Key Points 110\u003c\/p\u003e \u003cp\u003e4.10 Worked Example 110\u003c\/p\u003e \u003cp\u003e4.11 Homework Problems 111\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Polymeric Nanoparticles 117\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAndrew L. Vasilakes, Thomas D. Dziubla, and Paritosh P. Wattamwar\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 117\u003c\/p\u003e \u003cp\u003e5.2 PNP Design 124\u003c\/p\u003e \u003cp\u003e5.3 PNP Formulation Methods and Targeting 128\u003c\/p\u003e \u003cp\u003e5.4 Nanoparticle Targeting Overview 133\u003c\/p\u003e \u003cp\u003e5.5 PNP Characterization 139\u003c\/p\u003e \u003cp\u003e5.6 Major Clinical Achievements 147\u003c\/p\u003e \u003cp\u003e5.7 Key Points 148\u003c\/p\u003e \u003cp\u003e5.8 Worked Example 149\u003c\/p\u003e \u003cp\u003e5.9 Homework Problems 150\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Block Copolymer Micelles and Vesicles for Drug Delivery 163\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJames D. Robertson, Nisa Patikarnmonthon, Adrian S. Joseph, and Giuseppe Battaglia\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 163\u003c\/p\u003e \u003cp\u003e6.2 Drug Encapsulation and Release 165\u003c\/p\u003e \u003cp\u003e6.3 Bioavailability and Biodistribution 166\u003c\/p\u003e \u003cp\u003e6.4 Stimuli Responsiveness 170\u003c\/p\u003e \u003cp\u003e6.5 The Immune System 174\u003c\/p\u003e \u003cp\u003e6.6 Gene Therapy 177\u003c\/p\u003e \u003cp\u003e6.7 Cancer Therapy 180\u003c\/p\u003e \u003cp\u003e6.8 Conclusions 182\u003c\/p\u003e \u003cp\u003e6.9 Key Points 182\u003c\/p\u003e \u003cp\u003e6.10 Homework Problems 183\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III Implantable Polymeric Drug Delivery Systems 189\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Implantable Drug Delivery Systems 191\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eLuis Solorio, Angela Carlson, Haoyan Zhou, and Agata A. Exner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 191\u003c\/p\u003e \u003cp\u003e7.2 Nondegradable Polymeric Implants 193\u003c\/p\u003e \u003cp\u003e7.3 Biodegradable Polymeric Implants 198\u003c\/p\u003e \u003cp\u003e7.4 Conclusions and Future Perspectives 215\u003c\/p\u003e \u003cp\u003e7.5 Key Points 216\u003c\/p\u003e \u003cp\u003e7.6 Homework Problems 216\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Polymeric Drug Delivery Systems in Tissue Engineering 227\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eMatthew Skiles and James Blanchette\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 227\u003c\/p\u003e \u003cp\u003e8.2 Wound Healing as a Prototype for Adult Tissue Generation 228\u003c\/p\u003e \u003cp\u003e8.3 Bioactive Factors in Tissue Engineering and Regenerative Medicine 232\u003c\/p\u003e \u003cp\u003e8.4 Delivery of Growth Factors in Tissue Engineering and Regenerative Medicine 248\u003c\/p\u003e \u003cp\u003e8.5 Key Points 268\u003c\/p\u003e \u003cp\u003e8.6 Worked Example 269\u003c\/p\u003e \u003cp\u003e8.7 Homework Problems 270\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV Oral Polymeric Drug Delivery Systems 283\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Oral Controlled-release Polymeric Drug Delivery Systems 285\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJames W. McGinity, James C. DiNunzio, and Justin M. Keen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 285\u003c\/p\u003e \u003cp\u003e9.2 Release Mechanisms of Oral Polymeric Dosage Forms 288\u003c\/p\u003e \u003cp\u003e9.3 Oral Polymeric Release Modifiers 295\u003c\/p\u003e \u003cp\u003e9.4 Manufacturing Technologies and Industrial Applications of Controlled Release 297\u003c\/p\u003e \u003cp\u003e9.5 Worked Example 311\u003c\/p\u003e \u003cp\u003e9.6 Key Points 314\u003c\/p\u003e \u003cp\u003e9.7 Homework Problems 314\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Mucoadhesive Drug Delivery Systems 319\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSrinath Muppalaneni, David Mastropietro, and Hossein Omidian\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 319\u003c\/p\u003e \u003cp\u003e10.2 Factors Affecting Mucoadhesion 320\u003c\/p\u003e \u003cp\u003e10.3 Polymer–Mucus Interactions 320\u003c\/p\u003e \u003cp\u003e10.4 Mucoadhesion Mechanisms 322\u003c\/p\u003e \u003cp\u003e10.5 Mucoadhesive Polymers 324\u003c\/p\u003e \u003cp\u003e10.6 Novel Mucoadhesive Materials 327\u003c\/p\u003e \u003cp\u003e10.7 Mucoadhesion Testing 330\u003c\/p\u003e \u003cp\u003e10.8 Drug Release Studies 332\u003c\/p\u003e \u003cp\u003e10.9 Mucoadhesive Dosage Forms 332\u003c\/p\u003e \u003cp\u003e10.10 Conclusion 334\u003c\/p\u003e \u003cp\u003e10.11 Key Points 334\u003c\/p\u003e \u003cp\u003e10.12 Homework Questions 337\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Enhanced Oral Drug Delivery Through Metabolic Pathways 343\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eGregory Russell-Jones\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 343\u003c\/p\u003e \u003cp\u003e11.2 Uptake of Nutrients from the Intestine 344\u003c\/p\u003e \u003cp\u003e11.3 Nutrient Transport in the Intestine 349\u003c\/p\u003e \u003cp\u003e11.4 Use of Nutrient Transporters for Drug Delivery 352\u003c\/p\u003e \u003cp\u003e11.5 Case Study: The Use of the Vitamin B 2 Uptake System for Drug Delivery 352\u003c\/p\u003e \u003cp\u003e11.6 Key Points 365\u003c\/p\u003e \u003cp\u003e11.7 Worked Example 365\u003c\/p\u003e \u003cp\u003e11.8 Homework Problems 366\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V Advanced Polymeric Drug Delivery 375\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Stimuli-responsive Polymer Delivery Systems 377\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAmy Van Hove, Zhanwu Cui, and Danielle S.W. Benoit\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 377\u003c\/p\u003e \u003cp\u003e12.2 Temperature-Responsive Polymers for Drug Delivery 378\u003c\/p\u003e \u003cp\u003e12.3 pH-Responsive Polymers for Drug Delivery 387\u003c\/p\u003e \u003cp\u003e12.4 Reduction\/Oxidation (Redox)-Responsive Polymers 397\u003c\/p\u003e \u003cp\u003e12.5 Enzymatically Responsive Drug Delivery 403\u003c\/p\u003e \u003cp\u003e12.6 Key Points 415\u003c\/p\u003e \u003cp\u003e12.7 Homework Questions 416\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Affinity-based Drug Delivery 429\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAndrew S. Fu and Horst A. von Recum\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 429\u003c\/p\u003e \u003cp\u003e13.2 Association Constant 430\u003c\/p\u003e \u003cp\u003e13.3 Worked Example 432\u003c\/p\u003e \u003cp\u003e13.4 Affinity-Based Drug Delivery Systems 437\u003c\/p\u003e \u003cp\u003e13.5 Mathematical Modeling of Affinity-Based Systems 444\u003c\/p\u003e \u003cp\u003e13.6 Challenges and Future Directions 448\u003c\/p\u003e \u003cp\u003e13.7 Key Points 448\u003c\/p\u003e \u003cp\u003e13.8 Homework Problems 449\u003c\/p\u003e \u003cp\u003eIndex 453\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52417751843096,"sku":"9781118098479","price":90.79,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9781118098479.jpg?v=1784506646","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/engineering-polymer-systems-for-improved-drug-delivery-hardback-9781118098479","provider":"Freshly Printed Books","version":"1.0","type":"link"}