{"product_id":"endocrine-disrupters-hazard-testing-and-assessment-methods-hardback-9780470932094","title":"Endocrine Disrupters; Hazard Testing and Assessment Methods (Hardback) 9780470932094","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eEndocrine Disrupters\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eHazard Testing and Assessment Methods\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003ePeter Matthiessen (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470932094, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 26 April 2013\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e416 pages\u003cbr\u003e24.1 x 16.5 x 2.7 cm, 0.708 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eEnables researchers to assess the effects of endocrine disrupters as well as comply with new environmental regulations\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eEndocrine disrupters are chemicals—both man-made and natural—that interfere with the body's endocrine system, potentially resulting in adverse developmental, reproductive, neurological, and immune effects. In recent years, a number of regulatory authorities around the world have drafted or enacted legislation that requires the detection and assessment of the effects of endocrine disrupters on both humans and wildlife. In response, this book provides comprehensive, up-to-date information on the latest tested and proven methods used to detect and assess the environmental hazards posed by endocrine-disrupting chemicals.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eEndocrine Disrupters\u003c\/i\u003e is divided into chapters covering each major taxon as well as chapters dedicated to hazard assessment and regulation. The book covers testing methods for all the vertebrate groups and several invertebrate phyla, including:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eCrustaceans and mollusks\u003c\/li\u003e \u003cli\u003eInsects\u003c\/li\u003e \u003cli\u003eFish\u003c\/li\u003e \u003cli\u003eAmphibians and reptiles\u003c\/li\u003e \u003cli\u003eBirds and mammals\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eMoreover, the book emphasizes practical, ethical testing methods that combine sensitivity, efficiency, statistical power, and reasonable cost.\u003c\/p\u003e \u003cp\u003eEach chapter is written by one or more international experts in ecotoxicology, offering readers step-by-step guidance for implementing each method based on the latest research and the authors' firsthand laboratory experience. Furthermore, all the chapters have been subjected to a rigorous peer review and edited in light of the reviewers' comments. References at the end of each chapter guide readers to the literature in the field.\u003c\/p\u003e \u003cp\u003e\u003ci\u003eEndocrine Disrupters\u003c\/i\u003e is recommended for scientists who need to test chemicals for possible endocrine-disrupting properties. It is also recommended for regulatory authorities who need to decide whether particular chemicals can be safely marketed.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Ecotoxicity Test Methods for Endocrine-Disrupting Chemicals: An Introduction 1\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePeter Matthiessen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Background 1\u003c\/p\u003e \u003cp\u003e1.2 Regulatory Concerns 2\u003c\/p\u003e \u003cp\u003e1.3 Invertebrates 2\u003c\/p\u003e \u003cp\u003e1.4 Vertebrates 3\u003c\/p\u003e \u003cp\u003e1.5 Testing Schemes for EDCs 5\u003c\/p\u003e \u003cp\u003eReference 6\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Endocrine Disruption inWildlife: Background, Effects, and Implications 7\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eDick Vethaak and Juliette Legler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Background to Endocrine Disruption 8\u003c\/p\u003e \u003cp\u003e2.2 Effects of EDCs on Wildlife 19\u003c\/p\u003e \u003cp\u003e2.3 Weight of Evidence and Ecological Significance of ED Effects 32\u003c\/p\u003e \u003cp\u003e2.4 Implications for Effect Assessment and Toxicity Testing 36\u003c\/p\u003e \u003cp\u003e2.5 Need for More Field Studies and an Integrated Approach 38\u003c\/p\u003e \u003cp\u003e2.6 Concluding Points 39\u003c\/p\u003e \u003cp\u003eReferences 40\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 The Regulatory Need for Tests to Detect EDCs and Assess Their Hazards toWildlife 59\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eHans-Christian Stolzenberg, Tobias Frische, Vicki L. Dellarco, Gary Timm, Anne Gourmelon, Taisen Iguchi, Flemming Ingerslev, and Mike Roberts\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Emerging Concerns and Policy Responses: Focusing on EDCs as a Large Pseudo-Uniform Group of Substances 60\u003c\/p\u003e \u003cp\u003e3.2 General Approaches in Substance-Related Regulatory Frameworks (EU) 80\u003c\/p\u003e \u003cp\u003e3.3 How to Make EDC Definitions Operational for Substance-Related Regulatory Work 87\u003c\/p\u003e \u003cp\u003e3.4 Future Perspectives 91\u003c\/p\u003e \u003cp\u003e3.5 Conclusions 92\u003c\/p\u003e \u003cp\u003eReferences 93\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Techniques for Measuring Endocrine Disruption in Insects 100\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eLennart Weltje\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 100\u003c\/p\u003e \u003cp\u003e4.2 Methods 105\u003c\/p\u003e \u003cp\u003e4.3 Discussion 108\u003c\/p\u003e \u003cp\u003e4.4 Conclusion 110\u003c\/p\u003e \u003cp\u003e4.5 Acknowledgments 110\u003c\/p\u003e \u003cp\u003eReferences 110\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Crustaceans 116\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMagnus Breitholtz\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 116\u003c\/p\u003e \u003cp\u003e5.2 Background to Crustacean Endocrinology 118\u003c\/p\u003e \u003cp\u003e5.3 State of the Art: What Do We Know About Endocrine Disruption in Crustaceans? 121\u003c\/p\u003e \u003cp\u003e5.4 Available Subchronic\/Chronic Standard Test Protocols 128\u003c\/p\u003e \u003cp\u003e5.5 Complementary Tools for Identification of Endocrine Disruption 129\u003c\/p\u003e \u003cp\u003e5.6 Summary and Conclusions 132\u003c\/p\u003e \u003cp\u003eReferences 134\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Endocrine Disruption in Molluscs: Processes and Testing 143\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePatricia D. McClellan-Green\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Background and Introduction 143\u003c\/p\u003e \u003cp\u003e6.2 What Constitutes the Endocrine System in Molluscs? 145\u003c\/p\u003e \u003cp\u003e6.3 End Points and Biomarkers of Endocrine Disruption 154\u003c\/p\u003e \u003cp\u003e6.4 Current Test Methods Using Molluscs 164\u003c\/p\u003e \u003cp\u003e6.5 Proposed Test Methods 167\u003c\/p\u003e \u003cp\u003e6.6 Conclusions 171\u003c\/p\u003e \u003cp\u003eReferences 172\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Using Fish to Detect Endocrine Disrupters and Assess Their Potential Environmental Hazards 185\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePeter Matthiessen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 185\u003c\/p\u003e \u003cp\u003e7.2 International Efforts to Standardize Fish-Based Methods for Screening and Testing Endocrine-Disrupting\u003c\/p\u003e \u003cp\u003e7.3 Fish-Based Screens Developed by OECD for Endocrine-Disrupting Chemicals 189\u003c\/p\u003e \u003cp\u003e7.4 Progress with Developing Fish Partial Life Cycle Tests for Endocrine Disrupters 194\u003c\/p\u003e \u003cp\u003e7.5 Prospects for the Standardization of Fish Full Life Cycle and Multigeneration Tests 195\u003c\/p\u003e \u003cp\u003e7.6 Strengths and Weaknesses of a Hazard Evaluation Strategy Based Partly on Available and Proposed Fish Screens and Tests 197\u003c\/p\u003e \u003cp\u003e7.7 Conclusions 198\u003c\/p\u003e \u003cp\u003eReferences 198\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Screening and Testing for Endocrine-Disrupting Chemicals in Amphibian Models 202\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eDaniel B. Pickford\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 202\u003c\/p\u003e \u003cp\u003e8.2 Potential Uses of Amphibians in Endocrine Disrupter Screening and Testing Programs 203\u003c\/p\u003e \u003cp\u003e8.3 Embryonic Development 205\u003c\/p\u003e \u003cp\u003e8.4 Hatching 208\u003c\/p\u003e \u003cp\u003e8.5 Larval Development 209\u003c\/p\u003e \u003cp\u003e8.6 Higher-Tier Tests with Amphibians 224\u003c\/p\u003e \u003cp\u003e8.7 Other and Emerging Test Methods 227\u003c\/p\u003e \u003cp\u003e8.8 Summary and Conclusions 229\u003c\/p\u003e \u003cp\u003eReferences 232\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Endocrine Disruption and Reptiles: Using the Unique Attributes of Temperature-Dependent Sex Determination to Assess Impacts 245\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eSatomi Kohno and Louis J. Guillette, Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 245\u003c\/p\u003e \u003cp\u003e9.2 Approaches to Examine Effects of EDCs 252\u003c\/p\u003e \u003cp\u003e9.3 Induction of Sex Reversal In Ovo 255\u003c\/p\u003e \u003cp\u003e9.4 Analysis of Sex-Reversed Animals 260\u003c\/p\u003e \u003cp\u003e9.5 Conclusions 265\u003c\/p\u003e \u003cp\u003eReferences 266\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Birds 272\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePaul D. Jones, Markus Hecker, Steve Wiseman, and John P. Giesy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 272\u003c\/p\u003e \u003cp\u003e10.2 Differences Between Birds and Mammals and Among Bird Species 275\u003c\/p\u003e \u003cp\u003e10.3 In Vitro Techniques 278\u003c\/p\u003e \u003cp\u003e10.4 Studies with Embryos 280\u003c\/p\u003e \u003cp\u003e10.5 In Vivo Techniques 280\u003c\/p\u003e \u003cp\u003e10.6 Examples of EDC Effects from Field Studies 285\u003c\/p\u003e \u003cp\u003e10.7 Proposed Two-Generation Test 288\u003c\/p\u003e \u003cp\u003e10.8 Conclusions 291\u003c\/p\u003e \u003cp\u003eReferences 292\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Mammalian Methods for Detecting and Assessing Endocrine-Active Compounds 304\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eM. Sue Marty\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 304\u003c\/p\u003e \u003cp\u003e11.2 Mammalian Tier 1 Screening Assays 306\u003c\/p\u003e \u003cp\u003e11.3 Tier 2 Tests 326\u003c\/p\u003e \u003cp\u003e11.4 Human and Wildlife Relevance of Estrogen, Androgen, and Thyroid Screening Assays 329\u003c\/p\u003e \u003cp\u003e11.5 Potential Future Assays for Endocrine Screening 330\u003c\/p\u003e \u003cp\u003eReferences 332\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Application of the OECD Conceptual Framework for Assessing the Human Health and Ecological Effects of Endocrine Disrupters 341\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eThomas H. Hutchinson, Jenny Odum, and Anne Gourmelon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 342\u003c\/p\u003e \u003cp\u003e12.2 Overview of the OECD Revised CF 343\u003c\/p\u003e \u003cp\u003e12.3 Application of the Klimisch Criteria to the EE2 and VIN Case Studies 346\u003c\/p\u003e \u003cp\u003e12.4 Case Study: Data Examples for 17-Ethynylestradiol 346\u003c\/p\u003e \u003cp\u003e12.5 Case Study: Data Examples for Vinclozolin 357\u003c\/p\u003e \u003cp\u003e12.6 Conclusions 367\u003c\/p\u003e \u003cp\u003eReferences 368\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 The Prospects for Routine Testing of Chemicals for Endocrine-Disrupting Properties and Potential Ecological Impacts 373\u003c\/b\u003e\u003cbr\u003e \u003ci\u003ePeter Matthiessen\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 373\u003c\/p\u003e \u003cp\u003e13.2 Are There Gaps in the Test Suite for EDCs? 374\u003c\/p\u003e \u003cp\u003e13.3 “New” Modes of Endocrine-Disrupting Action 376\u003c\/p\u003e \u003cp\u003e13.4 How Should Tests for EDCs Be Deployed in an Integrated Fashion? 377\u003c\/p\u003e \u003cp\u003e13.5 Use of Weight of Evidence when Assessing Possible EDCs 380\u003c\/p\u003e \u003cp\u003e13.6 Conclusions 382\u003c\/p\u003e \u003cp\u003eReferences 382\u003c\/p\u003e \u003cp\u003eIndex 385\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52278118777112,"sku":"9780470932094","price":98.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470932094.jpg?v=1781458427","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/endocrine-disrupters-hazard-testing-and-assessment-methods-hardback-9780470932094","provider":"Freshly Printed Books","version":"1.0","type":"link"}