{"product_id":"encyclopedia-of-drug-metabolism-and-interactions-6-volume-set-hardback-9780470450154","title":"Encyclopedia of Drug Metabolism and Interactions, 6 Volume Set (Hardback) 9780470450154","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eEncyclopedia of Drug Metabolism and Interactions, 6 Volume Set\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eAlexander V. Lyubimov (Editor-in-chief), AV Lyubimov (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470450154, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 11 December 2012\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e4784 pages\u003cbr\u003e26 x 18.5 x 14.7 cm, 5.724 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e“This one-stop reference brings together information scattered throughout the literature, and it involved the efforts of 270 expert authors from 16 countries — a global endeavor accomplished under the leadership of editor Alexander Lyubimov (pharmacology, The U. of Illinois, Chicago).”  (\u003ci\u003eBook News\u003c\/i\u003e, 1 February 2013)\u003c\/p\u003e \u003cp\u003e\"Summing Up: Recommended.  Graduate students through professionals\/practitioners.”   (\u003ci\u003eChoice\u003c\/i\u003e, 1 March 2013)\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003e“This one-stop reference brings together information scattered throughout the literature, and it involved the efforts of 270 expert authors from 16 countries — a global endeavor accomplished under the leadership of editor Alexander Lyubimov.”\u003c\/i\u003e –Book News Inc., February 2013\u003c\/p\u003e \u003cp\u003e\u003cbr\u003e \u003cbr\u003e The \u003ci\u003eEncyclopedia of Drug Metabolism and Interactions\u003c\/i\u003e provides essential support during all phases of drug development, from drug design to drug action and interaction in patients.\u003c\/p\u003e \u003cp\u003eThis multivolume work covers both preclinical and clinical aspects of drug metabolism and interactions. It also provides a wealth of toxicological, regulatory, and marketing information, all written by leading international experts in the field. Using this reference you’ll discover:\u003c\/p\u003e \u003cp\u003e• Enzymes that can be inhibited or induced and their impact on drug toxicity and altered response in both animal and human models\u003cbr\u003e • Effect of genetic differences and non-genetic factors on drug metabolism\u003cbr\u003e • Balance among drug metabolism, its inactivation\/activation, and its potential toxicity\u003cbr\u003e • Examples demonstrating all aspects of drug metabolism and interactions in silico, in laboratory animals, and in humans\u003cbr\u003e • Methods and detailed protocols enabling you to perform seamless studies of metabolism and drug interactions\u003c\/p\u003e \u003cp\u003eThis reference is essential for researchers interested in all aspects of drug development, and chemists, pharmacologists, pharmaceutical specialists, toxicologists, molecular toxicologists, and clinicians, including practitioners and physicians.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eEnjoy the Online Advantage...\u003cbr\u003e \u003c\/b\u003eThe \u003ci\u003eEncyclopedia of Drug Metabolism and Interactions\u003c\/i\u003e is available online now. For further information visit \u003ca title=\"Encyclopedia of Drug Metabolism and Interactions\" href=\"http:\/\/onlinelibrary.wiley.com\/book\/10.1002\/9780470921920\" target=\"_blank\"\u003ewileyonlinelibrary.com\/ref\/lyubimov\u003c\/a\u003e\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eVOLUME I\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart 1: Basics Overview of Drug Metabolism\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Review of Drug Metabolism in Drug Discovery and Development\u003c\/p\u003e \u003cp\u003eChapter 2 Reactions and Models of Drug Metabolism\u003c\/p\u003e \u003cp\u003eChapter 3 Enzyme kinetics of drug metabolism reactions and drug-drug interactions\u003c\/p\u003e \u003cp\u003eChapter 4 Developmental changes in drug metabolizing enzymes\u003c\/p\u003e \u003cp\u003eChapter 5 Species differences in drug metabolizing enzymes\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II: Enzyme systems involved in drug metabolism and interactions in animals and humans\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 6 Structure and function of cytochrome P450 enzymes\u003c\/p\u003e \u003cp\u003eChapter 7 Mechanism of cytochrome P450 mediated reactions\u003c\/p\u003e \u003cp\u003eChapter 8 Transcriptional regulation of cytochrome P450 enzymes\u003c\/p\u003e \u003cp\u003eChapter 9 Cytochrome P450 polymorphisms\u003c\/p\u003e \u003cp\u003eChapter 10 Flavin monooxygenase\u003c\/p\u003e \u003cp\u003eChapter 11 Molybdenum containing enzymes\u003c\/p\u003e \u003cp\u003eChapter 12 Amine odidases and reductases\u003c\/p\u003e \u003cp\u003eChapter 13 Epoxide hydrolase\u003c\/p\u003e \u003cp\u003eChapter 14 Esterases and amidases\u003c\/p\u003e \u003cp\u003eChapter 15 UDP- glucuronosyltransferases\u003c\/p\u003e \u003cp\u003eChapter 16 Sulfotransferases\u003c\/p\u003e \u003cp\u003eChapter 17 Glutathione S- transferases\u003c\/p\u003e \u003cp\u003eChapter 18 Amino acid conjugation\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVOLUME II\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III: General principals of ADME. Drug transporters and other mechanisms of transport\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Introduction to ADME. Overview\u003c\/p\u003e \u003cp\u003eChapter 2 Anatomical and Physiological Parameters that Influence Gastrointestinal Absorption\u003c\/p\u003e \u003cp\u003eChapter 3 Absorption of drugs into the body\u003c\/p\u003e \u003cp\u003eChapter 4 General principles of drug distribution\u003c\/p\u003e \u003cp\u003eChapter 5 ABC drug transporters and their impact on drug disposition\/drug sensitivity and resistance\u003c\/p\u003e \u003cp\u003eChapter 6 SLC family transporters\u003c\/p\u003e \u003cp\u003eChapter 7 General principles of drug metabolism\u003c\/p\u003e \u003cp\u003eChapter 8 Systems where drug metabolism occurs\u003c\/p\u003e \u003cp\u003eChapter 9 Mass balance studies in animals and humans\u003c\/p\u003e \u003cp\u003eChapter 10 Bioavailability and bioequivalence\u003c\/p\u003e \u003cp\u003eChapter 11 Allometric scaling\u003c\/p\u003e \u003cp\u003eChapter 12 Effect of protein binding in ADME\u003c\/p\u003e \u003cp\u003eChapter 13 Excretion systems\u003c\/p\u003e \u003cp\u003eChapter 14 Pharmacokinetics (PK) and toxicokinetics (TK)\u003c\/p\u003e \u003cp\u003eChapter 15 Experimental design\/mathematical models and data analysis\/interpretation for PK \/TK studies\u003c\/p\u003e \u003cp\u003eChapter 16 Physiologically-Based Pharmacokinetic Modeling\u003c\/p\u003e \u003cp\u003eChapter 17 Pharmacodynamics\u003c\/p\u003e \u003cp\u003eChapter 18 Interrelationships between Pharmacokinetics \/ Pharmacodynamics and metabolism\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV: ADME of some specific groups of drugs and delivery systems\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 19 ADME of herbal and dietary constituents\u003c\/p\u003e \u003cp\u003eChapter 20 ADME of anticancer drugs\u003c\/p\u003e \u003cp\u003eChapter 21 ADME of cardiovascular drugs\u003c\/p\u003e \u003cp\u003eChapter 22 ADME of biological drugs\u003c\/p\u003e \u003cp\u003eChapter 23 ADME of natural toxins\u003c\/p\u003e \u003cp\u003eChapter 24 Metabolism and drug-drug interactions in pregnant mother\/placenta\/fetus\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVOLUME III\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart V: Drug Design and development\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Where and when does drug metabolism enter as a concern?\u003c\/p\u003e \u003cp\u003eChapter 2 Challenges in frontloading toxicity testing of anti- cancer drugs in drug discovery\u003c\/p\u003e \u003cp\u003eChapter 3 Role of ADME for selection of new drug candidates\u003c\/p\u003e \u003cp\u003eChapter 4 Efficient drug development. How to speed up the development process\u003c\/p\u003e \u003cp\u003eChapter 5 Metabolite profiling and identification\u003c\/p\u003e \u003cp\u003eChapter 6 Bioactivation and oxidative stress\u003c\/p\u003e \u003cp\u003eChapter 7 Metabolism in drug safety evaluation\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VI: Methods and protocols for prediction and evaluation of drug metabolism and drug interaction studies\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 8 In silico models of drug metabolism and drug interactions\u003c\/p\u003e \u003cp\u003eChapter 9 Methods for determination of enzyme kinetics and metabolic rates\u003c\/p\u003e \u003cp\u003eChapter 10 Assays and microarrays for metabolic pathways\u003c\/p\u003e \u003cp\u003eChapter 11 Applications using Caco-2 cells and TC7 cells for drug metabolism studies\u003c\/p\u003e \u003cp\u003eChapter 12 In vitro liver systems to study induction\/inhibition. Prediction of in vivo metabolism and drug-drug interactions\u003c\/p\u003e \u003cp\u003eChapter 13 Assessing the Hepatic Disposition and Toxicity of Xenobiotics Using Primary Hepatocytes\u003c\/p\u003e \u003cp\u003eChapter 14 Monoclonal Antibody Based Analyses of Human Drug Metabolism and Multifuctional Cytochromes P450\u003c\/p\u003e \u003cp\u003eChapter 15 Validation of precision- cut slices as a tool to study induction of drug metabolism\u003c\/p\u003e \u003cp\u003eChapter 16 Practical aspects of high throughput solubility and dissolution assessment in preformulation\u003c\/p\u003e \u003cp\u003eChapter 17 Integrated Approaches to Blood Brain Barrier and its role for drug metabolism and interactions\u003c\/p\u003e \u003cp\u003eChapter 18 In vivo models (not genetically modified)\u003c\/p\u003e \u003cp\u003eChapter 19 Using mouse knockout and transgenic models to study metabolism\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVOLUME IV\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart VII: Pharmacology and toxicology\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Introduction. Overview. Role of metabolism in drug toxicity\u003c\/p\u003e \u003cp\u003eChapter 2 Bioactivation I: Phase I (P450)\u003c\/p\u003e \u003cp\u003eChapter 3 Bioactivation II: Phase I (non P450)\u003c\/p\u003e \u003cp\u003eChapter 4 Bioactivation III: Phase II\u003c\/p\u003e \u003cp\u003eChapter 5 Covalent Binding\u003c\/p\u003e \u003cp\u003eChapter 6 MIST\u003c\/p\u003e \u003cp\u003eChapter 7 Cell- based predictors for Toxicities of Metabolites\u003c\/p\u003e \u003cp\u003eChapter 8 Toxicogenomics\u003c\/p\u003e \u003cp\u003eChapter 9 Metabonomics\u003c\/p\u003e \u003cp\u003eChapter 10 Proteomics\u003c\/p\u003e \u003cp\u003eChapter 11 Stereoselectivity in drug metabolism\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART VIII: Influence of physiological conditions, diseases, drug- food interactions, age, sex, and other factors on drug metabolism and effect\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 12 Genetic influence on metabolism\u003c\/p\u003e \u003cp\u003eChapter 13 Drug- Drug interactions 1: Inhibition\u003c\/p\u003e \u003cp\u003eChapter 14 Drug- Drug Interactions 2: Induction\u003c\/p\u003e \u003cp\u003eChapter 15 Ontogeny and Metabolism\u003c\/p\u003e \u003cp\u003eChapter 16 Natural Modulators of Human Drug Metabolism: Dietary supplements and their Clinical Relevance (Food Effects on Toxicity and Pharmacology)\u003c\/p\u003e \u003cp\u003eChapter 17 Idiosyncratic drug interactions\u003c\/p\u003e \u003cp\u003eChapter 18 Influence of inflammatory stress on drug (or xenobiotic) hepatotoxicity\u003c\/p\u003e \u003cp\u003eChapter 19 Regulation of Drug-Metabolizingnzymes and Transporters in Infection, Inflammation, and Cancer\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVOLUME V\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IX: Bioanalytical methods of studying metabolism\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Introduction. Importance of in vivo\/in vitro analytical results in drug development Walter\u003c\/p\u003e \u003cp\u003eChapter 2 General principles of mass spectrometry: LC-MS, LC-MS\/MS, and GC-MS\u003c\/p\u003e \u003cp\u003eChapter 3 Electrospray and Infusion nanospray ionization\u003c\/p\u003e \u003cp\u003eChapter 4 Emerging Atmospheric pressure ionization\u003c\/p\u003e \u003cp\u003eChapter 5 Matrix assisted laser desorption ionization (MALDI)\u003c\/p\u003e \u003cp\u003eChapter 6 Ion trap and quadrupole MS\u003c\/p\u003e \u003cp\u003eChapter 7 Hybrid LTQ- FTMS for Drug Metabolism Applications\u003c\/p\u003e \u003cp\u003eChapter 8 Mass Spectrometry Imaging (MSI)\u003c\/p\u003e \u003cp\u003eChapter 9 Ion Mobility Spectrometry and High Performance Tandem MS for metabolism studies and identification\u003c\/p\u003e \u003cp\u003eChapter 10 Inductively coupled plasma mass spectrometry (ICP MS) for element- containing drug metabolism analysis\u003c\/p\u003e \u003cp\u003eChapter 11 Online Electrochemical LC- MS Techniques for Profiling\u003c\/p\u003e \u003cp\u003eChapter 12 NMR\u003c\/p\u003e \u003cp\u003eChapter 13 Whole body autography and radioactive and non- radioactive isotope assays\u003c\/p\u003e \u003cp\u003eChapter 14 Ligand binding assays (immunoassays)\u003c\/p\u003e \u003cp\u003eChapter 16 Direct plasma analysis systems\u003c\/p\u003e \u003cp\u003eChapter 17 Analytical method development and validation in accordance to the regulatory guidelines\u003c\/p\u003e \u003cp\u003eChapter 18 Leveraging advances in HPLC to maximize DMPK data quality\u003c\/p\u003e \u003cp\u003eChapter 19 Methodologies to Increase Analytical Throughput\u003c\/p\u003e \u003cp\u003eChapter 20 Biomarkers to enable PK\/PD\u003c\/p\u003e \u003cp\u003eChapter 21 Bioanalytics for Human Microdosing\u003c\/p\u003e \u003cp\u003eChapter 22 Bioactivation and Reactive Metabolite Assays\u003c\/p\u003e \u003cp\u003eChapter 23 Plasma protein binding\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVOLUME VI\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart X: Clinical aspects of drug metabolism and interactions\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1 Overview and introduction. Role of drug metabolism and drug interactions in humans\u003c\/p\u003e \u003cp\u003eChapter 2 Human cytochrome P450 enzymes\u003c\/p\u003e \u003cp\u003eChapter 3 DDI Risk Assessment and Evaluation in Clinical Development: Interfacing Drug Metabolism and Clinical Pharmacology\u003c\/p\u003e \u003cp\u003eChapter 4 Current and future tools for predicting clinical drug interactions\u003c\/p\u003e \u003cp\u003eChapter 5 Predicting human biotransformation pathways\u003c\/p\u003e \u003cp\u003eChapter 6 Conjugation, transport, and elimination of drugs in humans\u003c\/p\u003e \u003cp\u003eChapter 7 Role and clinical consequences of human UDP- Glucuronosyltransferases\u003c\/p\u003e \u003cp\u003eChapter 8 Drug\/food and drug\/herb interactions\u003c\/p\u003e \u003cp\u003eChapter 9 Effects of disease on metabolism of drugs in humans\u003c\/p\u003e \u003cp\u003eChapter 10 Role of Phase I metabolism in drug activation and clinical treatment outcomes\u003c\/p\u003e \u003cp\u003eChapter 11 Role of metabolism in toxicity of drugs in humans\u003c\/p\u003e \u003cp\u003eChapter 12 Idiosyncratic drug reactions and the potential role of metabolism\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart XI Metabolism of specific drug groups and patient populations\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 13 Metabolism of psychotropic drugs\u003c\/p\u003e \u003cp\u003eChapter 14 Metabolic-based consequences of polytherapy with AED\u003c\/p\u003e \u003cp\u003eChapter 15 Oral chemotherapeutic agents: Understanding mechanisms of action and drug interactions\u003c\/p\u003e \u003cp\u003eChapter 16 Drug metabolism and interactions in pediatric patients\u003c\/p\u003e \u003cp\u003eChapter 17 Population- based pharmacokinetic modeling and simulation\u003c\/p\u003e \u003cp\u003eChapter 18 Clinical Pharmacology in drug labeling. The impact of drug metabolism and clinical pharmacology on recommended dose of drugs\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52276280918296,"sku":"9780470450154","price":1165.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470450154.jpg?v=1781366121","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/encyclopedia-of-drug-metabolism-and-interactions-6-volume-set-hardback-9780470450154","provider":"Freshly Printed Books","version":"1.0","type":"link"}