{"product_id":"dyneins-dynein-mechanics-dysfunction-and-disease-hardback-9780128094709","title":"Dyneins; Dynein Mechanics, Dysfunction, and Disease (Hardback) 9780128094709","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eDyneins\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eDynein Mechanics, Dysfunction, and Disease\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003e\u003cp\u003eWith its related volume, \u003ci\u003eThe Biology of Dynein Motors\u003c\/i\u003e, this volume provides a definitive view of the largest of the three families of motor proteins\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eStephen M. King (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780128094709\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 28 November 2017\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e530 pages\u003cbr\u003e23.4 x 19 x 3.1 cm, 1.29 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eDyneins: Structure, Biology and Disease, Second Edition, \u003c\/i\u003eoffers a broad view of dyneins mechanics, dysfunction, and disease, providing an overview of dyneins from structure and function, to dysfunction and disease.\u003c\/p\u003e  \u003cp\u003eSince the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development.\u003c\/p\u003e  \u003cp\u003eTo account for these enormous strides, the second edition is extensively revised. Additionally, the coverage has expanded from 24 to 42 chapters, and is now housed in two volumes. Much of the expanded coverage occurs in Volume 2 which focuses on dynein dysfunction and disease, such as the role of dynein and cancer.\u003c\/p\u003e  \u003cp\u003eVolume 1 covers the history and evolution of dyneins, dyneins in ciliary biology, and cytoplasmic dynein biology, while Volume 2 covers the structure and mechanics of dynein motors and dynein dysfunction and disease.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eI. Structure and Mechanics of Dynein Motors \u003c\/b\u003e1. Electron microscopy of isolated dynein complexes and the power stroke mechanism 2. Mechanism and regulation of dynein motors 3. Structural analysis of dynein intermediate and light chains 4. Biochemical purification of axonemal and cytoplasmic dyneins 5. Single molecule dynein motor mechanics in vitro 6. Biophysical properties of dynein in vivo 7. Mechanics of bidirectional cargo transport 8. Chemical probes for dynein 9. Computational modeling of dynein activity and the generation of flagellar beating waveforms\u003c\/p\u003e \u003cp\u003e\u003cb\u003eII. Dynein Dysfunction and Disease \u003c\/b\u003e10. Impacts of virus-mediated manipulation of host dynein 11. Use of mouse genetics to probe cytoplasmic dynein function 12. Cytoplasmic dynein and its regulators in neocortical development and disease 13. Cytoplasmic dynein dysfunction and neurodegenerative disease 14. Dynein dysfunction as a cause of primary ciliary dyskinesia and other ciliopathies 15. Severe skeletal abnormalities caused by defects in retrograde intraflagellar transport dyneins 16. Ciliary dynein dysfunction as a consequence of chronic alcohol exposure 17. Dynein-based motility of pathogenic protozoa 18. Dynein axonemal light chain 4: involvement in congenital mirror movement disorder 19. Does dynein influence the non-Mendelian inheritance of chromosome 17 homologues in male mice?\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Cellular biology [\u003ca title=\"See our other books on Cellular biology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Cellular%20biology%20%5Bcytology%5D%20%5BPSF%5D%22\"\u003ecytology PSF\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46649746129176,"sku":"9780128094709","price":87.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780128094709.jpg?v=1694103279","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/dyneins-dynein-mechanics-dysfunction-and-disease-hardback-9780128094709","provider":"Freshly Printed Books","version":"1.0","type":"link"}