{"product_id":"drug-resistance-in-cancer-mechanisms-and-models-paperback-9780521111706","title":"Drug Resistance in Cancer; Mechanisms and Models (Paperback) 9780521111706","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eDrug Resistance in Cancer\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eMechanisms and Models\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003eAn accessible and sophisticated account of the biological mechanisms of drug resistance in cancer and their mathematical modelling.\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eJames H. Goldie (Author), Andrew J. Coldman (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780521111706, Cambridge University Press\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback, published 11 June 2009\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e256 pages, 22 b\/w illus.  6 tables\u003cbr\u003e22.9 x 15.2 x 1.5 cm, 0.38 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e'… required reading for all trainees in oncology.' Paul P. Carbone, Oncology\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eDrug resistance in cancer, whereby a proportion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly understood and explained in this volume. However, a deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumour growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context. Clearly explained mathematical models are used to illustrate the biological principles and provide an insight into tumour development and the effectiveness and limitations of drug treatment. It is suitable for those with a non-mathematical background and aims to enhance the effectiveness of cancer therapy.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface\u003cbr\u003e 1. The biological basis of cancer and the problem of drug resistance\u003cbr\u003e 2. Tumour growth, stem cells and experimental chemotherapy\u003cbr\u003e 3. Molecular aspects of drug resistance\u003cbr\u003e 4. Quantitative descriptions of the origins of drug resistance\u003cbr\u003e 5. Development and exploration of the random mutation model for drug resistance\u003cbr\u003e 6. Extensions of the random mutation model for drug resistance\u003cbr\u003e 7. Clinical predictions of the random mutation model\u003cbr\u003e 8. Directed versus random mutation and the problem of intrinsic resistance\u003cbr\u003e 9. Some final thoughts on the problem of drug resistance\u003cbr\u003e Index.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Human biology [\u003ca title=\"See our other books on Human biology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Human%20biology%20%5BPSX%5D%22\"\u003ePSX\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Oncology [\u003ca title=\"See our other books on Oncology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Oncology%20%5BMJCL%5D%22\"\u003eMJCL\u003c\/a\u003e], Pre-clinical medicine: basic sciences [\u003ca title=\"See our other books on Pre-clinical medicine: basic sciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pre-clinical%20medicine:%20basic%20sciences%20%5BMF%5D%22\"\u003eMF\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":46006484697368,"sku":"9780521111706","price":49.89,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780521111706i_983157cc-aedc-4460-92c0-f1df3185ac16.jpg?v=1691371212","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/drug-resistance-in-cancer-mechanisms-and-models-paperback-9780521111706","provider":"Freshly Printed Books","version":"1.0","type":"link"}