{"product_id":"drug-discovery-in-cancer-epigenetics-hardback-9780128022085","title":"Drug Discovery in Cancer Epigenetics (Hardback) 9780128022085","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eDrug Discovery in Cancer Epigenetics\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cp\u003eProviding information on putative epigenetic targets, available drugs, tools for drug discovery, and routes for translation\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eGerda Egger (Edited by), Paola Arimondo (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780128022085\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 5 February 2016\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e498 pages, c. 60 color\u003cbr\u003e23.4 x 19 x 3 cm, 1.2 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eDrug Discovery in Cancer Epigenetics\u003c\/i\u003e is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface\u003cbr\u003eI. Introduction \u003cbr\u003e1: Basic Epigenetic Mechanisms and Phenomena\u003cbr\u003e2: Cancer Epigenetics\u003cbr\u003eII. Methods and Tools for Epigenetic Drug Development\u003cbr\u003e3: Drug Discovery Methods\u003cbr\u003e4: Preclinical Cancer Models with the Potential to Predict Clinical Response\u003cbr\u003e5: Discovery of Biomarkers for Drug Development\u003cbr\u003e6: Networks and Consortia for Epigenetic Drug Discovery\u003cbr\u003eIII. Classes of Epigenetic Drugs\u003cbr\u003e7: DNA Methyltransferase Inhibitors\u003cbr\u003e8: Small Molecule Inhibitors of Histone Deacetylases and Acetyltransferases as Potential Therapeutics in Oncology\u003cbr\u003e9: Targeting histone methylation. The development of selective methyltransferase and demethylase inhibitors\u003cbr\u003e10: Bromodomains as Anti-Cancer Targets\u003cbr\u003e11: Epigenetic Readers Interpreting the Lysine Methylome – Biological Roles and Drug Discovery\u003cbr\u003e12: Non coding RNAs: Clinical and Therapeutic Applications\u003cbr\u003eIV. Clinical Implications of Epigenetic Therapy\u003cbr\u003e13: Clinical Applications of Epigenetic Drugs\u003cbr\u003e14: Efficacy of Combined Epigenetic Therapies\u003cbr\u003e15: Predicting and Monitoring Responses to Epigenetic Drugs\u003cbr\u003e16: Episensitization: A New Word for A New Concept\u003cbr\u003e17: The Emerging Potential for Epigenetic Therapeutics in Non-Cancer Disorders\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Oncology [\u003ca title=\"See our other books on Oncology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Oncology%20%5BMJCL%5D%22\"\u003eMJCL\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46648972837144,"sku":"9780128022085","price":103.75,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780128022085_12b6d15d-2947-4574-a205-f113d274ec2b.jpg?v=1694353090","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/drug-discovery-in-cancer-epigenetics-hardback-9780128022085","provider":"Freshly Printed Books","version":"1.0","type":"link"}