{"product_id":"drug-discovery-and-development-volume-2-drug-development-hardback-9780471398479","title":"Drug Discovery and Development, Volume 2; Drug Development (Hardback) 9780471398479","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eDrug Discovery and Development, Volume 2\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eDrug Development\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eMukund S. Chorghade (Edited by), MS Chorghade (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780471398479, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 14 September 2007\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e400 pages\u003cbr\u003e25.6 x 18.5 x 2.8 cm, 0.807 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cb\u003eFrom first principles to real-world applications-here is the first comprehensive guide to drug discovery and development\u003c\/b\u003e  \u003cp\u003eModern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process.\u003c\/p\u003e \u003cp\u003eThe only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and develop-?ment-from initial conceptualization to commercialization to clinicians and medical practitioners.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVolume 1: Drug Discovery\u003c\/b\u003e describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eVolume 2: Drug Development\u003c\/b\u003e delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing-including drug coloring and delivery methods.\u003c\/p\u003e \u003cp\u003eFeaturing contributions from a world-class team of experts, \u003ci\u003eDrug Discovery and Development\u003c\/i\u003e:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eFeatures fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil)\u003c\/li\u003e \u003cli\u003eDiscusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer\u003c\/li\u003e \u003cli\u003eIncludes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eDrug Discovery and Development\u003c\/i\u003e is an indispensable working resource for industrial chemists, biologists, biochemists, and executives who work in the pharmaceutical industry.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cb\u003eContributors.\u003c\/b\u003e  \u003cp\u003e\u003cb\u003ePreface.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Bioactive Molecules in Medicinal Plants: A Perspective on Their Therapeutic Action\u003c\/b\u003e (\u003ci\u003eS. C. Taneja and G. N. Qazi\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e17.1 Introduction.\u003c\/p\u003e \u003cp\u003e17.2 Evolutionary Relationships Among Plants and Humans.\u003c\/p\u003e \u003cp\u003e17.3 Traditional Wisdom.\u003c\/p\u003e \u003cp\u003e17.4 Unique Libraries for Plants.\u003c\/p\u003e \u003cp\u003e17.5 Drugs and Bioactive Molecules from Plants.\u003c\/p\u003e \u003cp\u003e17.6 Synergism in Herbal Formulations.\u003c\/p\u003e \u003cp\u003e17.7 Interactions Between Modern Drugs and Natural Products.\u003c\/p\u003e \u003cp\u003e17.8 Bioavailability and Bioeffi cacy Enhancers.\u003c\/p\u003e \u003cp\u003e17.9 Combination Therapies in Modern Drugs.\u003c\/p\u003e \u003cp\u003e17.10 Role of Developments in Technologies and Analytical Tools.\u003c\/p\u003e \u003cp\u003e17.11 Herbal Medicine: The Best Possible Route to Health Care.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Natural Products as an Inspiration for the Discovery of New High-Throughput Chemical Synthesis Tools\u003c\/b\u003e (\u003ci\u003eSteven V. Ley, Ian R. Baxendale, Deborah A. Longbottom, and Rebecca M. Myers\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e18.1 Introduction.\u003c\/p\u003e \u003cp\u003e18.2 Solid-Supported Reagents as Tools in Natural Product Synthesis.\u003c\/p\u003e \u003cp\u003e18.3 Multistep Use of Supported Reagents in Natural Product Synthesis.\u003c\/p\u003e \u003cp\u003e18.4 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19 Insulin Sensitizers: Emerging Therapeutics\u003c\/b\u003e (\u003ci\u003eBraj B. Lohray and Vidya B. Lohray\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e19.1 Introduction.\u003c\/p\u003e \u003cp\u003e19.2 Therapeutic Interventions.\u003c\/p\u003e \u003cp\u003e19.3 Discovery of Insulin Sensitizers.\u003c\/p\u003e \u003cp\u003e19.4 Journey Toward New Drugs.\u003c\/p\u003e \u003cp\u003e19.5 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20 Criteria for Industrial Readiness of Chiral Catalysis Technology for the Synthesis of Pharmaceuticals\u003c\/b\u003e (\u003ci\u003eRaymond McCague and Ian C. Lennon\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e20.1 Introduction.\u003c\/p\u003e \u003cp\u003e20.2 Criteria for Technology Readiness.\u003c\/p\u003e \u003cp\u003e20.3 Examples of Industrially Ready Chiral Catalytic Technologies and Their Application.\u003c\/p\u003e \u003cp\u003e20.4 How Industrially Ready Technology Can Deliver Commercial Advantages.\u003c\/p\u003e \u003cp\u003e20.5 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21 Enantioselective Synthesis of Propargyl Alcohols as Multifunctional Synthons\u003c\/b\u003e (\u003ci\u003eJ. S. Yadav and S. Chandrasekhar\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e21.1 Introduction, 141\u003c\/p\u003e \u003cp\u003e21.2 Asymmetric Reduction of Prochiral α, β-Alkynyl Ketones, 142\u003c\/p\u003e \u003cp\u003e21.3 Addition of Acetylenic Anion to Carbonyl Carbon, 148\u003c\/p\u003e \u003cp\u003e21.4 Desymmetrization and Enzymatic Strategies for Chiral Propargyl Alcohol Synthesis.\u003c\/p\u003e \u003cp\u003e21.5 β-Elimination Strategy and Miscellaneous Approaches.\u003c\/p\u003e \u003cp\u003e21.6 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22 Carbohydrates: From Chirons to Mimics\u003c\/b\u003e (\u003ci\u003eG. V. M. Sharma and Palakodety Radha Krishna\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e22.1 Introduction.\u003c\/p\u003e \u003cp\u003e22.2 Synthetic Strategies for C-Glycosides.\u003c\/p\u003e \u003cp\u003e22.3 Synthetic Strategies for Carbon-Linked Disaccharides and Pseudosaccharides.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e23 Meeting the Challenges of Process Development and Scale-up of Active Pharmaceutical Ingredients\u003c\/b\u003e (\u003ci\u003eYatendra Kumar and B. Vijayaraghavan\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e23.1 Introduction.\u003c\/p\u003e \u003cp\u003e23.2 Process Development Cycle.\u003c\/p\u003e \u003cp\u003e23.3 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e24 Importance of Polymorphs and Salts in the Pharmaceutical Industry\u003c\/b\u003e (\u003ci\u003eBipin Pandey, Vidya B. Lohray, and Braj B. Lohray\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e24.1 Introduction.\u003c\/p\u003e \u003cp\u003e24.2 Drug Discovery and Development.\u003c\/p\u003e \u003cp\u003e24.3 Salt Selection.\u003c\/p\u003e \u003cp\u003e24.4 Pseudopolymorphs.\u003c\/p\u003e \u003cp\u003e24.5 Analytical Tools.\u003c\/p\u003e \u003cp\u003e24.6 Process Development.\u003c\/p\u003e \u003cp\u003e24.7 Formulation Development.\u003c\/p\u003e \u003cp\u003e24.8 Regulatory Concerns.\u003c\/p\u003e \u003cp\u003e24.9 Patent Implications.\u003c\/p\u003e \u003cp\u003e24.10 Predictions and Uncertainties.\u003c\/p\u003e \u003cp\u003e24.11 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e25 Role of Outsourcing in Drug Manufacture\u003c\/b\u003e (\u003ci\u003ePeter Pollak\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e25.1 Introduction.\u003c\/p\u003e \u003cp\u003e25.2 Outsourcing in the Pharmaceutical Industry.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e26 Regulation-Driven Process Chemistry\u003c\/b\u003e (\u003ci\u003eShrikant V. Kulkarni\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e26.1 Introduction.\u003c\/p\u003e \u003cp\u003e26.2 Chemical Industry Regulatory Guidelines.\u003c\/p\u003e \u003cp\u003e26.3 Manufacturing Techniques in Process Chemistry.\u003c\/p\u003e \u003cp\u003e26.4 Effects of Pesticide Industry Regulation.\u003c\/p\u003e \u003cp\u003e26.5 Efforts at Denitrifi cation.\u003c\/p\u003e \u003cp\u003e26.6 Evolution to Green Chemistry.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e27 Chemical Process Scale-up Tools: Mixing Calculations, Statistical Design of Experiments, and Automated Laboratory Reactors\u003c\/b\u003e (\u003ci\u003eAndrei A. Zlota\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e27.1 Chemical Process Scale-up Challenges.\u003c\/p\u003e \u003cp\u003e27.2 Case Study: Development of an Active Pharmaceutical Ingredient Crystallization Process.\u003c\/p\u003e \u003cp\u003e27.3 Case Study: Determination of a Scale-up Factor for the Bourne III Reactive System.\u003c\/p\u003e \u003cp\u003e27.4 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences and Notes.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e28 Library Quality Metrics\u003c\/b\u003e  (\u003ci\u003eRichard L. Wife and Johan Tijhuis\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e28.1 Drug Discovery and Development.\u003c\/p\u003e \u003cp\u003e28.2 Compound Libraries.\u003c\/p\u003e \u003cp\u003e28.3 Library Metrics.\u003c\/p\u003e \u003cp\u003e28.4 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e29 Tying a GABA from Copenhagen to Chicago: The Chemistry of Tiagabine\u003c\/b\u003e (\u003ci\u003eMukund S. Chorghade, Mahendra N. Deshpande, and Richard J. Pariza\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e29.1 Introduction.\u003c\/p\u003e \u003cp\u003e29.2 Synthesis of Symmetrical Analogs: Tiagabine.\u003c\/p\u003e \u003cp\u003e29.3 Synthesis of Unsymmetrical Analogs: Desmethyltiagabine.\u003c\/p\u003e \u003cp\u003e29.3.1 Syntheses of Regioisomers of Tiagabine.\u003c\/p\u003e \u003cp\u003e29.3.2 Human Metabolite of Tiagabine: 5-Hydroxytiagabine.\u003c\/p\u003e \u003cp\u003e29.4 Attempted Biomimetic Synthesis of 5-Hydroxytiagabine.\u003c\/p\u003e \u003cp\u003e29.5 Oxidative Degradation Products of Tiagabine.\u003c\/p\u003e \u003cp\u003e29.6 Metalloporphyrins as Chemical Mimics of Cytochrome P450 Systems.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e30 Building Contract Research Businesses Based on Integration of Basic and Applied Research\u003c\/b\u003e (\u003ci\u003eMukund S. Chorghade, Mukund K. Gurjar, C. V. Ramana, and Sreenivas Punna\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e30.1 Introduction.\u003c\/p\u003e \u003cp\u003e30.2 Solving Real-World Problems.\u003c\/p\u003e \u003cp\u003e30.3 Synthesis of Pharmaceutically Relevant Chiral Tetrahydrofurans.\u003c\/p\u003e \u003cp\u003e30.4 Drugs for the Treatment of Skin Disorders.\u003c\/p\u003e \u003cp\u003e30.5 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e31 Principles and Practice of Clinical Drug Development\u003c\/b\u003e (\u003ci\u003eColin Scott\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e31.1 Introduction.\u003c\/p\u003e \u003cp\u003e31.2 History of Ethical Medical Research.\u003c\/p\u003e \u003cp\u003e31.3 History of the Regulation of Medical Research.\u003c\/p\u003e \u003cp\u003e31.4 Preclinical Development.\u003c\/p\u003e \u003cp\u003e31.5 Clinical Development.\u003c\/p\u003e \u003cp\u003e31.6 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Interscience","offers":[{"title":"Brand New","offer_id":52293467734296,"sku":"9780471398479","price":96.79,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780471398479.jpg?v=1781640543","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/drug-discovery-and-development-volume-2-drug-development-hardback-9780471398479","provider":"Freshly Printed Books","version":"1.0","type":"link"}