{"product_id":"dopamine-transporters-chemistry-biology-and-pharmacology-hardback-9780470117903","title":"Dopamine Transporters; Chemistry, Biology, and Pharmacology (Hardback) 9780470117903","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eDopamine Transporters\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eChemistry, Biology, and Pharmacology\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eMark L. Trudell (Edited by), ML Trudell (Author), Sari Izenwasser (Edited by), Binghe Wang (Series edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470117903, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 19 August 2008\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e472 pages\u003cbr\u003e23.9 x 15.8 x 2.8 cm, 0.771 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"Much of what will be accomplished in the coming years will require an understanding of the issues and tools presented here. No doubt, those focused on other synaptic transporters will be jealous of this resource and should demand companion volumes.\" (\u003ci\u003eThe Quarterly Review of Biology\u003c\/i\u003e, March 2010)\u003cbr\u003e \u003cbr\u003e   \u003cp\u003e\"The book is well written and the chapters are well illustrated where appropriate. It is a valuable addition to the bookshelf of anyone interested in dopaminergic neurotransmission.\" (\u003ci\u003eJournal of Medicinal Chemistry\u003c\/i\u003e, March 2009)\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eUnderstanding the dopamine transporter can lead to new therapies for neurological disorders  \u003cp\u003eThis book consolidates current information on the dopamine transporter (DAT) in relationto medicinal chemistry and synthesis, biology and pathology, and pharmacology. Because of DAT's role in diseases such as Parkinson's, schizophrenia, attention deficit hyperactivity disorder (ADHD), Tourette syndrome, and drug abuse (in particular, cocaine addiction), DAT research is an exploding field. Tremendous advances have been made toward understanding how it impacts a variety of neurological disease states and disorders.\u003cbr\u003e \u003cbr\u003e This reference provides a broad overview of current knowledge that is detailed enough to furnish a basic understanding of the biological, chemical, and pharmacological aspects of DAT in one comprehensive reference. With contributions from eminent scientists who are experts in their particular areas, \u003ci\u003eDopamine Transporters: Chemistry, Biology, and Pharmacology\u003c\/i\u003e:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eReviews current studies and research in the areas of DAT function, pathological conditions, cloning, molecular structure, and electrochemical characterization\u003c\/li\u003e \u003cli\u003eCovers findings in the medicinal chemistry of DAT-inhibitory ligands and substrates, discussing the chemical syntheses and summarizing the various structure-activity relationships of important classes of dopamine uptake inhibitors and dopamine releasers\u003c\/li\u003e \u003cli\u003eHas chapters that focus on technologies for future DAT study, including imaging and in vivo and in vitro methods\u003c\/li\u003e \u003c\/ul\u003e This is a hands-on reference for researchers, medicinal chemists, pharmacologists, and biologists working with DAT or related proteins and for students in related areas of study.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eContributors.  \u003cp\u003ePreface.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I: Biochemistry and Molecular Biology.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 1: The Dopamine Transporter: An Anatomical Perspective (Hilary R. Smith, Thomas J. Beveridge, Colleen A. Hanlon, Linda J. Porrino).\u003c\/p\u003e \u003cp\u003eChapter 2: Dopamine Transporter, Disease States and Pathology (Deborah C. Mash).\u003c\/p\u003e \u003cp\u003eChapter 3: Cloning and Genetic Analysis of Dopamine Transporters (David J. Vandenbergh).\u003c\/p\u003e \u003cp\u003eChapter 4: Molecular Structure and Composition of Dopamine Transporters (M. Laura Parnas and Roxanne A. Vaughan).\u003c\/p\u003e \u003cp\u003eChapter 5: Electrochemical Characterization of Dopamine Transporters (Evgeny A. Budygin and Sara R. Jones).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II: Medicinal Chemistry.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 6: Tropane-Based Dopamine Transporter-uptake Inhibitors (Scott P. Runyon and F. Ivy Carroll).\u003c\/p\u003e \u003cp\u003eChapter 7: The Benztropines: Atypical Dopamine-Uptake Inhibitors that Provide Clues About Cocaine's Mechanism at the Dopamine Transporter (Amy Hauck Newman and Jonathan L. Katz).\u003c\/p\u003e \u003cp\u003eChapter 8. Structure-Activity Relationship of GBR 12909 Ligands (Thomas E. Prisinzano and Kenner C. Rice).\u003c\/p\u003e \u003cp\u003eChapter 9: Structure-Activity Relationship Study of Piperidine Derivatives for Dopamine Transporters (Prashant S. Kharkar, Maarten E. A. Reith, and Aloke K. Dutta).\u003c\/p\u003e \u003cp\u003eChapter 10: Non-Nitrogen-Containing Dopamine Transporter-Uptake Inhibitors (Peter C. Meltzer).\u003c\/p\u003e \u003cp\u003eChapter 11: Dopamine-Releasing Agents (Bruce E. Blough).\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III: Pharmacology.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eChapter 12: PET\/SPECT Imaging Studies of the Plasma Membrane Dopamine Transporter. (Paul Cumming, Weiguo Ye, Dean F. Wong).\u003c\/p\u003e \u003cp\u003eChapter 13: In Vitro Studies of Dopamine Transporter Function and Regulation (Brian R. Hoover, Bruce H. Mandt and Nancy R. Zahniser).\u003c\/p\u003e \u003cp\u003eChapter 14: In Vivo Studies of Dopamine Transporter Function (Jane B. Acri).\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52257073660184,"sku":"9780470117903","price":100.25,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470117903.jpg?v=1781276293","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/dopamine-transporters-chemistry-biology-and-pharmacology-hardback-9780470117903","provider":"Freshly Printed Books","version":"1.0","type":"link"}