{"product_id":"cyclic-nucleotide-phosphodiesterases-in-the-central-nervous-system-from-biology-to-drug-discovery-hardback-9780470566688","title":"Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System; From Biology to Drug Discovery (Hardback) 9780470566688","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eCyclic-Nucleotide Phosphodiesterases in the Central Nervous System\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eFrom Biology to Drug Discovery\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eNicholas J. Brandon (Edited by), NJ Brandon (Author), Anthony R. West (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470566688, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 8 August 2014\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e408 pages\u003cbr\u003e24.1 x 16.3 x 2.6 cm, 0.726 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThis book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003ePREFACE vii\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eCONTRIBUTORS ix\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 PHOSPHODIESTERASES AND CYCLIC NUCLEOTIDE SIGNALING IN THE CNS 1\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMarco Conti and Wito Richter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 PUTTING TOGETHER THE PIECES OF PHOSPHODIESTERASE DISTRIBUTION PATTERNS IN THE BRAIN: A JIGSAW PUZZLE OF CYCLIC NUCLEOTIDE REGULATION 47\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eMichy P. Kelly\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 COMPARTMENTALIZATION AND REGULATION OF CYCLIC NUCLEOTIDE SIGNALING IN THE CNS 59\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eManuela Zaccolo and Alessandra Stangherlin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 PHARMACOLOGICAL MANIPULATION OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASE SIGNALING FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS IN THE BRAIN 77\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eFrank S. Menniti, Niels Plath, Niels Svenstrup, and Christopher J. Schmidt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 RECENT RESULTS IN PHOSPHODIESTERASE INHIBITOR DEVELOPMENT AND CNS APPLICATIONS 115\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eDavid P. Rotella\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 CRYSTAL STRUCTURES OF PHOSPHODIESTERASES AND IMPLICATION ON DISCOVERY OF INHIBITORS 145\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eHengming Ke, Huanchen Wang, Mengchun Ye, and Yingchun Huang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 INHIBITION OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES TO REGULATE MEMORY 171\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eHan-Ting Zhang, Ying Xu, and James O’Donnell\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 EMERGING ROLE FOR PDE4 IN NEUROPSYCHIATRIC DISORDERS: TRANSLATING ADVANCES FROM GENETIC STUDIES INTO RELEVANT THERAPEUTIC STRATEGIES 211\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eSandra P. Zoubovsky, Nicholas J. Brandon, and Akira Sawa\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 BEYOND ERECTILE DYSFUNCTION: UNDERSTANDING PDE5 ACTIVITY IN THE CENTRAL NERVOUS SYSTEM 223\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eEva P.P. Bollen, Kris Rutten, Olga A.H. Reneerkens, Harry M.W. Steinbusch, and Jos Prickaerts\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 MOLECULAR AND CELLULAR UNDERSTANDING OF PDE10A: A DUAL-SUBSTRATE PHOSPHODIESTERASE WITH THERAPEUTIC POTENTIAL TO MODULATE BASAL\u003c\/b\u003e \u003cb\u003eGANGLIA FUNCTION 247\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eErik I. Charych and Nicholas J. Brandon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 ROLE OF CYCLIC NUCLEOTIDE SIGNALING AND PHOSPHODIESTERASE ACTIVATION IN THE\u003c\/b\u003e\u003cbr\u003e \u003cb\u003eMODULATION OF ELECTROPHYSIOLOGICAL ACTIVITY OF CENTRAL NEURONS 269\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eSarah Threlfell and Anthony R. West\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 THE ROLE OF PHOSPHODIESTERASES IN DOPAMINE SYSTEMS GOVERNING MOTIVATED BEHAVIOR 303\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eGretchen L. Snyder, Joseph P. Hendrick, and Akinori Nishi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 INHIBITION OF PHOSPHODIESTERASES AS A STRATEGY FOR TREATMENT OF SPINAL CORD INJURY 353\u003c\/b\u003e\u003cbr\u003e \u003ci\u003eElena Nikulina and Marie T. Filbin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eINDEX 375\u003c\/i\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52276364312856,"sku":"9780470566688","price":98.59,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470566688.jpg?v=1781367453","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/cyclic-nucleotide-phosphodiesterases-in-the-central-nervous-system-from-biology-to-drug-discovery-hardback-9780470566688","provider":"Freshly Printed Books","version":"1.0","type":"link"}