{"product_id":"chiral-drugs-chemistry-and-biological-action-hardback-9780470587201","title":"Chiral Drugs; Chemistry and Biological Action (Hardback) 9780470587201","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eChiral Drugs\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eChemistry and Biological Action\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eGuo-Qiang Lin (Edited by), GQ Lin (Author), Qi-Dong You (Edited by), Jie-Fei Cheng (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470587201, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 23 September 2011\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e472 pages\u003cbr\u003e24.4 x 16.3 x 3 cm, 0.835 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e““The book can be recommended to all those who are interested in this important and fast-growing field of research at the interface of chemistry, pharmacy, and medicine.”   (\u003ci\u003eChemMedChem\u003c\/i\u003e, 2012)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eAn integrated view of chiral drugs—from concept and synthesisto pharmaceutical properties\u003c\/p\u003e \u003cp\u003eChirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies—asymmetric synthesis, biocatalytic process, and chiral resolution—to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with:\u003c\/p\u003e \u003cul\u003e \u003cli\u003e \u003cp\u003eThe history of chiral drugs development and industrial applications of chiral technologies\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eA section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references\u003c\/p\u003e \u003c\/li\u003e \u003cli\u003e \u003cp\u003eAn interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology\u003c\/p\u003e \u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eNearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective—and safer—drugs.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cb\u003eABOUT THE EDITORS vii\u003c\/b\u003e  \u003cp\u003e\u003cb\u003eCONTRIBUTORS ix\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eINTRODUCTION 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 OVERVIEW OF CHIRALITY AND CHIRAL DRUGS 3\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eGuo-Qiang Lin, Jian-Ge Zhang, and Jie-Fei Cheng\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 CHIRAL DRUGS THROUGH ASYMMETRIC SYNTHESIS 29\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eGuo-Qiang Lin and Xing-Wen Sun\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 CHIRAL DRUGS VIA BIOCATALYTICAL APPROACHES 77\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJianqiang Wang and Wenya Lu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 RESOLUTION OF CHIRAL DRUGS 137\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eQi-Dong You\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 FLUORINE-CONTAINING CHIRAL DRUGS 195\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eXiao-Long Qiu, Xuyi Yue, and Feng-Ling Qing\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 INDUSTRIAL APPLICATION OF CHIRAL TECHNOLOGIES 253\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eHui-Yin (Harry) Li, Rui Liu, Carl Behrens, and Chao-Ying Ni\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 STRUCTURAL BASIS AND COMPUTATIONAL MODELING OF CHIRAL DRUGS 297\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDeping Wang and Eric Hu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 PHARMACOLOGY OF CHIRAL DRUGS 323\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eYongge Liu and Xiao-Hui Gu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 PHARMACOKINETICS OF CHIRAL DRUGS 347\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eHanqing Dong, Xiaochuan Guo and Zengbiao Li\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 TOXICOLOGY OF CHIRAL DRUGS 381\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eGuang Yang and Hai-Zhi Bu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 REPRESENTATIVE CHIRAL DRUGS 401\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJiangqin Sun, Dingguo Liu, and Zhimin Wang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eINDEX 449\u003c\/b\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52276367196440,"sku":"9780470587201","price":106.36,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470587201.jpg?v=1781367767","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/chiral-drugs-chemistry-and-biological-action-hardback-9780470587201","provider":"Freshly Printed Books","version":"1.0","type":"link"}