{"product_id":"chemical-synthesis-of-hormones-pheromones-and-other-bioregulators-paperback-softback-9780470697238","title":"Chemical Synthesis of Hormones, Pheromones and Other Bioregulators (Paperback \/ softback) 9780470697238","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eChemical Synthesis of Hormones, Pheromones and Other Bioregulators\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eKenji Mori (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470697238, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 13 August 2010\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e320 pages\u003cbr\u003e24.1 x 18.8 x 1.8 cm, 0.612 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"This volume will reward the attention of anyone interested in organic synthesis, in natural products chemistry, or in chemical ecology. It should inspire more synthetic organic chemists to pay attention to current research on the roles played by small molecules in the lives of organisms, and it should encourage biologists and structural chemists to identify, contact, and collaborate with chemical colleagues who are mentally and physically equipped to carry out stereospecific syntheses of nature's signal molecules.\"  \u003ci\u003e(\u003c\/i\u003e\u003ci\u003eJournal of the American Chemical Society\u003c\/i\u003e, 23 February 2011)\u003cbr\u003e \u003cbr\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eMany small molecules occur naturally as \"messenger\" chemicals which regulate the behaviour and functions of microbes, plants, insects and animals. Examples include hormones, pheromones, phytoalexins, and antifeedants. These biofunctional molecules are of great interest to researchers in helping develop our understanding of biological function and in the development of new drugs. However extracting them from nature can be prohibitively expensive, so there is great interest in devising methods of synthesising them from simple starting materials in the laboratory.  \u003cp\u003e\u003ci\u003eChemical Synthesis of Hormones, Pheromones and Other Bioregulators\u003c\/i\u003e is an introduction to the techniques and strategies for the synthesis of biofunctional small molecules. Topics include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003ewhat are biofunctional molecules?\u003c\/li\u003e \u003cli\u003ewhy must biofunctional molecules be synthesized?\u003c\/li\u003e \u003cli\u003ehow can we synthesize biofunctional molecules?\u003c\/li\u003e \u003cli\u003ethe synthesis of phytohormones, phytoalexins and other biofunctional molecules of plant origin\u003c\/li\u003e \u003cli\u003ethe synthesis of insect juvenile hormones and antifeedants\u003c\/li\u003e \u003cli\u003ethe synthesis of pheromones and the significance of chirality in pheromone science\u003c\/li\u003e \u003cli\u003ethe synthesis of microbial hormones and pheromones, antibiotics, and other biofunctional molecules of microbial origin\u003c\/li\u003e \u003cli\u003ethe synthesis of marine antifeedants and medicinal candidates\u003c\/li\u003e \u003cli\u003ea synthetic examination of incorrectly proposed structures of biomolecules\u003c\/li\u003e \u003cli\u003ereflections on science as a human endeavor\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eDrawing on a career of almost 50 years researching and teaching this subject, Kenji Mori's \u003ci\u003eChemical Synthesis of Hormones, Pheromones and Other Bioregulators\u003c\/i\u003e is a must-have textbook for students and researchers of organic synthesis and natural products, and a stimulating and inspiring account of a distinguished chemical career.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface.  \u003cp\u003eAbbreviations.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction—Biofunctional Molecules and Organic Synthesis.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 What are biofunctional molecules?\u003c\/p\u003e \u003cp\u003e1.2 Developmental stages of studies on biofunctional molecules.\u003c\/p\u003e \u003cp\u003e1.3 Small amounts of the samples are now sufficient for the elucidation of the structures of biofunctional molecules.\u003c\/p\u003e \u003cp\u003e1.4 Why must biofunctional molecules be synthesized?\u003c\/p\u003e \u003cp\u003e1.5 How can we synthesize biofunctional molecules?\u003c\/p\u003e \u003cp\u003e1.5.1 What is synthesis?\u003c\/p\u003e \u003cp\u003e1.5.2 What kind of consideration is necessary before starting a synthesis?\u003c\/p\u003e \u003cp\u003e1.5.3 Synthon.\u003c\/p\u003e \u003cp\u003e1.5.4 Molecular symmetry and synthesis.\u003c\/p\u003e \u003cp\u003e1.5.5 Criteria for 'A Good Synthesis'.\u003c\/p\u003e \u003cp\u003e1.6 What kind of knowledge and techniques are necessary to synthesize biofunctional molecules?\u003c\/p\u003e \u003cp\u003e1.6.1 Stereochemistry and reactivity.\u003c\/p\u003e \u003cp\u003e1.6.2 Stereochemistry and analytical methods.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Synthesis of Phytohormones, Phytoalexins and Other Biofunctional Molecules of Plant Origin.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Phytohormones.\u003c\/p\u003e \u003cp\u003e2.1.1 What are phytohormones?\u003c\/p\u003e \u003cp\u003e2.1.2 Gibberellins.\u003c\/p\u003e \u003cp\u003e2.1.3 Diterpenes related to gibberellins.\u003c\/p\u003e \u003cp\u003e2.1.4 Abscisic acid and its relatives—synthesis of optically active compounds.\u003c\/p\u003e \u003cp\u003e2.1.5 Brassinosteroids.\u003c\/p\u003e \u003cp\u003e2.1.6 Phyllanthrinolactone, a leaf-closing factor.\u003c\/p\u003e \u003cp\u003e2.2 Phytoalexins.\u003c\/p\u003e \u003cp\u003e2.2.1 What are phytoalexins?\u003c\/p\u003e \u003cp\u003e2.2.2 Synthesis of pisatin.\u003c\/p\u003e \u003cp\u003e2.2.3 Synthesis of 2-(4-hydroxyphenyl)naphthalene-1,8-dicarboxylic anhydride.\u003c\/p\u003e \u003cp\u003e2.2.4 Synthesis of oryzalexins 53\u003c\/p\u003e \u003cp\u003e2.2.5 Synthesis of phytocassanes.\u003c\/p\u003e \u003cp\u003e2.3 Plant allelochemicals.\u003c\/p\u003e \u003cp\u003e2.3.1 Synthesis of glycinoeclepin A.\u003c\/p\u003e \u003cp\u003e2.3.2 Synthesis of strigolactones.\u003c\/p\u003e \u003cp\u003e2.4 Other bioactive compounds of plant origin.\u003c\/p\u003e \u003cp\u003e2.4.1 Synthesis of arnebinol.\u003c\/p\u003e \u003cp\u003e2.4.2 Synthesis of magnosalicin.\u003c\/p\u003e \u003cp\u003e2.4.3 Synthesis of hernandulcin.\u003c\/p\u003e \u003cp\u003e2.4.4 Synthesis of \u003ci\u003eO\u003c\/i\u003e-methyl pisiferic acid.\u003c\/p\u003e \u003cp\u003e2.4.5 Synthesis of diospyrin.\u003c\/p\u003e \u003cp\u003e2.4.6 Synthesis of mispyric acid.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Synthesis of Insect Bioregulators Other than Pheromones.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Insect juvenile hormones.\u003c\/p\u003e \u003cp\u003e3.1.1 What are insect hormones?\u003c\/p\u003e \u003cp\u003e3.1.2 Synthesis of juvabione.\u003c\/p\u003e \u003cp\u003e3.1.3 Synthesis of the racemates of juvenile hormones.\u003c\/p\u003e \u003cp\u003e3.1.4 Synthesis of the enantiomers of juvenile hormones.\u003c\/p\u003e \u003cp\u003e3.2 Insect antifeedants.\u003c\/p\u003e \u003cp\u003e3.2.1 Synthesis of polygodial.\u003c\/p\u003e \u003cp\u003e3.2.2 Synthesis of warburganal.\u003c\/p\u003e \u003cp\u003e3.2.3 Synthesis of 3,4-dihydroxypropiophenone 3-β-d-glucopyranoside.\u003c\/p\u003e \u003cp\u003e3.2.4 Synthesis of homogynolide A.\u003c\/p\u003e \u003cp\u003e3.3 Insect repellents.\u003c\/p\u003e \u003cp\u003e3.3.1 Synthesis of rotundial.\u003c\/p\u003e \u003cp\u003e3.3.2 Synthesis of polyzonimine.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Synthesis of Pheromones.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 What are pheromones?\u003c\/p\u003e \u003cp\u003e4.2 Methods for enantioselective synthesis.\u003c\/p\u003e \u003cp\u003e4.2.1 Derivation from enantiopure natural products.\u003c\/p\u003e \u003cp\u003e4.2.2 Enantiomer separation (optical resolution).\u003c\/p\u003e \u003cp\u003e4.2.3 Asymmetric synthesis.\u003c\/p\u003e \u003cp\u003e4.2.4 Determination of enantiomeric purity.\u003c\/p\u003e \u003cp\u003e4.3 Why is it meaningful to synthesize enantiopure pheromones?\u003c\/p\u003e \u003cp\u003e4.3.1 Determination of absolute configuration (1). trogodermal.\u003c\/p\u003e \u003cp\u003e4.3.2 Determination of absolute configuration (2). hemiacetal pheromone of \u003ci\u003eBiprorulus bibax\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e4.3.3 Determination of absolute configuration (3). sesquiterpene pheromone of \u003ci\u003eEysarcoris lewisi\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e4.3.4 Clarification of the relationship between absolute configuration and pheromone activity—\u003ci\u003eexo\u003c\/i\u003e-brevicomin.\u003c\/p\u003e \u003cp\u003e4.3.5 Clarification of structure (1). lineatin.\u003c\/p\u003e \u003cp\u003e4.3.6 Clarification of structure (2). American cockroach pheromone.\u003c\/p\u003e \u003cp\u003e4.3.7 Clarification of structure (3). acoradiene.\u003c\/p\u003e \u003cp\u003e4.3.8 Clarification of structure (4). himachalene-type pheromone.\u003c\/p\u003e \u003cp\u003e4.3.9 Preparation of a pure sample for bioassay (1). disparlure.\u003c\/p\u003e \u003cp\u003e4.3.10 Preparation of a pure sample for bioassay (2). japonilure.\u003c\/p\u003e \u003cp\u003e4.3.11 Preparation of a pure sample for bioassay (3). pheromone of the palaearctic bee, \u003ci\u003eAndrena wilkella\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e4.4 Chiral pheromones whose single enantiomers show bioactivity.\u003c\/p\u003e \u003cp\u003e4.4.1 Dihydroactinidiolide, a pheromone component of the red imported fire ant.\u003c\/p\u003e \u003cp\u003e4.4.2 Lardolure, the aggregation pheromone of the acarid mite.\u003c\/p\u003e \u003cp\u003e4.4.3 Pheromone of the fall webworm moth.\u003c\/p\u003e \u003cp\u003e4.4.4 Posticlure, the female sex pheromone of \u003ci\u003eOrgyia postica\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e4.4.5 Faranal, the trail pheromone of the pharaoh's ant.\u003c\/p\u003e \u003cp\u003e4.4.6 (1\u003ci\u003eS\u003c\/i\u003e,3\u003ci\u003eS\u003c\/i\u003e,7\u003ci\u003eR\u003c\/i\u003e)-3-Methyl-α-himachalene, the male sex pheromone of the sandfly from Jacobina, Brazil.\u003c\/p\u003e \u003cp\u003e4.4.7 (\u003ci\u003eS\u003c\/i\u003e )-9-Methylgermacrene-B, the male sex pheromone of the sandfly from Lapinha, Brazil.\u003c\/p\u003e \u003cp\u003e4.4.8 (1\u003ci\u003eS\u003c\/i\u003e,5\u003ci\u003eR\u003c\/i\u003e)-Frontalin, the bark beetle pheromone.\u003c\/p\u003e \u003cp\u003e4.4.9 (1\u003ci\u003eR\u003c\/i\u003e,5\u003ci\u003eS\u003c\/i\u003e,7\u003ci\u003eR\u003c\/i\u003e)-3,4-Dehydro-\u003ci\u003eexo\u003c\/i\u003e-brevicomin and (\u003ci\u003eS\u003c\/i\u003e )-2-\u003ci\u003esec\u003c\/i\u003e-butyl-4,5-dihyrothiazole, the pheromone components of the male mouse.\u003c\/p\u003e \u003cp\u003e4.5 Chiral pheromones whose stereochemistry–bioactivity relationships are diverse and complicated.\u003c\/p\u003e \u003cp\u003e4.5.1 Sulcatol, the pheromone of \u003ci\u003eGnathotrichus sulcatus\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e4.5.2 Sex pheromone components of female German cockroach.\u003c\/p\u003e \u003cp\u003e4.5.3 Stigmolone, the pheromone of a myxobacterium \u003ci\u003eStigmatella aurantiaca\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e4.5.4 Ipsenol and ipsdienol, pheromones of \u003ci\u003eIps\u003c\/i\u003e bark beetles.\u003c\/p\u003e \u003cp\u003e4.5.5 Serricornin, the cigarette beetle pheromone.\u003c\/p\u003e \u003cp\u003e4.5.6 Stegobinone, the drugstore beetle pheromone.\u003c\/p\u003e \u003cp\u003e4.5.7 Supellapyrone, the sex pheromone of the brownbanded cockroach.\u003c\/p\u003e \u003cp\u003e4.5.8 Olean, the sex pheromone of the olive fruit fly.\u003c\/p\u003e \u003cp\u003e4.5.9 13,23-Dimethylpentatriacontane as the sex pheromone of a tsetse fly.\u003c\/p\u003e \u003cp\u003e4.6 Significance of chirality in pheromone science.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Synthesis of Biofunctional Molecules of Microbial Origin.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Microbial hormones.\u003c\/p\u003e \u003cp\u003e5.1.1 A-factor.\u003c\/p\u003e \u003cp\u003e5.1.2 Sch II and relatives, the fruiting-inducing cerebrosides.\u003c\/p\u003e \u003cp\u003e5.1.3 Basidifferquinone C.\u003c\/p\u003e \u003cp\u003e5.1.4 Sclerosporin.\u003c\/p\u003e \u003cp\u003e5.1.5 Sporogen-AO.\u003c\/p\u003e \u003cp\u003e5.1.6 Differolide.\u003c\/p\u003e \u003cp\u003e5.2 Antibiotics.\u003c\/p\u003e \u003cp\u003e5.2.1 Ascochlorin.\u003c\/p\u003e \u003cp\u003e5.2.2 Ascofuranone.\u003c\/p\u003e \u003cp\u003e5.2.3 Trichostatin A.\u003c\/p\u003e \u003cp\u003e5.2.4 Koninginin A.\u003c\/p\u003e \u003cp\u003e5.2.5 Cytoxazone.\u003c\/p\u003e \u003cp\u003e5.2.6 Neuchromenin.\u003c\/p\u003e \u003cp\u003e5.2.7 Nocardione A and B.\u003c\/p\u003e \u003cp\u003e5.2.8 Cytosporone E.\u003c\/p\u003e \u003cp\u003e5.3 Other bioactive metabolites of micro-organisms.\u003c\/p\u003e \u003cp\u003e5.3.1 Monocerin.\u003c\/p\u003e \u003cp\u003e5.3.2 Pinthunamide.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Synthesis of Marine Bioregulators, Medicinals and Related Compounds.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Marine natural products of ecological importance such as antifeedants.\u003c\/p\u003e \u003cp\u003e6.1.1 Stypoldione.\u003c\/p\u003e \u003cp\u003e6.1.2 \u003ci\u003emeso\u003c\/i\u003e- and (±)-Limatulone.\u003c\/p\u003e \u003cp\u003e6.1.3 Testudinariol A.\u003c\/p\u003e \u003cp\u003e6.1.4 Stellettadine A.\u003c\/p\u003e \u003cp\u003e6.2 Marine natural products of medicinal interest.\u003c\/p\u003e \u003cp\u003e6.2.1 Punaglandin 4.\u003c\/p\u003e \u003cp\u003e6.2.2 Bifurcarenone.\u003c\/p\u003e \u003cp\u003e6.2.3 Elenic acid.\u003c\/p\u003e \u003cp\u003e6.2.4 Symbioramide.\u003c\/p\u003e \u003cp\u003e6.2.5 Penazetidine A.\u003c\/p\u003e \u003cp\u003e6.2.6 Penaresidin A and B.\u003c\/p\u003e \u003cp\u003e6.2.7 Sulfobacin A, B and flavocristamide A.\u003c\/p\u003e \u003cp\u003e6.2.8 Plakoside A.\u003c\/p\u003e \u003cp\u003e6.3 Glycosphingolipids and sphingolipids of medical interest.\u003c\/p\u003e \u003cp\u003e6.3.1 Esterified cerebroside of human and pig epidermis.\u003c\/p\u003e \u003cp\u003e6.3.2 Ceramide B, 6-hydroxylated ceramide in human epidermis.\u003c\/p\u003e \u003cp\u003e6.3.3 KRN7000, a glycosphingolipid that stimulates natural killer T cell.\u003c\/p\u003e \u003cp\u003e6.3.4 Analogs of KRN7000 prepared in 2003–2006.\u003c\/p\u003e \u003cp\u003e6.3.5 Cyclitol, carbasugar and modified d-galactose analogs of KRN7000: RCAI-56 and RCAI-61.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Synthetic Examination of Incorrectly Proposed Structures of Biomolecules.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Origin of incorrect or obscure structures.\u003c\/p\u003e \u003cp\u003e7.2 Structure fabrications of historical interest.\u003c\/p\u003e \u003cp\u003e7.2.1 Kogl's auxin-a and -b, the plant-growth promoters.\u003c\/p\u003e \u003cp\u003e7.2.2 Chemical communication system of the green flagellate, \u003ci\u003eChlamydomonas\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e7.2.3 Early fabrications of the structures of insect pheromones.\u003c\/p\u003e \u003cp\u003e7.3 Incorrect structures resulting from inappropriate use of purification or analytical methods.\u003c\/p\u003e \u003cp\u003e7.4 Inappropriate structural proposal caused by problems in bioassay methods.\u003c\/p\u003e \u003cp\u003e7.4.1 Blattellastanoside A and B, putative components of the aggregation pheromone of the German cockroach.\u003c\/p\u003e \u003cp\u003e7.4.2 2,2,4,4-Tetramethyl-\u003ci\u003eN\u003c\/i\u003e,\u003ci\u003eN\u003c\/i\u003e-bis(2,6-dimethylphenyl)cyclobutane-1,3-diimine as a putative antifeedant against the cotton boll weevil.\u003c\/p\u003e \u003cp\u003e7.5 Human errors are inevitable in chemistry, too.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Conclusion—Science as a Human Endeavor.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Small molecules are also beautiful.\u003c\/p\u003e \u003cp\u003e8.2 Continuous efforts may bring something meaningful.\u003c\/p\u003e \u003cp\u003e8.3 Can a scientist eventually have a hope in the future?\u003c\/p\u003e \u003cp\u003eAcknowledgements.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand 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