{"product_id":"catalysis-in-asymmetric-synthesis-hardback-9781405190916","title":"Catalysis in Asymmetric Synthesis (Hardback) 9781405190916","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eCatalysis in Asymmetric Synthesis\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eVittorio Caprio (Author), Jonathan M. J. Williams (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781405190916, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 2 January 2009\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e408 pages\u003cbr\u003e23.6 x 16 x 2.8 cm, 0.717 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003e\u003ci\u003eCatalysis in Asymmetric Synthesis,\u003c\/i\u003e 2nd Edition\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eAsymmetric synthesis has become a major aspect of modern organic chemistry. The stereochemical properties of an organic compound are often essential to its bioactivity, and the need for stereochemically pure pharmaceutical products is a key example of the importance of stereochemical control in organic synthesis. However, achieving high levels of stereoselectivity in the synthesis of complex natural products represents a considerable intellectual and practical challenge for chemists.\u003c\/p\u003e \u003cp\u003eWritten from a synthetic organic chemistry perspective, this text provides a practical overview of the field, illustrating a wide range of transformations that can be achieved. The book captures the latest advances in asymmetric catalysis with emphasis placed on non-enzymatic methods.\u003c\/p\u003e \u003cp\u003eTopics covered include:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eReduction of alkenes, ketones and imines\u003c\/li\u003e \u003cli\u003eNucleophilic addition to carbonyl compounds\u003c\/li\u003e \u003cli\u003eCatalytic carbon-carbon bond forming reactions\u003c\/li\u003e \u003cli\u003eCatalytic reactions involving metal carbenoids\u003c\/li\u003e \u003cli\u003eConjugate addition reactions\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eCatalysis in Asymmetric Synthesis\u003c\/i\u003e bridges the gap between undergraduate and advanced level textbooks and provides a convenient point of entry to the primary literature for the experienced synthetic organic chemist.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface to the Second Edition.  \u003cp\u003ePreface to the First Edition.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Introduction.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Reactions Amenable to Asymmetric Catalysis.\u003c\/p\u003e \u003cp\u003e1.2 Assignment of (R) and (S) Stereochemical Descriptors.\u003c\/p\u003e \u003cp\u003eFuther Reading.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Reduction of Alkenes.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Asymmetric Hydrogenation with Rhodium Complexes.\u003c\/p\u003e \u003cp\u003e2.2 Asymmetric Hydrogenation with Ruthenium Catalysts.\u003c\/p\u003e \u003cp\u003e2.3 Alkene Hydrogenation with Titanium and Zirconium Catalysts.\u003c\/p\u003e \u003cp\u003e2.4 Alkene Hydrogenation with Iridium Catalysts.\u003c\/p\u003e \u003cp\u003e2.5 Alkene Hydrogenation with Organocatalysts.\u003c\/p\u003e \u003cp\u003e2.6 Alkene Hydrosilylation.\u003c\/p\u003e \u003cp\u003e2.7 Alkene Hydroboration.\u003c\/p\u003e \u003cp\u003e2.8 Hydroamination.\u003c\/p\u003e \u003cp\u003e2.9 Hydroformylation.\u003c\/p\u003e \u003cp\u003e2.10 Hydroacylation of Alkenes.\u003c\/p\u003e \u003cp\u003e2.11 Hydrocyanation of Alkenes.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Reduction of Ketones and Imines.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Hydrogenation of Ketones.\u003c\/p\u003e \u003cp\u003e3.2 Hydrogenation and Transfer Hydrogenation of Imines and Related Compounds.\u003c\/p\u003e \u003cp\u003e3.3 Transfer Hydrogenation of Ketones.\u003c\/p\u003e \u003cp\u003e3.4 Heterogeneous Hydrogenation.\u003c\/p\u003e \u003cp\u003e3.5 Reduction of Ketones Using Enantioselective Borohydride Reagents.\u003c\/p\u003e \u003cp\u003e3.6 Hydrosilylation of Ketones.\u003c\/p\u003e \u003cp\u003e3.7 Hydrosilylation of Imines and Nitrones.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Epoxidation.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Epoxidation of Allylic Alcohols.\u003c\/p\u003e \u003cp\u003e4.2 Epoxidation with Metal(salen) Complexes.\u003c\/p\u003e \u003cp\u003e4.3 Epoxidation Using Metal–Porphyrin-Based Catalysts.\u003c\/p\u003e \u003cp\u003e4.4 OtherMetal-Catalysed Epoxidations of Unfunctionalised Olefins.\u003c\/p\u003e \u003cp\u003e4.5 Epoxidation of Electron-Deficient Alkenes.\u003c\/p\u003e \u003cp\u003e4.6 Epoxidation with Iminium Salts.\u003c\/p\u003e \u003cp\u003e4.7 Epoxidation with Ketone Catalysts.\u003c\/p\u003e \u003cp\u003e4.8 Epoxidation of Aldehydes.\u003c\/p\u003e \u003cp\u003e4.9 Aziridination of Alkenes.\u003c\/p\u003e \u003cp\u003e4.10 Aziridination of Imines.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Further Oxidation Reactions.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Dihydroxylation.\u003c\/p\u003e \u003cp\u003e5.2 Aminohydroxylation.\u003c\/p\u003e \u003cp\u003e5.3 α-Heterofunctionalisation of Aldehydes and Ketones.\u003c\/p\u003e \u003cp\u003e5.4 Oxidation of C–H.\u003c\/p\u003e \u003cp\u003e5.5 Baeyer–Villiger Oxidation.\u003c\/p\u003e \u003cp\u003e5.6 Oxidation of Sulfides.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Nucleophilic Addition to Carbonyl Compounds.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Addition of Organozincs to Carbonyl Compounds.\u003c\/p\u003e \u003cp\u003e6.2 Addition of Cyanide to Aldehydes and Ketones.\u003c\/p\u003e \u003cp\u003e6.3 Allylation of Aldehydes.\u003c\/p\u003e \u003cp\u003e6.4 Hydrophosphonylation of Aldehydes.\u003c\/p\u003e \u003cp\u003e6.5 Nucleophilic Additions to Imines.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 The Aldol and Related Reactions.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 The Aldol Reaction.\u003c\/p\u003e \u003cp\u003e7.2 Isocyanide and Related Aldol Reactions.\u003c\/p\u003e \u003cp\u003e7.3 The Nitroaldol Reaction.\u003c\/p\u003e \u003cp\u003e7.4 Addition of Enolates to Imines.\u003c\/p\u003e \u003cp\u003e7.5 Darzens Condensation.\u003c\/p\u003e \u003cp\u003e7.6 Morita–Baylis–Hillman Reaction.\u003c\/p\u003e \u003cp\u003e7.7 Carbonyl-Ene Reactions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Cycloadditions.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Diels–Alder Reactions.\u003c\/p\u003e \u003cp\u003e8.2 Inverse Electron Demand Diels–Alder Reactions.\u003c\/p\u003e \u003cp\u003e8.3 Hetero-Diels–Alder Reactions.\u003c\/p\u003e \u003cp\u003e8.4 1,3-Dipolar Cycloaddition Reactions.\u003c\/p\u003e \u003cp\u003e8.5 [2+2] Cycloadditions.\u003c\/p\u003e \u003cp\u003e8.6 Pauson–Khand-Type Reactions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Catalytic Reactions Involving Carbenes and Ylides.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Cyclopropanation.\u003c\/p\u003e \u003cp\u003e9.2 Insertion Reactions.\u003c\/p\u003e \u003cp\u003e9.3 Asymmetric Ylide Reactions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Catalytic Carbon–Carbon Bond-Forming Reactions.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Cross-Coupling Reactions.\u003c\/p\u003e \u003cp\u003e10.2 Metal-Catalysed Allylic Substitution.\u003c\/p\u003e \u003cp\u003e10.3 Heck Reactions.\u003c\/p\u003e \u003cp\u003e10.4 Alkylmetalation of Alkenes.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Conjugate Addition Reactions.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Conjugate Addition of Enolates.\u003c\/p\u003e \u003cp\u003e11.2 Conjugate Addition of Sulfur Nucleophiles.\u003c\/p\u003e \u003cp\u003e11.3 Conjugate Addition of Nonstabilised Nucleophiles.\u003c\/p\u003e \u003cp\u003e11.4 Conjugate Addition with Nitrogen-Based Nucleophiles and Electrophiles.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Further Catalytic Reactions.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Isomerisations and Rearrangements.\u003c\/p\u003e \u003cp\u003e12.2 Deprotonation Reactions.\u003c\/p\u003e \u003cp\u003e12.3 Protonation Reactions.\u003c\/p\u003e \u003cp\u003e12.4 Alkylation and Allylation of Enolates.\u003c\/p\u003e \u003cp\u003e12.5 Formation of Alkenes.\u003c\/p\u003e \u003cp\u003e12.6 Oxyselenylation-Elimination Reactions.\u003c\/p\u003e \u003cp\u003e12.7 The Benzoin Condensation.\u003c\/p\u003e \u003cp\u003e12.8 Ester Formation and Hydrolysis.\u003c\/p\u003e \u003cp\u003e12.9 Ring-Opening of Epoxides.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003eIndex.\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Brand 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