{"product_id":"cancer-metastasis-biologic-basis-and-therapeutics-hardback-9780521887212","title":"Cancer Metastasis; Biologic Basis and Therapeutics (Hardback) 9780521887212","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eCancer Metastasis\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eBiologic Basis and Therapeutics\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003eThis text, written by internationally renowned authors, describes the processes underlying cancer metastasis and the clinical treatment of metastatic disease.\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eDavid Lyden (Edited by), Danny R.  Welch (Edited by), Bethan Psaila (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780521887212, Cambridge University Press\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 25 April 2011\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e660 pages, 87 b\/w illus.  76 colour illus.  40 tables\u003cbr\u003e28.7 x 22.3 x 3.1 cm, 2.05 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"As tumor metastasis remains the main cause of cancer-related death, this is  a timely book that brings together scientists and clinicians to address this  issue. An important feature is the way it gives equal emphasis to basic and  clinical research, succeeding in showing how basic research contributes to  better treatment for cancer patients, and how the clinical aspects of  metastasis help direct basic research.\"  \u003cbr\u003eHidayatullah G.  Munshi, MD, Doody's Review Service\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eMetastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eOverview: biology is the foundation of therapy\u003cbr\u003e Part I. Basic Research: Introduction to basic research\u003cbr\u003e Section 1. Models and Tools for Metastasis Studies: 1. Animal models of cancer metastasis\u003cbr\u003e 2. Drosophila and zebrafish: genetic models for cancer metastasis\u003cbr\u003e 3. Computational models\u003cbr\u003e 4. Intravital microscopy to visualize invasion and metastasis\u003cbr\u003e Section 2. Genes: 5. Metastasis-promoting genes\u003cbr\u003e 6. The role of metastasis suppressor genes in metastasis\u003cbr\u003e 7. Stromal-derived factors that dictate organ-specific metastasis\u003cbr\u003e 8. Metastasis genes: epigenetics\u003cbr\u003e 9. Germline variation and other host determinants of metastatic potential\u003cbr\u003e 10. The influence of aging and cellular senescence on metastasis\u003cbr\u003e Section 3. Various Properties of Cancer Cells: 11. The continuum of epithelial mesenchymal transition - implication of hybrid states for migration and survival in development and cancer\u003cbr\u003e 12. Apoptosis, anoikis, and senescence\u003cbr\u003e 13. Metastatic inefficiency and tumor dormancy\u003cbr\u003e Section 4. Stromal Cells\/Extracellular Matrix: 14. Role of inflammation in metastatic progression\u003cbr\u003e 15. Proteolytic cascades in invasion and metastasis\u003cbr\u003e 16. Role of matrix metalloproteinases in tumor invasion and metastasis\u003cbr\u003e 17. Cell-derived microvesicles and metastasis\u003cbr\u003e Section 5. Systemic Factors: 18. Exploring the earliest steps in metastasis: the pre-metastatic niche\u003cbr\u003e 19. Growth regulatory pathways contributing to organ selectivity of metastasis\u003cbr\u003e 20. Determinants of organ-specific metastasis\u003cbr\u003e 21. Function and expression of the uPA\/uPAR system in cancer metastasis\u003cbr\u003e 22. The lymphatics: on the route to cancer metastasis\u003cbr\u003e Part II. Clinical Research: 23. Introduction to clinical research\u003cbr\u003e 24. Sarcoma\u003cbr\u003e 25. Neuroblastoma\u003cbr\u003e 26. Retinoblastoma\u003cbr\u003e 27. Primary brain tumors and cerebral metastases\u003cbr\u003e 28. Head and neck cancer metastasis\u003cbr\u003e 29. Cutaneous melanoma: therapeutic approaches for metastatic disease\u003cbr\u003e 30. Gastric cancer metastasis\u003cbr\u003e 31. Metastatic pancreatic cancer\u003cbr\u003e 32. Metastasis of primary liver cancer\u003cbr\u003e 33. Advances in management of metastatic colorectal cancer\u003cbr\u003e 34. Lung cancer metastasis\u003cbr\u003e 35. Metastatic thyroid cancer: evaluation and treatment\u003cbr\u003e 36. Metastatic renal cell carcinoma\u003cbr\u003e 37. Bladder cancer\u003cbr\u003e 38. Bone complications of myeloma and lymphoma\u003cbr\u003e 39. Breast metastasis\u003cbr\u003e 40. Gynecologic malignancies\u003cbr\u003e 41. Prostate cancer metastasis: thoughts on biology and therapeutics\u003cbr\u003e 42. The biology and treatment of metastatic testicular cancer\u003cbr\u003e 43. Applications of proteomics to metastasis diagnosis and individualized therapy\u003cbr\u003e 44. Critical issues of research on circulating and disseminated tumor cells in cancer patients\u003cbr\u003e 45.  Lymphatic mapping and sentinel lymph node biopsy\u003cbr\u003e 46. Molecular imaging and metastasis\u003cbr\u003e 47. Preserving bone health in malignancy and complications of bone metastases\u003cbr\u003e 48. Role of platelets and thrombin in metastasis\u003cbr\u003e Section 6. Therapies: 49. Cancer nanotechnology offers great promise for cancer research and therapy\u003cbr\u003e 50. Metronomic chemotherapy for treatment of metastatic disease: from preclinical research to clinical trials\u003cbr\u003e 51. Immunotherapy\u003cbr\u003e 52. Discovery and development of drugs targeting tumor invasion and metastasis\u003cbr\u003e 53. The role of radiotherapy in the treatment of metastatic disease\u003cbr\u003e 54. Prospects for clinical trials of metastasis inhibitors.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Oncology [\u003ca title=\"See our other books on Oncology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Oncology%20%5BMJCL%5D%22\"\u003eMJCL\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":46265351635224,"sku":"9780521887212","price":119.35,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780521887212i.jpg?v=1692022026","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/cancer-metastasis-biologic-basis-and-therapeutics-hardback-9780521887212","provider":"Freshly Printed Books","version":"1.0","type":"link"}