{"product_id":"cancer-drug-design-and-discovery-hardback-9780123965219","title":"Cancer Drug Design and Discovery (Hardback) 9780123965219","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eCancer Drug Design and Discovery\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cp\u003eThe second edition of this authoritative reference features the latest on the design and development of new anticancer small molecules, including topics such as the identification of molecular targets, cancer genomics, personalized medicine and more.\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eStephen Neidle (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123965219\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 5 December 2013\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e640 pages, 50 illustrations\u003cbr\u003e23.4 x 19 x 3.5 cm, 1.55 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\"…offers unique information on the discovery and design of new anticancer agents, covering recent notable successes resulting from the human genome and cancer genomics projects…an excellent reference for translational researchers interested in cancer biology and medicine as well as students in pharmacy, pharmacology, or medicinal and biological chemistry…\" --\u003cb\u003eAnticancer Research 34, 2014\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\"The second edition of this book walks readers through the myriad cancer drugs and their molecular targets, with a special emphasis on past, present, and future drug design efforts... the book examines both drugs currently in the clinic and those merely on the drawing board…This comprehensive update of the 2008 edition will serve student or experienced cancer researchers well as a reference on anticancer drug development.\" Rating: 4 Stars --\u003cb\u003eDoody.com, March 21, 2014\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\"Specialists in cancer and pharmaceuticals, most in academic settings, look at basic principles of cancer drugs, methodology, drugs in the clinic, new agents, and the reality of cancer drugs in the clinic…They do include many case studies, and some chapters provide questions for classroom use.\" --\u003cb\u003eProtoView.com, February 2014\u003c\/b\u003e \u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eCancer Drug Design and Discovery, Second Edition\u003c\/i\u003e is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are now approved for human use and are in the marketplace, as well as those that are still under development. By highlighting some of the general principles involved in taking molecules through basic science to clinical development, this book offers a complete and authoritative reference on the design and discovery of anticancer drugs for translational scientists and clinicians involved in cancer research.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eIntroduction - Stephen Neidle\u003c\/p\u003e \u003cp\u003eForeword - Hilary Calvert\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I. Basic Principles and methodology\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eModern cancer drug discovery: integrating targets, technologies and treatments — Paul Workman and Ian Collins\u003c\/p\u003e \u003cp\u003ePharmacogenomics and personalised medicines in cancer treatment — Wei-Peng Yong, Ross Soo and Federico Innocenti\u003c\/p\u003e \u003cp\u003eStructural biology and anticancer drug design — Puja Pathuri, David Norton, Henriette Willems, Dominic Tisi and Harren Jhoti\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II. Drugs in the laboratory and clinic\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eTemozolomide: from cytotoxic to molecularly-targeted agent — Malcolm Stevens\u003c\/p\u003e \u003cp\u003eTemozolomide: patents and the perils of invention — Malcolm Stevens\u003c\/p\u003e \u003cp\u003eA new generation of cell-targeted drugs for cancer treatment — Paola B. Arimondo, Nicolas Guilbaud and Christian Bailly\u003c\/p\u003e \u003cp\u003eInhibition of DNA repair as a therapeutic target — Stephany Veuger and Nicola J Curtin Inhibitors of tumour angiogenesis — Adrian L. Harris and Daniele G Generali\u003c\/p\u003e \u003cp\u003eThe Renaissance of CYP17 Inhibitors for the Treatment of Prostate Cancer — Qingzhong Hu and Rolf W. Hartmann\u003c\/p\u003e \u003cp\u003eApoptosis in Cancer: Mechanisms, Deregulation and Therapeutic Targeting — Zahid H Siddik\u003c\/p\u003e \u003cp\u003eTargeting the MDM2-p53 protein-protein interaction: design, discovery and development of novel anticancer agents — Ian R Hardcastle\u003c\/p\u003e \u003cp\u003eTargeting altered metabolism – emerging cancer therapeutic strategy — Minsuh Seo, Robert Blake Crochet and Yong-Hwan Lee\u003c\/p\u003e \u003cp\u003eInhibitors of the Phosphatidylinositol 3-kinase (PI3K) Pathway — William A Denny and Gordon W. Rewcastle\u003c\/p\u003e \u003cp\u003eAntibody-drug conjugates delivering DNA cytotoxics — John A Hartley\u003c\/p\u003e \u003cp\u003eInhibition of telomerase: promise, progress and potential pitfalls — Christopher G. Tomlinson, Scott B. Cohen and Tracy M. Bryan\u003c\/p\u003e \u003cp\u003eTargeting B-RAF: the discovery and development of B-RAF inhibitors — Phillip A Harris\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III. The reality of cancer drugs in the clinic\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003eFailure Modes in Anticancer Drug Discovery and Development — Richard A. Walgren and Christopher. A. Slapak\u003c\/p\u003e \u003cp\u003eAnticancer drug registration and regulation: current challenges and possible solutions — David Taylor, Erling Donnelly and Silvia Chioato\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Oncology [\u003ca title=\"See our other books on Oncology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Oncology%20%5BMJCL%5D%22\"\u003eMJCL\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46648849072408,"sku":"9780123965219","price":84.69,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123965219_6975ffa4-1f49-4254-8cf9-1f36c8ccb43c.jpg?v=1694352184","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/cancer-drug-design-and-discovery-hardback-9780123965219","provider":"Freshly Printed Books","version":"1.0","type":"link"}