{"product_id":"calcium-oxygen-radicals-and-cellular-damage-paperback-9780521057615","title":"Calcium, Oxygen Radicals and Cellular Damage (Paperback \/ softback) 9780521057615","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eCalcium, Oxygen Radicals and Cellular Damage\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eA description of the biochemical processes that occur during cellular damage of specific organs; for example, what happens to the cells during heart attacks, strokes and muscular dystrophy.\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eC. J. Duncan (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780521057615, Cambridge University Press\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 28 January 2008\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e240 pages, 67 b\/w illus.  9 tables\u003cbr\u003e22.9 x 15.4 x 1.5 cm, 0.396 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"...a timely reminder of the much-needed research effort in this area.\"   John M. C. Gutteridge, Quarterly Review of Biology\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThe cellular events underlying rapid cellular damage in different organs are potentially of great medical importance, for example muscular dystrophy, liver damage and the preservation of kidneys for transplantation. Many hypotheses exist for the biochemical pathways involved in these damage processes. The roles of calcium and active oxygen metabolites are of particular interest. There is considerable literature on both these triggering agents and good evidence for their involvement in the genesis of damage, although little agreement on their precise roles. This volume records the proceedings of a meeting held by the Society for Experimental Biology that attempted to determine whether there are common mechanisms of cellular damage and to explore the ways in which calcium and oxygen radicals may interact to generate damage. The questions addressed, in particular, are whether there are any common biochemical pathways, and the specific and possibly interacting roles of calcium and active oxygen metabolites.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e1. Are there common biochemical pathways in cell damage and cell death? C. J. Duncan\u003cbr\u003e 2. Free radicals in the pathogenesis of tissue damage M. J. Jackson\u003cbr\u003e 3. Calcium and signal transduction in oxidative cell damage P. Nicotera, G. E. N. Kass, S. K. Duddy and S. Orrenius\u003cbr\u003e 4. Regulation of neutrophil oxidant production S. W. Edwards\u003cbr\u003e 5. Reperfusion arrhythmias: role of oxidant stress M. J. Shattock, H. Matsuura and D. J. Hearse\u003cbr\u003e 6. Biochemical pathways that lead to the release of cytosolic proteins in the perfused rat heart C. J. Duncan\u003cbr\u003e 7. Malignant hyperthermia: the roles of free radicals and calcium? J. R. Arthur and G. G. Duthie\u003cbr\u003e 8. Free radicals, calcium and damage in dystrophic and normal skeletal muscle M. J. Jackson, A. McArdle and R. H. T. Edwards\u003cbr\u003e 9. Ultrastructural changes in mitochondria during rapid damage triggered by calcium C. J. Duncan and N. Shamsadeen\u003cbr\u003e 10. The importance of oxygen free radicals, iron and calcium in renal ischaemia J. D. Gower, L. A. Cotterill and C. J. Green\u003cbr\u003e 11. The Rubicon Hypothesis: a quantal framework for understanding the molecular pathway of cell activation and injury A. K. Campbell.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Cellular biology [\u003ca title=\"See our other books on Cellular biology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Cellular%20biology%20%5Bcytology%5D%20%5BPSF%5D%22\"\u003ecytology PSF\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":46006291169560,"sku":"9780521057615","price":34.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780521057615i.jpg?v=1694968936","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/calcium-oxygen-radicals-and-cellular-damage-paperback-9780521057615","provider":"Freshly Printed Books","version":"1.0","type":"link"}