{"product_id":"brucella-melitensis-identification-and-characterization-of-potential-drug-targets-paperback-9780323856812","title":"Brucella Melitensis; Identification and Characterization of Potential Drug Targets (Paperback \/ softback) 9780323856812","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eBrucella Melitensis\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eIdentification and Characterization of Potential Drug Targets\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003eShows the potential of bioinformatic tools in the identification of virulence targets for pathogenic bacteria and viruses, B.militensis 16M in particular\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eJangampalli Adi Pradeepkiran (Edited by), S.B. Sainath (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780323856812, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 25 February 2021\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e200 pages, 25 illustrations (15 in full color)\u003cbr\u003e22.9 x 15.1 x 1.4 cm, 0.41 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eBrucella Miletensis: Identification and Characterization of Potential Drug Targets\u003c\/i\u003e presents a systematic approach to identifying and characterizing drug targets using bioinformatics. The book shows the potential of bioinformatic tools in the identification of virulence targets in pathogenic bacteria and viruses, in general, and in B. militensis 16M in particular. Chapters identify putative genes as potential drug targets, employ a subtractive genomic approach, consider the virulent genes of this bacteria that negatively affects humans, list twelve potential virulence genes as drug targets, and consider the screening of potential drugs against the bacteria’s virulence genes through molecular modeling, computational screening, drug discovery and molecular docking studies. \u003c\/p\u003e  \u003cp\u003eIn addition, the book demonstrates in silico approaches that offer insights into the identification of drug targets in B.melitensis 16M. The title employs a step-by-step approach to understanding drug targets by identifying and characterizing vaccine targets for Brucella melitensis, in silico screening, and the identification of novel drug targets from the total Brucella melitensis proteome. Other sections cover computational modeling and evaluation of the best potential drug targets through comparative modeling, molecular docking, and dynamics simulations of novel drug targets and in silico validation and ADMET analysis for best lead molecules. \u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e1. Introduction to Brucellosis 2. Identification and characterization of vaccine targets for Brucella melitensis through in silico approaches 3. Computational modeling and evaluation of best potential drug targets through comparative modeling 4. Molecular docking and dynamics simulations of novel drug targets 5. In silico validation and ADMET analysis for best lead molecules 6. Summary and Conclusions\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46650820690200,"sku":"9780323856812","price":116.85,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780323856812.jpg?v=1694992286","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/brucella-melitensis-identification-and-characterization-of-potential-drug-targets-paperback-9780323856812","provider":"Freshly Printed Books","version":"1.0","type":"link"}