{"product_id":"blood-substitutes-hardback-9780127597607","title":"Blood Substitutes (Hardback) 9780127597607","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eBlood Substitutes\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eBrings together current information about O2-carriers, or Blood Substitutes and how they are designed to be used in place of red blood cell transfusions\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eRobert M. Winslow (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780127597607, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 5 October 2005\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e576 pages\u003cbr\u003e27.8 x 21 x 3.3 cm, 1.94 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"Robert Winslow's new book Blood Substitutes, is useful in many ways. It brings together well-written summaries of the work of many of the most important investigators of the last 2 decades in the broad group of interrelated fields. Moreover, it also has some excellent chapters of scientific and medical background that provide context for the work. It also gives a historical snapshot of the thinking and attitudes of workers in the field. As an introduction to the field, this book is outstanding.\" \u003cb\u003e--John R. Hess MD, MPH, FACPa, University of Maryland Medical Center for TRANSFUSION MEDICINE REVIEWS (2006)\u003c\/b\u003e\"There aren't too many all in one books on this subject, let alone one written this clearly, concisely, and with perspective. If you are interested in this field, get this book.\" \u003cb\u003e--Doody's 3 Star Review by Valerie L. Ng, PhD, MD, Alameda County Medical Center\/Highland Hospital (2006)\u003c\/b\u003e\"This is a serious, comprehensive, authoritative and highly readable textbook on a most relevant and challenging topic – the search for blood substitutes. ...The Editor and publishers have clearly given considerable thought to the readability as well as the academic rigour of the 46 chapters and 548 pages. In this reviewer’s opinion, they have been most successful. The font and the page layouts are easy on the eye, the illustrations of good quality, and the references for each chapter are comprehensive and up to date. The potential readership for this book will undoubtedly be broadly based. This is a quality text book, and, although it is always difficult to define quality, we do recognise it when we come across it.\"\u003cb\u003e --Professor Ken Taylor, British Heart Foundation Professor of Cardiac Surgery, University of London and Director of Cardiac Services, Hammersmith Hospital, London, UK\u003c\/b\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eBlood substitutes are solutions designed for use in patients who need blood transfusions, but for whom whole blood is not available, or is not safe. This interest has intensified in the wake of the AIDS and hepatitis C epidemics. \u003cb\u003eBlood Substitutes\u003c\/b\u003e describes the rationale, current approaches, clinical efficacy, and design issues for all blood substitutes now in clinical trials. The many summary diagrams and tables help make the book accessible to readers such as surgeons and blood bankers, who have less technical expertise than the biochemists and hematologists who are designing and testing blood substitutes.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eSection 1: Background\u003c\/p\u003e \u003cp\u003eIntroduction\u003c\/p\u003e \u003cp\u003eChapter 1: Historical Background\u003c\/p\u003e \u003cp\u003eChapter 2: Transfusion Medicine\u003c\/p\u003e \u003cp\u003eChapter 3: Regulatory Perspectives on Clinical Trials for Oxygen Therapeutics in Trauma and Transfusion Practice\u003c\/p\u003e \u003cp\u003eSection 2: Physiological Basis\u003c\/p\u003e \u003cp\u003eIntroduction\u003c\/p\u003e \u003cp\u003eChapter 4: Clinical Physiology: Oxygen Transport and the Transfusion Trigger\u003c\/p\u003e \u003cp\u003eChapter 5: The Role of Oxygen and Hemoglobin Diffusion in Oxygen Transport by Cell-free Hemoglobins\u003c\/p\u003e \u003cp\u003eChapter 6: Oxygen Transport Properties of Hemoglobin-Based Oxygen Carriers: Studies using Artificial Capillaries and Mathematical Simulation\u003c\/p\u003e \u003cp\u003eChapter 7: Mechanisms of Oxygen Transport in the Microcirculation: Effects of Cell-Free Oxygen Carriers\u003c\/p\u003e \u003cp\u003eChapter 8: Shear Stress Mechanotransduction and the Flow Properties of Blood\u003c\/p\u003e \u003cp\u003eChapter 9: Local Regulation of Blood Flow\u003c\/p\u003e \u003cp\u003eSection 3: Clinical Applications\u003c\/p\u003e \u003cp\u003eIntroduction\u003c\/p\u003e \u003cp\u003eChapter 10: Clinical Indications for Blood Substitutes and Optimal Properties\u003c\/p\u003e \u003cp\u003eChapter 11: Crystalloid Solutions\u003c\/p\u003e \u003cp\u003eChapter 12: Hemoglobin-Based Oxygen Carriers as Resuscitative Solutions for Trauma and Combat Casualty Care\u003c\/p\u003e \u003cp\u003eChapter 13: Surgical Hemorrhage\u003c\/p\u003e \u003cp\u003eChapter 14: Clinical Trials in Cardiac Surgery\u003c\/p\u003e \u003cp\u003eChapter 15: Hemodilution\u003c\/p\u003e \u003cp\u003eChapter 16: Clinical Hemodilution\u003c\/p\u003e \u003cp\u003eChapter 17: Potential for Blood Substitutes in Tissue Ischemia\u003c\/p\u003e \u003cp\u003eSection 4: Toxicity and Side Effects\u003c\/p\u003e \u003cp\u003eIntroduction\u003c\/p\u003e \u003cp\u003eChapter 18: Redox and Radical Reactions of Hemoglobin Solutions: Toxicities and Protective Strategies\u003c\/p\u003e \u003cp\u003eChapter 19: Pro-Oxidant Activity of Hemoglobin and Endothelial Cytotoxicity\u003c\/p\u003e \u003cp\u003eChapter 20: Renal Toxicity\u003c\/p\u003e \u003cp\u003eChapter 21: Hemoglobin and Neurotoxicity\u003c\/p\u003e \u003cp\u003eChapter 22: The Role of Inflammation in the Toxicity of Hemoglobin-Based Oxygen Carriers\u003c\/p\u003e \u003cp\u003eChapter 23: Hemoglobin-Induced Myocardial Lesions\u003c\/p\u003e \u003cp\u003eSection 5: Perfluorocarbon-Based Oxygen Carriers\u003c\/p\u003e \u003cp\u003eIntroduction\u003c\/p\u003e \u003cp\u003eChapter 24: Fluorocarbon Emulsions as in vivo Oxygen Delivery Systems: Background and Chemistry\u003c\/p\u003e \u003cp\u003eChapter 25: Fluosol®: The First Commercial Injectable Perfluorocarbon Oxygen Carrier\u003c\/p\u003e \u003cp\u003eChapter 26: Perftoran®\u003c\/p\u003e \u003cp\u003eChapter 27: Rational Development of Oxyfluor™\u003c\/p\u003e \u003cp\u003eChapter 28: Oxygent™, a Perfluorochemical-Based Oxygen Therapeutic for Surgical Patients\u003c\/p\u003e \u003cp\u003eSection 6: Hemoglobin-Based Oxygen Carriers\u003c\/p\u003e \u003cp\u003eIntroduction\u003c\/p\u003e \u003cp\u003eChapter 29: The Structural and Functional Properties of Hemoglobin and their Relevance for a Hemoglobin-Based Blood Substitute\u003c\/p\u003e \u003cp\u003eChapter 30: Hemoglobin Modification\u003c\/p\u003e \u003cp\u003eChapter 31: Designing Recombinant Hemoglobin for Use as a Blood Substitute\u003c\/p\u003e \u003cp\u003eChapter 32: Design, Conformational, Functional and Physiological Characterization of Recombinant Polymeric Heme-Proteins\u003c\/p\u003e \u003cp\u003eChapter 33: aa-Crosslinked Hemoglobin\u003c\/p\u003e \u003cp\u003eChapter 34: DCLHb and rHb1.1\u003c\/p\u003e \u003cp\u003eChapter 35: Clinical Studies with DCLHb\u003c\/p\u003e \u003cp\u003eChapter 36: Hemopure® (HBOC-201, Hemoglobin Glutamer-250 (Bovine)): Preclinical Studies\u003c\/p\u003e \u003cp\u003eChapter 37: HBOC-201 (Hemoglobin Glutamer-250 (Bovine), Hemopure®): Clinical Studies\u003c\/p\u003e \u003cp\u003eChapter 38: Polyhemoglobin–Enzymes as New-Generation Blood Substitutes and Oxygen Therapeutics\u003c\/p\u003e \u003cp\u003eChapter 39: Surface Decoration of Hemoglobin with Polyethylene Glycol\u003c\/p\u003e \u003cp\u003eChapter 40: Hemospan® (MP4), A Human Hemoglobin Modified with Maleimide-Polyethylene Glycol\u003c\/p\u003e \u003cp\u003eChapter 41: Dextran–Hemoglobin\u003c\/p\u003e \u003cp\u003eChapter 42: Development of Non-Extravasating Hemoglobin-Based Oxygen Carriers\u003c\/p\u003e \u003cp\u003eSection 7: Liposomes and Related Products\u003c\/p\u003e \u003cp\u003eIntroduction\u003c\/p\u003e \u003cp\u003eChapter 43: Liposome-Encapsulated Hemoglobin: History, Preparation and Evaluation\u003c\/p\u003e \u003cp\u003eChapter 44: Hemoglobin Vesicles as a Molecular Assembly: Characteristics of Preparation Process and Performances as Artificial Oxygen Carriers\u003c\/p\u003e \u003cp\u003eChapter 45: Nanodimension Biodegradable Polymeric Membrane Artificial Red Blood Cells\u003c\/p\u003e \u003cp\u003eChapter 46: Albumin-Heme: A Synthetic Heme-Based Oxygen Carrier\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biotechnology [\u003ca title=\"See our other books on Biotechnology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biotechnology%20%5BTCB%5D%22\"\u003eTCB\u003c\/a\u003e], Physiology [\u003ca title=\"See our other books on Physiology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Physiology%20%5BMFG%5D%22\"\u003eMFG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649434702104,"sku":"9780127597607","price":122.79,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780127597607.jpg?v=1694100949","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/blood-substitutes-hardback-9780127597607","provider":"Freshly Printed Books","version":"1.0","type":"link"}