{"product_id":"biotransformation-and-metabolite-elucidation-of-xenobiotics-characterization-and-identification-hardback-9780470504789","title":"Biotransformation and Metabolite Elucidation of Xenobiotics; Characterization and Identification (Hardback) 9780470504789","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eBiotransformation and Metabolite Elucidation of Xenobiotics\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eCharacterization and Identification\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eAla F. Nassar (Edited by), AF Nassar (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470504789, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 12 November 2010\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e344 pages\u003cbr\u003e24.1 x 16.3 x 2.4 cm, 0.644 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"Contributors mostly from pharmaceutical companies provide a systematic introduction to characterizing metabolites, which has become an important element in drug discovery. They write for scientists involved in designing, developing, and advancing metabolic characterizations for drug discovery and development, and for researchers and students in fields that might call for such characterizations.\" (\u003ci\u003eBook News Inc\u003c\/i\u003e., February 2011)\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThe goal of this book is to improve the readers' knowledge of metabolite elucidation in drug metabolism by exposing them to in depth coverage of the biotransformation of xenobiotics, strategies for identifying and characterizing metabolites, FDA guidelines, and case studies on how to improve the decision-making process in structural modification of drug candidates to reduce toxicity.  \u003cp\u003eThe book consists of 8 chapters; it first provides an introduction on biotransformation of xenobiotics, and then presents modern approaches and strategies for dealing with metabolite characterization, using tools such as LC-MS, H-D exchange, stable isotopes LC-MS-NMR, and radiolabeled compounds. Also, strategies for dealing with reactive intermediates in drug discovery and development are presented as well as case studies on improving the decision-making process in the structural modification of drug candidates. The last chapter discusses the regulatory perspectives of safety testing of drug metabolites and why, how, and when to test their safety.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePREFACE.  \u003cp\u003eCONTRIBUTORS.\u003c\/p\u003e \u003cp\u003e1 HUMAN BIOTRANSFORMATION (\u003ci\u003eAndrew Parkinson, Brian W. Ogilvie, Brandy L. Paris, Tiffi ni N. Hensley, and Greg J. Loewen\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e2 ANALYTICAL TOOLS AND APPROACHES FOR METABOLITE IDENTIFICATION IN DRUG METABOLISM (\u003ci\u003eYongmei Li\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e3 TOOLS OF CHOICE FOR ACCELERATING METABOLITE IDENTIFICATION: MASS SPECTROMETRY TECHNOLOGY DRIVES METABOLITE IDENTIFICATION STUDIES FORWARD (\u003ci\u003eAla F. Nassar\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e4 IMPROVING DRUG DESIGN: CONSIDERATIONS FOR THE STRUCTURAL MODIFICATION PROCESS (\u003ci\u003eAla F. Nassar\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e5 CASE STUDY: THE UNANTICIPATED LOSS OF N\u003csub\u003e\u003csmall\u003e2\u003c\/small\u003e\u003c\/sub\u003e FROM NOVEL DNA ALKYLATING AGENT LAROMUSTINE BY COLLISION-INDUCED DISSOCIATION: NOVEL REARRANGEMENTS (\u003ci\u003eAla F. Nassar, Jing Du, David Roberts, Kevin Lin, Mike Belcourt, Ivan King, and TuKiet T. Lam\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e6 CASE STUDY: IDENTIFICATION OF \u003ci\u003eIN VITRO\u003c\/i\u003e METABOLITE\/DECOMPOSITION PRODUCTS OF THE NOVEL DNA ALKYLATING AGENT LAROMUSTINE (\u003ci\u003eAla F. Nassar, Jing Du, David Roberts, Kevin Lin, Mike Belcourt, Ivan King, and TuKiet T. Lam\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e7 STRATEGIES FOR THE DETECTION OF REACTIVE INTERMEDIATES IN DRUG DISCOVERY AND DEVELOPMENT (\u003ci\u003eMark P. Grillo\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003e8 SAFETY TESTING OF DRUG METABOLITES: MIST GUIDANCE IMPACT ON THE PRACTICE OF INDUSTRIAL DRUG METABOLISM (\u003ci\u003eJ. Greg Slatter\u003c\/i\u003e).\u003c\/p\u003e \u003cp\u003eINDEX.\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52276328923416,"sku":"9780470504789","price":100.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470504789.jpg?v=1781366767","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/biotransformation-and-metabolite-elucidation-of-xenobiotics-characterization-and-identification-hardback-9780470504789","provider":"Freshly Printed Books","version":"1.0","type":"link"}