{"product_id":"biophysical-methods-for-biotherapeutics-discovery-and-development-applications-hardback-9780470938430","title":"Biophysical Methods for Biotherapeutics; Discovery and Development Applications (Hardback) 9780470938430","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eBiophysical Methods for Biotherapeutics\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eDiscovery and Development Applications\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eTapan K. Das (Edited by), TK Das (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470938430, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 8 August 2014\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e376 pages\u003cbr\u003e24.1 x 16 x 2.5 cm, 0.649 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eWith a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.\u003c\/p\u003e \u003cp\u003e• Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods\u003cbr\u003e • Chapters organized according to the sequential nature of the drug development process\u003cbr\u003e • Helps formulation, analytical, and bioanalytical scientists in pharma and biotech better understand and usestrengths and limitations of biophysical methods\u003cbr\u003e • Explains how to use biophysical methods, the information obtained, and what needs to be presented in a regulatory filing, assess impact on quality and immunogenicity\u003cbr\u003e • With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003eAbout the Editor ix\u003c\/p\u003e \u003cp\u003eContributors xi\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 1 Early Discovery Stages and Biotherapeutic Candidate Selection\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 Biophysical Methods Applied in Early Discovery of a Biotherapeutic: Case Study of an EGFR-IGF1R Bispecific Adnectin 3\u003cbr\u003e\u003ci\u003eMichael L. Doyle, James W. Bryson, Virginie Lafont, Zheng Lin, Paul E. Morin, Lumelle A. Schneeweis, Aaron P. Yamniuk, and Joseph Yanchunas Jr.\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 X-Ray Crystallography for Biotherapeutics 25\u003cbr\u003e\u003ci\u003eGlen Spraggon\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Solubility and Early Assessment of Stability for Protein Therapeutics 65\u003cbr\u003e\u003ci\u003eSheng-Jiun Wu, Gary L. Gilliland, and Yiqing Feng\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 2 First-in-Human and up to Proof-of-Concept Clinical Trials\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4 Biophysical and Structural Characterization Needed Prior to Proof of Concept 95\u003cbr\u003e\u003ci\u003eAngela W. Blake-Haskins, Yen-Huei Lin, Zhuchun Wu, Melissa D. Perkins, and Thomas M. Spitznagel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Nucleation, Aggregation, and Conformational Distortion 125\u003cbr\u003e\u003ci\u003eChristopher J. Roberts\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Utilization of Chemical Labeling and Mass Spectrometry for the Biophysical Characterization of Biopharmaceuticals 151\u003cbr\u003e\u003ci\u003eJustin B. Sperry and Lisa M. Jones\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Application of Biophysical and High-Throughput Methods in the Preformulation of Therapeutic Proteins—Facts and Fictions 173\u003cbr\u003e\u003ci\u003eAhmad M. Abdul-Fattah and Hanns-Christian Mahler\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Bioanalytical Methods and Immunogenicity Assays 207\u003cbr\u003e\u003ci\u003eBonita Rup, Corinna Krinos-Fiorotti, Boris Gorovits, and Hendrik Neubert\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9 Structures and Dynamics of Proteins Probed by UV Resonance Raman Spectroscopy 243\u003cbr\u003e\u003ci\u003eBrian S. Leigh, Diana E. Schlamadinger, and Judy E. Kim\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10 Freezing- and Drying-Induced Micro- and Nano-Heterogeneity in Biological Solutions 269\u003cbr\u003e\u003ci\u003eAlptekin Aksan, Vishard Ragoonanan, and Carol Hirschmugl\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection 3 Phase III and Commercial Development\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11 Late-Stage Product Characterization: Applications in Formulation, Process, and Manufacturing Development 287\u003cbr\u003e\u003ci\u003eChristine P. Chan and Li Shi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12 Biophysical Analyses Suitable for Chemistry, Manufacturing, and Control Sections of the Biologic License Application (BLA) 317\u003cbr\u003e\u003ci\u003eZahra Shahrokh, Nazila Salamat-Miller, and John J. Thomas\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 355\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52278119137560,"sku":"9780470938430","price":92.19,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470938430.jpg?v=1781458432","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/biophysical-methods-for-biotherapeutics-discovery-and-development-applications-hardback-9780470938430","provider":"Freshly Printed Books","version":"1.0","type":"link"}