{"product_id":"biomechatronic-design-in-biotechnology-a-methodology-for-development-of-biotechnological-products-hardback-9780470573341","title":"Biomechatronic Design in Biotechnology; A Methodology for Development of Biotechnological Products (Hardback) 9780470573341","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eBiomechatronic Design in Biotechnology\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eA Methodology for Development of Biotechnological Products\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eCarl-Fredrik Mandenius (Author), Mats Björkman (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470573341, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 12 August 2011\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e304 pages\u003cbr\u003e24.4 x 16.3 x 2.1 cm, 0.581 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\"... a must-read for all modern bio-scientists and engineers working in the field of biotechnology.\" (\u003cem\u003eBiotechnology Journal,\u003c\/em\u003e July 2012)\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003e“… a must-read for all modern bio-scientists and engineers working in the field of biotechnology.”\u003c\/i\u003e – Biotechnology Journal, 2012, 7\u003c\/p\u003e \u003cp\u003e\u003cb\u003e \u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003eA cutting-edge guide on the fundamentals, theory, and applications of biomechatronic design principles\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003ci\u003eBiomechatronic Design in Biotechnology\u003c\/i\u003e presents a complete methodology of biomechatronics, an emerging variant of the mechatronics field that marries biology, electronics, and mechanics to create products where biological and biochemical, technical, human, management-and-goal, and information systems are combined and integrated in order to solve a mission that fulfills a human need. A biomechatronic product includes a biological, mechanical, and electronic part.\u003c\/p\u003e \u003cp\u003eBeginning with an overview of the fundamentals and theory behind biomechatronic technology, this book describes how general engineering design science theory can be applied when designing a technical system where biological species or components are integrated. Some research methods explored include schemes and matrices for analyzing the functionality of the designed products, ranking methods for screening and scoring the best design solutions, and structuring graphical tools for a thorough investigation of the subsystems and sub-functions of products.\u003c\/p\u003e \u003cp\u003eThis insightful guide also:\u003c\/p\u003e \u003cul\u003e \u003cli\u003eDiscusses tools for creating shorter development times, thereby reducing the need for prototype testing and verification\u003c\/li\u003e \u003cli\u003ePresents case study-like examples of the technology used such as a surface plasmon resonance sensor and a robotic cell culturing system for human embryonic stem cells\u003c\/li\u003e \u003cli\u003eProvides an interdisciplinary and unifying approach of the many fields of engineering and biotechnology used in biomechatronic design\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003eBy combining designs between traditional electronic and mechanical subsystems and biological systems, this book demonstrates how biotechnology and bioengineering design can utilize and benefit from commonly used design tools— and benefit humanity itself.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePREFACE xiii  \u003cp\u003e1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.1 Scope of Design \/ 1\u003c\/p\u003e \u003cp\u003e1.2 Definition of Biomechatronic Products \/ 3\u003c\/p\u003e \u003cp\u003e1.3 Principles of Biomechatronics \/ 4\u003c\/p\u003e \u003cp\u003e1.4 Brief History of the Development of Biomechatronic Products and Engineering \/ 7\u003c\/p\u003e \u003cp\u003e1.5 Aim of This Book \/ 9\u003c\/p\u003e \u003cp\u003eReferences \/ 10\u003c\/p\u003e \u003cp\u003ePART I FUNDAMENTALS 13\u003c\/p\u003e \u003cp\u003e2 Conceptual Design Theory 15\u003c\/p\u003e \u003cp\u003e2.1 Systematic Design \/ 15\u003c\/p\u003e \u003cp\u003e2.1.1 Design for Products \/ 15\u003c\/p\u003e \u003cp\u003e2.1.2 Origin of the Design Task \/ 18\u003c\/p\u003e \u003cp\u003e2.1.3 Development of Design Thinking \/ 18\u003c\/p\u003e \u003cp\u003e2.1.4 Recent Methods \/ 20\u003c\/p\u003e \u003cp\u003e2.2 Basics of Technical Systems \/ 21\u003c\/p\u003e \u003cp\u003e2.2.1 Energy, Material, and Signals and Their Conversion \/ 22\u003c\/p\u003e \u003cp\u003e2.2.2 Interrelationships of Functions \/ 22\u003c\/p\u003e \u003cp\u003e2.2.3 Interrelationship of Constructions \/ 25\u003c\/p\u003e \u003cp\u003e2.2.4 Interrelationship of Systems \/ 25\u003c\/p\u003e \u003cp\u003e2.3 Psychology in the Systematic Approach \/ 25\u003c\/p\u003e \u003cp\u003e2.4 A General Working Methodology \/ 26\u003c\/p\u003e \u003cp\u003e2.4.1 Analysis for Resolving Technical Problems \/ 27\u003c\/p\u003e \u003cp\u003e2.4.2 Abstraction of Interrelationships of Systems \/ 28\u003c\/p\u003e \u003cp\u003e2.4.3 Synthesis of the Technical System \/ 28\u003c\/p\u003e \u003cp\u003e2.5 Conceptual Design \/ 28\u003c\/p\u003e \u003cp\u003e2.6 Abstraction inOrder to Identify Essential Problems \/ 29\u003c\/p\u003e \u003cp\u003e2.7 Developing the Concepts \/ 31\u003c\/p\u003e \u003cp\u003e2.7.1 Organizing the Development Process \/ 33\u003c\/p\u003e \u003cp\u003e2.8 Concluding Remarks \/ 34\u003c\/p\u003e \u003cp\u003eReferences \/ 35\u003c\/p\u003e \u003cp\u003e3 Biotechnology and Mechatronic Design 37\u003c\/p\u003e \u003cp\u003e3.1 Transduction of the Biological Science into Biotechnology \/ 37\u003c\/p\u003e \u003cp\u003e3.2 Biological Sciences and Their Applications \/ 39\u003c\/p\u003e \u003cp\u003e3.3 Biotechnology and Bioengineering \/ 42\u003c\/p\u003e \u003cp\u003e3.4 Applying Mechatronic Theory to Biotechnology: Biomechatronics \/ 44\u003c\/p\u003e \u003cp\u003e3.5 Conclusions \/ 47\u003c\/p\u003e \u003cp\u003eReferences \/ 48\u003c\/p\u003e \u003cp\u003e4 Methodology for Utilization of Mechatronic Design Tools 49\u003c\/p\u003e \u003cp\u003e4.1 Idea of Applying the Mechatronic Design Tools \/ 49\u003c\/p\u003e \u003cp\u003e4.2 Table of User Needs \/ 51\u003c\/p\u003e \u003cp\u003e4.3 List of Target Specifications \/ 52\u003c\/p\u003e \u003cp\u003e4.4 Concept Generation Chart \/ 52\u003c\/p\u003e \u003cp\u003e4.4.1 Basic Concept Component Chart \/ 53\u003c\/p\u003e \u003cp\u003e4.4.2 Permutation Chart \/ 54\u003c\/p\u003e \u003cp\u003e4.5 Concept Screening Matrix \/ 55\u003c\/p\u003e \u003cp\u003e4.6 Concept Scoring Matrix \/ 56\u003c\/p\u003e \u003cp\u003e4.7 Hubka–Eder Mapping \/ 57\u003c\/p\u003e \u003cp\u003e4.7.1 Overview Hubka–Eder Map \/ 57\u003c\/p\u003e \u003cp\u003e4.7.2 Zoom-in Hubka–Eder Mapping \/ 59\u003c\/p\u003e \u003cp\u003e4.8 Functions Interaction Matrix \/ 60\u003c\/p\u003e \u003cp\u003e4.8.1 Functions Interaction Matrix for Systems and Subsystems \/ 60\u003c\/p\u003e \u003cp\u003e4.8.2 Functions Interaction Matrix for Systems and Transformation Process \/ 61\u003c\/p\u003e \u003cp\u003e4.8.3 Design Structure Matrix \/ 61\u003c\/p\u003e \u003cp\u003e4.9 Anatomical Blueprint \/ 62\u003c\/p\u003e \u003cp\u003e4.10 Conclusions \/ 63\u003c\/p\u003e \u003cp\u003eReferences \/ 63\u003c\/p\u003e \u003cp\u003ePART II APPLICATIONS 65\u003c\/p\u003e \u003cp\u003e5 Blood Glucose Sensors 67\u003c\/p\u003e \u003cp\u003e5.1 Background of Blood Glucose Analysis \/ 67\u003c\/p\u003e \u003cp\u003e5.2 Specification of Needs for Blood Glucose Analysis \/ 70\u003c\/p\u003e \u003cp\u003e5.3 Design of Blood Glucose Sensors \/ 71\u003c\/p\u003e \u003cp\u003e5.3.1 Generation of Sensor Concepts \/ 71\u003c\/p\u003e \u003cp\u003e5.4 Description of the Systems Involved in the Design Concepts for Glucose Blood Sensors \/ 76\u003c\/p\u003e \u003cp\u003e5.4.1 Biological Systems \/ 77\u003c\/p\u003e \u003cp\u003e5.4.2 Technical Systems \/ 77\u003c\/p\u003e \u003cp\u003e5.4.3 Information Systems \/ 78\u003c\/p\u003e \u003cp\u003e5.4.4 Management and Goal Systems \/ 78\u003c\/p\u003e \u003cp\u003e5.4.5 Human Systems \/ 79\u003c\/p\u003e \u003cp\u003e5.4.6 Active Environment \/ 79\u003c\/p\u003e \u003cp\u003e5.4.7 Interactions Between the Systems and Functions of the Design \/ 79\u003c\/p\u003e \u003cp\u003e5.4.8 Anatomical Blueprints from the Functions Interaction Matrix Analysis \/ 81\u003c\/p\u003e \u003cp\u003e5.5 Conclusions \/ 82\u003c\/p\u003e \u003cp\u003eReferences \/ 82\u003c\/p\u003e \u003cp\u003e6 Surface Plasmon Resonance Biosensor Devices 85\u003c\/p\u003e \u003cp\u003e6.1 Introduction \/ 85\u003c\/p\u003e \u003cp\u003e6.2 Design Requirements on SPR Systems \/ 88\u003c\/p\u003e \u003cp\u003e6.2.1 Needs and Specifications of an SPR Design \/ 88\u003c\/p\u003e \u003cp\u003e6.3 Mechatronic Design Approach of SPR Systems \/ 89\u003c\/p\u003e \u003cp\u003e6.3.1 Generation of Design Alternatives \/ 89\u003c\/p\u003e \u003cp\u003e6.3.2 Hubka–Eder Mapping of the Design Alternatives \/ 92\u003c\/p\u003e \u003cp\u003e6.4 Detailed Design of Critical SPR Subsystems \/ 99\u003c\/p\u003e \u003cp\u003e6.4.1 Design of the Sensor Surface \/ 100\u003c\/p\u003e \u003cp\u003e6.4.2 Design of the Fluidic System \/ 103\u003c\/p\u003e \u003cp\u003e6.5 Conclusions \/ 109\u003c\/p\u003e \u003cp\u003eReferences \/ 109\u003c\/p\u003e \u003cp\u003e7 A Diagnostic Device for Helicobacter pylori Infection 113\u003c\/p\u003e \u003cp\u003e7.1 Diagnostic Principle of Helicobacter Infection \/ 113\u003c\/p\u003e \u003cp\u003e7.2 Mechatronic Analysis of Urea Breath Test Systems \/ 117\u003c\/p\u003e \u003cp\u003e7.2.1 Mission and Specification for a Urea Breath Tests \/ 117\u003c\/p\u003e \u003cp\u003e7.2.2 Generation of UBT Design Concepts \/ 118\u003c\/p\u003e \u003cp\u003e7.2.3 Screening and Scoring of UBT Design Concepts \/ 119\u003c\/p\u003e \u003cp\u003e7.3 Description of the Systems Involved in the Design Concepts for the Urea Breath Tests \/ 124\u003c\/p\u003e \u003cp\u003e7.3.1 Biological Systems Involved \/ 124\u003c\/p\u003e \u003cp\u003e7.3.2 Technical Systems Alternatives \/ 126\u003c\/p\u003e \u003cp\u003e7.3.3 Information Systems (SIS) Required \/ 127\u003c\/p\u003e \u003cp\u003e7.3.4 Management and Goal Systems Required \/ 127\u003c\/p\u003e \u003cp\u003e7.3.5 Human Systems Involved in the Testing \/ 127\u003c\/p\u003e \u003cp\u003e7.3.6 Active Environment That Can Influence \/ 128\u003c\/p\u003e \u003cp\u003e7.4 Aspects of the Design for Efficient Manufacture \/ 128\u003c\/p\u003e \u003cp\u003e7.5 Conclusions \/ 131\u003c\/p\u003e \u003cp\u003eReferences \/ 131\u003c\/p\u003e \u003cp\u003e8 Microarray Devices 135\u003c\/p\u003e \u003cp\u003e8.1 Principles, Methods, and Applications of Microarrays \/ 135\u003c\/p\u003e \u003cp\u003e8.1.1 Principles and Technology \/ 135\u003c\/p\u003e \u003cp\u003e8.1.2 Fabrication Methods \/ 136\u003c\/p\u003e \u003cp\u003e8.1.3 Companies Developing Microarrays \/ 138\u003c\/p\u003e \u003cp\u003e8.1.4 Applications of DNA Microarrays \/ 139\u003c\/p\u003e \u003cp\u003e8.2 Specification of Needs \/ 141\u003c\/p\u003e \u003cp\u003e8.3 Design of Microarrays \/ 142\u003c\/p\u003e \u003cp\u003e8.3.1 Generation of cDNA Microarray Concepts \/ 142\u003c\/p\u003e \u003cp\u003e8.4 Description of the Systems Involved in the Design Concepts \/ 145\u003c\/p\u003e \u003cp\u003e8.4.1 Biological Systems \/ 146\u003c\/p\u003e \u003cp\u003e8.4.2 Technical Systems \/ 147\u003c\/p\u003e \u003cp\u003e8.4.3 Information System \/ 147\u003c\/p\u003e \u003cp\u003e8.4.4 Management and Goal Systems and the Human Systems \/ 147\u003c\/p\u003e \u003cp\u003e8.4.5 Active Environment \/ 147\u003c\/p\u003e \u003cp\u003e8.4.6 Interaction Analysis \/ 148\u003c\/p\u003e \u003cp\u003e8.5 Conclusions \/ 149\u003c\/p\u003e \u003cp\u003eReferences \/ 149\u003c\/p\u003e \u003cp\u003e9 Microbial and Cellular Bioreactors 153\u003c\/p\u003e \u003cp\u003e9.1 Bioreactor Development During the 1970s–1990s \/ 153\u003c\/p\u003e \u003cp\u003e9.2 Missions, User Needs, and Specifications for Bioreactors \/ 158\u003c\/p\u003e \u003cp\u003e9.2.1 Design Mission and User Needs \/ 158\u003c\/p\u003e \u003cp\u003e9.2.2 Target Specifications \/ 158\u003c\/p\u003e \u003cp\u003e9.3 Analysis of Systems for Conventional Bioreactors \/ 161\u003c\/p\u003e \u003cp\u003e9.3.1 Biological Systems in the Bioreactor \/ 161\u003c\/p\u003e \u003cp\u003e9.3.2 Technical Systems \/ 164\u003c\/p\u003e \u003cp\u003e9.3.3 Studying the Interactions of the Systems \/ 166\u003c\/p\u003e \u003cp\u003e9.3.4 Penicillin Production in a Metabolically Engineered Penicillium strain (Case 1) \/ 168\u003c\/p\u003e \u003cp\u003e9.3.5 A Bioreactor System Producing a Recombinant Protein in CHO Cell Culture (Case 2) \/ 171\u003c\/p\u003e \u003cp\u003e9.3.6 Information Systems \/ 173\u003c\/p\u003e \u003cp\u003e9.3.7 Management and Goal Systems \/ 177\u003c\/p\u003e \u003cp\u003e9.3.8 Human Systems \/ 179\u003c\/p\u003e \u003cp\u003e9.3.9 Active Environment \/ 179\u003c\/p\u003e \u003cp\u003e9.4 Novel Bioreactor Designs \/ 180\u003c\/p\u003e \u003cp\u003e9.4.1 Microbioreactors \/ 180\u003c\/p\u003e \u003cp\u003e9.4.2 Bioreactors with Immobilized Cells \/ 183\u003c\/p\u003e \u003cp\u003e9.4.3 Bioreactors for Tissue and Stem Cell Cultures \/ 185\u003c\/p\u003e \u003cp\u003e9.4.4 Bioreactors for Plant Cell Cultures \/ 186\u003c\/p\u003e \u003cp\u003e9.5 Conclusions \/ 187\u003c\/p\u003e \u003cp\u003eReferences \/ 187\u003c\/p\u003e \u003cp\u003e10 Chromatographic Protein Purification 193\u003c\/p\u003e \u003cp\u003e10.1 Background of Chromatographic Protein Purification \/ 193\u003c\/p\u003e \u003cp\u003e10.2 Specification of Needs for Protein Purification Systems \/ 197\u003c\/p\u003e \u003cp\u003e10.3 Design of Purification Systems \/ 199\u003c\/p\u003e \u003cp\u003e10.3.1 Generation of Design Alternatives \/ 199\u003c\/p\u003e \u003cp\u003e10.3.2 Screening the Design Alternatives \/ 201\u003c\/p\u003e \u003cp\u003e10.3.3 Analysis of the Generated Alternatives for a Chromatography System \/ 202\u003c\/p\u003e \u003cp\u003e10.3.4 Interactions Between Key Systems and the Transformation Process \/ 206\u003c\/p\u003e \u003cp\u003e10.4 Unit Operation Purification in a FVIII Production Process (Case 1) \/ 208\u003c\/p\u003e \u003cp\u003e10.5 Micropurification System Based on a Multichip Device (Case 2) \/ 209\u003c\/p\u003e \u003cp\u003e10.6 Conclusions \/ 211\u003c\/p\u003e \u003cp\u003eReferences \/ 212\u003c\/p\u003e \u003cp\u003e11 Stem Cell Manufacturing 215\u003c\/p\u003e \u003cp\u003e11.1 State of the Art of Stem Cell Manufacturing \/ 215\u003c\/p\u003e \u003cp\u003e11.2 Needs and Target Specifications for Scaled-Up Stem Cell Manufacturing \/ 218\u003c\/p\u003e \u003cp\u003e11.3 Setting Up an Efficient Manufacturing System by Using Biomechatronic Conceptual Design \/ 220\u003c\/p\u003e \u003cp\u003e11.3.1 Generating Process Alternatives \/ 220\u003c\/p\u003e \u003cp\u003e11.3.2 Hubka–Eder Map for a Human Embryonic Stem Cell Process \/ 220\u003c\/p\u003e \u003cp\u003e11.4 Conclusions \/ 225\u003c\/p\u003e \u003cp\u003eReferences \/ 226\u003c\/p\u003e \u003cp\u003e12 Bioartificial Organ-Simulating Devices 229\u003c\/p\u003e \u003cp\u003e12.1 Introduction \/ 229\u003c\/p\u003e \u003cp\u003e12.2 Design of Bioartificial Organ-Simulation Devices \/ 232\u003c\/p\u003e \u003cp\u003e12.2.1 Needs and Specifications \/ 232\u003c\/p\u003e \u003cp\u003e12.2.2 Evaluation of the Design Concepts \/ 236\u003c\/p\u003e \u003cp\u003e12.3 Analysis of Bioartificial Liver Systems \/ 239\u003c\/p\u003e \u003cp\u003e12.3.1 Biological Systems \/ 239\u003c\/p\u003e \u003cp\u003e12.3.2 Technical Systems \/ 241\u003c\/p\u003e \u003cp\u003e12.3.3 Information Systems \/ 242\u003c\/p\u003e \u003cp\u003e12.3.4 Management and Goals Systems \/ 243\u003c\/p\u003e \u003cp\u003e12.3.5 Human Systems \/ 243\u003c\/p\u003e \u003cp\u003e12.4 Conclusions \/ 244\u003c\/p\u003e \u003cp\u003eReferences \/ 244\u003c\/p\u003e \u003cp\u003e13 Applications to Process Analytical Technology and Quality by Design 249\u003c\/p\u003e \u003cp\u003e13.1 PAT and QbD Concepts \/ 249\u003c\/p\u003e \u003cp\u003e13.2 Needs of the PAT\/QbD Players and Resulting Specifications \/ 253\u003c\/p\u003e \u003cp\u003e13.3 Application of Design Methodology to PAT\/QbD \/ 255\u003c\/p\u003e \u003cp\u003e13.3.1 Concept Generation for a PAT\/QbD System Structure \/ 255\u003c\/p\u003e \u003cp\u003e13.3.2 Hubka–Eder Mapping of the PAT\/QbD Transformation Process for a Pharmaceutical\u003c\/p\u003e \u003cp\u003eProcess \/ 257\u003c\/p\u003e \u003cp\u003e13.3.3 Analysis of Effects \/ 259\u003c\/p\u003e \u003cp\u003e13.4 Applying Mechatronic Design on a PAT System for Online Software Sensing in a Bioprocess (Case) \/ 260\u003c\/p\u003e \u003cp\u003e13.5 Conclusions \/ 263\u003c\/p\u003e \u003cp\u003eReferences \/ 263\u003c\/p\u003e \u003cp\u003eGLOSSARY 267\u003c\/p\u003e \u003cp\u003eINDEX 275\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52276364902680,"sku":"9780470573341","price":65.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470573341.jpg?v=1781367460","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/biomechatronic-design-in-biotechnology-a-methodology-for-development-of-biotechnological-products-hardback-9780470573341","provider":"Freshly Printed Books","version":"1.0","type":"link"}