{"product_id":"biofoundry-techniques-for-biotechnology-applications-hardback-9781394309924","title":"Biofoundry Techniques for Biotechnology Applications (Hardback) 9781394309924","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eBiofoundry Techniques for Biotechnology Applications\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eAnuj Kumar Chandel (Edited by), Chandel (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781394309924, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 27 February 2026\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e384 pages\u003cbr\u003e24.4 x 17 x 2.2 cm, 0.85 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eExtensive reference on the integration of biofoundry techniques with lignocellulose biorefinery processes\u003c\/b\u003e \u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eBiofoundry Techniques for Biotechnology Applications\u003c\/i\u003e presents concepts, perspectives, and technical advancements on thermochemical and biochemical pathways in biochemical conversion of lignocellulosic feedstock into platform chemicals, specialty chemicals\/fuels, and materials. It covers a broad range of topics from biomass refining to synthetic biology and process automation, integrating recent advancements in biotechnology, process engineering, and sustainability assessment.  \u003c\/p\u003e\n\u003cp\u003eThis book helps readers solve several critical problems related to the development and implementation of lignocellulosic biorefineries and biofoundries, such as the costs, time, and labor associated with generating and testing experimental designs, through practical solutions and insights that are directly applicable to professional practice. The book also reviews the shift towards process automation and modeling, integration, process scaling, and machine learning which is revitalizing the traditional laboratory setting and powering a paradigm change in the field of biomanufacturing. \u003c\/p\u003e\n\u003cp\u003eContributed to by a diverse range of international experts in biorefinery research, synthetic biology, bioprocess engineering, and lean manufacturing, \u003ci\u003eBiofoundry Techniques for Biotechnology Applications\u003c\/i\u003e includes information on: \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e Key products, process limitations, and future outlooks in biomass refining and biofoundry\u003c\/li\u003e \u003cli\u003e Structural carbohydrate conversion into value-added sugars, fuels, chemicals, and sustainable materials through biotechnical interventions\u003c\/li\u003e \u003cli\u003e Sustainable production of advanced alcohol-based biofuels, such as sustainable aviation fuels, in biorefinery settings\u003c\/li\u003e \u003cli\u003e Biomanufacturing of smart packaging materials, cosmetics, therapeutics, and nanomaterials through a lignocellulosic biorefinery framework\u003c\/li\u003e \u003cli\u003e Synthetic biology in the realm of genome engineering for improved biocatalyst production\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003eBiofoundry Techniques for Biotechnology Applications\u003c\/i\u003e serves as an invaluable source of up-to-date information for researchers, academics, and graduate and postgraduate students in the fields of microbial biotechnology, applied microbiology, biochemical engineering, and environmental science and engineering.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eList of Contributors xv\u003c\/p\u003e \u003cp\u003eAbout the Editor xxi\u003c\/p\u003e \u003cp\u003ePreface xxiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 Biomass Refining and Biofoundry: Key Products, Process Limitations, and Future Aspects 1\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eLucas Ramos, Jesús Jiménez Ascencio, James Villar, Mónica Ma. Cruz- Santos, and Anuj Kumar Chandel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Introduction 1\u003c\/p\u003e \u003cp\u003e1.1.1 Biomass Diversity and Major Principle Feedstock in the World 2\u003c\/p\u003e \u003cp\u003e1.1.1.1 Major Feedstocks 3\u003c\/p\u003e \u003cp\u003e1.1.2 Biomass Refining Methods 4\u003c\/p\u003e \u003cp\u003e1.1.2.1 Sugars- First Approach 4\u003c\/p\u003e \u003cp\u003e1.1.2.2 Lignin- First Approach 5\u003c\/p\u003e \u003cp\u003e1.1.3 Key Products from Biorefinery Based from Listed Top 12 Biochemicals from U.S. Department of Energy 9\u003c\/p\u003e \u003cp\u003e1.1.4 Process Limitations and Net- Zero Environment 13\u003c\/p\u003e \u003cp\u003e1.1.5 Biofoundry and Advanced Bioeconomy 14\u003c\/p\u003e \u003cp\u003e1.1.6 Conclusion and Future Directions 16\u003c\/p\u003e \u003cp\u003eAcknowledgments 17\u003c\/p\u003e \u003cp\u003eReferences 17\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Structural Carbohydrates Conversion into Sugars, Fuels, Chemicals, and Sustainable Materials 27\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eKatarina Mihajlovski, Nevena Ilić, Galina Jevđenović, and Marija Milić\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 27\u003c\/p\u003e \u003cp\u003e2.1.1 What are Structural Carbohydrates? 27\u003c\/p\u003e \u003cp\u003e2.1.2 Cellulose 28\u003c\/p\u003e \u003cp\u003e2.1.2.1 Cellulose Conversions to Sugars 29\u003c\/p\u003e \u003cp\u003e2.1.2.2 Cellulose Conversions to Fuels 31\u003c\/p\u003e \u003cp\u003e2.1.2.3 Cellulose Conversions to Sustainable Materials 32\u003c\/p\u003e \u003cp\u003e2.1.3 Hemicellulose 33\u003c\/p\u003e \u003cp\u003e2.1.3.1 Hemicellulose Conversion to Sugars 33\u003c\/p\u003e \u003cp\u003e2.1.3.2 Hemicellulose Conversion to Chemicals 35\u003c\/p\u003e \u003cp\u003e2.1.3.3 Hemicellulose Conversion to Fuels 37\u003c\/p\u003e \u003cp\u003e2.1.3.4 Hemicellulose Conversion to Sustainable Materials 39\u003c\/p\u003e \u003cp\u003e2.1.4 Pectin 39\u003c\/p\u003e \u003cp\u003e2.1.4.1 Pectin Conversions to Sugars 41\u003c\/p\u003e \u003cp\u003e2.1.4.2 Pectin Conversions to Fuels 42\u003c\/p\u003e \u003cp\u003e2.1.4.3 Pectin Conversions to Chemicals 42\u003c\/p\u003e \u003cp\u003e2.1.4.4 Pectin Conversions to Sustainable Materials 45\u003c\/p\u003e \u003cp\u003e2.1.5 Oligosaccharides 46\u003c\/p\u003e \u003cp\u003e2.1.5.1 Oligosaccharides Conversions to Sugars 46\u003c\/p\u003e \u003cp\u003e2.1.5.2 Oligosaccharides Conversions to Fuels 48\u003c\/p\u003e \u003cp\u003e2.1.5.3 Oligosaccharides Conversions to Chemicals 48\u003c\/p\u003e \u003cp\u003e2.2 Conclusions 51\u003c\/p\u003e \u003cp\u003eReferences 51\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Integrating Lignocellulosic Biomass Processing, Biomanufacturing, and Biofoundries: Innovations and Challenges in the Bioeconomy 59\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eYaimé Delgado- Arcaño, Alisson Dias da Silva Ruy, Leila Maria Aguilera Campos, and Oscar Daniel Valmaña- García\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction 59\u003c\/p\u003e \u003cp\u003e3.2 Advances in Biomass Processing: Pretreatment and Purification Strategies 60\u003c\/p\u003e \u003cp\u003e3.2.1 Pretreatment Methods of Lignocellulosic Biomass 60\u003c\/p\u003e \u003cp\u003e3.2.2 Separation and Purification of the Interest Compounds 64\u003c\/p\u003e \u003cp\u003e3.3 Bioeconomy and Biofoundries: How Automation and Synthetic Biology can Enhance Biorefineries 65\u003c\/p\u003e \u003cp\u003e3.3.1 Bibliometric Analysis 66\u003c\/p\u003e \u003cp\u003e3.3.2 Design- Build- Test- Learn (DBTL) in Biofabrication and Synthetic Biology 68\u003c\/p\u003e \u003cp\u003e3.3.3 Biofoundry and Process Integration in Biorefinery 69\u003c\/p\u003e \u003cp\u003e3.3.4 Global Expansion of Biofoundries: Innovation and Collaboration 71\u003c\/p\u003e \u003cp\u003e3.4 Economic Competitiveness in the Production of Bioproducts of Commercial Interest 72\u003c\/p\u003e \u003cp\u003e3.4.1 Techno- Economic Analysis and Life Cycle Assessments for Sustainable Bioproducts 72\u003c\/p\u003e \u003cp\u003e3.4.2 Market of Bioproducts: Insights and Challenges 75\u003c\/p\u003e \u003cp\u003e3.4.3 Market Growth, Cost Challenges, and Policy Drivers in Biorefineries 76\u003c\/p\u003e \u003cp\u003e3.4.4 Biomanufacturing and Biofoundries: Addressing Technological and Operational Challenges 77\u003c\/p\u003e \u003cp\u003e3.5 Conclusions 78\u003c\/p\u003e \u003cp\u003eReferences 79\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Lignin Valorization Is the Key for a Win–Win Situation in a Biomass Refinery 87\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eLucas Ramos, Carina Prado, Maria Teresa Ferreira Ramos Raimundo, Uirajá C. M. Ruschoni, Vinícius Pereira Shibukawa, and Anuj Kumar Chandel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 87\u003c\/p\u003e \u003cp\u003e4.2 Lignin: Dispensable Source of Renewable Carbon 88\u003c\/p\u003e \u003cp\u003e4.3 Lignin Chemistry 90\u003c\/p\u003e \u003cp\u003e4.4 Lignin Extraction Methods 92\u003c\/p\u003e \u003cp\u003e4.5 Lignin Conversion Route 94\u003c\/p\u003e \u003cp\u003e4.6 Biological Routes 94\u003c\/p\u003e \u003cp\u003e4.6.1 Microbial Degradation 95\u003c\/p\u003e \u003cp\u003e4.6.2 Enzymatic Conversion 95\u003c\/p\u003e \u003cp\u003e4.6.3 Fermentation 96\u003c\/p\u003e \u003cp\u003e4.7 Chemical Routes 96\u003c\/p\u003e \u003cp\u003e4.7.1 Thermal Decomposition 96\u003c\/p\u003e \u003cp\u003e4.7.2 Catalytic Depolymerization 96\u003c\/p\u003e \u003cp\u003e4.7.3 Electrochemical Conversion 97\u003c\/p\u003e \u003cp\u003e4.8 Lignin in the Pulp and Paper Industry 97\u003c\/p\u003e \u003cp\u003e4.9 Conclusion and Future Directions 99\u003c\/p\u003e \u003cp\u003eAcknowledgment 99\u003c\/p\u003e \u003cp\u003eReferences 99\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Sustainable Production of Advanced Alcohol- Based Biofuels in Biorefinery: From Alcohols to Sustainable Aviation Fuels 105\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eDanielle Matias Rodrigues, Paula Zaghetto de Almeida, Allan H. Félix de Mélo, Juliana Velasco de Castro Oliveira, Ana Paula Jacobus, and Henrique Macedo Baudel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 105\u003c\/p\u003e \u003cp\u003e5.2 Bioethanol 106\u003c\/p\u003e \u003cp\u003e5.3 Advanced Alcohol- Based Fuels 108\u003c\/p\u003e \u003cp\u003e5.4 Biobutanol: The Biofoundry as a Tool to Optimize 109\u003c\/p\u003e \u003cp\u003e5.4.1 Clostridium Pathway: Acetone- Butanol- Ethanol (ABE) Synthesis 110\u003c\/p\u003e \u003cp\u003e5.4.2 S. cerevisiae 111\u003c\/p\u003e \u003cp\u003e5.4.3 E. coli 112\u003c\/p\u003e \u003cp\u003e5.5 Biofoundry Synthetic Biology Tools 113\u003c\/p\u003e \u003cp\u003e5.5.1 2,3- Bdo 115\u003c\/p\u003e \u003cp\u003e5.6 Sustainable Aviation Fuel (SAF) 117\u003c\/p\u003e \u003cp\u003e5.7 Conclusion 118\u003c\/p\u003e \u003cp\u003eReferences 119\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Biomanufacturing of Smart Packaging Materials, Cosmetics, Therapeutics, and Nanomaterials Through Lignocellulosic Biorefinery Framework 127\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSounak Maitra, Muskaan Sethi, Prisha Inani, Palak Shrivastava, C. Shriya, and Samuel Jacob\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 127\u003c\/p\u003e \u003cp\u003e6.2 Lignocellulosic Raw Materials and Their Potential as Industrial Raw Materials 128\u003c\/p\u003e \u003cp\u003e6.2.1 Corn Wastes 128\u003c\/p\u003e \u003cp\u003e6.2.2 Sugarcane and Sugar Beet Residues 129\u003c\/p\u003e \u003cp\u003e6.2.2.1 Bagasse 129\u003c\/p\u003e \u003cp\u003e6.2.2.2 Molasses 130\u003c\/p\u003e \u003cp\u003e6.2.2.3 Vinasse 130\u003c\/p\u003e \u003cp\u003e6.2.2.4 Wastewater from the Sugar Industry 130\u003c\/p\u003e \u003cp\u003e6.2.3 Paddy Processing Wastes 130\u003c\/p\u003e \u003cp\u003e6.2.4 Potato Processing Wastes 131\u003c\/p\u003e \u003cp\u003e6.2.4.1 Potato Peels 133\u003c\/p\u003e \u003cp\u003e6.2.4.2 Potato Starch from Processing Wastes 133\u003c\/p\u003e \u003cp\u003e6.2.4.3 Potato Protein 133\u003c\/p\u003e \u003cp\u003e6.2.4.4 Potato Wastewater 133\u003c\/p\u003e \u003cp\u003e6.2.5 Oil Processing Industry Residues 134\u003c\/p\u003e \u003cp\u003e6.3 Smart Packaging Materials 135\u003c\/p\u003e \u003cp\u003e6.3.1 Starch and Lignocellulose- Based Biopolymers 135\u003c\/p\u003e \u003cp\u003e6.3.1.1 Starch- Based Biopolymer 135\u003c\/p\u003e \u003cp\u003e6.3.1.2 Lignocellulosic- Based Biopolymer 136\u003c\/p\u003e \u003cp\u003e6.3.2 PLA, PHA, and PHB 136\u003c\/p\u003e \u003cp\u003e6.3.2.1 Polylactic Acid (PLA) 136\u003c\/p\u003e \u003cp\u003e6.3.2.2 Polyhydroxyalkanoates (PHA) 137\u003c\/p\u003e \u003cp\u003e6.3.2.3 Polyhydroxybutyrate (PHB) 137\u003c\/p\u003e \u003cp\u003e6.4 Cosmetics and Therapeutics 138\u003c\/p\u003e \u003cp\u003e6.4.1 Active Pharmaceutical Components from Bioresources 138\u003c\/p\u003e \u003cp\u003e6.4.2 Bio- Oil as a Resource for the Cosmetics Industry 139\u003c\/p\u003e \u003cp\u003e6.4.3 Application of Bio- Oils in the Cosmetics Industry 141\u003c\/p\u003e \u003cp\u003e6.5 Bio- Nanotechnology Through Biomass 141\u003c\/p\u003e \u003cp\u003e6.6 Conclusion 142\u003c\/p\u003e \u003cp\u003eReferences 142\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 White Biotechnology for Skincare: Unveiling the Power of Bioactives for the Cosmetic Industry 151\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSamatha Paladugu, Sarepalli Sai Sathwik, and Mamatha Potu\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 151\u003c\/p\u003e \u003cp\u003e7.2 Fermented Bioactives 153\u003c\/p\u003e \u003cp\u003e7.3 Innovative Approaches in Green Bio- ferment Cosmetic Formulations 156\u003c\/p\u003e \u003cp\u003e7.4 Green Bio Ferments 158\u003c\/p\u003e \u003cp\u003e7.5 Active Compounds from Bioferments 160\u003c\/p\u003e \u003cp\u003e7.5.1 Organic Acids 160\u003c\/p\u003e \u003cp\u003e7.5.2 Amino Acids 161\u003c\/p\u003e \u003cp\u003e7.5.2.1 The Function of Amino Acids in Skin and Hair Care 162\u003c\/p\u003e \u003cp\u003e7.5.3 Gaba 164\u003c\/p\u003e \u003cp\u003e7.5.3.1 Efficacy of Lactobacillus- Fermented GABA on Dermal Fibroblasts 165\u003c\/p\u003e \u003cp\u003e7.5.4 Peptides 166\u003c\/p\u003e \u003cp\u003e7.5.4.1 Types of Peptides 167\u003c\/p\u003e \u003cp\u003e7.5.5 Antioxidant Substances 168\u003c\/p\u003e \u003cp\u003e7.5.6 Short- Chain Fatty Acids 169\u003c\/p\u003e \u003cp\u003e7.6 Application of Bioferments in Skincare 170\u003c\/p\u003e \u003cp\u003e7.6.1 Reducing Wrinkles and Signs of Aging 170\u003c\/p\u003e \u003cp\u003e7.6.2 Strengthening Skin Barrier 170\u003c\/p\u003e \u003cp\u003e7.6.3 Reducing Inflammation 171\u003c\/p\u003e \u003cp\u003e7.6.4 Helping Wound Healing 172\u003c\/p\u003e \u003cp\u003e7.6.5 Fighting Acne 172\u003c\/p\u003e \u003cp\u003e7.7 KINMATI: The Advanced Probiotic Biofermented Raw Material for Skincare 173\u003c\/p\u003e \u003cp\u003e7.8 Future of Bio- ferments, Active Ingredients, and Green Formulations 173\u003c\/p\u003e \u003cp\u003e7.8.1 Increasing Demand for Eco- Friendly Ingredients 174\u003c\/p\u003e \u003cp\u003e7.8.2 Shift to Natural Emollients, Solvents, Surfactants, Thickeners, Exfoliators, Fragrances, Colourants, and Antioxidants 174\u003c\/p\u003e \u003cp\u003e7.8.3 Safer Preservation Methods 175\u003c\/p\u003e \u003cp\u003e7.8.4 Balancing Efficacy and Stability with NaDES 175\u003c\/p\u003e \u003cp\u003e7.8.5 Sustainability Commitments of Industry Leaders 175\u003c\/p\u003e \u003cp\u003e7.9 Conclusion 176\u003c\/p\u003e \u003cp\u003e7.9.1 Regulatory Challenges 176\u003c\/p\u003e \u003cp\u003e7.9.2 Challenges in Sustainable Packaging 177\u003c\/p\u003e \u003cp\u003e7.9.3 Manufacturing Challenges 177\u003c\/p\u003e \u003cp\u003e7.9.4 Challenges for Biotech Skincare Startups 177\u003c\/p\u003e \u003cp\u003e7.9.5 From a Consumer Perspective 178\u003c\/p\u003e \u003cp\u003eAcknowledgments 178\u003c\/p\u003e \u003cp\u003eReferences 178\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 Biotechnological Advancements in Lactic Acid Bacteria Fermentation: Metabolic Pathways and Metabolite Profiles 189\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSamatha Paladugu, Sarepalli Sai Sathwik, and Sreelatha Beemagani\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 189\u003c\/p\u003e \u003cp\u003e8.2 Metabolism of Carbohydrates (Mono, Di, Oligo, and Polysaccharides) 190\u003c\/p\u003e \u003cp\u003e8.2.1 Homofermentation 190\u003c\/p\u003e \u003cp\u003e8.2.2 Heterofermentation 191\u003c\/p\u003e \u003cp\u003e8.3 Monosaccharides 191\u003c\/p\u003e \u003cp\u003e8.4 Disaccharides 192\u003c\/p\u003e \u003cp\u003e8.5 Oligosaccharides 193\u003c\/p\u003e \u003cp\u003e8.6 Polysaccharides and Indigestible Carbohydrates 193\u003c\/p\u003e \u003cp\u003e8.7 Indigestible Starch\/Resistant Starch 193\u003c\/p\u003e \u003cp\u003e8.8 Metabolism of Nitrogen Source (Proteins) 195\u003c\/p\u003e \u003cp\u003e8.8.1 Metabolism of Amino Acids 197\u003c\/p\u003e \u003cp\u003e8.8.2 Arginine Deiminase Pathway 197\u003c\/p\u003e \u003cp\u003e8.8.3 Glutamate Decarboxylase Pathway 197\u003c\/p\u003e \u003cp\u003e8.8.4 Metabolism of Branched- Chain and Aromatic Amino Acids 198\u003c\/p\u003e \u003cp\u003e8.8.5 d- Amino Acid Production 198\u003c\/p\u003e \u003cp\u003e8.9 Utilization and Metabolism of Malic Acid and Citric Acid 199\u003c\/p\u003e \u003cp\u003e8.10 Metabolite Profiles of Lactobacillus Ferments 200\u003c\/p\u003e \u003cp\u003e8.10.1 Organic Acids 200\u003c\/p\u003e \u003cp\u003e8.10.2 Bacteriocins 200\u003c\/p\u003e \u003cp\u003e8.11 Vitamins 201\u003c\/p\u003e \u003cp\u003e8.12 Short- chain Fatty Acids 202\u003c\/p\u003e \u003cp\u003e8.13 Exopolysaccharides 202\u003c\/p\u003e \u003cp\u003e8.14 Antioxidant Substances 202\u003c\/p\u003e \u003cp\u003e8.15 Production of Polyols 203\u003c\/p\u003e \u003cp\u003e8.16 Metabolomic Profiles of Different Lactic Acid Bacteria in the Rice Fermentation 203\u003c\/p\u003e \u003cp\u003e8.16.1 Nonvolatile Compounds 204\u003c\/p\u003e \u003cp\u003e8.16.2 Volatile Compounds 204\u003c\/p\u003e \u003cp\u003e8.16.3 Other Volatile Compounds 204\u003c\/p\u003e \u003cp\u003eAcknowledgments 208\u003c\/p\u003e \u003cp\u003eReferences 208\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Biofoundry in Microbial Protein Production: Process Challenges and Future Scenario 219\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eSimab Kanwal, Sher Zaman Safi, Aphichart Karnchanatat, and Piroonporn Srimongkol\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 219\u003c\/p\u003e \u003cp\u003e9.2 Microorganisms and Protein Production 220\u003c\/p\u003e \u003cp\u003e9.3 Strain Selection for Protein Production 221\u003c\/p\u003e \u003cp\u003e9.4 Protein- Rich Biomass Production 222\u003c\/p\u003e \u003cp\u003e9.5 Microbial Bioprocessing 223\u003c\/p\u003e \u003cp\u003e9.6 Cultivation Systems 224\u003c\/p\u003e \u003cp\u003e9.7 Bioreactors for Protein Production 224\u003c\/p\u003e \u003cp\u003e9.8 Downstream Processing 225\u003c\/p\u003e \u003cp\u003e9.9 Strategies in Synthetic Bioengineering 227\u003c\/p\u003e \u003cp\u003e9.9.1 Microbial Engineering 227\u003c\/p\u003e \u003cp\u003e9.9.2 Metabolic Pathway Optimization 228\u003c\/p\u003e \u003cp\u003e9.9.3 High- Throughput Screening 228\u003c\/p\u003e \u003cp\u003e9.10 Challenges and Future Prospects 229\u003c\/p\u003e \u003cp\u003e9.11 Conclusions 231\u003c\/p\u003e \u003cp\u003eReferences 231\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Nanotechnological Interventions in the Advancement of Lignocellulose Bio- Foundry: Current Status and Future Prospects 237\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eCarlos Lopez- Ortiz, Alan Chavez- Hita Wong, Aldo Sosa, and Nagamani Balagurusamy\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 237\u003c\/p\u003e \u003cp\u003e10.2 Advancing Lignocellulose Bio- Foundries: Pretreatment Strategies and Nanotechnology Integration 238\u003c\/p\u003e \u003cp\u003e10.3 Catalytic Nanomaterials and Enzyme Immobilization for Lignocellulose Biomass Conversion 239\u003c\/p\u003e \u003cp\u003e10.4 Underlying the Interactions of Nanotechnology Mechanism in Lignocellulose Bio- Foundry 242\u003c\/p\u003e \u003cp\u003e10.5 Factors Affecting Nanotechnology Use and Its Performance in Bio- Foundry Using Lignocellulosic Biomass 245\u003c\/p\u003e \u003cp\u003e10.6 Challenges and Considerations Using Nanotechnology in Lignocellulose Bio- Foundry 246\u003c\/p\u003e \u003cp\u003e10.7 Future Perspectives of Nanotechnology in Biofuel Production 248\u003c\/p\u003e \u003cp\u003e10.8 Conclusion 248\u003c\/p\u003e \u003cp\u003eReferences 249\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Synthetic Biology in the Realm of Genome Engineering for Improved Biocatalysts and Production 257\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eJosé Daniel Cano Montoya, Diego Hernandez, and Josman Velasco\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction 257\u003c\/p\u003e \u003cp\u003e11.2 The Design–Build–Test–Learn Cycle for Optimizing Biological Systems 258\u003c\/p\u003e \u003cp\u003e11.3 The Synthetic Biology Toolkit for Genome Engineering 259\u003c\/p\u003e \u003cp\u003e11.3.1 DNA Fragment Assembly Tools 259\u003c\/p\u003e \u003cp\u003e11.3.1.1 Ligation- Independent Cloning 260\u003c\/p\u003e \u003cp\u003e11.3.1.2 Gibson Assembly 260\u003c\/p\u003e \u003cp\u003e11.3.1.3 Yeast- Assisted DNA Assembly 261\u003c\/p\u003e \u003cp\u003e11.3.2 Genome- Editing Techniques 261\u003c\/p\u003e \u003cp\u003e11.3.2.1 Clustered Regularly Interspaced Short Palindromic Repeats 261\u003c\/p\u003e \u003cp\u003e11.3.2.2 Transcription Activator- Like Effector Nucleases 263\u003c\/p\u003e \u003cp\u003e11.3.2.3 Zinc Finger Nucleases 264\u003c\/p\u003e \u003cp\u003e11.4 Production and Improvement of Biocatalysts 264\u003c\/p\u003e \u003cp\u003e11.4.1 Chassis Organisms for the Production of Biocatalysts 265\u003c\/p\u003e \u003cp\u003e11.4.1.1 Escherichia coli 265\u003c\/p\u003e \u003cp\u003e11.4.1.2 Bacillus subtilis 267\u003c\/p\u003e \u003cp\u003e11.4.1.3 Pseudomonas putida 268\u003c\/p\u003e \u003cp\u003e11.4.1.4 Filamentous Fungi 268\u003c\/p\u003e \u003cp\u003e11.4.1.5 Pichia pastoris 269\u003c\/p\u003e \u003cp\u003e11.4.1.6 Mammalian Cell Expression Systems 269\u003c\/p\u003e \u003cp\u003e11.4.1.7 Plant Cells 270\u003c\/p\u003e \u003cp\u003e11.4.2 Techniques for the Improvement of Biocatalysts 271\u003c\/p\u003e \u003cp\u003e11.4.2.1 Directed Evolution 271\u003c\/p\u003e \u003cp\u003e11.4.2.2 Rational Design 272\u003c\/p\u003e \u003cp\u003e11.4.2.3 Chemical Modification of Enzymes 272\u003c\/p\u003e \u003cp\u003e11.5 Conclusions and Final Remarks 273\u003c\/p\u003e \u003cp\u003eAcknowledgment 273\u003c\/p\u003e \u003cp\u003eDeclaration 273\u003c\/p\u003e \u003cp\u003eReferences 274\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Multi- omics Technologies Paving the Way for the Success of Biorefinery 279\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eShruti Ahlawat, Somya Gupta, Ritika Yadav, and Krishna Kant Sharma\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 279\u003c\/p\u003e \u003cp\u003e12.2 Lignocellulosic Biomass 280\u003c\/p\u003e \u003cp\u003e12.3 Steps in Biorefinery 280\u003c\/p\u003e \u003cp\u003e12.3.1 Step 1- Pretreatment of LC Biomass 281\u003c\/p\u003e \u003cp\u003e12.3.1.1 Physical Pretreatment 281\u003c\/p\u003e \u003cp\u003e12.3.1.2 Chemical Pretreatment 281\u003c\/p\u003e \u003cp\u003e12.3.1.3 Physio- chemical Pretreatment Processes 282\u003c\/p\u003e \u003cp\u003e12.3.1.4 Biological Pretreatment Method 283\u003c\/p\u003e \u003cp\u003e12.3.2 Step 2- Saccharification 283\u003c\/p\u003e \u003cp\u003e12.3.3 Step 3- Fermentation 284\u003c\/p\u003e \u003cp\u003e12.4 Various Value- Added Products Generated from Lignocellulosic Biomass 284\u003c\/p\u003e \u003cp\u003e12.5 Cellulose- Based Value- Added Products 285\u003c\/p\u003e \u003cp\u003e12.5.1 Lactic Acid 285\u003c\/p\u003e \u003cp\u003e12.5.2 Bioethanol 286\u003c\/p\u003e \u003cp\u003e12.5.3 Biomethane 286\u003c\/p\u003e \u003cp\u003e12.5.4 Biodiesel 286\u003c\/p\u003e \u003cp\u003e12.5.5 Biobutanol 286\u003c\/p\u003e \u003cp\u003e12.6 Hemicellulose- Based Value- Added Products 287\u003c\/p\u003e \u003cp\u003e12.6.1 Xylitol 287\u003c\/p\u003e \u003cp\u003e12.6.2 Xylooligosaccharides (XOS) 287\u003c\/p\u003e \u003cp\u003e12.6.3 Furfural 288\u003c\/p\u003e \u003cp\u003e12.7 Lignin- Based Value- Added Products 288\u003c\/p\u003e \u003cp\u003e12.7.1 Biopolymers 288\u003c\/p\u003e \u003cp\u003e12.7.2 Biochar 288\u003c\/p\u003e \u003cp\u003e12.8 CRISPR\/Cas9 and - Omics Technologies 289\u003c\/p\u003e \u003cp\u003e12.9 Utilization of - Omics Technologies Toward Biorefinery Success 289\u003c\/p\u003e \u003cp\u003e12.10 Role in Efficient Enzyme Production 293\u003c\/p\u003e \u003cp\u003e12.11 Role in Microalgae- Based Biorefinery 296\u003c\/p\u003e \u003cp\u003e12.12 Conclusion 297\u003c\/p\u003e \u003cp\u003eConflict of Interest 298\u003c\/p\u003e \u003cp\u003eAuthor Contributions 298\u003c\/p\u003e \u003cp\u003eFunding 298\u003c\/p\u003e \u003cp\u003eReferences 298\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Sustainability Assessment of Genetically Engineered Biocatalysts Producing Biofuels and Biochemicals 309\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eAndreza A. Longati, Christian de Oliveira Martins, Gabriel Baioni, Adilson José da Silva, Thais Suzane Milessi, and Felipe Fernando Furlan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 309\u003c\/p\u003e \u003cp\u003e13.2 The Role of Genetically Modified Organisms in Biorefineries 310\u003c\/p\u003e \u003cp\u003e13.3 Metabolic Modeling in the Development of Genetically Modified Organisms 312\u003c\/p\u003e \u003cp\u003e13.3.1 Metabolic Modeling 313\u003c\/p\u003e \u003cp\u003e13.3.2 Metabolic Modeling for Genetically Modified Organisms 315\u003c\/p\u003e \u003cp\u003e13.4 Parameters to Evaluate the Sustainability of Genetically Modified Organisms 315\u003c\/p\u003e \u003cp\u003e13.4.1 Environmental Perspective 316\u003c\/p\u003e \u003cp\u003e13.4.2 Economic Perspective 321\u003c\/p\u003e \u003cp\u003e13.4.3 Social Perspective 323\u003c\/p\u003e \u003cp\u003e13.5 Case Studies of Genetically Modified Organisms 324\u003c\/p\u003e \u003cp\u003e13.6 Conclusions 327\u003c\/p\u003e \u003cp\u003eAcknowledgments 328\u003c\/p\u003e \u003cp\u003eReferences 328\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Lean Manufacturing Toward Minimum Waste Discharge and Potential Gains in the Biorefinery and Biotechnology Industries 337\u003cbr\u003e \u003c\/b\u003e\u003ci\u003eFabricio M. Gomes, Messias Borges Silva, Giovani Maltempi- Mendes, and Anuj Kumar Chandel\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 337\u003c\/p\u003e \u003cp\u003e14.2 The Fundamentals of Lean Manufacturing 337\u003c\/p\u003e \u003cp\u003e14.3 The Five Principles of Lean 338\u003c\/p\u003e \u003cp\u003e14.4 Waste Reduction in Biotechnology: Unique Challenges 338\u003c\/p\u003e \u003cp\u003e14.5 Types of Waste in Biotechnology 338\u003c\/p\u003e \u003cp\u003e14.6 Managing Biohazardous Waste 339\u003c\/p\u003e \u003cp\u003e14.7 Lean Tools for Biotechnology 339\u003c\/p\u003e \u003cp\u003e14.7.1 Kaizen 340\u003c\/p\u003e \u003cp\u003e14.7.2 Value Stream Mapping (VSM) 340\u003c\/p\u003e \u003cp\u003e14.7.3 5s 340\u003c\/p\u003e \u003cp\u003e14.7.4 Kanban 341\u003c\/p\u003e \u003cp\u003e14.8 Total Productive Maintenance 341\u003c\/p\u003e \u003cp\u003e14.9 Lean Manufacturing and Digitalization in Biotechnology 341\u003c\/p\u003e \u003cp\u003e14.10 Real- Time Data Analytics 341\u003c\/p\u003e \u003cp\u003e14.11 Digital Twins 342\u003c\/p\u003e \u003cp\u003e14.12 Potential Gains from Lean Implementation in Biotechnology 342\u003c\/p\u003e \u003cp\u003e14.13 Cost Savings 342\u003c\/p\u003e \u003cp\u003e14.13.1 Improved Process Efficiency 343\u003c\/p\u003e \u003cp\u003e14.13.2 Environmental Sustainability 343\u003c\/p\u003e \u003cp\u003e14.14 Lean Manufacturing’s Role in Addressing Sustainability Goals 343\u003c\/p\u003e \u003cp\u003e14.15 Regulatory Compliance and Lean in Biotechnology 344\u003c\/p\u003e \u003cp\u003e14.16 Commercial Aspects of Lean Implementation in Biorefineries 344\u003c\/p\u003e \u003cp\u003e14.17 Case Study: Lean Implementation at Pfizer 345\u003c\/p\u003e \u003cp\u003e14.18 Case Study: Novartis and Lean Implementation in Biopharma 348\u003c\/p\u003e \u003cp\u003e14.19 Conclusion 348\u003c\/p\u003e \u003cp\u003eAcknowledgments 348\u003c\/p\u003e \u003cp\u003eReferences 348\u003c\/p\u003e \u003cp\u003eIndex 351\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biology, life sciences [\u003ca title=\"See our other books on Biology, life sciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biology,%20life%20sciences%20%5BPS%5D%22\"\u003ePS\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52433530749208,"sku":"9781394309924","price":137.87,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9781394309924.jpg?v=1784853442","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/biofoundry-techniques-for-biotechnology-applications-hardback-9781394309924","provider":"Freshly Printed Books","version":"1.0","type":"link"}