{"product_id":"bacterial-population-genetics-in-infectious-disease-hardback-9780470424742","title":"Bacterial Population Genetics in Infectious Disease (Hardback) 9780470424742","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eBacterial Population Genetics in Infectious Disease\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eD. Ashley Robinson (Edited by), DA Robinson (Author), Edward J Feil (Edited by), Daniel Falush (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470424742, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 14 May 2010\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e448 pages\u003cbr\u003e25.9 x 18.5 x 2.5 cm, 0.93 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"I enjoyed reading Chapters 9, 12, and 15 because these topics interested me. Other chapters can be recommended as sources of citations for specialists interested in those particular bacteria.\" (The Quarterly Review of Biology, 1 December 2011)  \u003cp\u003e\"On the whole, this book is of general interest for teachers of microbiology, who need to explain bacteriology in the genomic age, and it may also help clinical microbiologists choose tools for identifying circulating clones.  Finally, it can be useful to specialists in the field of emerging bacteria for whom the need to synthesize genomic data is part of their professional routine. I recommend this book most strongly for all of these bacteriology specialists.\" (Emerging Infectious Diseases Journal, 1 March 2011)\u003cbr\u003e \u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThis book is a unique synthesis of the major concepts and methods in bacterial population genetics in infectious disease, a field that is now about 35 yrs old.  Emphasis is given to explaining population-level processes that shape genetic variation in bacterial populations and statistical methods of analysis of bacterial genetic data.  \u003cul type=\"disc\"\u003e \u003cli\u003eA \"how to\" of bacterial population genetics, which covers an extremely large range of organisms\u003c\/li\u003e \u003cli\u003eExpanding area of science due to high-throughput genome sequencing of bacterial pathogens\u003c\/li\u003e \u003cli\u003eCovers both fundamental approaches to analyzing bacterial population structures with conceptual background in bacterial population biology\u003c\/li\u003e \u003cli\u003eDetailed treatment of statistical methods\u003c\/li\u003e \u003c\/ul\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eForeword.  \u003cp\u003ePreface.\u003c\/p\u003e \u003cp\u003eContributors.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I Concepts and Methods in Bacterial Population Genetics.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1 The Coalescent of Bacterial Populations.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1.1 Background and Motivation.\u003c\/p\u003e \u003cp\u003e1.2 Population Reproduction Models.\u003c\/p\u003e \u003cp\u003e1.3 Time and the Effective Population Size.\u003c\/p\u003e \u003cp\u003e1.4 The Genealogy of a Sample of Size \u003ci\u003en\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e1.5 From Coalescent Time to Real Time.\u003c\/p\u003e \u003cp\u003e1.6 Mutations.\u003c\/p\u003e \u003cp\u003e1.7 Demography.\u003c\/p\u003e \u003cp\u003e1.8 Recombination and Gene Conversion.\u003c\/p\u003e \u003cp\u003e1.9 Summary.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2 Linkage, Selection, and the Clonal Complex.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction—Historical Overview.\u003c\/p\u003e \u003cp\u003e2.2 Recombination, Linkage, and Substructure.\u003c\/p\u003e \u003cp\u003e2.3 Neutrality versus Selection.\u003c\/p\u003e \u003cp\u003e2.4 Clustering Techniques.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3 Sequence-Based Analysis of Bacterial Population Structures.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e3.1 Introduction.\u003c\/p\u003e \u003cp\u003e3.2 Alignments.\u003c\/p\u003e \u003cp\u003e3.3 Phylogenetic Methods.\u003c\/p\u003e \u003cp\u003e3.4 Measures of Uncertainty.\u003c\/p\u003e \u003cp\u003e3.5 Beyond the Tree Model.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4 Genetic Recombination and Bacterial Population Structure.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction.\u003c\/p\u003e \u003cp\u003e4.2 Constraints on LGT.\u003c\/p\u003e \u003cp\u003e4.3 Infl uences of LGT on Sequence Analyses.\u003c\/p\u003e \u003cp\u003e4.4 The Detection of Individual LGT Events.\u003c\/p\u003e \u003cp\u003e4.5 The Estimation of Homologous Recombination Rates.\u003c\/p\u003e \u003cp\u003e4.6 Properly Accounting for LGT During Sequence Analyses.\u003c\/p\u003e \u003cp\u003e4.7 Questions Relating Directly to LGT.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5 Statistical Methods for Detecting the Presence of Natural Selection in Bacterial Populations.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction.\u003c\/p\u003e \u003cp\u003e5.2 Natural Selection.\u003c\/p\u003e \u003cp\u003e5.3 Statistical Methods for Detecting the Presence of Natural Selection.\u003c\/p\u003e \u003cp\u003e5.4 Statistical Methods for Bacterial Populations.\u003c\/p\u003e \u003cp\u003e5.5 An Example.\u003c\/p\u003e \u003cp\u003e5.6 Discussion and Perspective.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6 Demographic Infl uences on Bacterial Population Structure.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6.1 Bacterial Population Size.\u003c\/p\u003e \u003cp\u003e6.2 Measures of Genetic Diversity.\u003c\/p\u003e \u003cp\u003e6.3 The Concept of Effective Population Size.\u003c\/p\u003e \u003cp\u003e6.4 Inferring Past Demography from Genetic Sequence Data.\u003c\/p\u003e \u003cp\u003e6.5 Population Subdivision.\u003c\/p\u003e \u003cp\u003e6.6 What is a Bacterial Population?\u003c\/p\u003e \u003cp\u003e6.7 Conclusion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7 Population Genomics of Bacteria.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction.\u003c\/p\u003e \u003cp\u003e7.2 Classical Bacterial Population Genetics.\u003c\/p\u003e \u003cp\u003e7.3 The Genomics Era.\u003c\/p\u003e \u003cp\u003e7.4 Bacterial Population Genomics.\u003c\/p\u003e \u003cp\u003e7.5 Next-Gen Bacterial Population Genomics.\u003c\/p\u003e \u003cp\u003e7.6 Next-Gen Genomics Technology.\u003c\/p\u003e \u003cp\u003e7.7 Next-Gen Genomic Data Analysis.\u003c\/p\u003e \u003cp\u003e7.8 Conclusions\/Future Prospects.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8 The Use of MLVA and SNP Analysis to Study the Population Genetics of Pathogenic Bacteria.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction.\u003c\/p\u003e \u003cp\u003e8.2 MLVA and Other DNA Fragment-Based Methods.\u003c\/p\u003e \u003cp\u003e8.3 SNP and DNA Sequence-Based Methods.\u003c\/p\u003e \u003cp\u003e8.4 Conclusion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II Population Genetics of Select Bacterial Pathogens.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9 Population Genetics of \u003ci\u003eBacillus\u003c\/i\u003e: Phylogeography of Anthrax in North America.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction.\u003c\/p\u003e \u003cp\u003e9.2 History of Anthrax in North America.\u003c\/p\u003e \u003cp\u003e9.3 The Anthrax Districts after 1944.\u003c\/p\u003e \u003cp\u003e9.4 Molecular Genotyping of \u003ci\u003eB. anthracis\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e9.5 Genotypes within the Anthrax Districts in North America.\u003c\/p\u003e \u003cp\u003e9.6 Phylogenetic Resolution within the WNA Lineage.\u003c\/p\u003e \u003cp\u003e9.7 Phylogeographic Resolution within the Ames Lineage.\u003c\/p\u003e \u003cp\u003e9.8 Additional \u003ci\u003eB. anthracis\u003c\/i\u003e Genotypes in North America.\u003c\/p\u003e \u003cp\u003e9.9 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10 Population Genetics of \u003ci\u003eCampylobacter\u003c\/i\u003e.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction.\u003c\/p\u003e \u003cp\u003e10.2 Human Infection.\u003c\/p\u003e \u003cp\u003e10.3 Genetic Structure.\u003c\/p\u003e \u003cp\u003e10.4 Models of \u003ci\u003eCampylobacter\u003c\/i\u003e Evolution.\u003c\/p\u003e \u003cp\u003e10.5 Clades and Species.\u003c\/p\u003e \u003cp\u003e10.6 Conclusion.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11 Population Genetics of \u003ci\u003eEnterococcus.\u003c\/i\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e11.1 Introduction.\u003c\/p\u003e \u003cp\u003e11.2 Antibiotic Resistance.\u003c\/p\u003e \u003cp\u003e11.3 Vancomycin Resistance.\u003c\/p\u003e \u003cp\u003e11.4 VRE: A Zoonosis or Not?\u003c\/p\u003e \u003cp\u003e11.5 Population Structure and Genetic Evolution: Similarities and Differences Between \u003ci\u003eE. faecium\u003c\/i\u003e and \u003ci\u003eE. faecalis\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e11.6 What Is Driving GD in \u003ci\u003eE. faecium\u003c\/i\u003e and \u003ci\u003eE. faecalis\u003c\/i\u003e?\u003c\/p\u003e \u003cp\u003e11.7 The Accessory Genome of \u003ci\u003eE. faecium\u003c\/i\u003e and \u003ci\u003eE. faecalis\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e11.8 Summary, Conclusions, and Future Perspectives.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12 Population Biology of Lyme Borreliosis Spirochetes.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction.\u003c\/p\u003e \u003cp\u003e12.2 Genome Organization of LB Spirochetes.\u003c\/p\u003e \u003cp\u003e12.3 Genotyping of LB Spirochetes and Phylogenetic Tools.\u003c\/p\u003e \u003cp\u003e12.4 Population Biology and Evolution of LB Spirochetes.\u003c\/p\u003e \u003cp\u003e12.5 Do LB Species Exist?\u003c\/p\u003e \u003cp\u003e12.6 Future Research Avenues.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13 Population Genetics of \u003ci\u003eNeisseria meningitidis\u003c\/i\u003e.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction.\u003c\/p\u003e \u003cp\u003e13.2 A Brief History of Typing of Meningococci.\u003c\/p\u003e \u003cp\u003e13.3 Species Separation.\u003c\/p\u003e \u003cp\u003e13.4 Sampling Strategies.\u003c\/p\u003e \u003cp\u003e13.5 The Clonal Complexes of Meningococci.\u003c\/p\u003e \u003cp\u003e13.6 Forces Shaping the Meningococcal Metalineage.\u003c\/p\u003e \u003cp\u003e13.7 Virulence, a Mysterious Trait.\u003c\/p\u003e \u003cp\u003e13.8 Population Effect of Meningococcal Vaccines.\u003c\/p\u003e \u003cp\u003e13.9 Antibiotic Resistance and Meningococcal Lineages.\u003c\/p\u003e \u003cp\u003e13.10 Concluding Remarks.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14 Population Genetics of Pathogenic \u003ci\u003eEscherichia coli\u003c\/i\u003e.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction.\u003c\/p\u003e \u003cp\u003e14.2 \u003ci\u003eE. coli\u003c\/i\u003e Population Genetics: Clonal or not Clonal?\u003c\/p\u003e \u003cp\u003e14.3 The \u003ci\u003eE. coli\u003c\/i\u003e Phylogenetic Structure.\u003c\/p\u003e \u003cp\u003e14.4 The Evolutionary History of a Host-Specifi c Obligate Pathogen: The \u003ci\u003eShigella\u003c\/i\u003e and EIEC Case Study.\u003c\/p\u003e \u003cp\u003e14.5 What Makes You an Opportunistic Pathogen?\u003c\/p\u003e \u003cp\u003e14.6 The Virulence Resistance Trade-off.\u003c\/p\u003e \u003cp\u003e14.7 Concluding Remarks.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15 Population Genetics of \u003ci\u003eSalmonella\u003c\/i\u003e: Selection for Antigenic Diversity.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction.\u003c\/p\u003e \u003cp\u003e15.2 Generation Timescale Diversifi cation.\u003c\/p\u003e \u003cp\u003e15.3 Antigenic Diversity in \u003ci\u003eSalmonella\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e15.4 Why Are Diverse H and O Antigens Maintained in \u003ci\u003eSalmonella\u003c\/i\u003e?\u003c\/p\u003e \u003cp\u003e15.5 Conclusions.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16 Population Genetics of \u003ci\u003eStaphylococcus\u003c\/i\u003e.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction.\u003c\/p\u003e \u003cp\u003e16.2 Overview of The Staphylococcal Population Structure.\u003c\/p\u003e \u003cp\u003e16.3 Staphylococcal Population Structure in Specific Disease Contexts.\u003c\/p\u003e \u003cp\u003e16.4 Origin and Maintenance of Staphylococcal Genetic Variation.\u003c\/p\u003e \u003cp\u003e16.5 Macroevolutionary Considerations and Concluding Remarks.\u003c\/p\u003e \u003cp\u003eAppendix 1—Diversity and Differentiation.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17 Population Genetics of \u003ci\u003eStreptococcus\u003c\/i\u003e.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e17.1 Habitats, Transmission, and Disease.\u003c\/p\u003e \u003cp\u003e17.2 Classical Strain Typing.\u003c\/p\u003e \u003cp\u003e17.3 Multilocus Sequence Typing (MLST) Based on Housekeeping Genes.\u003c\/p\u003e \u003cp\u003e17.4 Species Boundaries and Gene Flow.\u003c\/p\u003e \u003cp\u003e17.5 Niche-driving Genes.\u003c\/p\u003e \u003cp\u003e17.6 Bacterial Population Dynamics and Selection.\u003c\/p\u003e \u003cp\u003e17.7 Machinery of Genetic Change, Revisited.\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18 Population Genetics of Vibrios.\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction.\u003c\/p\u003e \u003cp\u003e18.2 \u003ci\u003eV. cholerae\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e18.3 \u003ci\u003eV. parahaemolyticus\u003c\/i\u003e .\u003c\/p\u003e \u003cp\u003e18.4 \u003ci\u003eV. vulnificus\u003c\/i\u003e.\u003c\/p\u003e \u003cp\u003e18.5 Conclusions.\u003c\/p\u003e \u003cp\u003eReferences.\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIndex.\u003c\/b\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Biology, life sciences [\u003ca title=\"See our other books on Biology, life sciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biology,%20life%20sciences%20%5BPS%5D%22\"\u003ePS\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Brand 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