{"product_id":"applications-of-transition-metal-catalysis-in-drug-discovery-and-development-an-industrial-perspective-hardback-9780470631324","title":"Applications of Transition Metal Catalysis in Drug Discovery and Development; An Industrial Perspective (Hardback) 9780470631324","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eApplications of Transition Metal Catalysis in Drug Discovery and Development\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eAn Industrial Perspective\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003e\u003cp\u003e“’Applications of Transition Metal Catalysis in Drug Discovery and Development’ is a valuable resource in synthetic chemistry which libraries of Chemistry should have, especially those serving medicinal chemists. It captures authoritatively the rich body of information recently generated by many pharmaceutical companies on workable ways to access drug candidates, and constitutes a unique review of modern synthetic practice. The authors (all from industry) also include much relevant academic research. A high proportion of the cited literature is from the last 25 years. It emphasizes catalytic C-C and C-hetero coupling, cyclization, oxidation and reduction reactions. The writing is clear and concise.” —\u003cb\u003eE J Corey\u003c\/b\u003e, Harvard University\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eMatthew L. Crawley (Edited by), ML Crawley (Author), Barry M. Trost (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470631324, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 26 July 2012\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e384 pages, Drawings: 1000 B\u0026amp;W, 0 Color\u003cbr\u003e23.6 x 16.3 x 2.5 cm, 0.658 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e“The book will be particularly appreciated by young scientists, especially those aspiring to a future in the pharmaceutical industry, because it shows what kind of problems they will be asked to solve once they start their industrial career.”  (\u003ci\u003eChemMedChem\u003c\/i\u003e, 1 March 2013)\u003c\/p\u003e \u003cp\u003e“All chapters are well-written and comprehensive with lots of examples from OPR and D.  The book is highly recommended to all process chemists.”  (\u003ci\u003eOrganic Process Research \u0026amp; Development Journal\u003c\/i\u003e, 1 November 2012)\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThis book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs.  The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003eContributors ix\u003c\/p\u003e \u003cp\u003eAbout the Authors xi\u003c\/p\u003e \u003cp\u003e1 Transition Metal Catalysis in the Pharmaceutical Industry 1\u003cbr\u003e\u003ci\u003eCarl A. Busacca, Daniel R. Fandrick, Jinhua J. Song, and Chris H. Senanayake (Boehringer Ingelheim\u003c\/i\u003e \u003ci\u003ePharmaceuticals)\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2 Selected Applications of Transition Metal-Catalyzed Carbon–Carbon Cross-Coupling Reactions in the Pharmaceutical Industry 25\u003cbr\u003e\u003ci\u003eHong C. Shen (Roche)\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3 Selected Applications of Pd- and Cu-Catalyzed Carbon–Heteroatom Cross-Coupling Reactions in the Pharmaceutical Industry 97\u003cbr\u003e\u003ci\u003eJingjun Yin (Merck)\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4 Asymmetric Cross-Coupling Reactions 165\u003cbr\u003e\u003ci\u003eVince Yeh (Novartis) and William A. Szabo (Consultant in Drug Development)\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5 Metathesis Reactions 215\u003cbr\u003e\u003ci\u003eOliver R. Thiel (Amgen)\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6 Transition Metal-Catalyzed Synthesis of Five- and Six-Membered Heterocycles 257\u003cbr\u003e\u003ci\u003eCheol K. Chung (Merck) and Matthew L. Crawley (Main Line Health)\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7 Oxidative Catalysis 277\u003cbr\u003e\u003ci\u003eLamont Terrell (GlaxoSmithKline)\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8 Industrial Asymmetric Hydrogenation 315\u003cbr\u003e\u003ci\u003eHans-Ulrich Blaser (Solvias)\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 243\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52276371095832,"sku":"9780470631324","price":86.79,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470631324.jpg?v=1781368118","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/applications-of-transition-metal-catalysis-in-drug-discovery-and-development-an-industrial-perspective-hardback-9780470631324","provider":"Freshly Printed Books","version":"1.0","type":"link"}