{"product_id":"antimalarial-agents-design-and-mechanism-of-action-paperback-9780081012109","title":"Antimalarial Agents; Design and Mechanism of Action (Paperback \/ softback) 9780081012109","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAntimalarial Agents\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eDesign and Mechanism of Action\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003e\u003cp\u003eAn indispensable guide to current developments in medicinal chemistry for the creation of enhanced antimalarial drugs\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eGraham L. Patrick (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780081012109\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 2 June 2020\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e622 pages\u003cbr\u003e23.4 x 19 x 3.8 cm, 1.42 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eAntimalarial Agents: Design and Mechanism of Action\u003c\/i\u003e seeks to support medicinal chemists in their work toward antimalarial solutions, providing practical guidance on past and current developments and highlighting promising leads for the future.\u003c\/p\u003e  \u003cp\u003eMalaria is a deadly disease which threatens half of the world’s population. Advances over several decades have seen vast improvements in the eff ectiveness of both preventative measures and treatments, but the rapid adaptability of the disease means that the ongoing search for improved and novel antimalarial drugs is essential.\u003c\/p\u003e  \u003cp\u003eBeginning with a historical overview of malaria and antimalarial research, this book goes on to describe the biological aspects of malaria, highlighting the lifecycle of the parasite responsible for malaria, the problem of resistance, genetic mapping of the parasite’s genome, established drug targets, and potential drug targets for the future. This sets the scene for the following chapters which provide a detailed study of the medicinal chemistry of antimalarial agents, with a focus on the design of antimalarial drugs.\u003c\/p\u003e  \u003cp\u003eDrawing on the knowledge of its experienced authors, and coupling historic research with current fi ndings to provide a full picture of both past and current milestones, \u003ci\u003eAntimalarial Agents: Design and Mechanism of Action\u003c\/i\u003e is a comprehensive yet accessible guide for all those involved in the design, development, and administration of antimalarial drugs, including student academic researchers, medicinal chemists, malaria researchers, and pharmaceutical scientists.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e1. History of malaria and its treatment 2. Knowing one's enemy: the \u003ci\u003ePlasmodium\u003c\/i\u003e parasite 3. The cinchona alkaloids and the aminoquinolines 4. Artemisinin and artemisinin-related agents 5. Agents acting on pyrimidine metabolism 6. Antimalarial agents acting on hemoglobin degradation 7. Plasmepsins as targets for antimalarial agents 8. Falcipains as drug targets in antimalarial therapy 9. Drug targets in the apicoplast 10. Drugs targeting mitochondrial functions 11. The \u003ci\u003ePlasmodium falciparum\u003c\/i\u003e proteasome as a drug target 12. Transferases and their inhibition 13. Kinases and kinase inhibitors 14. Miscellaneous agents of clinical interest 15. Inhibitors of purine and pyrimidine pathways 16. Miscellaneous targets\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46649152438552,"sku":"9780081012109","price":137.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780081012109_d2b88808-df50-4986-98e5-fa3ee1b8905d.jpg?v=1695004187","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/antimalarial-agents-design-and-mechanism-of-action-paperback-9780081012109","provider":"Freshly Printed Books","version":"1.0","type":"link"}