{"product_id":"annual-reports-in-medicinal-chemistry-paperback-9780123809025","title":"Annual Reports in Medicinal Chemistry (Paperback \/ softback) 9780123809025","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAnnual Reports in Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eJohn E. Macor (Series edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123809025, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 25 November 2010\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e648 pages\u003cbr\u003e22.9 x 15.1 x 4 cm, 0.86 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eAnnual Reports in Medicinal Chemistry \u003c\/i\u003eprovides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eSection I: Central Nervous System Diseases – ROBICHAUD\u003c\/p\u003e \u003col\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eVoltage-Gated Calcium Channel Antagonists for the Central Nervous System\u003c\/li\u003e \u003cp\u003eJames C. Barrow and Joseph L. Duffy\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eRecent Developments in Glycine Transporter-1 Inhibitors\u003c\/li\u003e \u003cp\u003eChristopher L. Cioffi, Shuang Liu and Mark A.Wolf\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eModulators of Transient Receptor Potential Ion Channels\u003c\/li\u003e \u003cp\u003eRajagopal Bakthavatchalam and S. David Kimball\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eDefining Neuropharmacokinetic Parameters in CNS Drug Discovery to Determine Cross-species Pharmacologic Exposure-Response Relationships\u003c\/li\u003e \u003cp\u003eChristopher L. Shaffer\u003c\/p\u003e \u003cp\u003eSection II: Cardiovascular and Metabolic Diseases - STAMFORD\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eHigh Affinity Niacin Receptor GPR109A Agonists\u003c\/li\u003e \u003cp\u003eHong C. Shen and Steven L. Colletti\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eRecent Advances in Acetyl CoA Carboxylase (ACC) Inhibitors\u003c\/li\u003e \u003cp\u003eMatthew P. Bourbeau, John G. Allen, and Wei Gu\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eEnzymatic Targets in the Triglyceride Synthesis Pathway\u003c\/li\u003e \u003cp\u003eDmitry O. Koltun and Jeff Zablocki\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eInhibitors of HIF Prolyl Hydroxylases\u003c\/li\u003e \u003cp\u003eMichael H. Rabinowitz, Terrance D. Barrett, Mark D. Rosen, Hariharan Venkatesan\u003c\/p\u003e \u003cp\u003eSection III: Inflammation \/ Pulmonary \/ GI - BARRISH\/Weinstein\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eOpioid Receptor Antagonists for Gastrointestinal Dysfunction\u003c\/li\u003e \u003cp\u003eR. William Hipkin and Roland E. Dolle\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eCFTR Modulators for the Treatment of Cystic Fibrosis\u003c\/li\u003e \u003cp\u003eSabine Hadida, Frederick Van Goor and Peter D. J. Grootenhuis\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eTargeting B-cells in inflammatory disease\u003c\/li\u003e \u003cp\u003eKevin S. Currie\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eModulators of Toll-Like Receptor (TLR) Signaling\u003c\/li\u003e \u003cp\u003eMark Spyvee, Lynn Hawkins, and Sally Ishizaka\u003c\/p\u003e \u003cp\u003eSection IV: Oncology - McAlpine\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eJanus Kinase 2 (JAK2) inhibitors for the treatment of myeloproliferative neoplasm (MPN)\u003c\/li\u003e \u003cp\u003eAshok V. Purandare, Matthew V. Lorenzi and Louis J. Lombardo\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eDevelopment of poly(ADP-ribose)polymerase (PARP) inhibitors in oncology\u003c\/li\u003e \u003cp\u003ePhilip Jones\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eEpigenetic Targets and Cancer Drug Discovery\u003c\/li\u003e \u003cp\u003ePatrick M. Woster, Ph.D\u003c\/p\u003e \u003cp\u003eSection V: Infectious Diseases - Primeau\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eHIV-1 Integrase Strand Transfer Inhibitors\u003c\/li\u003e \u003cp\u003eBrian A. Johns\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eRecent Advances in Drug Discovery for Neglected Tropical Diseases Caused by Infective Kinetoplastid Parasites\u003c\/li\u003e \u003cp\u003eRobert T. Jacobs and Charles Ding\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eRecent Advances in the Inhibition of Bacterial Fatty Acid Biosynthesis\u003c\/li\u003e \u003cp\u003eVincent Gerusz\u003c\/p\u003e \u003cp\u003eSection VI: Topics in Biology - LOWE\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eBack to the Plaque: Emerging Studies That Re-Focus Attention on the Neuritic Plaque in Alzheimer’s Disease\u003c\/li\u003e \u003cp\u003eDr. Robert B. Nelson\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eTargeting Methyl Lysine\u003c\/li\u003e \u003cp\u003eStephen V. Frye, Tom Heightman and Jian Jin\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eChemical Proteomic Technologies for Drug Target Identification\u003c\/li\u003e \u003cp\u003eKieran F. Geoghegan and Douglas S. Johnson\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eNIH Translational Programs for Assisting Pre-Clinical Drug Discovery and Development\u003c\/li\u003e \u003cp\u003eRaj N. Misra\u003c\/p\u003e \u003cp\u003eSection VII: Topics in Drug Design and Discovery - DESAI\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eRole of Physicochemical Properties and Lipophilic Ligand Efficiency (LipE or LLE) in addressing Drug Safety Risks\u003c\/li\u003e \u003cp\u003eMartin P. Edwards and David A. Price\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eReducing the Risk of Drug Attrition Associated with Physicochemical Properties\u003c\/li\u003e \u003cp\u003ePaul D. Leeson and James R. Empfield\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eCompound Collection Enhancement and Paradigms for High Throughput Screening - an Update\u003c\/li\u003e \u003cp\u003eStevan W Djuric, Irini Akritopoulou-Zanze, Philip B Cox and Scott Galasinski\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eThe Role of Fluorine in the Discovery and Optimization of CNS Agents: Modulation of Drug-Like Properties\u003c\/li\u003e \u003cp\u003eKevin J. Hodgetts, Kerry J. Combs, Amy M. Elder and Geraldine C. Harriman\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003ePatents in Drug Discovery: Case Studies, Examples, and Simple Steps Medicinal Chemists Can Take to Protect Hard-Won Intellectual Property\u003c\/li\u003e \u003cp\u003eCharles J. Andres, Jr. and Richard L. Treanor\u003c\/p\u003e \u003cp\u003eSection VIII: Trends and Perspectives\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eTo Market, To Market – 2009\u003c\/li\u003e \u003c\/ol\u003e \u003cp\u003eShridhar Hegde and Michelle Schmidt\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649311658264,"sku":"9780123809025","price":73.29,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123809025.jpg?v=1695013999","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/annual-reports-in-medicinal-chemistry-paperback-9780123809025","provider":"Freshly Printed Books","version":"1.0","type":"link"}