{"product_id":"aneurysms-osteoarthritis-syndrome-smad3-gene-mutations-paperback-9780128027080","title":"Aneurysms-Osteoarthritis Syndrome; SMAD3 Gene Mutations (Paperback) 9780128027080","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAneurysms-Osteoarthritis Syndrome\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eSMAD3 Gene Mutations\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003e\u003cp\u003eAn overview on the Aneurysms-Osteoarthritis Syndrome caused by SMAD3 mutations that is a first-of-its-kind compilation of discovery, research, and care\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eDenise van der Linde (Author), Jolien Roos-Hesselink (Author), Bart L. Loeys (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780128027080\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback, published 24 November 2016\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e178 pages\u003cbr\u003e22.9 x 15.1 x 1.3 cm, 0.29 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eApprox.164 pages\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e1. Genetics (the discovery, broadened to include aspects as genotype\/phenotype correlations, functional role of SMAD3, insights into the role of TGFbeta signaling in aortic disease)2. Cardiovascular phenotype3. Systemic features (skeletal, joints, auto-immune, craniofacial features)4. Differential diagnosis heritable thoracic aortic diseases5a. Marfan5b. Loeys-Dietz5c. Ehlers-Danlos5d. Bicuspid aortic valve5e. Turner Syndrome6. Cardiovascular imaging7. Treatment options7a. Optimal cardiovascular medical treatment (Losartan etc.)7b. Cardiothoracic surgical experience7c. Vascular interventions and surgical experience7d. Orthopedic treatment options7e. Genetic counseling7f. Approach to clinical management (including proposed clinical follow-up chart)\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Genetics [\u003ca title=\"See our other books on Genetics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Genetics%20%5Bnon-medical%5D%20%5BPSAK%5D%22\"\u003enon-medical PSAK\u003c\/a\u003e], Orthopaedics \u0026amp; fractures [\u003ca title=\"See our other books on Orthopaedics \u0026amp; fractures\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Orthopaedics%20\u0026amp;%20fractures%20%5BMNS%5D%22\"\u003eMNS\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46649594511640,"sku":"9780128027080","price":91.19,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780128027080.jpg?v=1694102072","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/aneurysms-osteoarthritis-syndrome-smad3-gene-mutations-paperback-9780128027080","provider":"Freshly Printed Books","version":"1.0","type":"link"}