{"product_id":"an-introduction-to-statistics-in-early-phase-trials-hardback-9780470059852","title":"An Introduction to Statistics in Early Phase Trials (Hardback) 9780470059852","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAn Introduction to Statistics in Early Phase Trials\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eSteven Julious (Author), Say Beng Tan (Author), David Machin (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470059852, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 16 March 2010\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e272 pages\u003cbr\u003e25.2 x 17.5 x 2.2 cm, 0.621 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"An Introduction to Statistics in Early Phase Trials\" is an admirably concise and practical guide to the pertinent context, principles and formulae for statisticians inexpert in the application of their discipline to Phase I and II clinical research\". (Journal of Clinical Research Best Practices, 1 March 2011)\u003cbr\u003e \u003cbr\u003e   \u003cp\u003e“\u003ci\u003eAn Introduction to Statistics in Early Phase Trials\u003c\/i\u003e provides concise descriptions of many early phase trial designs, along with the statistical equations necessary to gather and analyze the data”  (\u003ci\u003eAnnals of Pharmacotherapy, 2010\u003c\/i\u003e)\u003c\/p\u003e \u003cp\u003e\"I enjoyed reading the work of Dr. Julious, Tan, and Machin,found it quite useful, and recommend it to others teaching about, working with, or considering work in the learning phase of drug development.\" (\u003ci\u003eJournal of Biopharmaceutical Statistics\u003c\/i\u003e, \u003ci\u003e2011\u003c\/i\u003e)\u003c\/p\u003e \u003cbr\u003e \u003cbr\u003e  \u003cbr\u003e \u003cbr\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eAll new medicines and devices undergo early phase trials to assess, interpret and better understand their efficacy, tolerability and safety. \u003ci\u003eAn Introduction to Statistics in Early Phase Trials\u003c\/i\u003e describes the practical design and analysis of these important early phase clinical trials and provides the crucial statistical basis for their interpretation. It clearly and concisely provides an overview of the most common types of trials undertaken in early phase clinical research and explains the different methodologies used. The impact of statistical technologies on clinical development and the statistical and methodological basis for making clinical and investment decisions are also explained.  \u003cul\u003e \u003cli\u003eConveys key ideas in a concise manner understandable by non-statisticians\u003c\/li\u003e \u003cli\u003eExplains how to optimise designs in a constrained or fixed resource setting\u003c\/li\u003e \u003cli\u003eDiscusses decision making criteria at the end of Phase II trials\u003c\/li\u003e \u003cli\u003eHighlights practical day-to-day issues and reporting of early phase trials\u003c\/li\u003e \u003c\/ul\u003e \u003cp\u003e\u003ci\u003eAn Introduction to Statistics in Early Phase Trials\u003c\/i\u003e is an essential guide for all researchers working in early phase clinical trial development, from clinical pharmacologists and pharmacokineticists through to clinical investigators and medical statisticians. It is also a valuable reference for teachers and students of pharmaceutical medicine learning about the design and analysis of clinical trials.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eChapter 1 Early phase trials 1\u003c\/p\u003e \u003cp\u003eChapter 2 Introduction to pharmacokinetics 13\u003c\/p\u003e \u003cp\u003eChapter 3 Sample size calculations for clinical trials 37\u003c\/p\u003e \u003cp\u003eChapter 4 Crossover trial basics 55\u003c\/p\u003e \u003cp\u003eChapter 5 Multi-period crossover trials 71\u003c\/p\u003e \u003cp\u003eChapter 6 First time into man 87\u003c\/p\u003e \u003cp\u003eChapter 7 Bayesian and frequentist methods 113\u003c\/p\u003e \u003cp\u003eChapter 8 First-time-into-new-population studies 125\u003c\/p\u003e \u003cp\u003eChapter 9 Bioequivalence studies 139\u003c\/p\u003e \u003cp\u003eChapter 10 Other Phase I trials 169\u003c\/p\u003e \u003cp\u003eChapter 11 Phase II trials: general issues 187\u003c\/p\u003e \u003cp\u003eChapter 12 Dose–response studies 197\u003c\/p\u003e \u003cp\u003eChapter 13 Phase II trials with toxic therapies 211\u003c\/p\u003e \u003cp\u003eChapter 14 Interpreting and applying early phase trial results 223\u003c\/p\u003e \u003cp\u003eChapter 15 Go\/No-Go criteria 231\u003c\/p\u003e \u003cp\u003eAppendix 245\u003c\/p\u003e \u003cp\u003eReferences 251\u003c\/p\u003e \u003cp\u003eIndex 257\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Other branches of medicine [\u003ca title=\"See our other books on Other branches of medicine\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Other%20branches%20of%20medicine%20%5BMM%5D%22\"\u003eMM\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52256845922584,"sku":"9780470059852","price":71.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470059852.jpg?v=1781275217","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/an-introduction-to-statistics-in-early-phase-trials-hardback-9780470059852","provider":"Freshly Printed Books","version":"1.0","type":"link"}