{"product_id":"amyloid-prions-and-other-protein-aggregates-part-b-hardback-9780121828172","title":"Amyloid, Prions, and Other Protein Aggregates, Part B (Hardback) 9780121828172","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAmyloid, Prions, and Other Protein Aggregates, Part B\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003ePresents methods and protocols for working with amyloid proteins.\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eRonald Wetzel (Volume editor), Indu Kheterpal (Volume editor)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780121828172, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 23 October 2006\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e430 pages, Illustrated\u003cbr\u003e22.9 x 15.1 x 2.7 cm, 0.76 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThe ability of polypeptides to form alternatively folded, polymeric structures such as amyloids and related aggregates is being increasingly recognized as a major new frontier in protein research. This new volume of \u003ci\u003eMethods in Enzymology\u003c\/i\u003e along with Part C (volume 413) on Amyloid, Prions and other Protein Aggregates continue in the tradition of the first volume (309) in containing detailed protocols and methodological insights, provided by leaders in the field, into the latest methods for investigating the structures, mechanisms of formation, and biological activities of this important class of protein assemblies.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cb\u003eCharacterization of protein deposition in vivo and ex vivo.\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eChapter 1: PMCA for diagnosis and prion propagation studies.\u003cbr\u003eChapter 2: Fractionation of prion protein aggregates by asymmetrical flow field-flow fractionation.\u003cbr\u003eChapter 3: Analysis of Amyloid Aggregates Using Agarose Gel Electrophoresis.\u003cbr\u003eChapter 4: Characterization of Systemic Amyloid Deposits by Mass Spectrometry.\u003cbr\u003eChapter 5: Proteomics of Polyglutamine Aggregates.\u003cbr\u003eChapter 6: Merger of Laser Capture Microdissection and Mass Spectrometry: A Window into the Amyloid Plaque Proteome.\u003cbr\u003eChapter 7: MALDI MS Imaging of Amyloid.\u003cbr\u003eChapter 8: Imaging polyglutamine deposits in brain tissue.\u003cbr\u003eChapter 9: X-34 labeling of abnormal protein aggregates during the progression of Alzheimer’s disease. \u003cbr\u003eChapter 10: Visualizing Pathology Deposits in the Living Brain of Alzheimer’s Disease Patients.\u003cbr\u003eChapter 11: Micro-Imaging of Amyloid in Mice\u003cbr\u003e\u003cbr\u003e\u003cb\u003eCell and animal models of amyloid formation and toxicity\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eChapter 12: An efficient protein transformation protocol for introducing prions into yeast.\u003cbr\u003eChapter 13: Screening for genetic modifiers of amyloid toxicity in yeast. \u003cbr\u003eChapter 14: Searching for anti-prion compounds: Cell-based high-throughput in vitro assays and animal testing strategies.\u003cbr\u003eChapter 15: A Drosophila Model of Alzheimer’s Disease.\u003cbr\u003eChapter 16: A C. elegans model of polyglutamine disease.\u003cbr\u003e\u003cbr\u003e\u003cb\u003eComputational Approaches and Theory\u003c\/b\u003e\u003cbr\u003e\u003cbr\u003eChapter 17: Nucleation: the Connections between Equilibrium and Kinetic Behavior.\u003cbr\u003eChapter 18: Computational Approaches to Amyloid beta Fibril Core Structure.\u003cbr\u003eChapter 19: Amyloid beta-protein aggregations: Ab initio discrete molecular dynamics approaches.\u003cbr\u003eChapter 20: Computational approaches to fibril structure and formation\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Cellular biology [\u003ca title=\"See our other books on Cellular biology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Cellular%20biology%20%5Bcytology%5D%20%5BPSF%5D%22\"\u003ecytology PSF\u003c\/a\u003e], Biochemistry [\u003ca title=\"See our other books on Biochemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemistry%20%5BPSB%5D%22\"\u003ePSB\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649193529624,"sku":"9780121828172","price":121.19,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780121828172_62f1df95-4681-4c4f-82e8-4c170b22b357.jpg?v=1695006670","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/amyloid-prions-and-other-protein-aggregates-part-b-hardback-9780121828172","provider":"Freshly Printed Books","version":"1.0","type":"link"}