{"product_id":"aminoglycoside-antibiotics-from-chemical-biology-to-drug-discovery-hardback-9780471743026","title":"Aminoglycoside Antibiotics; From Chemical Biology to Drug Discovery (Hardback) 9780471743026","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAminoglycoside Antibiotics\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eFrom Chemical Biology to Drug Discovery\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eDev P. Arya (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780471743026, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 3 August 2007\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e336 pages\u003cbr\u003e24.3 x 16.3 x 2.4 cm, 0.621 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"This is a 'must-have' text for anyone involved in AGA teaching or research. No better comprehensive treatise exists…\" (\u003ci\u003eJournal of Medicinal Chemistry\u003c\/i\u003e, October 18, 2007)  \u003cp\u003e \u003c\/p\u003e \u003cp\u003e\"There is little doubt that this volume will be a tremendous resource for any investigator interested in the biochemistry of aminoglycosides.\" (\u003ci\u003eJournal of the American Chemical Society\u003c\/i\u003e, September 26, 2007)\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eAdvances that open new avenues in developing aminoglycoside antibiotics\u003cbr\u003e \u003cbr\u003e During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention. This is the first book to provide a complete overview of recent advances in the field and explore their tremendous potential for drug discovery and rational drug design. With chapters written by one or more leading experts in their specialty areas, the book addresses the chemistry, biology, and toxicology of aminoglycosides.\u003cbr\u003e \u003cbr\u003e Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery is a great resource for academic and industrial researchers in drug design and mechanism studies and for researchers studying antibiotic resistance, antibiotic design and synthesis, and the discovery of novel pharmaceuticals. It is also a valuable reference for graduate students in pharmacy, pharmaceutical science, biophysics, medicinal chemistry, and chemical biology.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003eContributors ix\u003c\/p\u003e \u003cp\u003e1. In the Beginning There Was Streptomycin 1\u003cbr\u003e \u003ci\u003eJulian Davies\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2. The Biochemistry and Genetics of Aminoglycoside Producers 15\u003cbr\u003e \u003ci\u003eWolfgang Piepersberg, Khaled M. Aboshanab, Heike Schmidt-Beißner, and Udo F. Wehmeier\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3. Mechanisms of Aminoglycoside Antibiotic Resistance 119\u003cbr\u003e \u003ci\u003eTushar Shakya and Gerard D. Wright\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4. Design, Chemical Synthesis, and Antibacterial Activity of Kanamycin and Neomycin Class Aminoglycoside Antibiotics 141\u003cbr\u003e \u003ci\u003eJinhua Wang and Cheng-Wei Tom Chang\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5. NMR Structural Studies of Aminoglycoside: RNA Interaction 181\u003cbr\u003e \u003ci\u003eR. Andrew Marshall and Joseph D. Puglisi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6. Structural Comparisons Between Prokaryotic and Eukaryotic Ribosomal Decoding a Sites Free and Complexed with Aminoglycosides 209\u003cbr\u003e \u003ci\u003eJiro Kondo and Eric Westhof\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7. Binding of Antibiotics to the Aminoacyl-tRNA Site of Bacterial Ribosome 225\u003cbr\u003e \u003ci\u003eDale Kling, Christine Chow, and Shahriar Mobashery\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8. Metalloaminoglycosides: Chemistry and Biological Relevance 235\u003cbr\u003e \u003ci\u003eNikhil Gokhale, Anjali Patwardhan, and J. A. Cowan\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9. Adverse Effects of Aminoglycoside Therapy 255\u003cbr\u003e \u003ci\u003eAndra E. Talaska and Jochen Schacht\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10. Targeting HIV-1 RNA with Aminoglycoside Antibiotics and Their Derivatives 267\u003cbr\u003e \u003ci\u003eLev Elson-Schwab and Yitzhak Tor\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11. Novel Targets for Aminoglycosides 289\u003cbr\u003e \u003ci\u003eDev P. Arya, Nicholas Shaw, and Hongjuan Xi\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 315\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Interscience","offers":[{"title":"Brand New","offer_id":52298049421592,"sku":"9780471743026","price":135.89,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780471743026.jpg?v=1781732820","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/aminoglycoside-antibiotics-from-chemical-biology-to-drug-discovery-hardback-9780471743026","provider":"Freshly Printed Books","version":"1.0","type":"link"}