{"product_id":"advances-in-enzymology-and-related-areas-of-molecular-biology-volume-78-hardback-9781118014288","title":"Advances in Enzymology and Related Areas of Molecular Biology, Volume 78 (Hardback) 9781118014288","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAdvances in Enzymology and Related Areas of Molecular Biology, Volume 78\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eEric J. Toone (Edited by), EJ Toone (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781118014288, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 16 December 2011\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e560 pages\u003cbr\u003e23.6 x 16.3 x 3.6 cm, 0.943 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThis book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation\/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eContributors vii  \u003cp\u003ePreface ix\u003c\/p\u003e \u003cp\u003eStructure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functions and Pathological Roles 1\u003cbr\u003e \u003ci\u003eCarlo M. Bergamini, Russell J. Collighan, Zhuo Wang, and Martin Griffin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003ePhysiopathological Roles of Human Transglutaminase 2 47\u003cbr\u003e \u003ci\u003eVittorio Gentile\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eTransglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross-Linking Substrate 97\u003cbr\u003e \u003ci\u003eGuylaine Hoffner, Amandine VanHoutteghem, William Andre, and Philippe Djian\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eTransglutaminase 2: A New Paradigm for NF-B Involvement in Disease 161\u003cbr\u003e \u003ci\u003eSoo-Youl Kim\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eTransglutaminase 2 At the Crossroads between Cell Death and Survival 197\u003cbr\u003e \u003ci\u003eMauro Piacentini, Manuela D’Eletto, Laura Falasca, Maria Grazia Farrace, and Carlo Rodolfo\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eTissue Transglutaminase and Its Role in Human Cancer Progression 247\u003cbr\u003e \u003ci\u003eBo Li, Richard A. Cerione, and Marc Antonyak\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eTransglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2−\/−Mouse 295\u003cbr\u003e \u003ci\u003eZsuzsa Szondy, Ilma Korponay-Szabo, Robert Kiraly, and Laszlo Fesus\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eEffects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases 347\u003cbr\u003e \u003ci\u003eZoltan Nemes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eTransglutaminase-Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan 385\u003cbr\u003e \u003ci\u003eLaszlo Lorand, S. N. Prasanna Murthy, Anwar A. Khan, Weihua XUE, Oksana Lockridge, and Athar H. Chishti\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIrreversible Inhibitors of Tissue Transglutaminase 415\u003cbr\u003e \u003ci\u003eJeffrey W. Keillor, Nicolas Chabot, Isabelle Roy, Amina Mulani, Olivier Leogane, and Christophe Pardin\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eMethionine Adenosyltransferase (\u003ci\u003eS\u003c\/i\u003e-Adenosylmethionine Synthetase) 449\u003cbr\u003e \u003ci\u003eMarıa A. Pajares and George D. Markham\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003eIndex 523\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52417746174232,"sku":"9781118014288","price":108.79,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9781118014288.jpg?v=1784506180","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/advances-in-enzymology-and-related-areas-of-molecular-biology-volume-78-hardback-9781118014288","provider":"Freshly Printed Books","version":"1.0","type":"link"}