{"product_id":"a-textbook-of-modern-toxicology-hardback-9780470462065","title":"A Textbook of Modern Toxicology (Hardback) 9780470462065","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eA Textbook of Modern Toxicology\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eErnest Hodgson (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780470462065, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 13 July 2010\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e672 pages\u003cbr\u003e25.7 x 17.8 x 4.1 cm, 1.247 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"The book assumes a good knowledge of general toxicology and some knowledge of specialist areas, and would be a useful aid if studying for a higher degree where basic understanding has been.\" (British Toxicology Society, Winter 2010)\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eA Textbook of Modern Toxicology\u003c\/i\u003e is a unique resource that provides both students and practitioners with a wide-ranging, accessible overview of the discipline. Suitable for courses in environmental, pharmacological, medical, and veterinary toxicology, this essential text features chapters written by experts who address a range of key topics.  \u003cp\u003eThe Fourth Edition includes additional chapters on new approaches to toxicology - molecular methods (-omics: toxicogenomics, proteomics, and metabolomics), bioinformatics, and systems biology – and continues the legacy of its predecessors to provide up-to-date insights into acute toxicity and chemical carcinogenesis, organ toxicity, in vitro and in vivo toxicity testing, ecological risk assessment, and many other areas of toxicology that help foster a solid comprehension of the field.\u003c\/p\u003e \u003cp\u003eAlso featured in the Fourth Edition are end-of-chapter questions and a Solutions Manual available separately for academic adopters.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePREFACE TO THE FOURTH EDITION xxi\u003c\/p\u003e \u003cp\u003eCONTRIBUTORS xxiii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART I INTRODUCTION 1\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e1. Introduction to Toxicology 3\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e1.1 Definition and Scope 3\u003c\/p\u003e \u003cp\u003e1.2 Relationship to Other Sciences 9\u003c\/p\u003e \u003cp\u003e1.3 A Brief History of Toxicology 10\u003c\/p\u003e \u003cp\u003e1.4 Dose–Response Relationships 11\u003c\/p\u003e \u003cp\u003e1.5 Sources of Toxic Compounds 12\u003c\/p\u003e \u003cp\u003e1.6 Movement of Toxicants in the Environment 12\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 13\u003c\/p\u003e \u003cp\u003eSample Questions 14\u003c\/p\u003e \u003cp\u003e\u003cb\u003e2. Introduction to Biochemical and Molecular Methods in Toxicology 15\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson, Gerald A. Leblanc, Sharon A. Meyer, and Robert C. Smart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e2.1 Introduction 15\u003c\/p\u003e \u003cp\u003e2.2 Cell Culture Techniques 15\u003c\/p\u003e \u003cp\u003e2.3 Molecular Techniques 19\u003c\/p\u003e \u003cp\u003e2.4 Immunochemical Techniques 23\u003c\/p\u003e \u003cp\u003e2.5 Proteomics 26\u003c\/p\u003e \u003cp\u003e2.6 Metabolomics 26\u003c\/p\u003e \u003cp\u003e2.7 Bioinformatics 26\u003c\/p\u003e \u003cp\u003e2.8 Summary and Conclusions 27\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 27\u003c\/p\u003e \u003cp\u003eSample Questions 27\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART II CLASSES OF TOXICANTS 29\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e3. Exposure Classes, Toxicants in Air, Water, Soil, Domestic, and Occupational Settings 31\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eW. Gregory Cope\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e3.1 Air Pollutants 31\u003c\/p\u003e \u003cp\u003e3.2 Water and Soil Pollutants 38\u003c\/p\u003e \u003cp\u003e3.3 Occupational Toxicants 42\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 46\u003c\/p\u003e \u003cp\u003eAir Pollutants 46\u003c\/p\u003e \u003cp\u003eWater and Soil Pollutants 47\u003c\/p\u003e \u003cp\u003eOccupational Toxicants 47\u003c\/p\u003e \u003cp\u003eSample Questions 47\u003c\/p\u003e \u003cp\u003e\u003cb\u003e4. Classes of Toxicants: Use Classes 49\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eW. Gregory Cope and Ernest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e4.1 Introduction 49\u003c\/p\u003e \u003cp\u003e4.2 Metals 49\u003c\/p\u003e \u003cp\u003e4.3 Agricultural Chemicals (Pesticides) 55\u003c\/p\u003e \u003cp\u003e4.4 Food Additives and Contaminants 65\u003c\/p\u003e \u003cp\u003e4.5 Toxins 66\u003c\/p\u003e \u003cp\u003e4.6 Solvents 71\u003c\/p\u003e \u003cp\u003e4.7 Therapeutic Drugs 71\u003c\/p\u003e \u003cp\u003e4.8 Drugs of Abuse 72\u003c\/p\u003e \u003cp\u003e4.9 Combustion Products 72\u003c\/p\u003e \u003cp\u003e4.10 Cosmetics 74\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 74\u003c\/p\u003e \u003cp\u003eGeneral 74\u003c\/p\u003e \u003cp\u003eMetals 74\u003c\/p\u003e \u003cp\u003ePesticides 75\u003c\/p\u003e \u003cp\u003eToxins 75\u003c\/p\u003e \u003cp\u003eSolvents 75\u003c\/p\u003e \u003cp\u003eTherapeutic Drugs 75\u003c\/p\u003e \u003cp\u003eSample Questions 75\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART III TOXICANT PROCESSING IN VIVO 77\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e5. Absorption and Distribution of Toxicants 79\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRonald E. Baynes and Ernest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e5.1 Introduction 79\u003c\/p\u003e \u003cp\u003e5.2 Cell Membranes 80\u003c\/p\u003e \u003cp\u003e5.3 Mechanisms of Transport 82\u003c\/p\u003e \u003cp\u003e5.4 Physicochemical Properties Relevant to Diffusion 87\u003c\/p\u003e \u003cp\u003e5.5 Routes of Absorption 90\u003c\/p\u003e \u003cp\u003e5.6 Toxicant Distribution 99\u003c\/p\u003e \u003cp\u003e5.7 Toxicokinetics 108\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 112\u003c\/p\u003e \u003cp\u003eSample Questions 113\u003c\/p\u003e \u003cp\u003e\u003cb\u003e6. Metabolism of Toxicants 115\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson and Randy L. Rose\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e6.1 Introduction 115\u003c\/p\u003e \u003cp\u003e6.2 Phase I Reactions 116\u003c\/p\u003e \u003cp\u003e6.3 Phase II Reactions 143\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 154\u003c\/p\u003e \u003cp\u003eSample Questions 155\u003c\/p\u003e \u003cp\u003e\u003cb\u003e7. Reactive Metabolites 157\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson and Randy L. Rose\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e7.1 Introduction 157\u003c\/p\u003e \u003cp\u003e7.2 Activation Enzymes 158\u003c\/p\u003e \u003cp\u003e7.3 Nature and Stability of Reactive Metabolites 160\u003c\/p\u003e \u003cp\u003e7.4 Fate of Reactive Metabolites 161\u003c\/p\u003e \u003cp\u003e7.5 Factors Affecting Toxicity of Reactive Metabolites 162\u003c\/p\u003e \u003cp\u003e7.6 Reactive Oxygen Species 163\u003c\/p\u003e \u003cp\u003e7.7 Examples of Activating Reactions 164\u003c\/p\u003e \u003cp\u003e7.8 Summary and Conclusions 170\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 171\u003c\/p\u003e \u003cp\u003eSample Questions 171\u003c\/p\u003e \u003cp\u003e\u003cb\u003e8. Chemical and Physiological Effects on Xenobiotic Metabolism 173\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAndrew D. Wallace and Ernest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e8.1 Introduction 173\u003c\/p\u003e \u003cp\u003e8.2 Nutritional Effects 173\u003c\/p\u003e \u003cp\u003e8.3 Physiological Effects 176\u003c\/p\u003e \u003cp\u003e8.4 Comparative and Genetic Effects 182\u003c\/p\u003e \u003cp\u003e8.5 Chemical Effects 191\u003c\/p\u003e \u003cp\u003e8.6 Environmental Effects 207\u003c\/p\u003e \u003cp\u003e8.7 Summary and Conclusions 209\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 210\u003c\/p\u003e \u003cp\u003eSample Questions 211\u003c\/p\u003e \u003cp\u003e\u003cb\u003e9. Elimination of Toxicants 213\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGerald A. Leblanc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e9.1 Introduction 213\u003c\/p\u003e \u003cp\u003e9.2 Transport 215\u003c\/p\u003e \u003cp\u003e9.3 Renal Elimination 216\u003c\/p\u003e \u003cp\u003e9.4 Hepatic Elimination 217\u003c\/p\u003e \u003cp\u003e9.5 Respiratory Elimination 220\u003c\/p\u003e \u003cp\u003e9.6 Conclusion 221\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 221\u003c\/p\u003e \u003cp\u003eSample Questions 222\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART IV TOXIC ACTION 223\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e10. Acute Toxicity 225\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGerald A. Leblanc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e10.1 Introduction 225\u003c\/p\u003e \u003cp\u003e10.2 Acute Exposure and Effect 225\u003c\/p\u003e \u003cp\u003e10.3 Dose–Response Relationships 227\u003c\/p\u003e \u003cp\u003e10.4 Nonconventional Dose–Response Relationships 229\u003c\/p\u003e \u003cp\u003e10.5 Alternative Methods 230\u003c\/p\u003e \u003cp\u003e10.6 Mechanisms of Acute Toxicity 231\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 236\u003c\/p\u003e \u003cp\u003eSample Questions 236\u003c\/p\u003e \u003cp\u003e\u003cb\u003e11. Chemical Carcinogenesis and Mutagenesis 237\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRobert C. Smart\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e11.1 DNA Damage and Mutagenesis 237\u003c\/p\u003e \u003cp\u003e11.2 General Aspects of Cancer 239\u003c\/p\u003e \u003cp\u003e11.3 Human Cancer 242\u003c\/p\u003e \u003cp\u003e11.4 Classes of Agents That Are Associated with Carcinogenesis 251\u003c\/p\u003e \u003cp\u003e11.5 General Aspects of Chemical Carcinogenesis 254\u003c\/p\u003e \u003cp\u003e11.6 Oncogenes 259\u003c\/p\u003e \u003cp\u003e11.7 Tumor Suppressor Genes 262\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 264\u003c\/p\u003e \u003cp\u003eSample Questions 264\u003c\/p\u003e \u003cp\u003e\u003cb\u003e12. Teratogenesis 265\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJill A. Barnes and Ida M. Washington\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e12.1 Introduction 265\u003c\/p\u003e \u003cp\u003e12.2 Overview of Embryonic Development 266\u003c\/p\u003e \u003cp\u003e12.3 Principles of Teratogenesis 268\u003c\/p\u003e \u003cp\u003e12.4 Mechanisms of Teratogenesis 268\u003c\/p\u003e \u003cp\u003e12.5 Future Considerations 272\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 272\u003c\/p\u003e \u003cp\u003eSample Questions 272\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART V ORGAN TOXICITY 275\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e13. Hepatotoxicity 277\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eAndrew D. Wallace and Sharon A. Meyer\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e13.1 Introduction 277\u003c\/p\u003e \u003cp\u003e13.2 Susceptibility of the Liver 279\u003c\/p\u003e \u003cp\u003e13.3 Types of Liver Injury 279\u003c\/p\u003e \u003cp\u003e13.4 Mechanisms of Hepatotoxicity 283\u003c\/p\u003e \u003cp\u003e13.5 Examples of Hepatotoxicants 285\u003c\/p\u003e \u003cp\u003e13.6 Metabolic Activation of Hepatotoxicants 288\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 289\u003c\/p\u003e \u003cp\u003eSample Questions 289\u003c\/p\u003e \u003cp\u003e\u003cb\u003e14. Nephrotoxicity 291\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJoan B. Tarloff and Andrew D. Wallace\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e14.1 Introduction 291\u003c\/p\u003e \u003cp\u003e14.2 Factors Contributing to Nephrotoxicity 292\u003c\/p\u003e \u003cp\u003e14.3 Examples of Nephrotoxicants 293\u003c\/p\u003e \u003cp\u003e14.4 Summary 301\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 301\u003c\/p\u003e \u003cp\u003eSample Questions 302\u003c\/p\u003e \u003cp\u003e\u003cb\u003e15. Toxicology of the Nervous System 303\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eBonita L. Blake\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e15.1 Introduction 303\u003c\/p\u003e \u003cp\u003e15.2 The Nervous System 303\u003c\/p\u003e \u003cp\u003e15.3 Toxicant Effects on the Nervous System 312\u003c\/p\u003e \u003cp\u003e15.4 Neurotoxicity Testing 317\u003c\/p\u003e \u003cp\u003e15.5 Summary 321\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 322\u003c\/p\u003e \u003cp\u003eSample Questions 322\u003c\/p\u003e \u003cp\u003e\u003cb\u003e16. Reproductive System 323\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eHeather Patisaul\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e16.1 Introduction 323\u003c\/p\u003e \u003cp\u003e16.2 The Hypothalamic-Pituitary-Gonadal Axis 324\u003c\/p\u003e \u003cp\u003e16.3 Male Reproductive Physiology 326\u003c\/p\u003e \u003cp\u003e16.4 Disruption of Male Reproduction By Toxicants 330\u003c\/p\u003e \u003cp\u003e16.5 Female Reproductive Physiology 332\u003c\/p\u003e \u003cp\u003e16.6 Disruption of Female Reproduction by Toxicants 335\u003c\/p\u003e \u003cp\u003e16.7 Summary 341\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 341\u003c\/p\u003e \u003cp\u003eSample Questions 343\u003c\/p\u003e \u003cp\u003e\u003cb\u003e17. Endocrine Toxicology 345\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGerald A. Leblanc\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e17.1 Introduction 345\u003c\/p\u003e \u003cp\u003e17.2 Endocrine System 345\u003c\/p\u003e \u003cp\u003e17.3 Endocrine Disruption 352\u003c\/p\u003e \u003cp\u003e17.4 Incidents of Endocrine Toxicity 358\u003c\/p\u003e \u003cp\u003e17.5 Conclusion 361\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 362\u003c\/p\u003e \u003cp\u003eSample Questions 362\u003c\/p\u003e \u003cp\u003e\u003cb\u003e18. Respiratory Toxicology 363\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eJames C. Bonner\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e18.1 Introduction 363\u003c\/p\u003e \u003cp\u003e18.2 Anatomy and Function of the Respiratory Tract 363\u003c\/p\u003e \u003cp\u003e18.3 Toxicant-Induced Lung Injury, Remodeling, and Repair 373\u003c\/p\u003e \u003cp\u003e18.4 Occupational and Environmental Lung Diseases 380\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 385\u003c\/p\u003e \u003cp\u003eSample Questions 385\u003c\/p\u003e \u003cp\u003e\u003cb\u003e19. Immune System 387\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eMaryJane K. Selgrade\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e19.1 Introduction 387\u003c\/p\u003e \u003cp\u003e19.2 The Immune System 388\u003c\/p\u003e \u003cp\u003e19.3 Immune Suppression 391\u003c\/p\u003e \u003cp\u003e19.4 Classification of Immune-Mediated Injury (Hypersensitivity) 396\u003c\/p\u003e \u003cp\u003e19.5 Effects of Chemicals on Allergic Disease 398\u003c\/p\u003e \u003cp\u003e19.6 Other Issues: Autoimmunity and the Developing\u003c\/p\u003e \u003cp\u003eImmune System 403\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 404\u003c\/p\u003e \u003cp\u003eSample Questions 404\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART VI APPLIED TOXICOLOGY 407\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e20. Toxicity Testing 409\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson and Helen Cunny\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e20.1 Introduction 409\u003c\/p\u003e \u003cp\u003e20.2 Experimental Administration of Toxicants 412\u003c\/p\u003e \u003cp\u003e20.3 Chemical and Physical Properties 414\u003c\/p\u003e \u003cp\u003e20.4 Exposure and Environmental Fate 414\u003c\/p\u003e \u003cp\u003e20.5 In Vivo Tests 415\u003c\/p\u003e \u003cp\u003e20.6 In Vitro and Other Short-Term Tests 442\u003c\/p\u003e \u003cp\u003e20.7 Ecological Effects 451\u003c\/p\u003e \u003cp\u003e20.8 Risk Analysis 453\u003c\/p\u003e \u003cp\u003e20.9 The Future of Toxicity Testing 453\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 454\u003c\/p\u003e \u003cp\u003eSample Questions 455\u003c\/p\u003e \u003cp\u003e\u003cb\u003e21. Forensic and Clinical Toxicology 457\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSharon A. Meyer and Bonita L. Blake\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e21.1 Introduction 457\u003c\/p\u003e \u003cp\u003e21.2 Forensic Toxicology 457\u003c\/p\u003e \u003cp\u003e21.3 Clinical Toxicology 462\u003c\/p\u003e \u003cp\u003e21.4 Analytical Methods in Forensic and Clinical Toxicology 469\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 472\u003c\/p\u003e \u003cp\u003eSample Questions 473\u003c\/p\u003e \u003cp\u003e\u003cb\u003e22. Prevention of Toxicity 475\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e22.1 Introduction 475\u003c\/p\u003e \u003cp\u003e22.2 Legislation and Regulation 475\u003c\/p\u003e \u003cp\u003e22.3 Prevention in Different Environments 482\u003c\/p\u003e \u003cp\u003e22.4 Education 485\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 486\u003c\/p\u003e \u003cp\u003eSample Questions 487\u003c\/p\u003e \u003cp\u003e\u003cb\u003e23. Human Health Risk Assessment 489\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eRonald E. Baynes\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e23.1 Introduction 489\u003c\/p\u003e \u003cp\u003e23.2 Risk Assessment Methods 490\u003c\/p\u003e \u003cp\u003e23.3 Noncancer Risk Assessment 493\u003c\/p\u003e \u003cp\u003e23.4 Cancer Risk Assessment 500\u003c\/p\u003e \u003cp\u003e23.5 PBPK Modeling 503\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 504\u003c\/p\u003e \u003cp\u003eSample Questions 505\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART VII ENVIRONMENTAL TOXICOLOGY 507\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e24. Toxicant Analysis: Analytical Methods and Quality Assurance 509\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eChris Hofelt\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e24.1 Introduction 509\u003c\/p\u003e \u003cp\u003e24.2 Environmental Sample Collection Methods 510\u003c\/p\u003e \u003cp\u003e24.3 Analytical Techniques 514\u003c\/p\u003e \u003cp\u003e24.4 Quantifi cation, QA, and QC 525\u003c\/p\u003e \u003cp\u003e24.5 Summary 528\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 528\u003c\/p\u003e \u003cp\u003eSample Questions 529\u003c\/p\u003e \u003cp\u003e\u003cb\u003e25. Basics of Environmental Toxicology 531\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eGerald A. Leblanc and David B. Buchwalter\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e25.1 Introduction 531\u003c\/p\u003e \u003cp\u003e25.2 Environmental Persistence 532\u003c\/p\u003e \u003cp\u003e25.3 Bioaccumulation 535\u003c\/p\u003e \u003cp\u003e25.4 Toxicity 539\u003c\/p\u003e \u003cp\u003e25.5 Conclusion 546\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 547\u003c\/p\u003e \u003cp\u003eSample Questions 547\u003c\/p\u003e \u003cp\u003e\u003cb\u003e26. Transport and Fate of Toxicants in the Environment 549\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eDamian Shea\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e26.1 Introduction 549\u003c\/p\u003e \u003cp\u003e26.2 Sources of Toxicants to the Environment 550\u003c\/p\u003e \u003cp\u003e26.3 Transport Processes 553\u003c\/p\u003e \u003cp\u003e26.4 Equilibrium Partitioning 557\u003c\/p\u003e \u003cp\u003e26.5 Transformation Processes 560\u003c\/p\u003e \u003cp\u003e26.6 Environmental Fate Models 567\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 569\u003c\/p\u003e \u003cp\u003eSample Questions 569\u003c\/p\u003e \u003cp\u003e\u003cb\u003e27. Environmental Risk Assessment 571\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eDamian Shea\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e27.1 Introduction 571\u003c\/p\u003e \u003cp\u003e27.2 Formulating the Problem 573\u003c\/p\u003e \u003cp\u003e27.3 Analyzing Exposure and Effects Information 578\u003c\/p\u003e \u003cp\u003e27.4 Characterizing Risk 582\u003c\/p\u003e \u003cp\u003e27.5 Managing Risk 587\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 588\u003c\/p\u003e \u003cp\u003eSample Questions 589\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART VIII NEW APPROACHES IN TOXICOLOGY 591\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\u003cb\u003e28. Perspectives on Informatics in Toxicology 593\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eSeth W. Kullman, Carolyn J. Mattingly, Joel N. Meyer, and Andrew Whitehead\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e28.1 Introduction 593\u003c\/p\u003e \u003cp\u003e28.2 Transcriptomics 594\u003c\/p\u003e \u003cp\u003e28.3 Annotation Resources 595\u003c\/p\u003e \u003cp\u003e28.4 Genome Sequencing, Resequencing and Genotyping 597\u003c\/p\u003e \u003cp\u003e28.5 Epigenomic Profi ling 598\u003c\/p\u003e \u003cp\u003e28.6 Computational Toxicology 599\u003c\/p\u003e \u003cp\u003e28.7 Informatics Tools in Toxicology 601\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 602\u003c\/p\u003e \u003cp\u003eSample Question 605\u003c\/p\u003e \u003cp\u003e\u003cb\u003e29. Future Considerations 607\u003c\/b\u003e\u003cbr\u003e\u003ci\u003eErnest Hodgson\u003c\/i\u003e\u003c\/p\u003e \u003cp\u003e29.1 Introduction 607\u003c\/p\u003e \u003cp\u003e29.2 Risk Assessment 609\u003c\/p\u003e \u003cp\u003e29.3 Risk Management 613\u003c\/p\u003e \u003cp\u003e29.4 Risk Communication 613\u003c\/p\u003e \u003cp\u003e29.5 In Vivo Toxicity 614\u003c\/p\u003e \u003cp\u003e29.6 In Vitro Toxicity 614\u003c\/p\u003e \u003cp\u003e29.7 Molecular and Biochemical Toxicology 614\u003c\/p\u003e \u003cp\u003e29.8 Development of Selective Toxicants 615\u003c\/p\u003e \u003cp\u003e29.9 Summary and Conclusions 616\u003c\/p\u003e \u003cp\u003eBibliography and Suggested Reading 616\u003c\/p\u003e \u003cp\u003eSample Questions 617\u003c\/p\u003e \u003cp\u003eGLOSSARY 619\u003c\/p\u003e \u003cp\u003eINDEX 638\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley","offers":[{"title":"Brand New","offer_id":52502998810904,"sku":"9780470462065","price":83.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9780470462065.jpg?v=1786322928","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/a-textbook-of-modern-toxicology-hardback-9780470462065","provider":"Freshly Printed Books","version":"1.0","type":"link"}