{"product_id":"a-guide-to-sample-size-for-animal-based-studies-paperback-softback-9781119799979","title":"A Guide to Sample Size for Animal-based Studies (Paperback \/ softback) 9781119799979","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eA Guide to Sample Size for Animal-based Studies\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003ePenny S. Reynolds (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781119799979, Wiley\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 22 September 2023\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e288 pages\u003cbr\u003e24.4 x 17 x 11.3 cm, 0.709 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cb\u003eA Guide to Sample Size for Animal-based Studies\u003c\/b\u003e \u003cp\u003e\u003cb\u003eUnderstand a foundational area of experimental design with this innovative reference\u003c\/b\u003e \u003c\/p\u003e\n\u003cp\u003eAnimal-based research is an essential part of basic and preclinical research, but poses a unique set of experimental design challenges. The most important of these are the 3Rs − Replacement, Reduction and Refinement − the principles comprising the ethical framework for humane animal-based studies. However, many researchers have difficulty navigating the design trade-offs necessary to simultaneously minimize animal use, and produce scientific information that is both rigorous and reliable.  \u003c\/p\u003e\n\u003cp\u003e\u003ci\u003eA Guide to Sample Size for Animal-based Studies\u003c\/i\u003e meets this need with a thorough, accessible reference work to the subject. This book provides a straightforward systematic approach to “rightsizing” animal-based experiments, with sample size estimates based on the fundamentals of statistical thinking: structured research questions, variation control and appropriate design of experiments. The result is a much-needed guide to planning animal-based experiments to ensure scientifically valid and reliable results. \u003c\/p\u003e\n\u003cp\u003eThis book offers: \u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eStep-by-step guidance in diverse methods for approximating and refining sample size\u003c\/li\u003e \u003cli\u003eDetailed treatment of research topics specific to animal-based research, including pilot, feasibility and proof-of-concept studies\u003c\/li\u003e \u003cli\u003eSample size approximation methods for different types of data − binary, continuous, ordinal, time to event − and different study types − description, comparison, nested designs, reference interval construction and dose-response studies\u003c\/li\u003e \u003cli\u003eNumerous worked examples, using real data from published papers, together with SAS and R code\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003e\u003ci\u003eA Guide to Sample Size for Animal-based Studies\u003c\/i\u003e is a must-have reference for preclinical and veterinary researchers, as well as ethical oversight committees and policymakers.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface vii\u003c\/p\u003e \u003cp\u003eAcknowledgements viii\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart I. What is Sample Size?\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1 The Sample Size Problem in Animal-Based Research 3\u003c\/p\u003e \u003cp\u003e2 Sample Size Basics 9\u003c\/p\u003e \u003cp\u003e3 Ten Strategies to Increase Information (and Reduce Sample Size) 17\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart II. Sample Size for Feasibility and Pilot Studies\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e4 Why Pilot Studies? 35\u003c\/p\u003e \u003cp\u003e5 Operational Pilot Studies: ‘Can It Work?’ 47\u003c\/p\u003e \u003cp\u003e6 Empirical and Translational Pilots 57\u003c\/p\u003e \u003cp\u003e7 Feasibility Calculations: Arithmetic 81\u003c\/p\u003e \u003cp\u003e8 Feasibility: Counting Subjects 89\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart III. Sample Size for Description\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9 Descriptions and Summaries 103\u003c\/p\u003e \u003cp\u003e10 Confidence Intervals and Precision 111\u003c\/p\u003e \u003cp\u003e11 Prediction Intervals 127\u003c\/p\u003e \u003cp\u003e12 Tolerance Intervals 133\u003c\/p\u003e \u003cp\u003e13 Reference Intervals 143\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePart IV. Sample Size for Comparison\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e14 Sample Size and Hypothesis Testing 155\u003c\/p\u003e \u003cp\u003e15 A Bestiary of Effect Sizes 167\u003c\/p\u003e \u003cp\u003e16 Comparing Two Groups: Continuous Outcomes 181\u003c\/p\u003e \u003cp\u003e17 Comparing Two Groups: Proportions 189\u003c\/p\u003e \u003cp\u003e18 Time-to-Event (Survival) Data 199\u003c\/p\u003e \u003cp\u003e19 Comparing Multiple Factors 211\u003c\/p\u003e \u003cp\u003e20 Hierarchical or Nested Data 233\u003c\/p\u003e \u003cp\u003e21 Ordinal Data 249\u003c\/p\u003e \u003cp\u003e22 Dose-Response Studies 257\u003c\/p\u003e \u003cp\u003eIndex 267\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Mathematics [\u003ca title=\"See our other books on Mathematics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Mathematics%20%5BPB%5D%22\"\u003ePB\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Wiley-Blackwell","offers":[{"title":"Brand New","offer_id":52511739445528,"sku":"9781119799979","price":57.49,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/files\/9781119799979.jpg?v=1786609288","url":"https:\/\/freshlyprintedbooks.co.uk\/products\/a-guide-to-sample-size-for-animal-based-studies-paperback-softback-9781119799979","provider":"Freshly Printed Books","version":"1.0","type":"link"}