{"title":"Pharmaceutical technology","description":"Books on the subject of Pharmaceutical technology","products":[{"product_id":"fed-batch-cultures-principles-and-applications-of-semi-batch-bioreactors-hardback-9780521513364","title":"Fed-Batch Cultures; Principles and Applications of Semi-Batch Bioreactors (Hardback) 9780521513364","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eFed-Batch Cultures\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003ePrinciples and Applications of Semi-Batch Bioreactors\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003eThis first book dealing exclusively with every aspect of fed-batch operations, used in most industrially important fermentation and bioreactor operations.\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eHenry C. Lim (Author), Hwa Sung Shin (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780521513364, Cambridge University Press\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 22 April 2013\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e471 pages, 121 b\/w illus.  41 tables\u003cbr\u003e26 x 18.2 x 2.7 cm, 0.99 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eMany, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e1. Introduction to fed-batch bioreactors\u003cbr\u003e 2. Idealised reactors and fed-batch reactors\u003cbr\u003e 3. Maximisation of reaction rates and fed-batch operation\u003cbr\u003e 4. Phenomena that favour fed-batch operations\u003cbr\u003e 5. Classification and characteristics of fed-batch cultures\u003cbr\u003e 6. Models based on mass balance equations\u003cbr\u003e 7. Non-equation-based models\u003cbr\u003e 8. Experimental determination of specific rates\u003cbr\u003e 9. Optimization via Pontryagin's maximum principle\u003cbr\u003e 10. Computational techniques\u003cbr\u003e 11. Optimization of single and multiple isothermal reactions\u003cbr\u003e 12. Optimization of fed-batch cultures for cell mass production\u003cbr\u003e 13. Optimization of fed-batch cultures for metabolites\u003cbr\u003e 14. Simple, intuitive adaptive optimization\u003cbr\u003e 15. Measurements, estimation and control\u003cbr\u003e 16. Feasibility assessment and implementable feed rates.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Mechanical engineering \u0026amp; materials [\u003ca title=\"See our other books on Mechanical engineering \u0026amp; materials\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Mechanical%20engineering%20\u0026amp;%20materials%20%5BTG%5D%22\"\u003eTG\u003c\/a\u003e], Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Chemical engineering [\u003ca title=\"See our other books on Chemical engineering\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemical%20engineering%20%5BTDCB%5D%22\"\u003eTDCB\u003c\/a\u003e], Industrial chemistry \u0026amp; manufacturing technologies [\u003ca title=\"See our other books on Industrial chemistry \u0026amp; manufacturing technologies\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Industrial%20chemistry%20\u0026amp;%20manufacturing%20technologies%20%5BTD%5D%22\"\u003eTD\u003c\/a\u003e], Microbiology [\u003ca title=\"See our other books on Microbiology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Microbiology%20%5Bnon-medical%5D%20%5BPSG%5D%22\"\u003enon-medical PSG\u003c\/a\u003e], Biomedical engineering [\u003ca title=\"See our other books on Biomedical engineering\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biomedical%20engineering%20%5BMQW%5D%22\"\u003eMQW\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Cambridge University Press","offers":[{"title":"Default Title","offer_id":46019725525272,"sku":"9780521513364","price":107.39,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780521513364i_bce6bffd-fe88-4d5b-b51c-052f83e04a30.jpg?v=1691383200"},{"product_id":"natural-products-and-drug-discovery-an-integrated-approach-paperback-9780081020814","title":"Natural Products and Drug Discovery; An Integrated Approach (Paperback \/ softback) 9780081020814","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eNatural Products and Drug Discovery\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eAn Integrated Approach\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003e\u003cp\u003eA review of the changing role of natural products in contemporary drug discovery from traditional medicinal targets, to cutting-edge molecular techniques\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eSubhash C. Mandal (Edited by), Vivekananda Mandal (Edited by), Tetsuya Konishi (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780081020814\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 23 February 2018\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e776 pages\u003cbr\u003e22.9 x 15.1 x 4.7 cm, 1.24 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eNatural Products and Drug Discovery: An Integrated Approach\u003c\/i\u003e provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. \u003c\/p\u003e  \u003cp\u003eCombining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. \u003ci\u003eNatural Products \u0026amp; Drug Discovery: An Integrated Approach\u003c\/i\u003e reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R\u0026amp;D professionals, and drug discovery students and researchers.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003eSection I: Traditional medicine and Drug discovery\u003c\/b\u003e1. Drug discovery from Ayurveda: Mode of approach and applications2. Traditional and folk medicine as target for drug discovery3. Bioactivity guided phyto-fractions: an emerging natural drug discovery tool for safe and effective disease management4. Development of Chinese herbal health products for the prevention of aging-associated diseases5. Ethnobotany \/ ethnopharmacology and bioprospecting: Issues on knowledge and uses of medicinal plants by Moroccan people6. Chemotaxonomy of medicinal plants: Possibilities and limitations \u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection II: Leads from Natural Products\u003c\/b\u003e7. The role of natural products from plants in the development of anticancer agents8. Plant drugs in the treatment of osteoporosis9. Phytodrugs and immunomodulators for the therapy of Leishmaniasis10. Natural products targeting inflammation processes and multiple mediators11. Biologically functional compounds from mushroom-forming fungi12. Natural products in lifestyle diseases: In vitro screening13. Common toxic plants and their forensic significance14. Role of stress in diseases and its remedial approach by herbal and natural products in stress related disease management: Experimental studies and clinical reports15. Anti-inflammatory medicinal plants: A remedy for most disease conditions\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III: Herbal drug research\u003c\/b\u003e16. Techniques and technologies for the biodiscovery of novel small molecule drug lead compounds from natural products17. Herb and drug interaction18. Toxicity studies related to medicinal plants19.Prebiotics: A functional food in health and disease20. Cultivation of medicinal plants21. Digitization of traditional knowledge22. Good agricultural practices: Requirement for the production of quality herbal medicines23. Fundamentals of microwave based sample preparation for plant based drug discovery\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46648123818264,"sku":"9780081020814","price":91.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780081020814_0a71847c-41a6-4fcd-b28b-33b953873266.jpg?v=1695006383"},{"product_id":"the-organic-chemistry-of-drug-design-and-drug-action-hardback-9780123820303","title":"The Organic Chemistry of Drug Design and Drug Action (Hardback) 9780123820303","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eThe Organic Chemistry of Drug Design and Drug Action\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cp\u003e\u003ci\u003eThe Organic Chemistry of Drug Design and Drug Action, Third Edition\u003c\/i\u003e, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows the reader to extrapolate those core principles and mechanisms to many related classes of drug molecules\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eRichard B. Silverman (Author), Mark W. Holladay (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123820303, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 21 May 2014\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e536 pages\u003cbr\u003e27.6 x 21.6 x 3.1 cm, 1.72 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eThe Organic Chemistry of Drug Design and Drug Action, Third Edition,\u003c\/i\u003e represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules.\u003c\/p\u003e  \u003cp\u003eThis new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage.\u003c\/p\u003e  \u003cp\u003eThis text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003e1. Introduction \u003c\/b\u003e1.1. Overview 1.2. Drugs Discovered without Rational Design      1.2.1. Medicinal Chemistry Folklore      1.2.2. Discovery of Penicillins      1.2.3. Discovery of Librium      1.2.4. Discovery of Drugs through Metabolism Studies      1.2.5. Discovery of Drugs through Clinical Observations 1.3. Overview of Modern Rational Drug Design      1.3.1. Overview of Drug Targets      1.3.2. Identification and Validation of Targets for Drug Discovery      1.3.3. Alternatives to Target-Based Drug Discovery      1.3.4. Lead Discovery      1.3.5. Lead Modification (Lead Optimization)           1.3.5.1. Potency           1.3.5.2. Selectivity           1.3.5.3. Absorption, Distribution, Metabolism, and Excretion (ADME)           1.3.5.4. Intellectual Property Position      1.3.6. Drug Development           1.3.6.1. Preclinical Development           1.3.6.2. Clinical Development (Human Clinical Trials)           1.3.6.3. Regulatory Approval to Market the Drug 1.4. Epilogue 1.5. General References 1.6. Problems References \u003cb\u003e2. Lead Discovery and Lead Modification \u003c\/b\u003e2.1. Lead Discovery      2.1.1. General Considerations      2.1.2. Sources of Lead Compounds           2.1.2.1. Endogenous Ligands           2.1.2.2. Other Known Ligands           2.1.2.3. Screening of Compounds                2.1.2.3.1. Sources of Compounds for Screening                     2.1.2.3.1.1. Natural Products                     2.1.2.3.1.2. Medicinal Chemistry Collections and Other \"Handcrafted\" Compounds                     2.1.2.3.1.3. High-Throughput Organic Synthesis                          2.1.2.3.1.3.1. Solid-Phase Library Synthesis                          2.1.2.3.1.3.2. Solution-Phase Library Synthesis                          2.1.2.3.1.3.3. Evolution of HTOS                2.1.2.3.2. Drug-Like, Lead-Like, and Other Desirable Properties of Compounds for Screening                2.1.2.3.3. Random Screening                2.1.2.3.4. Targeted (or Focused) Screening, Virtual Screening, and Computational Methods in Lead Discovery                     2.1.2.3.4.1. Virtual Screening Database                     2.1.2.3.4.2. Virtual Screening Hypothesis                2.1.2.3.5. Hit-To-Lead Process                2.1.2.3.6. Fragment-based Lead Discovery 2.2. Lead Modification      2.2.1. Identification of the Active Part: The Pharmacophore      2.2.2. Functional Group Modification      2.2.3. Structure–Activity Relationships      2.2.4. Structure Modifications to Increase Potency, Therapeutic Index, and ADME Properties           2.2.4.1. Homologation           2.2.4.2. Chain Branching           2.2.4.3. Bioisosterism           2.2.4.4. Conformational Constraints and Ring-Chain Transformations           2.2.4.5. Peptidomimetics      2.2.5. Structure Modifications to Increase Oral Bioavailability and Membrane Permeability           2.2.5.1. Electronic Effects: The Hammett Equation           2.2.5.2. Lipophilicity Effects                2.2.5.2.1. Importance of Lipophilicity                2.2.5.2.2. Measurement of Lipophilicities                2.2.5.2.3. Computer Automation of log P Determination                2.2.5.2.4. Membrane Lipophilicity           2.2.5.3. Balancing Potency of Ionizable Compounds with Lipophilicity and Oral Bioavailability           2.2.5.4. Properties that Influence Ability to Cross the Blood–Brain Barrier           2.2.5.5. Correlation of Lipophilicity with Promiscuity and Toxicity      2.2.6. Computational Methods in Lead Modification           2.2.6.1. Overview           2.2.6.2. Quantitative Structure–Activity Relationships (QSARs)                2.2.6.2.1. Historical Overview. Steric Effects: The Taft Equation and Other Equations                2.2.6.2.2. Methods Used to Correlate Physicochemical Parameters with Biological Activity                     2.2.6.2.2.1. Hansch Analysis: A Linear Multiple Regression Analysis                     2.2.6.2.2.2. Manual Stepwise Methods: Topliss Operational Schemes and Others                     2.2.6.2.2.3. Batch Selection Methods: Batchwise Topliss Operational Scheme, Cluster Analysis, and Others                     2.2.6.2.2.4. Free and Wilson or de Novo Method                     2.2.6.2.2.5. Computational Methods for ADME Descriptors           2.2.6.3. Scaffold Hopping           2.2.6.4. Molecular Graphics-Based Lead Modification      2.2.7. Epilogue 2.3. General References 2.4. Problems References \u003cb\u003e3. Receptors \u003c\/b\u003e3.1. Introduction 3.2. Drug–Receptor Interactions      3.2.1. General Considerations      3.2.2. Important Interactions (Forces) Involved in the Drug–Receptor Complex           3.2.2.1. Covalent Bonds           3.2.2.2. Ionic (or Electrostatic) Interactions           3.2.2.3. Ion–Dipole and Dipole–Dipole Interactions           3.2.2.4. Hydrogen Bonds           3.2.2.5. Charge–Transfer Complexes           3.2.2.6. Hydrophobic Interactions           3.2.2.7. Cation–p Interaction           3.2.2.8. Halogen Bonding           3.2.2.9. van der Waals or London Dispersion Forces           3.2.2.10. Conclusion      3.2.3. Determination of Drug–Receptor Interactions      3.2.4. Theories for Drug–Receptor Interactions           3.2.4.1. Occupancy Theory           3.2.4.2. Rate Theory           3.2.4.3. Induced-Fit Theory           3.2.4.4. Macromolecular Perturbation Theory           3.2.4.5. Activation–Aggregation Theory           3.2.4.6. The Two-State (Multistate) Model of Receptor Activation      3.2.5. Topographical and Stereochemical Considerations           3.2.5.1. Spatial Arrangement of Atoms           3.2.5.2. Drug and Receptor Chirality           3.2.5.3. Diastereomers           3.2.5.4. Conformational Isomers           3.2.5.5. Atropisomers           3.2.5.6. Ring Topology      3.2.6. Case History of the Pharmacodynamically Driven Design of a Receptor Antagonist: Cimetidine      3.2.7. Case History of the Pharmacokinetically Driven Design of Suvorexant 3.3. General References 3.4. Problems References \u003cb\u003e4. Enzymes \u003c\/b\u003e4.1. Enzymes as Catalysts      4.1.1. What are Enzymes?      4.1.2. How do Enzymes Work?           4.1.2.1. Specificity of Enzyme-Catalyzed Reactions                4.1.2.1.1. Binding Specificity                4.1.2.1.2. Reaction Specificity           4.1.2.2. Rate Acceleration 4.2. Mechanisms of Enzyme Catalysis      4.2.1. Approximation      4.2.2. Covalent Catalysis      4.2.3. General Acid–Base Catalysis      4.2.4. Electrostatic Catalysis      4.2.5. Desolvation      4.2.6. Strain or Distortion      4.2.7. Example of the Mechanisms of Enzyme Catalysis 4.3. Coenzyme Catalysis      4.3.1. Pyridoxal 5'-Phosphate           4.3.1.1. Racemases           4.3.1.2. Decarboxylases           4.3.1.3. Aminotransferases (Formerly Transaminases)           4.3.1.4. PLP-Dependent ß-Elimination      4.3.2. Tetrahydrofolate and Pyridine Nucleotides      4.3.3. Flavin           4.3.3.1. Two-Electron (Carbanion) Mechanism           4.3.3.2. Carbanion Followed by Two One-Electron Transfers           4.3.3.3. One-Electron Mechanism           4.3.3.4. Hydride Mechanism      4.3.4. Heme      4.3.5. Adenosine Triphosphate and Coenzyme A 4.4. Enzyme Catalysis in Drug Discovery      4.4.1. Enzymatic Synthesis of Chiral Drug Intermediates      4.4.2. Enzyme Therapy 4.5. General References 4.6. Problems References \u003cb\u003e5. Enzyme Inhibition and Inactivation \u003c\/b\u003e5.1. Why Inhibit an Enzyme? 5.2. Reversible Enzyme Inhibitors      5.2.1. Mechanism of Reversible Inhibition      5.2.2. Selected Examples of Competitive Reversible Inhibitor Drugs           5.2.2.1. Simple Competitive Inhibition                5.2.2.1.1. Epidermal Growth Factor Receptor Tyrosine Kinase as a Target for Cancer                5.2.2.1.2. Discovery and Optimization of EGFR Inhibitors           5.2.2.2. Stabilization of an Inactive Conformation: Imatinib, an Antileukemia Drug                5.2.2.2.1. The Target: Bcr-Abl, a Constitutively Active Kinase                5.2.2.2.2. Lead Discovery and Modification                5.2.2.2.3. Binding Mode of Imatinib to Abl Kinase                5.2.2.2.4. Inhibition of Other Kinases by Imatinib           5.2.2.3. Alternative Substrate Inhibition: Sulfonamide Antibacterial Agents (Sulfa Drugs)                5.2.2.3.1. Lead Discovery                5.2.2.3.2. Lead Modification                5.2.2.3.3. Mechanism of Action      5.2.3. Transition State Analogs and Multisubstrate Analogs           5.2.3.1. Theoretical Basis           5.2.3.2. Transition State Analogs                5.2.3.2.1. Enalaprilat                5.2.3.2.2. Pentostatin                5.2.3.2.3. Forodesine and DADMe-ImmH                5.2.3.2.4. Multisubstrate Analogs      5.2.4. Slow, T ight-Binding Inhibitors           5.2.4.1. Theoretical Basis           5.2.4.2. Captopril, Enalapril, Lisinopril, and Other Antihypertensive Drugs                5.2.4.2.1. Humoral Mechanism for Hypertension                5.2.4.2.2. Lead Discovery                5.2.4.2.3. Lead Modification and Mechanism of Action                5.2.4.2.4. Dual-Acting Drugs: Dual-Acting Enzyme Inhibitors           5.2.4.3. Lovastatin (Mevinolin) and Simvastatin, Antihypercholesterolemic Drugs                5.2.4.3.1. Cholesterol and Its Effects                5.2.4.3.2. Lead Discovery                5.2.4.3.3. Mechanism of Action                5.2.4.3.4. Lead Modification           5.2.4.4. Saxagliptin, a Dipeptidyl Peptidase-4 Inhibitor and Antidiabetes Drug      5.2.5. Case History of Rational Drug Design of an Enzyme Inhibitor: Ritonavir           5.2.5.1. Lead Discovery           5.2.5.2. Lead Modification 5.3. Irreversible Enzyme Inhibitors      5.3.1. Potential of Irreversible Inhibition      5.3.2. Affinity Labeling Agents           5.3.2.1. Mechanism of Action           5.3.2.2. Selected Affinity Labeling Agents                5.3.2.2.1. Penicillins and Cephalosporins\/Cephamycins                5.3.2.2.2. Aspirin      5.3.3. Mechanism-Based Enzyme Inactivators           5.3.3.1. Theoretical Aspects           5.3.3.2. Potential Advantages in Drug Design Relative to Affinity Labeling Agents           5.3.3.3. Selected Examples of Mechanism-Based Enzyme Inactivators                5.3.3.3.1. Vigabatrin, an Anticonvulsant Drug                5.3.3.3.2. Eflornithine, an Antiprotozoal Drug and Beyond                5.3.3.3.3. Tranylcypromine, an Antidepressant Drug                5.3.3.3.4. Selegiline (l-Deprenyl) and Rasagiline: Antiparkinsonian Drugs                5.3.3.3.5. 5-Fluoro-2\u003cb\u003e'\u003c\/b\u003e-deoxyuridylate, Floxuridine, and 5-Fluorouracil: Antitumor Drugs 5.4. General References 5.5. Problems References \u003cb\u003e6. DNA-Interactive Agents \u003c\/b\u003e6.1. Introduction      6.1.1. Basis for DNA-Interactive Drugs      6.1.2. Toxicity of DNA-Interactive Drugs      6.1.3. Combination Chemotherapy      6.1.4. Drug Interactions      6.1.5. Drug Resistance 6.2. DNA Structure and Properties      6.2.1. Basis for the Structure of DNA      6.2.2. Base Tautomerization      6.2.3. DNA Shapes      6.2.4. DNA Conformations 6.3. Classes of Drugs that Interact with DNA      6.3.1. Reversible DNA Binders           6.3.1.1. External Electrostatic Binding           6.3.1.2. Groove Binding           6.3.1.3. Intercalation and Topoisomerase-Induced DNA Damage                6.3.1.3.1. Amsacrine, an Acridine Analog                6.3.1.3.2. Dactinomycin, the Parent Actinomycin Analog                6.3.1.3.3. Doxorubicin (Adriamycin) and Daunorubicin (Daunomycin), Anthracycline Antitumor Antibiotics                6.3.1.3.4. Bis-intercalating Agents      6.3.2. DNA Alkylators           6.3.2.1. Nitrogen Mustards                6.3.2.1.1. Lead Discovery                6.3.2.1.2. Chemistry of Alkylating Agents                6.3.2.1.3. Lead Modification                6.3.2.2. Ethylenimines                6.3.2.3. Methanesulfonates                6.3.2.4. (+)-CC-1065 and Duocarmycins                6.3.2.5. Metabolically Activated Alkylating Agents                     6.3.2.5.1. Nitrosoureas                     6.3.2.5.2. Triazene Antitumor Drugs                     6.3.2.5.3. Mitomycin C                     6.3.2.5.4. Leinamycin      6.3.3. DNA Strand Breakers           6.3.3.1. Anthracycline Antitumor Antibiotics           6.3.3.2. Bleomycin           6.3.3.3. Tirapazamine           6.3.3.4. Enediyne Antitumor Antibiotics                6.3.3.4.1. Esperamicins and Calicheamicins                6.3.3.4.2. Dynemicin A                6.3.3.4.3. Neocarzinostatin (Zinostatin)           6.3.3.5. Sequence Specificity for DNA-Strand Scission 6.4. General References 6.5. Problems References \u003cb\u003e7. Drug Resistance and Drug Synergism\u003c\/b\u003e 7.1. Drug Resistance      7.1.1. What is Drug Resistance?      7.1.2. Mechanisms of Drug Resistance           7.1.2.1. Altered Target Enzyme or Receptor           7.1.2.2. Overproduction of the Target Enzyme or Receptor           7.1.2.3. Overproduction of the Substrate or Ligand for the Target Protein           7.1.2.4. Increased Drug-Destroying Mechanisms           7.1.2.5. Decreased Prodrug-Activating Mechanism           7.1.2.6. Activation of New Pathways Circumventing the Drug Effect           7.1.2.7. Reversal of Drug Action           7.1.2.8. Altered Drug Distribution to the Site of Action 7.2. Drug Synergism (Drug Combination)      7.2.1. What is Drug Synergism?      7.2.2. Mechanisms of Drug Synergism           7.2.2.1. Inhibition of a Drug-Destroying Enzyme           7.2.2.2. Sequential Blocking           7.2.2.3. Inhibition of Targets in Different Pathways           7.2.2.4. Efflux Pump Inhibitors           7.2.2.5. Use of Multiple Drugs for the Same Target 7.3. General References 7.4. Problems References \u003cb\u003e8. Drug Metabolism \u003c\/b\u003e8.1. Introduction 8.2. Synthesis of Radioactive Compounds 8.3. Analytical Methods in Drug Metabolism      8.3.1. Sample Preparation      8.3.2. Separation      8.3.3. Identification      8.3.4. Quantification 8.4. Pathways for Drug Deactivation and Elimination      8.4.1. Introduction      8.4.2. Phase I Transformations           8.4.2.1. Oxidative Reactions                8.4.2.1.1. Aromatic Hydroxylation                8.4.2.1.2. Alkene Epoxidation                8.4.2.1.3. Oxidations of Carbons Adjacent to sp2 Centers                8.4.2.1.4. Oxidation at Aliphatic and Alicyclic Carbon Atoms                8.4.2.1.5. Oxidations of Carbon–Nitrogen Systems                8.4.2.1.6. Oxidations of Carbon–Oxygen Systems                8.4.2.1.7. Oxidations of Carbon–Sulfur Systems                8.4.2.1.8. Other Oxidative Reactions                8.4.2.1.9. Alcohol and Aldehyde Oxidations           8.4.2.2. Reductive Reactions                8.4.2.2.1. Carbonyl Reduction                8.4.2.2.2. Nitro Reduction                8.4.2.2.3. Azo Reduction                8.4.2.2.4. Azido Reduction                8.4.2.2.5. Tertiary Amine Oxide Reduction                8.4.2.2.6. Reductive Dehalogenation           8.4.2.3. Carboxylation Reaction           8.4.2.4. Hydrolytic Reactions      8.4.3. Phase II Transformations: Conjugation Reaction           8.4.3.1. Introduction           8.4.3.2. Glucuronic Acid Conjugation           8.4.3.3. Sulfate Conjugation           8.4.3.4. Amino Acid Conjugation           8.4.3.5. Glutathione Conjugation           8.4.3.6. Water Conjugation           8.4.3.7. Acetyl Conjugation           8.4.3.8. Fatty Acid and Cholesterol Conjugation           8.4.3.9. Methyl Conjugation      8.4.4. Toxicophores and Reactive Metabolites (RMs)      8.4.5. Hard and Soft (Antedrugs) Drugs 8.5. General References 8.6. Problems References \u003cb\u003e9. Prodrugs and Drug Delivery Systems \u003c\/b\u003e9.1. Enzyme Activation of Drugs      9.1.1. Utility of Prodrugs           9.1.1.1. Aqueous Solubility           9.1.1.2. Absorption and Distribution           9.1.1.3. Site Specificity           9.1.1.4. Instability           9.1.1.5. Prolonged Release           9.1.1.6. Toxicity           9.1.1.7. Poor Patient Acceptability           9.1.1.8. Formulation Problems      9.1.2. Types of Prodrugs 9.2. Mechanisms of Drug Inactivation      9.2.1. Carrier-Linked Prodrugs           9.2.1.1. Carrier Linkages for Various Functional Groups                9.2.1.1.1. Alcohols, Carboxylic Acids, and Related                9.2.1.1.2. Amines and Amidines                9.2.1.1.3. Sulfonamides                9.2.1.1.4. Carbonyl Compounds           9.2.1.2. Examples of Carrier-Linked Bipartite Prodrugs                9.2.1.2.1. Prodrugs for Increased Water Solubility                9.2.1.2.2. Prodrugs for Improved Absorption and Distribution                9.2.1.2.3. Prodrugs for Site Specificity                9.2.1.2.4. Prodrugs for Stability                9.2.1.2.5. Prodrugs for Slow and Prolonged Release                9.2.1.2.6. Prodrugs to Minimize Toxicity                9.2.1.2.7. Prodrugs to Encourage Patient Acceptance                9.2.1.2.8. Prodrugs to Eliminate Formulation Problems           9.2.1.3. Macromolecular Drug Carrier Systems                9.2.1.3.1. General Strategy                9.2.1.3.2. Synthetic Polymers                9.2.1.3.3. Poly(a-Amino Acids)                9.2.1.3.4. Other Macromolecular Supports           9.2.1.4. Tripartite Prodrugs           9.2.1.5. Mutual Prodrugs (also called Codrugs)      9.2.2. Bioprecursor Prodrugs           9.2.2.1. Origins           9.2.2.2. Proton Activation: An Abbreviated Case History of the Discovery of Omeprazole           9.2.2.3. Hydrolytic Activation           9.2.2.4. Elimination Activation           9.2.2.5. Oxidative Activation                9.2.2.5.1. N- and O-Dealkylations                9.2.2.5.2. Oxidative Deamination                9.2.2.5.3. N-Oxidation                9.2.2.5.4. S-Oxidation                9.2.2.5.5. Aromatic Hydroxylation                9.2.2.5.6. Other Oxidations           9.2.2.6. Reductive Activation                9.2.2.6.5. Nitro Reduction           9.2.2.7. Nucleotide Activation           9.2.2.8. Phosphorylation Activation           9.2.2.9. Sulfation Activation           9.2.2.10. Decarboxylation Activation 9.3. General References 9.4. Problems References Appendix Index\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46648234475800,"sku":"9780123820303","price":64.59,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123820303.jpg?v=1695014033"},{"product_id":"nonclinical-development-of-novel-biologics-biosimilars-vaccines-and-specialty-biologics-hardback-9780123948106","title":"Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics (Hardback) 9780123948106","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eNonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cp\u003eA wide-ranging reference detailing the process of preclinical safety assessment of all types of biologics, including vaccines, biosimilars, novel biopharmaceuticals and more\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eLisa Plitnick (Edited by), Danuta Herzyk (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123948106, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 29 August 2013\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e432 pages, 50 illustrations\u003cbr\u003e23.4 x 19 x 2.8 cm, 1.07 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\"…brings nonclinical testing of biological and follow-on biological drugs, vaccines plus cell and gene therapy drugs right up to date. It is written in a very readable, yet highly scientific manner and most of the relevant publications…on the topic are referenced…Overall, a ‘must read’ book for all in the nonclinical field of developing biological drugs.\" --\u003cb\u003ebtsNews, June 2014\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\"Researchers in pharmaceuticals, toxicology, and other biological sciences summarize the current status of developing medicines from biological material, pointing out where the process is different from developing small-molecule medicines and where it is the same. The topics include regulatory guidelines and their application in the non-clinical evaluation of biological medicines, early de-risking strategy for novel biotherapeutics…\" --\u003cb\u003eReference \u0026amp; Research Book News, December 2013\u003c\/b\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eNonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics\u003c\/i\u003e is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface Acknowledgement Dedication\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection I: Biopharmaceuticals\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e1. Novel Biopharmaceuticals  2. Global Regulatory Guidances 3. Early de-risking strategies for Novel Biopharmaceuticals vs. Small Molecule Drugs   4. PK\/PD assessments and Assays 5. Antibody-Drug Conjugates\u003c\/p\u003e \u003cp\u003e \u003cb\u003eSection II: Biosimilar Therapeutics\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e6. Description of Biosimilar Therapeutics and  Compare\/contrast Biosimilar Therapeuticss and Novel Biopharmaceuticals  7. Global Regulatory Guidelines 8. Early characterization of Biosimilar Therapeutics vs. Novel Biopharmaceuticals\/Studies Required and Principles of Study Design\/PK\/PD assessments\/Assays\u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection III: Vaccines\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e9. Vaccines Description and Comparison\/Contrast of Vaccines and Novel Biopharmaceuticals 10. Global Regulatory Guidances 11. Early de-risking strategies for Vaccines vs. Novel Biopharmaceuticals  \u003c\/p\u003e \u003cp\u003e\u003cb\u003eSection IV: Specialty Biologics and Indications\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e12. Cell Therapies 13. Gene Therapies 14. Blood Products 15. Oncology Drugs 16. Dual and Multi-Function Modalities 17. Stem Cell-Based Therapeutics\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Scientific standards [\u003ca title=\"See our other books on Scientific standards\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Scientific%20standards%20%5BPDD%5D%22\"\u003ePDD\u003c\/a\u003e], Medical toxicology [\u003ca title=\"See our other books on Medical toxicology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Medical%20toxicology%20%5BMMGT%5D%22\"\u003eMMGT\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46648514445592,"sku":"9780123948106","price":114.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123948106.jpg?v=1694092004"},{"product_id":"specification-of-drug-substances-and-products-development-and-validation-of-analytical-methods-paperback-9780081028247","title":"Specification of Drug Substances and Products; Development and Validation of Analytical Methods (Paperback) 9780081028247","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eSpecification of Drug Substances and Products\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eDevelopment and Validation of Analytical Methods\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003e\u003cp\u003eA comprehensive analysis of the requirements and approaches to setting specifications for new pharmaceutical products\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eChristopher M. Riley (Edited by), Thomas W. Rosanske (Edited by), George L. Reid (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780081028247, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback, published 24 July 2020\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e694 pages, 175 illustrations (15 in full color)\u003cbr\u003e23.4 x 19 x 4.2 cm, 1.54 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eSpecification of Drug Substances and Products: Development and Validation of Analytical Methods, Second Edition,\u003c\/i\u003e presents a comprehensive and critical analysis of the requirements and approaches to setting specifications for new pharmaceutical products, with an emphasis on phase-appropriate development, validation of analytical methods, and their application in practice. This thoroughly revised second edition covers topics not covered or not substantially covered in the first edition, including method development and validation in the clinical phase, method transfer, process analytical technology, analytical life cycle management, special challenges with generic drugs, genotoxic impurities, topical products, nasal sprays and inhalation products, and biotechnology products. \u003c\/p\u003e  \u003cp\u003eThe book's authors have been carefully selected as former members of the ICH Expert Working Groups charged with developing the ICH guidelines, and\/or subject-matter experts in the industry, academia and in government laboratories. \u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003cb\u003ePART 1 INTRODUCTION \u003c\/b\u003e1. Introduction  2. General Principles and Regulatory Considerations: Specifications and Shelf Life Setting  3. General Principles and Regulatory Considerations: Method Development and Validation  4. Application of Quality by Design (QbD) to the Development and Validation of Analytical Methods  5. Analytical Methods in the Clinical Phase of Development  6. Method Transfer  7. Process Analytical Technology\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 2 UNIVERSAL TESTS \u003c\/b\u003e8. Description and Identification  9. Assay and Impurities: Specifications  10. Assay and Impurities: Method Development and Life-Cycle Management  11. Assay and Impurities: Method Validation  12. Mutagenic Impurities  13. Residual Solvents  14. Inorganic Impurities (Elemental Impurities)\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 3 SPECIFIC TESTS: DRUG SUBSTANCES \u003c\/b\u003e15. Solid State Characterization  16. Chiral Methods  17. Water Determination \u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 4 SPECIFIC TESTS DRUG PRODUCT \u003c\/b\u003e18. Drug Release: Oral Products  19. Topical Products  20. Extractables and Leachables \u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 5 BIOTECHNOLOGY PRODUCTS \u003c\/b\u003e21. Regulatory Requirements for Setting Drug Substance and Drug Product Specifications  22. Validation of Analytical Methods for Biotechnology Products\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 6 PHARMACOPEIAL METHODS \u003c\/b\u003e23. Pharmacopeial Methods and Test (Updated)\u003c\/p\u003e \u003cp\u003e\u003cb\u003ePART 7 BIOLOGICAL FLUIDS \u003c\/b\u003e24. Biological Fluids\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Analytical chemistry [\u003ca title=\"See our other books on Analytical chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Analytical%20chemistry%20%5BPNF%5D%22\"\u003ePNF\u003c\/a\u003e], Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Elsevier","offers":[{"title":"Default Title","offer_id":46648544657688,"sku":"9780081028247","price":146.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780081028247.jpg?v=1694092197"},{"product_id":"colloid-and-interface-science-in-pharmaceutical-research-and-development-hardback-9780444626141","title":"Colloid and Interface Science in Pharmaceutical Research and Development (Hardback) 9780444626141","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eColloid and Interface Science in Pharmaceutical Research and Development\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eThe first comprehensive book on pharmaceutical research based on colloid and interface science\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eHiroyuki Ohshima (Edited by), Kimiko Makino (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444626141, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 18 July 2014\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e532 pages, 20 illustrations\u003cbr\u003e23.4 x 19 x 3.1 cm, 1.12 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eColloid and Interface Science in Pharmaceutical Research and Development\u003c\/i\u003e describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement. \u003c\/p\u003e  \u003cp\u003eThe book starts with fundamentals in Part I, covering fundamental aspects of colloid and interface sciences as applied to pharmaceutical sciences and thus should be suitable for teaching. Parts II and III treat applications and measurements, and they explains the application of these properties and their influence and use for the development of new drugs. \u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePart I Fundamentals\u003c\/p\u003e \u003cp\u003eInteraction between drugs\u003c\/p\u003e \u003cp\u003ePharmaceutical suspensions\u003c\/p\u003e \u003cp\u003eResponse of colloidal drugs to external fields\u003c\/p\u003e \u003cp\u003eAggregation of drugs\u003c\/p\u003e \u003cp\u003eConcentrated drug particles\u003c\/p\u003e \u003cp\u003eRheology of colloidal suspensions\u003c\/p\u003e \u003cp\u003ePart II Applications of Colloid and Interface Science in Pharmaceutical sciences\u003c\/p\u003e \u003cp\u003eLiposomes and micelles\u003c\/p\u003e \u003cp\u003eBinding of drugs on liposomes\u003c\/p\u003e \u003cp\u003eDrug delivery system\u003c\/p\u003e \u003cp\u003eGold nanoparticles \u003c\/p\u003e \u003cp\u003eDrug permeation through biological membranes\u003c\/p\u003e \u003cp\u003eEPR effects\u003c\/p\u003e \u003cp\u003ePart III Measurements\u003c\/p\u003e \u003cp\u003eZeta potential of colloidal drugs\u003c\/p\u003e \u003cp\u003eAtomic force microscope\u003c\/p\u003e \u003cp\u003eSurface force apparatus\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Chemical engineering [\u003ca title=\"See our other books on Chemical engineering\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemical%20engineering%20%5BTDCB%5D%22\"\u003eTDCB\u003c\/a\u003e], Surface chemistry \u0026amp; adsorption [\u003ca title=\"See our other books on Surface chemistry \u0026amp; adsorption\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Surface%20chemistry%20\u0026amp;%20adsorption%20%5BPNRX%5D%22\"\u003ePNRX\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Elsevier","offers":[{"title":"Default Title","offer_id":46648658002200,"sku":"9780444626141","price":107.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444626141_ddc404fd-cc61-4cc2-8836-fd6c0ec82d48.jpg?v=1694987269"},{"product_id":"pharmacology-in-drug-discovery-understanding-drug-response-paperback-9780123848567","title":"Pharmacology in Drug Discovery; Understanding Drug Response (Paperback) 9780123848567","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003ePharmacology in Drug Discovery\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eUnderstanding Drug Response\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003e\u003cp\u003eAids the reader in making more informed predictions of drug behavior during the drug-discovery process\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eTerry P. Kenakin (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123848567, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback, published 25 October 2011\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e260 pages, 25 illustrations\u003cbr\u003e23.4 x 19 x 1.7 cm, 0.54 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003e\"…an excellent introductory text…rich on examples and case studies…Although, there are many books that cover these subjects in greater depth, few have been able to integrate knowledge across fields so well and concisely.\"--\u003cb\u003eBritish Toxicology Society Newsletter Winter 2012, Issue 41\u003c\/b\u003e\u003c\/i\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cb\u003ePharmacology in Drug Discovery: Understanding Drug Response\u003c\/b\u003e is designed for all students, recent graduates, and new researchers in the pharmaceutical and biotechnology industries who need to interpret change in physiology induced by a chemical substance. Physiological systems customize chemical signal input to their own needs; therefore the same drug can have different effects in different physiological systems. The field of pharmacology is unique in that it furnishes the tools to analyze these different behaviors and traces them to their root cause. This enables predictions of drug behavior to be made in all systems, an invaluable tool for drug discovery because almost all drugs are developed in test systems far removed from the therapeutic one.  This valuable resource provides simple explanations of the ways in which biological systems use basic biochemical mechanisms to produce fine chemical control of physiology, allowing for more informed predictions of drug effects in all systems and forming the basis of the drug-discovery process. Chapters follow a logical progression on how to characterize the pharmacology of any given molecule, and include important terminology, chapter summaries, references, and review questions to aid the reader in understanding and retention of the material.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eChapter 1: Pharmacology: The Chemical Control of Physiology\u003c\/p\u003e \u003cp\u003eChapter 2: Drug Affinity and Efficacy\u003c\/p\u003e \u003cp\u003eChapter 3: Predicting Agonist Effect\u003c\/p\u003e \u003cp\u003eChapter 4: Drug Antagonism: Orthosteric Drug Effects \u003c\/p\u003e \u003cp\u003eChapter 5: Allosteric Drug Effects \u003c\/p\u003e \u003cp\u003eChapter 6: Enzymes as Drug Targets\u003c\/p\u003e \u003cp\u003eChapter 7: Pharmacokinetics I: Permeation and Metabolism\u003c\/p\u003e \u003cp\u003eChapter 8: Pharmacokinetics II: Distribution and Multiple Dosing\u003c\/p\u003e \u003cp\u003eChapter 9: In Vivo Pharmacology \u003c\/p\u003e \u003cp\u003eChapter 10: Safety Pharmacology \u003c\/p\u003e \u003cp\u003eChapter 11: Answers to Chapter Questions \u003c\/p\u003e \u003cp\u003eChapter 12: Derivations and Proofs\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46648697389336,"sku":"9780123848567","price":53.65,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123848567.jpg?v=1694093405"},{"product_id":"inhaled-pharmaceutical-product-development-perspectives-challenges-and-opportunities-paperback-9780128122099","title":"Inhaled Pharmaceutical Product Development Perspectives; Challenges and Opportunities (Paperback) 9780128122099","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eInhaled Pharmaceutical Product Development Perspectives\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eChallenges and Opportunities\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003e\u003cp\u003eThis cutting edge guide provides the latest methods and protocols for inhaled pharmaceutical product development to support regulatory submissions\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eAnthony J. Hickey (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780128122099, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback, published 23 November 2017\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e110 pages\u003cbr\u003e22.9 x 15.1 x 0.9 cm, 0.18 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eInhaled Pharmaceutical Product Development Perspectives: Challenges and Opportunities\u003c\/i\u003e describes methods and procedures for consideration when developing inhaled pharmaceuticals, while commenting on product development strategies and their suitability to support regulatory submission. It bridges the gap between the aspirations of scientists invested in new technology development and the requirements that must be met for any new product. \u003c\/p\u003e  \u003cp\u003eThe book brings together emerging analytical and inhalation technologies, providing perspectives that illuminate formulation and device design, development, regulatory compliance, and practice. Focusing on underlying scientific and technical principles known to be acceptable from the current regulatory perspective, this monograph will remain useful as a high-level guide to inhaled product development for the foreseeable future.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e1. Introduction–Historical Perspective2. Dosage Forms3. Quality and Performance Tests4. Preclinical and Clinical Considerations5. Regulatory Strategy6. 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Castell (Edited by), Maria Jose Gmez-Lechn (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780121633905, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 4 October 1996\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e467 pages\u003cbr\u003e24.1 x 16.5 x 2.9 cm, 1.03 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"A compilation of in-depth chapters. This volume makes an important and significant contribution to the field.\" --\u003cb\u003eALAN M. GOLDBERG, PhD, Director, Centre for Alternatives to Animal Testing, Johns Hopkins University\u003c\/b\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cb\u003e\u003ci\u003eIn Vitro\u003c\/i\u003e Methods in Pharmaceutical Research\u003c\/b\u003e provides a comprehensive guide to laboratory techniques for evaluating \u003ci\u003ein vitro\u003c\/i\u003e organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular \u003ci\u003ein vitro\u003c\/i\u003e models for toxicology and pharmacology studies.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eD.W. Straughan, J.H. Fentem, and M. Balls\u003c\/i\u003e, Replacement Alternative and Complementary \u003ci\u003eIn Vitro\u003c\/i\u003e Methods in Pharamaceutical Research.\u003cbr\u003e\u003ci\u003eM.D. Barratt and M. Chamberlain\u003c\/i\u003e, Integration of QSAR and \u003ci\u003eIn Vitro\u003c\/i\u003e Toxicology.\u003cbr\u003e\u003ci\u003eF.A. Barile\u003c\/i\u003e, Continuous Cell Lines as a Model for Drug Toxicity Assessment.\u003cbr\u003e\u003ci\u003eP. Bach\u003c\/i\u003e, \u003ci\u003eIn Vitro\u003c\/i\u003e Models for Nephrotoxicity Studies.\u003cbr\u003e\u003ci\u003eA.E.M. Vickers\u003c\/i\u003e, Experimental \u003ci\u003eIn Vitro\u003c\/i\u003e Models to Evaluate Hepatotoxicity.\u003cbr\u003e\u003ci\u003eM.J. Gomez-Lechon, T. Donato, X. Ponsoda, R. Fabra, R. Trullenque, and J.V. Castell\u003c\/i\u003e, Isolation, Culture and Use of Human Hepatocytes in Drug Research.\u003cbr\u003e\u003ci\u003eE. McFarlane-Abdulla, and I.C. Campbell\u003c\/i\u003e, Studies of Nephrotoxicity in Cellular Studies.\u003cbr\u003e\u003ci\u003eM. Adolphe, S. Thenet-Gauci, and S. Demignot\u003c\/i\u003e, Chondrocyte Culture: A Target System to Evaluate Pharmaco-Toxicological Effects of Drugs.\u003cbr\u003e\u003ci\u003eE. Chacon, D. Acosta, and J.J. Lemasters\u003c\/i\u003e, Primary Cultures of Cardiac Myocytes as \u003ci\u003eIn Vitro\u003c\/i\u003e Models for Pharmacological andToxicological Assessments.\u003cbr\u003e\u003ci\u003eR. Roguet\u003c\/i\u003e, Cutaneous Pharmacotoxicology \u003ci\u003eIn Vitro\u003c\/i\u003e.\u003cbr\u003e\u003ci\u003eH. Spielmann\u003c\/i\u003e, Ocular Irritation.\u003cbr\u003e\u003ci\u003eM.A. Miranda\u003c\/i\u003e, Phototoxicity of Drugs.\u003cbr\u003e\u003ci\u003eI. de G. Mitchell and R.D. Combes\u003c\/i\u003e, \u003ci\u003eIn Vitro\u003c\/i\u003e Genotoxicity and Cell Transformation Assessment.\u003cbr\u003e\u003ci\u003eB. Schmid, R. Bechter, and P. Kucera\u003c\/i\u003e, The Use of Whole Embryo Cultures in \u003ci\u003eIn Vitro\u003c\/i\u003e Teratogenicity Testing.\u003cbr\u003e\u003ci\u003eJ.V. Castell, M.J. Gomez-Lechon, X. Ponsoda, and R. Bort\u003c\/i\u003e, \u003ci\u003eIn Vitro\u003c\/i\u003e Investigation of the Molecular Mechanisms of Hepatotoxicity.\u003cbr\u003e\u003ci\u003eA. Guillouzo\u003c\/i\u003e, Biotransformation of Drugs by Hepatocytes.\u003cbr\u003e\u003ci\u003eK. Mace, E.A. Offord, and A.M.A. Pfeifer\u003c\/i\u003e, Drug Metabolism and Carcinogen Activation Studies with Human Genetically Engineered Cells.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Medical toxicology [\u003ca title=\"See our other books on Medical toxicology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Medical%20toxicology%20%5BMMGT%5D%22\"\u003eMMGT\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Medical laboratory testing \u0026amp; techniques [\u003ca title=\"See our other books on Medical laboratory testing \u0026amp; techniques\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Medical%20laboratory%20testing%20\u0026amp;%20techniques%20%5BMBGL%5D%22\"\u003eMBGL\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46648977916184,"sku":"9780121633905","price":98.29,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780121633905_24f53639-8c12-4fae-883b-076c45c49140.jpg?v=1695006647"},{"product_id":"advances-in-pharmaceutical-sciences-hardback-9780120323074","title":"Advances in Pharmaceutical Sciences (Hardback) 9780120323074","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAdvances in Pharmaceutical Sciences\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eDavid Ganderton (Volume editor), Trevor Jones (Volume editor), James McGinity (Volume editor)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780120323074, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 28 September 1995\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e278 pages\u003cbr\u003e22.9 x 15.2 x 2.2 cm, 0.49 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThe seventh volume of \u003cb\u003eAdvances in Pharmaceutical Sciences\u003c\/b\u003e heralds a welcome continuation of this well-respected series. Acknowledged experts provide comprehensive statements of current research and development in selected fields of pharmaceutical technology. This book will be of great value to those working in academia and the pharmaceutical industry.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eR.C. Rowe and R.J. Roberts\u003c\/i\u003e, The Mechanical Properties of Powders.\u003cbr\u003e\u003ci\u003eA. Urtti\u003c\/i\u003e, Kinetic Aspects in the Design of Prolonged Action Ocular Drug Delivery Systems.\u003cbr\u003e\u003ci\u003eJ.G. Nairn\u003c\/i\u003e, Coacervation-Phase Separation Technology.\u003cbr\u003e\u003ci\u003eH.G. Kristensen\u003c\/i\u003e, Particle Agglomeration.\u003cbr\u003eSubject Index.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Biotechnology [\u003ca title=\"See our other books on Biotechnology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biotechnology%20%5BTCB%5D%22\"\u003eTCB\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649176260888,"sku":"9780120323074","price":40.89,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780120323074_1fe5b0d3-63e7-4156-8862-05f5c478c192.jpg?v=1695006576"},{"product_id":"annual-reports-in-medicinal-chemistry-paperback-9780120405411","title":"Annual Reports in Medicinal Chemistry (Paperback \/ softback) 9780120405411","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAnnual Reports in Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eThis series continues to provide a concise summary of new and significant contributions to the fields of medicinal chemistry\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eAnthony Wood (Series edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780120405411, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 15 December 2006\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e556 pages\u003cbr\u003e24 x 16.5 x 3.4 cm, 1.01 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eAnnual Reports in Medicinal Chemistry\u003c\/i\u003e provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design. Section VII looks at Trends and Perspectives in the pharmaceuticals market.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eI.   Central Nervous System Diseases (A.J. Robichaud).\u003cbr\u003eII.  Cardiovascular and Metabolic Diseases (A. Stamford).\u003cbr\u003eIII. Inflammatory, Pulmonary, and Gastrointestinal Diseases (M.G. Bock). \u003cbr\u003eIV.  Cancer and Infectious Diseases (D. Myles). \u003cbr\u003eV.   Topics in Biology (D. Cohen).\u003cbr\u003eVI.  Topics in Drug Design and Discovery (M.C. Desai).\u003cbr\u003eVII. Trends and Perspectives (A. Wood).\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Biochemistry [\u003ca title=\"See our other books on Biochemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemistry%20%5BPSB%5D%22\"\u003ePSB\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649181765912,"sku":"9780120405411","price":77.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780120405411.jpg?v=1695006576"},{"product_id":"genetic-algorithms-in-molecular-modeling-hardback-9780122138102","title":"Genetic Algorithms in Molecular Modeling (Hardback) 9780122138102","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eGenetic Algorithms in Molecular Modeling\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eJames Devillers (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780122138102, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 7 June 1996\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e327 pages\u003cbr\u003e22.9 x 15.1 x 2.4 cm, 0.64 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\"The series is a welcome addition to scattered literature on QSAR and drug design in over a dozen journals, and if judged by this first volume, the introduction of the series is timely. ...the book is a valuable addition to the growling literature associeated with the use of computers in chemistry. With the remaining books in this series, it ought to find a place on the desk of anyone who wishes to be kept abreast of recent advances in QSAR.\" --\u003cb\u003eMilan Radic, Drake University, JOURNAL OF CHEMISTRY INFORMATION COMPUTER SCIENCES\u003c\/b\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eGenetic Algorithms in Molecular Modeling\u003c\/i\u003e is the first book available on the use of genetic algorithms in molecular design. This volume marks the beginning of an ew series of books, Principles in Qsar and Drug Design, which will be an indispensible reference for students and professionals involved in medicinal chemistry, pharmacology, (eco)toxicology, and agrochemistry. Each comprehensive chapter is written by a distinguished researcher in the field.\u003c\/p\u003e  \u003cp\u003eThrough its up to the minute content, extensive bibliography, and essential information on software availability, this book leads the reader from the theoretical aspects to the practical applications. It enables the uninitiated reader to apply genetic algorithms for modeling the biological activities and properties of chemicals, and provides the trained scientist with the most up to date information on the topic.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eGenetic Algorithms in Computer-Aided Molecular Design. An Overviewe of Genetic Methods. Genetic Algorithms in Feature Selection. Some Theory and Examples of Genetic Function Approximation with Comparision to Evolutionary Techniques. Genetic Partial Least Squares in QSAR. Application of Genetic Algorithms to the General QSAR Problem and to Guiding Molecular Diversity Experiments. Prediction of the Progesterone Receptor Binding of Steroids Using a Combination of Genetic Algorithms and Neural Networks. Genetically Evolved Receptor Models (GERM): A Procedure for Construction of Atomic-Level Receptor Site Models in the Absence of a Receptor Crystal Structure. Genetic Algorithms for Chemical Structure Handling and Molecular Recognition. Genetic Selection of Aromatic Substituents for Designing Test Series. Computer-Aided Molecular Design Using Nerual Networks and Genetic Algorithms. Designing Biodegradable Molecules from the Combined Use of a Backpropagation Neural Network and a Genetic Algorithm.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Maths for engineers [\u003ca title=\"See our other books on Maths for engineers\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Maths%20for%20engineers%20%5BTBJ%5D%22\"\u003eTBJ\u003c\/a\u003e], Genetics [\u003ca title=\"See our other books on Genetics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Genetics%20%5Bnon-medical%5D%20%5BPSAK%5D%22\"\u003enon-medical PSAK\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649197625624,"sku":"9780122138102","price":70.28,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780122138102_d919bf67-9a6a-489f-b388-c94e40e2cfcb.jpg?v=1695006721"},{"product_id":"neuropeptide-y-and-drug-development-hardback-9780123049902","title":"Neuropeptide Y and Drug Development (Hardback) 9780123049902","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eNeuropeptide Y and Drug Development\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eLars Grundemar (Edited by), Stephen R. Bloom (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123049902, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 15 November 1996\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e209 pages\u003cbr\u003e22.9 x 15.1 x 2 cm, 0.48 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eNeuropeptide Y (NPY)\u003c\/i\u003e is a ubiquitous and important messenger in the nervous system, with a wide range of physiological roles. It is involved in the body energy balance and is one of the most potent stimuli of food intake known. NPY also acts to regulate central and peripheral autonomic functions.\u003c\/p\u003e  \u003cp\u003eThis book, written by academic and industrial experts in the field, links the most recent basic experimental knowledge about NPY and its receptors with areas of clinical importance.\u003c\/p\u003e  \u003cp\u003eThis book will be of interest to those working in all areas of research affected by NPY, such as food intake and energy homeostasis, cardiovascular regulation and G-protein-coupled receptors, as well as those interested in the development of drugs as NPY targets.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eMultiple Receptors and Multiple Actions Central Effects of Neuropeptide Y and Its Role in Obesity and Diabetes Neuropeptide Y in Sympathetic Nerves-Evidence for Y1 Receptor-Mediated Vascular Control Neuropeptide Y Receptor Types in Mammalian Brain Species Differences and Status in the Human Central Nervous System Extraordinary Structural Diversity of Neuropeptide Y Family Receptors The Importance of Various Parts of the Neuropeptide Y Molecule for Receptor Recognition Peptide Antagonists of Neuropeptide Y: Design, Structure, And Pharmacological Characterization SR 120819A or the First Generation of Orally-Active Neuropeptide Y1 Receptor Antagonists BIBP3226, A Potent and Selective Y1 Receptor Antagonist First Structure-Activity Studies and Localization of the Human Y1 Receptor Binding Site Discovery of Neuropeptide Y Receptor Antagonists \u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Proteins [\u003ca title=\"See our other books on Proteins\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Proteins%20%5BPSBC%5D%22\"\u003ePSBC\u003c\/a\u003e], Neurosciences [\u003ca title=\"See our other books on Neurosciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Neurosciences%20%5BPSAN%5D%22\"\u003ePSAN\u003c\/a\u003e], Biophysics [\u003ca title=\"See our other books on Biophysics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biophysics%20%5BPHVN%5D%22\"\u003ePHVN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Endocrinology [\u003ca title=\"See our other books on Endocrinology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Endocrinology%20%5BMJG%5D%22\"\u003eMJG\u003c\/a\u003e], Physiology [\u003ca title=\"See our other books on Physiology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Physiology%20%5BMFG%5D%22\"\u003eMFG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649200869656,"sku":"9780123049902","price":102.49,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123049902_464bb051-3d9c-407b-bd91-ca71ed595500.jpg?v=1695006756"},{"product_id":"the-pharmacology-of-neurogenesis-and-neuroenhancement-hardback-9780123736789","title":"The Pharmacology of Neurogenesis and Neuroenhancement (Hardback) 9780123736789","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eThe Pharmacology of Neurogenesis and Neuroenhancement\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eDonard Dwyer (Volume editor)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123736789, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 6 February 2007\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e344 pages, Illustrated\u003cbr\u003e22.9 x 15.1 x 2.4 cm, 0.67 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eCurrently, few drugs are available for the effective treatment of neurodegenerative diseases and neurodevelopmental disorders.  Recent advances in neuroscience research offer hope that future strategies for treating these brain disorders will include neurogenesis and neuroenhancement as therapeutic endpoints.  This volume reviews cutting-edge findings related to the pharmacological aspects of neurogenesis and neuroprotection.  A broad range of topics are covered from basic lab bench research to drug discovery efforts and important clinical issues.  This collection of reviews is a perfect way to become acquainted with these exciting new fields in the space of a single volume.  Chapters are written with a general audience in mind, but with enough high-level discussion to appeal to specialists and experts as well.  The authors have done an excellent job of challenging current paradigms and pushing the boundaries of exploration in keeping with the pioneering spirit that gave rise to these emerging areas of research.  Consequently, this will be an indispensable resource for many years to come.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eRegenerating the Brain\u003c\/p\u003e \u003cp\u003eSerotonin and Brain: Evolution, Neuroplasticity, and Homeostasis\u003c\/p\u003e \u003cp\u003eTherapeutic Approaches to Promoting Axonal Regeneration in the Adult Mammalian Spinal Cord\u003c\/p\u003e \u003cp\u003eEvidence for Neuroprotective Effects of Antipsychotic Drugs: Implications for the Pathophysiology and Treatment of Schizophrenia\u003c\/p\u003e \u003cp\u003eNeurogenesis and Neuroenhancement in the Pathophysiology and Treatment of Bipolar Disorder\u003c\/p\u003e \u003cp\u003eNeuroreplacement, Growth Factor, and Small Molecule Neurotrophic Approaches for Treating Parkinson’s Disease\u003c\/p\u003e \u003cp\u003eUsing Caenorhabditis elegans Models of Neurodegenerative Disease to Identify Neuroprotective Strategies\u003c\/p\u003e \u003cp\u003eNeuroprotection and Enhancement of Neurite Outgrowth With Small Molecular Weight Compounds From Screens of Chemical Libraries\u003c\/p\u003e \u003cp\u003eIndex\u003c\/p\u003e \u003cp\u003eContents of Recent Volumes\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Biochemistry [\u003ca title=\"See our other books on Biochemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemistry%20%5BPSB%5D%22\"\u003ePSB\u003c\/a\u003e], Neurosciences [\u003ca title=\"See our other books on Neurosciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Neurosciences%20%5BPSAN%5D%22\"\u003ePSAN\u003c\/a\u003e], Biophysics [\u003ca title=\"See our other books on Biophysics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biophysics%20%5BPHVN%5D%22\"\u003ePHVN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Neurology \u0026amp; clinical neurophysiology [\u003ca title=\"See our other books on Neurology \u0026amp; clinical neurophysiology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Neurology%20\u0026amp;%20clinical%20neurophysiology%20%5BMJN%5D%22\"\u003eMJN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649276006680,"sku":"9780123736789","price":127.59,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123736789.jpg?v=1695013812"},{"product_id":"statistical-methods-in-food-and-consumer-research-hardback-9780123737168","title":"Statistical Methods in Food and Consumer Research (Hardback) 9780123737168","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eStatistical Methods in Food and Consumer Research\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eMaximo C. Gacula Jr. (Author), Jagbir Singh (Author), Jian Bi (Author), Stan Altan (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123737168, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 1 December 2008\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e888 pages, Approx. 130 illustrations\u003cbr\u003e24.6 x 18.7 x 4.3 cm, 1.75 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eStatistical Methods in Food and Consumer Research, Second Edition\u003c\/i\u003e, continues to be the only book to focus solely on the statistical techniques used in sensory testing of foods, pharmaceuticals, cosmetics, and other consumer products. This new edition includes the most recent applications of statistical methods, and features significant updates as well as two new chapters.\u003c\/p\u003e  \u003cp\u003eCovering the application of techniques including R-index, the Bayesian approach for sensory differences tests, and preference mapping in addition to several other methodologies, this is the comprehensive reference needed by those studying sensory evaluation and applied statistics in agriculture and biological sciences.\u003c\/p\u003e  \u003cp\u003eResearch professionals working with food, beverages, healthcare, cosmetics, and other related areas will find the book a valuable guide to the variety of statistical methods available.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e1-Introduction\u003cbr\u003e2-Statistical Sensory Testing\u003cbr\u003e3-The Analysis of Variance and Multiple Comparison Tests\u003cbr\u003e4-Experimental Design\u003cbr\u003e5-Incomplete Block Experimental Designs\u003cbr\u003e6-Factorial Experiments\u003cbr\u003e7-Response Surface Designs and Analysis\u003cbr\u003e8-Shelf Life Testing Experiments\u003cbr\u003e9-Nonparametric Statistical Methods\u003cbr\u003e10-Sensory Difference and Similarity Tests\t\u003cbr\u003e11-The Method of Paired Comparisons in Sensory Tests and Thurstonian Scaling\u003cbr\u003e12-Descriptive Analysis and Perceptual Mapping \u003cbr\u003e13-Sensory Evaluation in Cosmetic Studies\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Food \u0026amp; beverage technology [\u003ca title=\"See our other books on Food \u0026amp; beverage technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Food%20\u0026amp;%20beverage%20technology%20%5BTDCT%5D%22\"\u003eTDCT\u003c\/a\u003e], Cosmetics technology [\u003ca title=\"See our other books on Cosmetics technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Cosmetics%20technology%20%5BTDCJ1%5D%22\"\u003eTDCJ1\u003c\/a\u003e], Probability \u0026amp; statistics [\u003ca title=\"See our other books on Probability \u0026amp; statistics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Probability%20\u0026amp;%20statistics%20%5BPBT%5D%22\"\u003ePBT\u003c\/a\u003e], Sales \u0026amp; marketing [\u003ca title=\"See our other books on Sales \u0026amp; marketing\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Sales%20\u0026amp;%20marketing%20%5BKJS%5D%22\"\u003eKJS\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649277251864,"sku":"9780123737168","price":88.19,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123737168_2480f1c8-f92d-42d5-9c82-bb0799b179df.jpg?v=1695013819"},{"product_id":"animal-and-translational-models-for-cns-drug-discovery-neurological-disorders-hardback-9780123738554","title":"Animal and Translational Models for CNS Drug Discovery: Neurological Disorders (Hardback) 9780123738554","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAnimal and Translational Models for CNS Drug Discovery: Neurological Disorders\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eYour guide for understanding the selection and use of animal translational models for neurological drugs\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eRobert A. McArthur (Edited by), Franco Borsini (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123738554\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 18 November 2008\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e416 pages\u003cbr\u003e26 x 18.3 x 2.7 cm, 0.94 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eNeurological Disorders\u003c\/i\u003e is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for neurological disorders such as neurofibromatosis, Alzheimer’s disease, Parkinson’s disease, Huntington disease, ALS, and the epilepsies. \u003ci\u003eNeurological Disorders \u003c\/i\u003ehas introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on \u003ci\u003eAnimal and Translational Models for CNS Drug Discovery\u003c\/i\u003e is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.\u003c\/p\u003e  \u003cp\u003eThis is the second volume in the three volume-set, \u003ci\u003eAnimal and Translational Models for CNS Drug Discovery\u003c\/i\u003e 978-0-12-373861-5, which is also available for purchase individually. \u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface: What Do You Mean By “Translational Research?? An Enquiry through Animal and Translational Models for CNS Drug Discovery: Neurological Disorders\u003cbr\u003eRobert A McArthur and Franco Borsini\u003cbr\u003e\u003cbr\u003e1.\t\u003ci\u003eA. Jackie Hunter.\u003c\/i\u003e Animal and Translational Models of Neurological Disorders: An Industrial Perspective\u003cbr\u003e\u003cbr\u003e2.\t\u003ci\u003eLon S Schneider.\u003c\/i\u003e Issues in Design and Conduct of Clinical Trials for Cognitive-Enhancing Drugs\u003cbr\u003e\u003cbr\u003e3.\t\u003ci\u003eC. Shilyansky et al.\u003c\/i\u003e Molecular And Cellular Mechanisms Of Learning Disabilities: A Focus On Neurofibromatosis Type I\u003cbr\u003e\u003cbr\u003e4.\t\u003ci\u003eM. Lindner et al.\u003c\/i\u003e Development, Optimization and Use of Preclinical Behavioral Models to Maximize the Productivity of Drug Discovery for Alzheimer’s Disease\u003cbr\u003e\u003cbr\u003e5.\t\u003ci\u003eK. Merchant et al.\u003c\/i\u003e Animal Models of Parkinson’s Disease to Aid Drug Discovery and Development\u003cbr\u003e\u003cbr\u003e6.\t\u003ci\u003eT. Wagner et al.\u003c\/i\u003e Huntington Disease\u003cbr\u003e\u003cbr\u003e7.\t\u003ci\u003eJ. Montes.\u003c\/i\u003e Translational Research in ALS\u003cbr\u003e\u003cbr\u003e8.\t\u003ci\u003eH. Klitgaard.\u003c\/i\u003e Animal and Translational Models of the Epilepsies\u003cbr\u003e\u003cbr\u003eEpilogue:\u003cbr\u003eTranslational Models for the 21st century: Reminiscence, Reflections and Some Recommendations\u003cbr\u003ePaul Willner, Franco Borsini, and Robert A McArthur\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Psychopharmacology [\u003ca title=\"See our other books on Psychopharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Psychopharmacology%20%5BMMGW%5D%22\"\u003eMMGW\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Neurology \u0026amp; clinical neurophysiology [\u003ca title=\"See our other books on Neurology \u0026amp; clinical neurophysiology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Neurology%20\u0026amp;%20clinical%20neurophysiology%20%5BMJN%5D%22\"\u003eMJN\u003c\/a\u003e], Psychology [\u003ca title=\"See our other books on Psychology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Psychology%20%5BJM%5D%22\"\u003eJM\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46649277907224,"sku":"9780123738554","price":58.58,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123738554.jpg?v=1695013830"},{"product_id":"animal-and-translational-models-for-cns-drug-discovery-psychiatric-disorders-hardback-9780123738561","title":"Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders (Hardback) 9780123738561","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAnimal and Translational Models for CNS Drug Discovery: Psychiatric Disorders\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eYour guide for understanding the selection and use of animal translational models for psychiatric drugs\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eRobert A. McArthur (Edited by), Franco Borsini (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123738561, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 17 November 2008\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e528 pages\u003cbr\u003e26 x 18.3 x 3.1 cm, 1.14 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003ePsychiatric Disorders\u003c\/i\u003e is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for psychiatric disorders such as anxiety, obsessive-compulsive disorder, depression, schizophrenia, bipolar disorder, ADHD, and autistic spectrum disorder. \u003ci\u003ePsychiatric Disorders \u003c\/i\u003ehas introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. The aim of this series of volumes on \u003ci\u003eAnimal and Translational Models for CNS Drug Discovery\u003c\/i\u003e is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.\u003c\/p\u003e  \u003cp\u003eThis is the first volume in the three volume-set, \u003ci\u003eAnimal and Translational Models for CNS Drug Discovery\u003c\/i\u003e 978-0-12-373861-5, and is also available for purchase individually. \u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface to Psychiatric Disorders Volume:\u003cbr\u003eWhat Do You Mean By “Translational Research?? An Enquiry through Animal and Translational Models for CNS Drug Discovery: Psychiatric Disorders\u003cbr\u003eRobert A McArthur and Franco Borsini\u003cbr\u003e\u003cbr\u003e1.\tMark J. Millan. The Discovery and Development of Pharmacotherapy for Psychiatric Disorders: A Critical Survey of Animal and Translational Models, and Perspectives for their Improvement\u003cbr\u003e\u003cbr\u003e2.\tL. Winsky et al. Drug Discovery and Development Initiatives at the National Institute of Mental Health:  From Cell-Based System to Proof of Concept\u003cbr\u003e\u003cbr\u003e3.\tJ. McEvoy and Freudenreich. Issues in the Design and Conductance of Clinical Trials\u003cbr\u003e\u003cbr\u003e4.\tKlaus A. Miczek. Challenges for Translational Psychopharmacology Research – The Need for Conceptual Principles\u003cbr\u003e\u003cbr\u003e5.\tT. Steckler et al. Developing Novel Anxiolytics:  Improving Preclinical Detection and Clinical Assessment\u003cbr\u003e\u003cbr\u003e6.\tD. Joel et al. Animal Models of Obsessive-Compulsive Disorder:  From Bench to Beside Via Endophenotypes and Biomarkers\u003cbr\u003e\u003cbr\u003e7.\tJ. Cryan et al. Developing More Efficacious Antidepressant Medications:\u003cbr\u003eImproving and Aligning Preclinical and Clinical Assessment Tools\u003cbr\u003e\u003cbr\u003e8.\tD. Jones et al. Developing New Drugs for Schizophrenia: From Animals to the Clinic\u003cbr\u003e\u003cbr\u003e9.\tC. Large et al. Developing Therapeutics for Bipolar Disorder (BPD):  From Animal Models to the Clinic\u003cbr\u003e\u003cbr\u003e10.\tR. Tannock et al. Towards a Biological Understanding of ADHD and the Discovery of Novel Therapeutic Approaches\u003cbr\u003e\u003cbr\u003e11.\tJ. Bartz et al. Preclinical Animal Models of Autistic Spectrum Disorders (ASD)\u003cbr\u003e\u003cbr\u003e12.\t S. Doran et al. Translational Models of Sleep and Sleep Disorders\t\u003cbr\u003e\u003cbr\u003eEpilogue:\u003cbr\u003eTranslational Models for the 21st century: Reminiscence, Reflections and Some Recommendations\u003cbr\u003ePaul Willner, Franco Borsini, and Robert A McArthur\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Psychiatry [\u003ca title=\"See our other books on Psychiatry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Psychiatry%20%5BMMH%5D%22\"\u003eMMH\u003c\/a\u003e], Psychopharmacology [\u003ca title=\"See our other books on Psychopharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Psychopharmacology%20%5BMMGW%5D%22\"\u003eMMGW\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Pharmaceutical industries [\u003ca title=\"See our other books on Pharmaceutical industries\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20industries%20%5BKNDP%5D%22\"\u003eKNDP\u003c\/a\u003e], Psychology [\u003ca title=\"See our other books on Psychology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Psychology%20%5BJM%5D%22\"\u003eJM\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649278431512,"sku":"9780123738561","price":64.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123738561.jpg?v=1695013826"},{"product_id":"animal-and-translational-models-for-cns-drug-discovery-reward-deficit-disorders-hardback-9780123738608","title":"Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders (Hardback) 9780123738608","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAnimal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eYour guide for understanding the selection and use of animal translational models for reward deficit drugs\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eRobert A. McArthur (Edited by), Franco Borsini (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123738608, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 15 November 2008\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e432 pages\u003cbr\u003e26 x 18.3 x 2.8 cm, 0.96 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eReward Deficit Disorders\u003c\/i\u003e is written for researchers in both academia and the pharmaceutical industry who use animal models in research and development of drugs for reward deficit disorders such as alcohol dependence, nicotine dependence, heroin and cocaine addiction, obesity, and gambling and impulse control disorders. \u003ci\u003eReward Deficit Disorders \u003c\/i\u003ehas introductory chapters expressing the view of the role and relevance of animal models for drug discovery and development for the treatment of psychiatric disorders from the perspective of (a) academic basic neuroscientific research, (b) applied pharmaceutical drug discovery and development, and (c) issues of clinical trial design and regulatory agencies limitations. Each volume examines the rationale, use, robustness and limitations of animal models in each therapeutic area covered and discuss the use of animal models for target identification and validation. The clinical relevance of animal models is discussed in terms of major limitations in cross-species comparisons, clinical trial design of drug candidates, and how clinical trial endpoints could be improved. \u003ci\u003eReward Deficit Disorders\u003c\/i\u003e also has a section dedicated to the specifics of the regulatory aspects to abuse liability testing. The aim of this series of volumes on \u003ci\u003eAnimal and Translational Models for CNS Drug Discovery\u003c\/i\u003e is to identify and provide common endpoints between species that can serve to inform both the clinic and the bench with the information needed to accelerate clinically-effective CNS drug discovery.\u003c\/p\u003e  \u003cp\u003eThis is the third volume in the three volume-set, \u003ci\u003eAnimal and Translational Models for CNS Drug Discovery\u003c\/i\u003e 978-0-12-373861-5, which is also available for purchase individually.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface to Reward Deficit Disorders Volume:\u003cbr\u003eWhat Do You Mean By “Translational Research?? An Enquiry through Animal and Translational Models for CNS Drug Discovery: Reward Deficit Disorders\u003cbr\u003eRobert A McArthur and Franco Borsini\u003cbr\u003e\u003cbr\u003e1.\tC. Heidbreder. Impulse and Reward Deficit Disorders:  Drug Discovery and Development\u003cbr\u003e\u003cbr\u003e2.\tD. McCann et al. Drug Discovery and Development for Reward Disorders:  Views from Government\u003cbr\u003e\u003cbr\u003e3.\tT. Gardner et al. Issues in Designing and Conduction Clinical Trails for Reward Disorders:  A Clinical View\u003cbr\u003e\u003cbr\u003e4.\tG. Koob. The Role of Animal Models in Reward Deficit Disorders:  Views of Academia\u003cbr\u003e\u003cbr\u003e5.\tHilary J Little et al. Pharmacotherapy of Alcohol Dependence: Improving Translation from the Bench to the Clinic\u003cbr\u003e\u003cbr\u003e6.\tA. Markou et al. Contribution of Animal Models and Preclinical Human Studies to Medication:  Development for Nicotine Dependence\u003cbr\u003e\u003cbr\u003e7.\tB. Rocha et al. Development of Medication for Heroin and Cocaine Addiction and Regulatory Aspects of Abuse Liability Testing\u003cbr\u003e\u003cbr\u003e8.\tC. Dourish et al. Anti-obesity Drugs:  From Animal Models to Clinical Efficacy\u003cbr\u003e\u003cbr\u003e9.\tW. Williams et al. Current Concepts in the Classification, Treatment and Modeling of Pathological Gambling and other Impulse Control Disorders\u003cbr\u003e\u003cbr\u003eEpilogue:\u003cbr\u003eTranslational Models for the 21st century: Reminiscence, Reflections and Some Recommendations\u003cbr\u003ePaul Willner, Franco Borsini, and Robert A McArthur\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Neurosciences [\u003ca title=\"See our other books on Neurosciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Neurosciences%20%5BPSAN%5D%22\"\u003ePSAN\u003c\/a\u003e], Psychopharmacology [\u003ca title=\"See our other books on Psychopharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Psychopharmacology%20%5BMMGW%5D%22\"\u003eMMGW\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Clinical trials [\u003ca title=\"See our other books on Clinical trials\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Clinical%20trials%20%5BMBGR1%5D%22\"\u003eMBGR1\u003c\/a\u003e], Psychology [\u003ca title=\"See our other books on Psychology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Psychology%20%5BJM%5D%22\"\u003eJM\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649278791960,"sku":"9780123738608","price":64.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123738608_7749af79-9b32-4483-943d-6cf4916f3933.jpg?v=1695013827"},{"product_id":"annual-reports-in-medicinal-chemistry-paperback-9780123739124","title":"Annual Reports in Medicinal Chemistry (Paperback \/ softback) 9780123739124","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAnnual Reports in Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eThis series continues to provide a concise summary of new and significant contributions to the fields of medicinal chemistry\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eJohn E. Macor (Series edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123739124, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 7 December 2007\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e646 pages\u003cbr\u003e24 x 16.5 x 3.9 cm, 1.12 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eAnnual Reports in Medicinal Chemistry\u003c\/i\u003e provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eCentral Nervous System Diseases\u003cbr\u003eCardiovascular and Metabolic Diseases\u003cbr\u003eInflammation, Pulmonary and Gastro Intestinal Diseases\u003cbr\u003eCancer and Infectious Diseases\u003cbr\u003eTopics in Biology\u003cbr\u003eTopics in Drug Design and Discovery\u003cbr\u003eTo Market, To Market 2006\u003cbr\u003eIndexes including cumulative NCE indexes\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Biochemistry [\u003ca title=\"See our other books on Biochemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemistry%20%5BPSB%5D%22\"\u003ePSB\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Biophysics [\u003ca title=\"See our other books on Biophysics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biophysics%20%5BPHVN%5D%22\"\u003ePHVN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Medicine: general issues [\u003ca title=\"See our other books on Medicine: general issues\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Medicine:%20general%20issues%20%5BMB%5D%22\"\u003eMB\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649281511704,"sku":"9780123739124","price":79.29,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123739124_8c84c40d-61bf-4b63-b172-cd7fc194ecb8.jpg?v=1695013838"},{"product_id":"modern-biopolymer-science-bridging-the-divide-between-fundamental-treatise-and-industrial-application-hardback-9780123741950","title":"Modern Biopolymer Science; Bridging the Divide between Fundamental Treatise and Industrial Application (Hardback) 9780123741950","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eModern Biopolymer Science\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eBridging the Divide between Fundamental Treatise and Industrial Application\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cem\u003eA guide to direct application of biopolymer science to real-world product situations\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eStefan Kasapis (Edited by), Ian T. Norton (Edited by), Johan B Ubbink (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123741950, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 11 September 2009\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e640 pages\u003cbr\u003e23.4 x 19 x 3.5 cm, 1.45 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eIndustrialists developing new food and pharmaceutical products face the challenge of innovation in an increasingly competitive market that must consider incredient cost, product added-value, expectations of a healthy life-style, improved sensory impact, controlled delivery of active compounds and last, but not lease, product stability.  While much work has been done to explore, understand, and address these issues, a gap has emerged between recent advances in fundamental knowledge and its direct application to product situations with a growing need for scientific input.\u003cbr\u003e\u003cbr\u003eModern Biopolymer Science matches science to application by first acknowledging the differing viewpoints between those working with low-solids and those working with high-solids, and then sharing the expertise of those two camps under a unified framework of materials science.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eLow- and High-Solid Biopolymer\/co-Solute Mixtures\u003cbr\u003e Mapping the Different States of Food as a Function of Solids Content and Temperature Using a State Diagram\u003cbr\u003e Microstructural Advances in the Understanding of Carbohydrate Glasses\u003cbr\u003e Molecular Mobility of Bioactive Compounds in Biopolymer Matrices\u003cbr\u003e Hydroccoloids and Medical Chemistry Applications\u003cbr\u003e Fundamentals and Application of Protein Gelation\u003cbr\u003e Biopolymer Composite Theory in Relation to Novel Product Development\u003cbr\u003e Effect of Processing on Biopolymer Interactions\u003cbr\u003e Molecular Theory of Polysaccharide Gels and Applications\u003cbr\u003e Unifying Theory of Molecular Dynamics for Synthetic and Bio-macromolecules across the Viscoelastic Spectrum\u003cbr\u003e Self Assembling Structures\u003cbr\u003e Coacervates as Food Ingredients or Microencapsulation Delivery Systems\u003cbr\u003e Biopolymer Films and Composite Coatings\u003cbr\u003e Applications of Single-Molecule Techniques\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Food \u0026amp; beverage technology [\u003ca title=\"See our other books on Food \u0026amp; beverage technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Food%20\u0026amp;%20beverage%20technology%20%5BTDCT%5D%22\"\u003eTDCT\u003c\/a\u003e], Plastics \u0026amp; polymers technology [\u003ca title=\"See our other books on Plastics \u0026amp; polymers technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Plastics%20\u0026amp;%20polymers%20technology%20%5BTDCP%5D%22\"\u003eTDCP\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649284690200,"sku":"9780123741950","price":86.87,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123741950_928273dd-644b-4452-82d2-09b69fcbba51.jpg?v=1695013862"},{"product_id":"annual-reports-in-medicinal-chemistry-paperback-9780123743442","title":"Annual Reports in Medicinal Chemistry (Paperback \/ softback) 9780123743442","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAnnual Reports in Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eJohn E. Macor (Series edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123743442, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 17 December 2008\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e584 pages\u003cbr\u003e24 x 16.5 x 3.6 cm, 1.04 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eAnnual Reports in Medicinal Chemistry\u003c\/i\u003e provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePart I.   Central Nervous System Diseases ¨C ROBICHAUD\u003cbr\u003e\u003cbr\u003eChapter 1\tRecent Advances in Corticotropin Releasing Factor Receptor Antagonists\u003cbr\u003eCarolyn D. Dzierba; Richard A. Hartz; Joanne J. Bronson\u003cbr\u003e\u003cbr\u003eChapter 2\tRecent Advances on the 5-HT5A, 5-HT6 and 5-HT7 Receptors\u003cbr\u003eBrock T. Shireman, Pascal Bonaventure and Nicholas I. Carruthers\u003cbr\u003e\u003cbr\u003eChapter 3\tRecent Advances in Voltage Gated Sodium Channel Blockers: Therapeutic Potential as Drug Targets in the CNS\u003cbr\u003eAndreas Termin, Esther Martinborough and Dean Wilson\u003cbr\u003e\u003cbr\u003eChapter 4\tMedication Development for the Treatment of Substance Abuse\u003cbr\u003eBrian Fulton \u003cbr\u003e\u003cbr\u003e\u003cbr\u003ePart II.   Cardiovascular and Metabolic Diseases - STAMFORD\u003cbr\u003e\u003cbr\u003eChapter 5\tGPR40 (FFAR1) Modulators\u003cbr\u003eJulio C. Medina and Jonathan B. Houze\u003cbr\u003e\u003cbr\u003eChapter 6\tRho-Kinase Inhibitors for Cardiovascular Disease\u003cbr\u003eRobert A. Stavenger\u003cbr\u003e\u003cbr\u003eChapter 7\tLXR Agonists for the Treatment of Atherosclerosis - Recent Highlights\u003cbr\u003eJonathan Bennett, Andrew Cooke, Heather J. McKinnon and Olaf Nimz\u003cbr\u003e\u003cbr\u003eChapter 8\tGlucagon Receptor Antagonists for Type II Diabetes  \u003cbr\u003eDuaneE.  DeMong,  Michael W. Miller and Jean Lachowicz\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003ePart III.   Inflammation \/ Pulmonary \/ GI ¨C BARRISH\u003cbr\u003e\u003cbr\u003eChapter 9\tAdvances Towards Dissociated Non-Steroidal Glucocorticoid Receptor Agonists\u003cbr\u003eJohn Regan, Hossein Razavi, David Thomson\u003cbr\u003e\u003cbr\u003eChapter 10\tAdvances in the Discovery of IkB Kinase Inhibitors\u003cbr\u003eWilliam J. Pitts and James Kempson\u003cbr\u003e\u003cbr\u003eChapter 11\tProtease Inhibitors for the Potential Treatment of Chronic Obstructive Pulmonary Disease and Asthma  \u003cbr\u003eWeimin Liu and Eugene Hickey\u003cbr\u003e\u003cbr\u003e\u003cbr\u003e\u003cbr\u003ePart IV.   Oncology - MYLES\u003cbr\u003e\u003cbr\u003eChapter 12\tmTor Inhibitors in Oncology\u003cbr\u003eJeroen Verheijen, Ker Yu and Arie Zask\u003cbr\u003e\u003cbr\u003eChapter 13\tOncology Drug Targets in the Sphingomyelin Signaling Path\u003cbr\u003eBill Garland, Amy Cavalli and Genevi¨¨ve Hansen\u003cbr\u003e\u003cbr\u003e\u003cbr\u003ePart V.   Infectious Diseases - Primeau\u003cbr\u003e\u003cbr\u003eChapter 14\tInhibitors of Respiratory Syncytial Virus  \u003cbr\u003eMalcolm Carter and G. Stuart Cockerill \u003cbr\u003e\u003cbr\u003eChapter 15\tRecent Developments in ¦Â-Lactamases and Inhibitors\u003cbr\u003eTarek S. Mansour, Patricia A. Bradford and Aranapakam M. Venkatesan\u003cbr\u003e\u003cbr\u003eChapter 16\tRecent Development in the Treatment of Clostridium Difficile Associated Disease (CDAD)\u003cbr\u003eXicheng Sun, Joseph Guiles and Nebojsa Janjic\u003cbr\u003e\u003cbr\u003eChapter 17\tRecent Advances in the Discovery of Hybrid Antibacterial Agents\u003cbr\u003eMike Barbachyn\u003cbr\u003e\u003cbr\u003e\u003cbr\u003ePart VI.   Topics in Biology - LOWE\u003cbr\u003e\u003cbr\u003eChapter 18\tRecent Renaissance of Prostaglandin Research\u003cbr\u003eRobert Burk\u003cbr\u003e\u003cbr\u003eChapter 19\tHuman Exposure and Dose Projections\u003cbr\u003ePunit H. Marathe, Christine Huang and A. David Rodrigues\u003cbr\u003e\u003cbr\u003eChapter 20\tModeling Networks of Glycolysis, Overall Energy Metabolism and Drug Metabolism under a Systems Biology Approach\u003cbr\u003eZoltan Sarnyai and Laszlo G. Boros\u003cbr\u003e\u003cbr\u003e \u003cbr\u003ePart VII.   Topics in Drug Design and Discovery ¨C DESAI\u003cbr\u003e\u003cbr\u003eChapter 21\tContrasting the Gastrointestinal Tracts of Mammals: Factors that Influence Absorption\u003cbr\u003eJohn DeSesso and Amy Lavin Williams\u003cbr\u003e\u003cbr\u003eChapter 22\tThe Emerging Utility of Co-Crystals in Drug Discovery and Development\u003cbr\u003eNicholas Meanwell\u003cbr\u003e\u003cbr\u003eChapter 23\tPregnane X Receptor: Prediction and Attenuation of Human CYP3A4 Enzyme Induction and Drug-Drug Interactions  \u003cbr\u003eMichael W. Sinz\u003cbr\u003e\u003cbr\u003eChapter 24\tFormulation in Drug Discovery  \u003cbr\u003eRobert Strictly\u003cbr\u003e\u003cbr\u003e\u003cbr\u003ePart VIII.   To Market, To Market\u003cbr\u003e\u003cbr\u003eChapter 25\tTo Market, To Market - 2007\u003cbr\u003eShridhar Hegde and Michelle Schmidt\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649290981656,"sku":"9780123743442","price":83.89,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123743442_8e7d7c49-b7dc-413a-b8af-347ebd74433c.jpg?v=1695013897"},{"product_id":"annual-reports-in-medicinal-chemistry-paperback-9780123747662","title":"Annual Reports in Medicinal Chemistry (Paperback \/ softback) 9780123747662","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAnnual Reports in Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eJohn E. Macor (Series edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123747662, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback \/ softback, published 21 December 2009\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e736 pages\u003cbr\u003e22.9 x 15.1 x 4.5 cm, 1.2 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eAnnual Reports in Medicinal Chemistry \u003c\/i\u003eprovides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e1 Recent advances in the discovery of GSK-3 inhibitors and a\u003c\/p\u003e \u003cp\u003eperspective on their utility for the treatment of Alzheimer’s\u003c\/p\u003e \u003cp\u003edisease\u003c\/p\u003e \u003cp\u003eRobert G. Gentles, Shuanghua Hu,\u003c\/p\u003e \u003cp\u003eand. Gene Dubowchik\u003c\/p\u003e \u003cp\u003e2 Advances in the Development of Nitric Oxide Synthase Inhibitors\u003c\/p\u003e \u003cp\u003eShawn Maddaford, Subhash\u003c\/p\u003e \u003cp\u003eAnnendi, Jailall Remnauth, and\u003c\/p\u003e \u003cp\u003eSuman Rakhit\u003c\/p\u003e \u003cp\u003e3 Small Molecule Protein–Protein Interaction Inhibitors as\u003c\/p\u003e \u003cp\u003eTherapeutic Agents for Neurodegenerative Diseases: Current\u003c\/p\u003e \u003cp\u003eProgress and Future Hurdles\u003c\/p\u003e \u003cp\u003eSimon Haydar and Warren Hirst \u003c\/p\u003e \u003cp\u003e4 Case History: Chantix (varenicline tartrate) a Nicotinic Partial\u003c\/p\u003e \u003cp\u003eAgonist Aid to Smoking Cessation\u003c\/p\u003e \u003cp\u003eJotham W. Coe, Hans Rollema and\u003c\/p\u003e \u003cp\u003eBrian T. O’Neill \u003c\/p\u003e \u003cp\u003e5 Case History on Tekturna® \/Rasilez® (Aliskiren), a Highly\u003c\/p\u003e \u003cp\u003eEfficacious Direct Oral Renin Inhibitor as a New Therapy for\u003c\/p\u003e \u003cp\u003eHypertension\u003c\/p\u003e \u003cp\u003eJuergen Maibaum and David Feldman\u003c\/p\u003e \u003cp\u003e6 Advances in Vasopressin Receptor Agonists and Antagonists Thomas Ryckmans \u003c\/p\u003e \u003cp\u003e7 The Emergence of GPR119 Agonists as Anti-diabetic Agents Robert Jones \u003c\/p\u003e \u003cp\u003e8 Non-peptide Ligands for the Gonadotropin Receptors Nicole van Straten, Marco Timmers\u003c\/p\u003e \u003cp\u003e9 Recent Advances in Coagulation Serine Protease Inhibitors\u003c\/p\u003e \u003cp\u003eMimi Quan and Joanne Smallheer\u003c\/p\u003e \u003cp\u003e10 Advances in the Discovery of Anti-Inflammatory FMS Inhibitors Mark Player and Carl Manthey\u003c\/p\u003e \u003cp\u003e11 Recent Advances in the Discovery of CB2 Selective Agonists Jayant Thatte, Sangdon Han, and Rob Jones \u003c\/p\u003e \u003cp\u003e12 Advances in the Discovery of Small Molecule JAK3 Inhibitors Stephen Wrobleski \u003c\/p\u003e \u003cp\u003e13 Recent Advances in Adenosine Receptor (AR) Ligands in\u003c\/p\u003e \u003cp\u003ePulmonary Diseases\u003c\/p\u003e \u003cp\u003eJeff Zablocki and Rao Kalla \u003c\/p\u003e \u003cp\u003e14 Recent Progress in the Development of Small Molecule Inhibitors\u003c\/p\u003e \u003cp\u003eof Insulin-like Growth Factor Receptor (IGF-1R) Kinase Dinesh Vyas and Mark Wittman \u003c\/p\u003e \u003cp\u003e15 Case History: Discovery of Ixabepilone (IXEMPRA[TM]), a First-inclass\u003c\/p\u003e \u003cp\u003eEpothilone Analogue for Treatment of Metastatic Breast Cancer\u003c\/p\u003e \u003cp\u003eRobert M. Borzilleri and Gregory D.\u003c\/p\u003e \u003cp\u003e16 Hedgehog Signaling Pathway Inhibitors as Cancer Therapeutics Stefan Peuker and Karen Miller-Moslin \u003c\/p\u003e \u003cp\u003e17 Emerging Therapies Based on Inhibitors of Phosphatidyl-Inositol-\u003c\/p\u003e \u003cp\u003e3-Kinases (PI3Ks)\u003c\/p\u003e \u003cp\u003eJohn M. Nuss, Amy Lew Tsuhako\u003c\/p\u003e \u003cp\u003eand Neel K. Anand Exelixis\u003c\/p\u003e \u003cp\u003e18 Anti-infective Activity of Artemisinin and its Semi-synthetic\u003c\/p\u003e \u003cp\u003eDerivatives John G. D'Angelo\u003c\/p\u003e \u003cp\u003e19 Recent Advances in the Inhibition of Bacterial Type II\u003c\/p\u003e \u003cp\u003eTopoisomerases\u003c\/p\u003e \u003cp\u003eGreg Bisacchi \u0026amp; Jacques Dumas\u003c\/p\u003e \u003cp\u003e20 Progress Towards the Discovery and Development of Specifically\u003c\/p\u003e \u003cp\u003eTargeted Inhibitors of Hepatitis C Virus\u003c\/p\u003e \u003cp\u003eNicholas A. Meanwell John F.\u003c\/p\u003e \u003cp\u003eKadow and Paul M. Scol \u003c\/p\u003e \u003cp\u003e21 Inhibitors of Nuclear Hormone Receptor\/Steroid Receptor\u003c\/p\u003e \u003cp\u003eCoactivator Interactions\u003c\/p\u003e \u003cp\u003eTerry Moore, John Katzenellenbogen \u003c\/p\u003e \u003cp\u003e22 Safety Testing of Drug Metabolites Tom Thompson \u003c\/p\u003e \u003cp\u003e23 A Path to Innovation: Gene Knockouts Model New Drug Action Brian Zambrowicz \u003c\/p\u003e \u003cp\u003e24 Discovery of Novel Positron Emission Tomography (PET) Tracers Dennis McCarthy \u003c\/p\u003e \u003cp\u003e25 The Use of Isotopically Labeled Compounds in Drug Discovery (Chad) Charles S. Elmore\u003c\/p\u003e \u003cp\u003e26 Mechanism based inhibition of CYP3A4 and other cytochromes P450 Bernard Murray \u003c\/p\u003e \u003cp\u003e27 Nonclinical Toxicogenomics in the Pharmaceutical Environment Bruce D. Car \u003c\/p\u003e \u003cp\u003e28 To Market, To Market 2008 Shridhar Hegde and Michelle Schmidt\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Yearbooks, annuals, almanacs [\u003ca title=\"See our other books on Yearbooks, annuals, almanacs\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Yearbooks,%20annuals,%20almanacs%20%5BGBCY%5D%22\"\u003eGBCY\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649298321688,"sku":"9780123747662","price":111.39,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123747662_c4822934-21d1-4e2b-91d2-a1f366a5eb39.jpg?v=1695013942"},{"product_id":"annual-reports-in-medicinal-chemistry-paperback-9780123964922","title":"Annual Reports in Medicinal Chemistry (Paperback) 9780123964922","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eAnnual Reports in Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eTimely and critical reviews of important topics in medicinal chemistry\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eJohn E. Macor (Series edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123964922\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePaperback, published 16 November 2012\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e472 pages\u003cbr\u003e22.9 x 15.1 x 3 cm, 0.89 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eThis series is one of the very few annual publications which justify the title of an absolute must for the pharmacologist, chemist, or physician who is interested in the chemistry of drug development.\" \u003cb\u003e--Enzymologia\u003c\/b\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eAnnual Reports in Medicinal Chemistry \u003c\/i\u003eprovides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePersonal Essay\u003c\/p\u003e \u003col\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eReflections on Medicinal Chemistry at Merck, West Point\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003ePaul S. Anderson\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eMy Path in Seeking New Medicines\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003ePeter R. Bernstein\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eTales of Drug Discovery \u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eM. Ross Johnson\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003eI. Central Nervous System Diseases\u003c\/p\u003e \u003cp\u003eSection Editor: Albert J. Robichaud; Sage Therapeutics, Inc. Cambridge, Massachusetts\u003c\/p\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003e\u003cb\u003eRecent Developments in Targeting Neuroinflammation in Disease\u003c\/b\u003e\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eAllen T. Hopper, Brian M. Campbell, Henry Kao, Sean A. Pintchovski and Roland G. W. Staal\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eSecretase Inhibitors and Modulators as a Disease Modifying Approach Against Alzheimer’s Disease\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eHarrie J. M. Gijsen and François P. Bischoff\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003emGluR2 Activators and mGluR5 Blockers Advancing in the Clinic for Major CNS Disorders\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eSylvain Célanire, Guillaume Duvey, Sonia Poli and Jean-Philippe Rocher\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eNMDA Antagonists of GluN2B Subtype and Modulators of GluN2A, GluN2C and GluN2D Subtypes – Recent Results and Developments \u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eKamalesh B. Ruppa, Dalton King and Richard Olson\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eRecent Advances in the Development of PET and SPECT Tracers for Brain Imaging\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eLei Zhang and Anabella Villalobos\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003eII. Cardiovascular and Metabolic Diseases\u003c\/p\u003e \u003cp\u003eSection Editor: Andy Stamford, Merck Research Laboratories, Kenilworth, New Jersey\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eCase History: Eliquis\u003csup\u003eTM\u003c\/sup\u003e (Apixaban), a Potent and Selective Inhibitor of Coagulation Factor Xa for the Prevention and Treatment of Thrombotic Diseases\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eDonald J. P. Pinto, Pancras C. Wong, Robert M. Knabb and Ruth R. R. Wexler \u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eAMPK Activation in Health and Disease\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eIyassu K. Sebhat and Robert W. Myers\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eType-2 Diabetes and Associated Co-Morbidities as an Inflammatory Syndrome\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eJuan C. Jaen, Jay P. Powers and Tim Sullivan\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eBeyond PPARs \u0026amp; Metformin: New Insulin Sensitizers for the Treatment of Type 2 Diabetes\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003ePhilip A. Carpino and David Hepworth\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003eIII. Inflammatory Pulmonary and Gastrointestinal Diseases\u003c\/p\u003e \u003cp\u003eSection Editor: David S. Weinstein, Bristol-Myers Squibb R\u0026amp;D, Princeton, New Jersey\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eRecent Advances in the Discovery and Development of Sphingosine-1-Phosphate-1 Receptor Agonists\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eAlaric J. Dyckman\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eBifunctional Compounds for the Treatment of COPD \u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eGary Phillips and Michael Salmon\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eInflammatory Targets for the Treatment of Atherosclerosis \u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eRobert O. Hughes, Alessandra Bartolozzi and Hidenori Takahashi\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003eIV. Oncology\u003c\/p\u003e \u003cp\u003eSection Editor: Shelli R. McAlpine, School of Chemistry, University of New South Wales, Sydney, Australia\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eNanotechnology Therapeutics in Oncology – Recent Developments and Future Outlook\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003ePaul F. Richardson\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eSmall-Molecule Antagonists of Bcl-2 Family Proteins\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eSean P. Brown and Joshua P. Taygerly\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eNotch Pathway Modulators as Anti-Cancer Chemotherapeutics\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eVibhavari Sail and M. Kyle Hadden\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eAnaplastic Lymphoma Kinase (ALK) Inhibitors for the Treatment of ALK-Positive Cancers \u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eKazutomo Kinoshita, Nobuhiro Oikawa and Takuo Tsukuda\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003eV. Infectious Diseases\u003c\/p\u003e \u003cp\u003eSection Editor: John Primeau, Westford, Massachusetts\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eRecent Advances in the Discovery of Dengue Virus Inhibitors\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eJeremy Green, Upul Bandarage, Kate Luisi and Rene Rijnbrand\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eNon Fluoro-Quinolone Based Inhibitors of Mycobacterial Type II Topoisomerase as Potential Therapeutic Agents for TB\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003ePravin S. Shirude and Shahul Hameed\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eHCV Inhibition Mediated through the Nonstructural Protein 5A (NS5A) Replication Complex \u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eRobert Hamatake, Andrew Maynard and Wieslaw M. Kazmierski\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003eVI. Topics in Biology\u003c\/p\u003e \u003cp\u003eSection Editor: John Lowe, JL3Pharma LLC, Stonington, Connecticut\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eAntibody-Drug Conjugates for Targeted Cancer Therapy\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eVictor S. Goldmacher, Thomas Chittenden, Ravi V. J. Chari, Yelena V. Kovtun and John M. Lambert\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003e3D Cell Cultures: Mimicking in Vivo Tissues for Improved Predictability in Drug Discovery\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eIndira Padmalayam and Mark J. Suto\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eVirally Encoded G Protein-Coupled Receptors: Overlooked Therapeutic Opportunities?\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eNuska Tschammer\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eRecent Advances in Wnt\/b-Catenin Pathway Small Molecule Inhibitors\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eDaniel D. Holsworth and Stefan Krauss\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003eVII. Topics in Drug Design and Discovery\u003c\/p\u003e \u003cp\u003eSection Editor: Peter R. Bernstein, PhaRmaB LLC, Rose Valley, Pennsylvania\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eTargeted Covalent Enzyme Inhibitors\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eMark C. Noe and Adam M. Gilbert\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eDrug Design Strategies for GPCR Allosteric Modulators\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eP. Jeffrey Conn, Scott D. Kuduk and Darío Doller\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eProgress in the Development of Non-ATP Competitive Protein Kinase Inhibitors for Oncology\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eCampbell M\u003csup\u003ec\u003c\/sup\u003eInnes\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003eVIII. Trends\u003c\/p\u003e \u003cp\u003eSection Editor: Joanne Bronson, Bristol-Myers Squibb, Wallingford, Connecticut\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eNew Chemical Entities Entering Phase III Trials in 2011\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eGregory T. Notte\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eTo Market, To Market – 2011\u003ci\u003eJoanne Bronson, Murali Dhar, William Ewing and Nils Lonberg\u003c\/i\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Yearbooks, annuals, almanacs [\u003ca title=\"See our other books on Yearbooks, annuals, almanacs\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Yearbooks,%20annuals,%20almanacs%20%5BGBCY%5D%22\"\u003eGBCY\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46649332990232,"sku":"9780123964922","price":105.69,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123964922.jpg?v=1694099786"},{"product_id":"synthetic-vaccines-hardback-9780123965486","title":"Synthetic Vaccines (Hardback) 9780123965486","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eSynthetic Vaccines\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eThis series continually publishes cutting-edge reviews in the field of immunology\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eCornelius Melief (Volume editor)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780123965486\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 22 May 2012\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e280 pages\u003cbr\u003e22.9 x 15.1 x 2.2 cm, 0.68 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\"The series which all immunologists need.\" \u003cb\u003e--The Pharmaceutical Journal\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions.\" \u003cb\u003e--Science\u003c\/b\u003e\u003c\/p\u003e \u003cp\u003e\"Deserves a permanent place in biomedical libraries as an aid in research and in teaching.\" \u003cb\u003e--Journal of Immunological Methods\u003c\/b\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eApprox.266 pages\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003col\u003e \u003cli\u003eNucleic acid adjuvants: towards an educated vaccine Jasper G. van den Boorn, Winfried Barchet and Gunther Hartmann\u003c\/li\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eStructure-based design for high-hanging vaccine fruits Johannes P.M. Langedijk and Jaap W. Back\u003c\/li\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eMechanisms of peptide vaccination in mouse models: tolerance, immunity and hyper-reactivity Thorbald van Hall and Sjoerd H van der Burg\u003c\/li\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eExperience with synthetic vaccines for cancer and persistent virus infections in non-human primates and patients Esther D. Quakkelaar and Cornelis J.M. Melief\u003c\/li\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eMalaria vaccine development using synthetic peptides as a technical platform Giampietro Corradin, Nora Céspedes, Antonio Verdini, Andrey V. Kajava, Myriam Arévalo and Sócrates Herrera\u003c\/li\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eEnhancing cancer immunotherapy by intracellular delivery of cell penetrating peptides and stimulation of pattern-recognition receptor signaling Helen Y. Wang and Rong-Fu Wang\u003c\/li\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eTLR ligand-peptide conjugate vaccines: towards clinical application Gijs GP Zom, Selina Khan, Dmitri V Filippov, Ferry Ossendorp\u003c\/li\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eBehaviour and function of Tissue-resident Memory T cells Silvia Ariotti, John B. Haanen and Ton N. Schumacher\u003c\/li\u003e \u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eRational Design of Vaccines: Learning from Immune Evasion Mechanisms of Persistent Viruses and Tumors Ramon Arens\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Cellular biology [\u003ca title=\"See our other books on Cellular biology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Cellular%20biology%20%5Bcytology%5D%20%5BPSF%5D%22\"\u003ecytology PSF\u003c\/a\u003e], Biochemical immunology [\u003ca title=\"See our other books on Biochemical immunology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemical%20immunology%20%5BPSBM%5D%22\"\u003ePSBM\u003c\/a\u003e], Immunology [\u003ca title=\"See our other books on Immunology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Immunology%20%5BMJCM%5D%22\"\u003eMJCM\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46649334366488,"sku":"9780123965486","price":117.38,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780123965486.jpg?v=1694099796"},{"product_id":"profiles-of-drug-substances-excipients-and-related-methodology-hardback-9780124076914","title":"Profiles of Drug Substances, Excipients, and Related Methodology (Hardback) 9780124076914","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProfiles of Drug Substances, Excipients, and Related Methodology\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cp\u003eThis widely revered series presents comprehensive reviews of drug substances, excipients and additional materials, written by experts in the field\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eHarry G. Brittain (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780124076914, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 2 August 2013\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e528 pages\u003cbr\u003e22.9 x 15.1 x 3.1 cm, 0.81 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eVolumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceutical community and allows for the development of a timely vehicle for publishing review materials on this topic. The scope of the Profiles series encompasses review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003col\u003e\n\u003cb\u003e \u003cli\u003eAlendronate Sodium\u003c\/li\u003e\u003c\/b\u003e\u003ci\u003e \u003c\/i\u003e\u003cp\u003eGennady Ananchenko, Jasmina Novakovic, and Anna Tikhomirova\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eAripiprazole\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eFebry Ardiana, Maria L.A.D. Lestari, and Gunawan Indrayanto\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eButyl Methoxy Dibenzoylmethane\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eJutta Kockler, Sherryl Robertson, Michael Oelgemöller, Murray Davies, Bruce Bowden, Harry G. Brittain, and Beverley D. Glass\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eCarvedilol\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eKevin Beattie, Geeta Phadke, and Jasmina Novakovic\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eMelatonin\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eFatmah A.M. Al-Omary\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eMenadione\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eGhada S. Hassan\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eAnalytical Profile of Moxidectin\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eAtul Awasthi, Majid Razzak, Raida Al-Kassas, Joanne Harvey, and Sanjay Garg\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eParoxetine Hydrochloride\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eDavid Germann, George Ma, Feixue Han, and Anna Tikhomirova\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eParoxetine Hydrochloride: Polymorphs and Solvatomorphs\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eHarry G. Brittain\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eSucralose\u003c\/li\u003e \u003ci\u003e \u003c\/i\u003e\u003cp\u003eOmar A.A. AlDeeb, Hoda Mahgoub, and Nagwa H. Foda\u003c\/p\u003e\n\u003cb\u003e \u003c\/b\u003e\u003cp\u003e \u003c\/p\u003e\n\u003cli\u003eTramadol Hydrochloride  \u003ci\u003eRobert Smyj, Xiao-Ping Wang, and Feixue Han\u003c\/i\u003e\n\u003c\/li\u003e\n\u003c\/ol\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Analytical chemistry [\u003ca title=\"See our other books on Analytical chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Analytical%20chemistry%20%5BPNF%5D%22\"\u003ePNF\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649391939864,"sku":"9780124076914","price":130.89,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780124076914.jpg?v=1694100724"},{"product_id":"organic-synthesis-using-biocatalysis-hardback-9780124115187","title":"Organic Synthesis Using Biocatalysis (Hardback) 9780124115187","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eOrganic Synthesis Using Biocatalysis\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cp\u003eA concise background of the application of biocatalysis for the synthesis of organic compounds, including biocatalysis in organic synthesis, biocatalysis for selective organic transformation, and enzymes as catalysis for organic synthesis\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eAnimesh Goswami (Edited by), Jon D. Stewart (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780124115187\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 3 September 2015\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e438 pages\u003cbr\u003e23.4 x 19 x 2.8 cm, 1.06 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eOrganic Synthesis Using Biocatalysis\u003c\/i\u003e provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas.\u003c\/p\u003e  \u003cp\u003eThe book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules. \u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eCHAPTER 1 Introduction, Types of Reactions, and\u003c\/p\u003e \u003cp\u003eSources of Biocatalysts \u003c\/p\u003e \u003cp\u003eAnimesh Goswami, Jon D. Stewart\u003c\/p\u003e \u003cp\u003eCHAPTER 2 Practical and Engineering Aspects of Running Enzyme\u003c\/p\u003e \u003cp\u003eReactions\u003c\/p\u003e \u003cp\u003eHarald Gröger\u003c\/p\u003e \u003cp\u003eCHAPTER 3 Biocatalysis in Organic Solvents, Supercritical\u003c\/p\u003e \u003cp\u003eFluids and Ionic Liquids \u003c\/p\u003e \u003cp\u003eChen Cao, Tomoko Matsuda\u003c\/p\u003e \u003cp\u003eCHAPTER 4 Enzyme Immobilization for Organic Synthesis \u003c\/p\u003e \u003cp\u003eMelissa L.E. Gutarra, Leandro S.M. Miranda,\u003c\/p\u003e \u003cp\u003eRodrigo O.M.A. de Souza\u003c\/p\u003e \u003cp\u003eCHAPTER 5 Hydrolysis and Formation of Carboxylic Acid\u003c\/p\u003e \u003cp\u003eand Alcohol Derivatives \u003c\/p\u003e \u003cp\u003eRomas Kazlauskas\u003c\/p\u003e \u003cp\u003eCHAPTER 6 Modern Biocatalytic Ketone Reduction \u003c\/p\u003e \u003cp\u003eThomas S. Moody, J. David Rozzell\u003c\/p\u003e \u003cp\u003eCHAPTER 7 Organic Synthesis with Amino Acid Dehydrogenases,\u003c\/p\u003e \u003cp\u003eTransaminases, Amine Oxidases, and Amine\u003c\/p\u003e \u003cp\u003eDehydrogenases \u003c\/p\u003e \u003cp\u003eSamantha K. Au, Jonathan Groover, Brent D. Feske,\u003c\/p\u003e \u003cp\u003eAndreas S. Bommarius\u003c\/p\u003e \u003cp\u003eCHAPTER 8 Biocatalysis for Organic Chemists: Hydroxylations \u003c\/p\u003e \u003cp\u003eLaila Roper, Gideon Grogan\u003c\/p\u003e \u003cp\u003eCHAPTER 9 Miscellaneous Key Non-C_C Bond Forming Enzyme\u003c\/p\u003e \u003cp\u003eReactions.......................................................................243\u003c\/p\u003e \u003cp\u003eFlorian Rudroff, Michael J. Fink, Marko D. Mihovilovic\u003c\/p\u003e \u003cp\u003eCHAPTER 10 Enzymatic C_C Bond Formation .....................................285\u003c\/p\u003e \u003cp\u003ePere Clapés\u003c\/p\u003e \u003cp\u003eCHAPTER 11 Applications of Biocatalysis for Pharmaceuticals\u003c\/p\u003e \u003cp\u003eand Chemicals ................................................................339\u003c\/p\u003e \u003cp\u003eRamesh N. Patel\u003c\/p\u003e \u003cp\u003eCHAPTER 12 Future of Biocatalysis in the Synthesis of Organic\u003c\/p\u003e \u003cp\u003eCompounds ....................................................................413\u003c\/p\u003e \u003cp\u003eAnimesh Goswami, Jon D. Stewart\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46649404522776,"sku":"9780124115187","price":88.19,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780124115187_274a7124-939f-4796-9a93-032027dbb900.jpg?v=1694352984"},{"product_id":"protein-engineering-for-therapeutics-part-a-hardback-9780124160392","title":"Protein Engineering for Therapeutics, Part A (Hardback) 9780124160392","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProtein Engineering for Therapeutics, Part A\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cp\u003eWith an international board of authors, this volume is split into sections that cover subjects such as Antibodies, Protein conjugates, Peptides, Enzymes and Scaffolds\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eK. Dane Wittrup (Volume editor), Gregory L. Verdine (Volume editor)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780124160392, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 23 February 2012\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e392 pages\u003cbr\u003e22.9 x 15.1 x 2.6 cm, 0.75 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eThis volume of Methods in Enzymology looks at Protein Engineering for Therapeutics. The chapters provide an invaluable resource for academics, researchers and students alike. With an international board of authors, this volume is split into sections that cover subjects such as Antibodies, Protein conjugates, Peptides, Enzymes and Scaffolds\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003col\u003e \u003cli\u003e\u003cb\u003eSimplified Synthetic Antibody Libraries\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e \u003c\/p\u003e\n\u003cli\u003e\u003cb\u003eGeneration of Dual Variable Domain Immunoglobulin Molecules for Dual-specific Targeting\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eDiscovery of internalizing antibodies to tumor antigens from phage libraries\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\n\u003cb\u003eOptimizing properties of anti-receptor antib\u003c\/b\u003e\u003cb\u003eodies using kinetic computational models and experiments\u003c\/b\u003e\n\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eCell-specific siRNA delivery by peptides and antibodies\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eConjugation of Anticancer Drugs Through Endogenous Monoclonal Antibody Cysteine Residues\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eBuilding and characterizing antibody-targeted lipidic nanotherapeutics\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eCell-Targeting Fusion Constructs Containing Recombinant Gelonin\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eStapled Peptides for Intracellular Drug Targets\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eMapping of vascular zip codes by phage display\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eEngineering cyclic peptide toxins\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003ePeptide Discovery using Bacterial Display and Flow Cytometry\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eOral enzyme therapy for celiac sprue\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eRational Design and Evaluation of Mammalian Ribonuclease Cytotoxins\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eEngineering Reduced-Immunogenicity Enzymes for Amino Acid Depletion Therapy in Cancer\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eDesigned Ankyrin Repeat Proteins (DARPins): From research to therapy\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eTarget-binding proteins based on the tenth human fibronectin type III domain (\u003csup\u003e10\u003c\/sup\u003eFn3)\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eAnticalins: small engineered binding proteins based on the lipocalin scaffold\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eT Cell Receptor Engineering\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eEngineering Knottins as Novel Binding Agents\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eRe-Engineering Biopharmaceuticals for Targeted Delivery Across the Blood-Brain Barrier\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003ePractical Theoretic Guidance for the Design of Tumor Targeting Agents\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eFusions of elastin-like polypeptides to pharmaceutical proteins\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e \u003cli\u003e\u003cb\u003eEngineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells\u003c\/b\u003e\u003c\/li\u003e \u003cp\u003e\u003cb\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003c\/ol\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Enzymology [\u003ca title=\"See our other books on Enzymology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Enzymology%20%5BPSBZ%5D%22\"\u003ePSBZ\u003c\/a\u003e], Biochemistry [\u003ca title=\"See our other books on Biochemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemistry%20%5BPSB%5D%22\"\u003ePSB\u003c\/a\u003e], Biomedical engineering [\u003ca title=\"See our other books on Biomedical engineering\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biomedical%20engineering%20%5BMQW%5D%22\"\u003eMQW\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Academic Press","offers":[{"title":"Default Title","offer_id":46649409011992,"sku":"9780124160392","price":121.96,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780124160392.jpg?v=1694100810"},{"product_id":"progress-in-medicinal-chemistry-hardback-9780444511430","title":"Progress in Medicinal Chemistry (Hardback) 9780444511430","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProgress in Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eF.D. King (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444511430, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 15 April 2004\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e0 pages\u003cbr\u003e22.9 x 15.1 x 1.3 cm, 0.69 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eThis volume includes information on recent advances in five important areas: an account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis; and a survey of semi-synthetic and totally synthetic antibiotics and anti-HIV agents and their sites of interaction; the development of inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) for the treatment of hypercholesterolemia; a description of recent progress in growth hormone secretagogues, with the focus on strategies to improve oral bioavailability and duration of action; and information on inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), (required for vital replication) as one of the most attractive targets for HCV infections.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e], Medicine: general issues [\u003ca title=\"See our other books on Medicine: general issues\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Medicine:%20general%20issues%20%5BMB%5D%22\"\u003eMB\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Elsevier","offers":[{"title":"Default Title","offer_id":46651426734360,"sku":"9780444511430","price":84.85,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444511430.jpg?v=1694112381"},{"product_id":"progress-in-medicinal-chemistry-hardback-9780444515728","title":"Progress in Medicinal Chemistry (Hardback) 9780444515728","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProgress in Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eA highly valuable reference for medicinal chemists, biologists, doctors, and pharmacists.\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eF.D. King (Series edited by), G. Lawton (Series edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444515728, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 16 April 2005\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e302 pages\u003cbr\u003e27.9 x 21 x 2.3 cm, 0.51 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003ePraise for the Series:\u003cbr\u003e\"...may the Progress in Medicinal Chemistry series continue its invaluable service...\" \u003cb\u003e--Chemistry and Industry\u003cbr\u003e\u003c\/b\u003e\u003cbr\u003e\"... a valuable source of reference\" \u003cb\u003e--British Medical Journal\u003cbr\u003e\u003c\/b\u003e\u003cbr\u003e\"...These volumes should be on the shelves of all specialist libraries which claim to cater for chemists, biologists, doctors and pharmacists and should be available to everyone interested in the contemporary controversy about drugs, drug firms and the community.\" \u003cb\u003e--Pharmaceutical Journal\u003cbr\u003e\u003c\/b\u003e\u003cbr\u003e\"...the consistently high standards for this series have been maintained in the present volume. This volume should certainly take its place next to the previous volumes in this series in libraries devoted to medicinal chemistry and drug research...\" \u003cb\u003e--Journal of Medicinal Chemistry\u003c\/b\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThe \u003cb\u003eProgress in Medicinal Chemistry\u003c\/b\u003e series spans a wide range of topics of interest to the drug discovery community.  This particular volume touches upon the following:\u003cbr\u003e* The Herg ion channel \u003cbr\u003e* Fluorescence-based high throughput assay \u003cbr\u003e* Aprepitant and neurokinin receptors \u003cbr\u003e* Muscarinic receptor targets \u003cbr\u003e* Gene activation pathways \u003cbr\u003e* Malaria and antimalarial drugs \u003cbr\u003e* HIV virus mutation and new therapeutics\u003cbr\u003e\u003cbr\u003e\u003ca href=\"http:\/\/www.sciencedirect.com\/science\/bookseries\/00796468\"\u003eProgress in Medicinal Chemistry\u003c\/a\u003e is available online on \u003ca href=\"http:\/\/www.sciencedirect.com\"\u003eScienceDirect\u003c\/a\u003e — full-text online of volumes 41 onwards. \u003cbr\u003e\u003cbr\u003e\u003cbr\u003eElsevier book series on ScienceDirect gives multiple users throughout an institution simultaneous online access to an important compliment to primary research. Digital delivery ensures users reliable, 24-hour access to the latest peer-reviewed content. The Elsevier book series are compiled and written by the most highly regarded authors in their fields and are selected from across the globe using Elsevier’s extensive researcher network. \u003cbr\u003e\u003cbr\u003e\u003cbr\u003eFor more information about the Elsevier Book Series on ScienceDirect Program, please visit:\u003cbr\u003e\u003ca href=\"http:\/\/www.info.sciencedirect.com\/bookseries\/\"\u003ehttp:\/\/www.info.sciencedirect.com\/bookseries\/\u003c\/a\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface\u003cbr\u003e1. Human Ether-a-go-go Related Gene (Herg): A Chemist's Perspective \u003cbr\u003e2. Fluorescence Based Assays\u003cbr\u003e3. Selective and Combined Neurokinin Receptor Antagonists\u003cbr\u003e4. Muscarinic Receptor Subtype Pharmacology and Physiology\u003cbr\u003e5. The Transcription Factor NF-êB as Drug Target\u003cbr\u003e6. Recent Advances in the Search for New Antimarial Agents\u003cbr\u003e7. The Discovery of the CCR5 Receptor Antagonist UK-427857. A new agent for the Treatment of HIV infection and AIDS\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Pharmaceutical industries [\u003ca title=\"See our other books on Pharmaceutical industries\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20industries%20%5BKNDP%5D%22\"\u003eKNDP\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":46651429978392,"sku":"9780444515728","price":94.89,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444515728.jpg?v=1694979955"},{"product_id":"progress-in-medicinal-chemistry-hardback-9780444517371","title":"Progress in Medicinal Chemistry (Hardback) 9780444517371","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProgress in Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eA highly valuable reference for medicinal chemists, biologists, doctors, and pharmacists\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eF.D. King (Edited by), G. Lawton (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444517371, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 25 April 2006\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e404 pages\u003cbr\u003e27.9 x 21 x 2.7 cm, 0.63 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003ePraise for the Series: \u003cbr\u003e\"...may the Progress in Medicinal Chemistry series continue its invaluable service...\" \u003cb\u003e--Chemistry and Industry \u003cbr\u003e\u003c\/b\u003e\u003cbr\u003e\"... a valuable source of reference\" \u003cb\u003e--British Medical Journal \u003cbr\u003e\u003c\/b\u003e\u003cbr\u003e\"...These volumes should be on the shelves of all specialist libraries which claim to cater for chemists, biologists, doctors and pharmacists and should be available to everyone interested in the contemporary controversy about drugs, drug firms and the community.\" \u003cb\u003e--Pharmaceutical Journal \u003cbr\u003e\u003c\/b\u003e\u003cbr\u003e\"...the consistently high standards for this series have been maintained in the present volume. This volume should certainly take its place next to the previous volumes in this series in libraries devoted to medicinal chemistry and drug research...\" \u003cb\u003e--Journal of Medicinal Chemistry\u003c\/b\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThe perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical\/biotechnology industry as escalating R\u0026amp;D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease pathology and are ‘druggable’, is the best starting point for improved productivity.\u003cbr\u003e\u003cbr\u003eThe seven chapters of this volume describe recent progress towards drugs acting at a range of ‘druggable’ targets. One chapter addresses kinases, one covers an ion channel, two proteases are featured and three of the chapters cover G-protein coupled receptors, which has historically perhaps been the most fruitful area for medicinal chemists.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e1. Finding Protein Kinase Hits Using Structural Information\u003cbr\u003e2. Blunting the Swiss Army Knife\u003cbr\u003e3. Peptide Deformylase Inhibitors\u003cbr\u003e4. Clinically Useful Vanilloid Receptor TRPV1 Antagonists\u003cbr\u003e5. Recent Medicinal Chemistry of the Histamine H3 Receptor\u003cbr\u003e6. Recent Progress in Cannabinoid research\u003cbr\u003e7. Oxytocin Antagonists as Potential Therapeutic Agents\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Pharmaceutical industries [\u003ca title=\"See our other books on Pharmaceutical industries\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20industries%20%5BKNDP%5D%22\"\u003eKNDP\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":46651435450648,"sku":"9780444517371","price":103.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444517371.jpg?v=1694980007"},{"product_id":"progress-in-medicinal-chemistry-hardback-9780444528087","title":"Progress in Medicinal Chemistry (Hardback) 9780444528087","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProgress in Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eA highly valuable reference for medicinal chemists, biologists, doctors, and pharmacists\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eF.D. King (Edited by), G. Lawton (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444528087, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 19 February 2007\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e232 pages\u003cbr\u003e27.9 x 21 x 2.1 cm, 0.42 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eThe success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a ‘quality lead’, where these ‘quality leads’ come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry, relies upon defining those properties that historically have led to successful drug discovery. This volume addresses these questions and specifically discusses diabetes, obesity and tuberculosis.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface\u003cbr\u003eList of Contributors\u003cbr\u003eHit and Lead Identification: Efficient practices for drug discovery\u003cbr\u003eDPPIV Inhibition: Promising Therapy for the Treatment of Type 2 Diabetes\u003cbr\u003eRecent Progress Towards Nonpeptide Ligands for the Melanocortin-4 Receptor\u003cbr\u003eTuberculosis chemotherapy: recent developments and future perspectives\u003cbr\u003eSubject Index\u003cbr\u003eAuthor Index (Volumes 1-45)\u003cbr\u003eSubject Index (Volumes 1-45)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":46651488796952,"sku":"9780444528087","price":107.69,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444528087.jpg?v=1694113411"},{"product_id":"progress-in-medicinal-chemistry-hardback-9780444533586","title":"Progress in Medicinal Chemistry (Hardback) 9780444533586","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProgress in Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eThe latest in the series with a focus on biochemical targets and pharmacokinetics\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eG. Lawton (Series edited by), David R. Witty (Series edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444533586, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 1 December 2009\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e264 pages\u003cbr\u003e21 x 14.8 x 2.2 cm, 0.48 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003ci\u003eProgress in Medicinal Chemistry\u003c\/i\u003e provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":46651496235288,"sku":"9780444533586","price":129.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444533586_d4983ee2-a5f3-4188-8a4a-b2f33de7e0ff.jpg?v=1694987210"},{"product_id":"membrane-processes-in-biotechnology-and-pharmaceutics-hardback-9780444563347","title":"Membrane Processes in Biotechnology and Pharmaceutics (Hardback) 9780444563347","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eMembrane Processes in Biotechnology and Pharmaceutics\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eCatherine Charcosset (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444563347\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 31 January 2012\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e350 pages\u003cbr\u003e22.9 x 15.1 x 2.5 cm, 0.68 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eMembrane processes are increasingly used in pharmaceutical and biochemical engineering and biotechnology for concentration and purification, synthesis of molecules and drug delivery systems, and support for biochemical reactions. This book provides a state-of-the art overview of the classical membrane processes used in pharmaceutical and biochemical engineering and biotechnology, such as ultrafiltration, microfiltration, virus filtration, membrane chromatography, membrane emulsification, liquid membranes and membrane bioreactors. It describes the general rules (principles, choice of configurations, membranes, parameters, etc.), recent developments (fouling control, increase permeate flux and selectivity, etc.), applications, and theoretical descriptions. Further, it presents emerging processes such as solvent resistant nanofiltration and membrane crystallization.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003ePreface1. Principles on Membrane and Membrane Processes2. Ultrafiltration3. Microfiltration4. Virus Filtration5. Membrane Chromatography6. Membranes for the Preparation of Emulsions and Particles7. Other Membrane Processes8. Some PerspectivesIndex\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Biotechnology [\u003ca title=\"See our other books on Biotechnology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biotechnology%20%5BTCB%5D%22\"\u003eTCB\u003c\/a\u003e], Biochemical engineering [\u003ca title=\"See our other books on Biochemical engineering\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biochemical%20engineering%20%5BTC%5D%22\"\u003eTC\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46651501969688,"sku":"9780444563347","price":114.96,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444563347.jpg?v=1694113529"},{"product_id":"biophysical-characterization-of-proteins-in-developing-biopharmaceuticals-hardback-9780444595737","title":"Biophysical Characterization of Proteins in Developing Biopharmaceuticals (Hardback) 9780444595737","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eBiophysical Characterization of Proteins in Developing Biopharmaceuticals\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cp\u003eA general resource for industrial scientists to guide them in implementing biophysical methodologies for analysis of biopharmaceutical proteins.\u003c\/p\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eDamian J. Houde (Edited by), Steven A. Berkowitz (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444595737\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 9 September 2014\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e426 pages\u003cbr\u003e23.4 x 19 x 2.7 cm, 0.93 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\u003ci\u003eBiophysical Characterization of Proteins in Developing Biopharmaceuticals\u003c\/i\u003e is concerned with the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure this book takes the reader on a journey on how to best achieve this goal using the key relevant and practical methods commonly employed in the biopharmaceutical industry today as well as up and coming promising methods that are now gaining increasing attention.\u003c\/p\u003e \u003cp\u003eAs a general resource guide this book has been written with the intent to help today’s industrial scientists working in the biopharmaceutical industry or the scientists of tomorrow who are planning a career in this industry on how to successfully implement these biophysical methodologies. In so doing a keen focus is placed on understanding the capability of these methodologies in terms of what information they can deliver. Aspects of how to best acquire this biophysical information on these very complex drug molecules, while avoiding potential pitfalls, in order to make concise, well informed productive decisions about their development are key points that are also covered.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eList of Contributors About the Editors Preface List of Abbreviations and Symbols\u003c\/p\u003e \u003cp\u003e\u003cb\u003eI: Proteins and Biophysical Characterization in the Biopharmaceutical Industry \u003c\/b\u003eChapter 1 - The Complexity of Protein Structure and the Challenges it Poses in Developing Biopharmaceuticals (Steven A. Berkowitz, Damian J. Houde) Chapter 2 - Biophysical Characterization and Its Role in the Biopharmaceutical Industry (Damian J. Houde, Steven A. Berkowitz) Chapter 3 - Biopharmaceutical Industry's Biophysical Toolbox (Damian J. Houde, Steven A. Berkowitz)\u003c\/p\u003e \u003cp\u003e\u003cb\u003eII: The Selected Biophysical Tools in the Biopharmaceutical Industry \u003c\/b\u003eChapter 4 - An Introduction and Hierarchical Organization of the Biophysical Tool in Section II (Damian J. Houde, Steven A. Berkowitz) Chapter 5 - The Value of UV, Fluorescence, and FTIR Spectroscopy in Biopharmaceutical Development (Mark Brader) Chapter 6 - Circular Dichroism Spectroscopy for Protein Characterization: Biopharmaceutical Applications (A.J. Miles, B.A. Wallace) Chapter 7 - Size-Exclusion Chromatograph (SEC) in Biopharmaceutical Process Development (Steven A. Berkowitz, Damian J. Houde) Chapter 8 - Scattering Techniques for the Characterization of Biopharmaceuticals, Pages 171-209, Lee Makowski, Steven A. Berkowitz, Damian J. Houde Chapter 9 - Characterizing Biopharmaceuticals using Analytical Ultracentrifugation (Steven A. Berkowitz, John S. Philo) Chapter 10 - Subvisible and Visible Particle Analysis in Biopharmaceutical Research and Development, Pages 261-286, Andrea Hawe, Sarah Zölls, Angelika Freitag, John F. Carpenter Chapter 11 - Differential Scanning Calorimetry in the Biopharmaceutical Sciences (Stephen J. Demarest, Verna Frasca) Chapter 12 - Biophysical Mass Spectrometry for Biopharmaceutical Process Development: Focus on Hydrogen\/Deuterium Exchange (George M. Bou-Assaf, Alan G. Marshall) Chapter 13 - One- and Two-Dimensional NMR Techniques for Biopharmaceuticals (Yves Aubin, Daron I. Freedberg, David A. Keire)\u003c\/p\u003e \u003cp\u003e\u003cb\u003eIII: Concluding Remarks on the Biophysical Characterization of Biopharmaceuticals \u003c\/b\u003eChapter 14 - Biophysical Characterization: An Integral Part of the “Totality of the Evidence? Concept (Damian J. Houde, Steven A. Berkowitz)\u003c\/p\u003e \u003cp\u003eIndex\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Chemical engineering [\u003ca title=\"See our other books on Chemical engineering\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemical%20engineering%20%5BTDCB%5D%22\"\u003eTDCB\u003c\/a\u003e], Proteins [\u003ca title=\"See our other books on Proteins\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Proteins%20%5BPSBC%5D%22\"\u003ePSBC\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Freshly Printed Books","offers":[{"title":"Default Title","offer_id":46651503083800,"sku":"9780444595737","price":132.39,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444595737.jpg?v=1694113534"},{"product_id":"progress-in-medicinal-chemistry-hardback-9780444826329","title":"Progress in Medicinal Chemistry (Hardback) 9780444826329","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eProgress in Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eG. P. Ellis (Volume editor), D.K. Luscombe (Volume editor)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444826329, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 18 August 1997\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e276 pages\u003cbr\u003e22.9 x 15.1 x 2.2 cm, 0.47 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cem\u003e\u003cfont size=\"3\"\u003e\u003cp\u003e\"...a valuable source of reference.\" \u003cb\u003e--British Medical Journal\u003c\/b\u003e \"...may the Progress in Medicinal Chemistry series continue its invaluable service...\" \u003cb\u003e--Chemistry and Industry \u003c\/b\u003e\"These volumes should be on the shelves of all specialist libraries which claim to cater for chemists, biologists, doctors and pharmacists and should be available to everyone interested in the contemporary controversy about drugs, drug firms and the community.\" \u003cb\u003e--Pharmaceutical Journal\u003c\/b\u003e\u003c\/p\u003e\u003c\/font\u003e\u003c\/em\u003e\u003c\/p\u003e\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eThere are five main subject areas in this volume in the series on medicinal chemistry. The first is a review of the understanding of Alzheimer's disease and the development of drugs for its treatment; the second, looking at recent efforts in modifying a naturally occuring anticancer (campothecin) for chemotherapy; the third covers the problem of getting a drug to a specific site within the context of phosphates and phosphonates; a survey of sterilization using aldehydes for the destruction of microbes both inside and outside the human body is reviewed in the fourth; and the last chapter is an account of the progress made in the biologically active enantiomer for complex synthetic asymmetric drug molecules.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Chemistry [\u003ca title=\"See our other books on Chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Chemistry%20%5BPN%5D%22\"\u003ePN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Medical research [\u003ca title=\"See our other books on Medical research\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Medical%20research%20%5BMBGR%5D%22\"\u003eMBGR\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":46651524022552,"sku":"9780444826329","price":110.59,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444826329_aaf8652d-ef21-4be4-b4f4-468463644de1.jpg?v=1694987435"},{"product_id":"xivth-international-symposium-on-medicinal-chemistry-hardback-9780444827982","title":"XIVth International Symposium on Medicinal Chemistry (Hardback) 9780444827982","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eXIVth International Symposium on Medicinal Chemistry\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eF. Awouters (Author)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444827982, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 12 September 1997\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e560 pages\u003cbr\u003e24.1 x 15.9 x 3.2 cm, 1.04 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eVaso-occlusive disorders including unstable angina, myocardial infarction, transient ischemic attacks, stroke and peripheral artery disease remain the major sources of morbidity and mortality in western civilization. Platelet activation and resulting platelet aggregation play a major role in the pathogenesis of these thromboembolic diseases. Recognition of the contribution of platelets to the pathophysiology of cardiovascular disease has provided impetus for the continued search for new antiplatelet agents. Hence, over the past two decades many strategies have been evaluated in the search for efficacious mechanisms to reduce platelet function. The medical need for more efficacious antithrombotic drugs and the growing understanding of the role of platelets in vascular injury have catalyzed the extensive evaluation of novel approaches to control platelet function. Along these lines, the volume therefore provides an in-depth assessment of ongoing clinical trials, new and clinically established agents, and other developments in this rapidly developing field.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e1. The fungal cell wall as a drug discovery target: SAR of novel echinocandin analogs. 2. Dual inhibition of angiotensin converting enzyme and neutral endopeptidase. 3. Novel esterase-sensitive cyclic prodrugs of a model hexapeptide having enhanced membrane permeability and enzymatic stability. 4. Analogs of NPFF a neuropeptide which modulate morphine analgesia. 5. Chirality and Kinetics. 6. Antidyrhythmic agents. 7. G proteins and drug targets. 8. Novel glycine antagonists as potent neuroprotective agents. 9. Hypertension-treatment by blockade of the renin-angiotensin system. 10. Metabolism of endobiotics and therapeutic aspects of P450 inhibitors. 11. Cholesterol significantly affects drug interactions with membranes. 12. Progress in the development of potent and selective cholinergic channel modulators (ChCMs). 13. Molecular modelling studies on histamine H2- and H3-receptor agonists. 14. \u003ci\u003eaci\u003c\/i\u003e-Reductones: Drug design, enantioselective syntheses and biological activities within lipid membranes. 15. New methods for the preparation of optically pure nitrogen containing compounds of biological interest. 16. Challenges and new directions in computer assisted structure based drug design. 17. Biomimetic synthesis of racemic alkaloids. 18. From monotherapy to multiple drug therapy through long term pharmacology. 19. Challenges in antibacterial antifungal drug discovery. 20. Cytochrome P450 in the metabolism of xenobiotics and drug-drug interactions. 21. Design and structure activity relationships of naphthalenic ligands of the melatonin receptors. 22. From histamine H2 receptor regulation to a reclassification of H2 antagonists: inverse agonisms as the basis for H2 receptor upregulation. 23. Interception of tyrosine kinase signaling pathways as a therapeutic modality. 24. Chirality in drug design. 25. Dopamine D4 selective ligands as potential antipsychotics. 26. Combinatorial chemistry: a basic necessity inspired by nature's own approaches. 27. Gene therapy for HIV-1 infection and aids. 28. Signalling in the \u0026amp;bgr\u003cbr\u003e-adrenergic receptor system. 29. SAR and chemistry of glycopeptides active against multi-resistant bacteria. 30. In search of new peptides involved in cell-cell communication. 31. Identification of the second extracellular loop in G-protein neurotransmitter receptors as a site for ligand recognition, using spectral map analysis. 32. Structure-based design of epitope mimetics. 33. Functional characterization of novel G.protein-coupled receptors involved in nociception and HIV-1 infection. 34. Structure-activity relationships in a series of C2-symmetric HIV-protease inhibitors. 35. Medicinal chemistry as we start the next millennium. 35. Constitutively active \u0026amp;agr\u003cbr\u003e 1 B-adrenergic receptor mutants: potential mechanisms underlying receptor activation. 37. Cl-1011: an atypical ACAT inhibitor with antiatherosclerotic activity. 38. Angiogenesis and (anti)angiogenic drugs. 39. Anti-atherosclerotics -bile acid sequrstrants, cholesterol absorption and fibrates. 40. Cardiovascular new drug discovery of the future: molecules, genes and machines. 41. The action of serpins and heparin as leads in drug discovery. 42. Inverse isostere strategies in the developments of coleinergic agonists with multiple therapeutic potentials. 43. Computer-aided design of novel inhibitors of human leukocyte elastase. 44. Antiplatelet agents. 45. ucb L059, a new antiepileptic agent with a novel mode of action.\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Cytology [\u003ca title=\"See our other books on Cytology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Cytology%20%5BMFCC%5D%22\"\u003eMFCC\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":46651525497112,"sku":"9780444827982","price":98.29,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444827982_fbdc1f8b-372d-47d2-bc35-93c081d46415.jpg?v=1694987444"},{"product_id":"the-histamine-h-inf-3-inf-receptor-a-target-for-new-drugs-hardback-9780444829368","title":"The Histamine H\u003cINF\u003e3\u003c\/INF\u003e Receptor; A Target for New Drugs (Hardback) 9780444829368","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eThe Histamine H\u003cinf\u003e3\u003c\/inf\u003e Receptor\u003c\/font\u003e\u003cbr\u003e\r\n\u003cfont size=\"5\"\u003eA Target for New Drugs\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\u003cp\u003e\u003cfont size=\"4\"\u003eR. Leurs (Edited by), H. Timmerman (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444829368, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 9 December 1998\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e290 pages\u003cbr\u003e24 x 16.5 x 2.3 cm, 0.63 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eIn the early eighties when the H\u003cinf\u003e3\u003c\/inf\u003e receptor was identified, many thought that an H\u003cinf\u003e3\u003c\/inf\u003e ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive.\u003cp\u003eThe H\u003cinf\u003e3\u003c\/inf\u003e receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). Both the H\u003cinf\u003e3\u003c\/inf\u003e agonist and the H\u003cinf\u003e3\u003c\/inf\u003e antagonist cause important pharmacological effects. Several ligands have become available now, including radiolabelled analogues.\u003c\/p\u003e\n\u003cp\u003eIn this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H\u003cinf\u003e3\u003c\/inf\u003e receptor and the several ligands available are presented by a number of experts in the field. The book presents an extended review of what has happened since the first H\u003cinf\u003e3\u003c\/inf\u003e paper appeared. The editors hope that publication of this work will lead to an increase in interest of both academia and industry for the H\u003cinf\u003e3\u003c\/inf\u003e receptor, especially as a target for drug development.\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003ePreface. Subclassification of histamine receptors, H\u003cinf\u003e3\u003c\/inf\u003e-receptor subtypes? Localization of H\u003cinf\u003e3\u003c\/inf\u003e receptors in the brain (J.M. Arrang \u003ci\u003eet al.\u003c\/i\u003e). Modulation of \u003ci\u003ein vitro\u003c\/i\u003e neurotransmission in the CNS and in the retina via H\u003cinf\u003e3\u003c\/inf\u003e heteroreceptors (E. Schlicker, M. Kathmann). H\u003cinf\u003e3\u003c\/inf\u003e receptor modulation of the release of neurotransmitters \u003ci\u003ein vivo\u003c\/i\u003e (P. Blandina \u003ci\u003eet al.\u003c\/i\u003e). H\u003cinf\u003e3\u003c\/inf\u003e receptor modulation of neuroendocrine responses to histamine and stress (U. Knigge \u003ci\u003eet al.\u003c\/i\u003e). Functional role of histamine H\u003cinf\u003e3\u003c\/inf\u003e receptors in peripheral tissues (G. Bertaccini \u003ci\u003eet al.\u003c\/i\u003e). Biochemical properties of the histamine H\u003cinf\u003e3\u003c\/inf\u003e receptor (M. Hoffman \u003ci\u003eet al.\u003c\/i\u003e). Radioligands for the histamine H\u003cinf\u003e3\u003c\/inf\u003e receptor and their use in pharmacology (F.P. Jansen \u003ci\u003eet al.\u003c\/i\u003e). Substituted imidazoles, the key to histaminergic receptors (W.M.P.B. Menge, H. Timmerman). Synthesis of radioligands for the histamine H\u003cinf\u003e3\u003c\/inf\u003e receptor (A.D. Windhorst \u003ci\u003eet al.\u003c\/i\u003e). Medicinal chemistry of histamine H\u003cinf\u003e3\u003c\/inf\u003e receptor antagonists (J.G. Phillips, S.M. Ali). Molecular modelling studies of histamine H\u003cinf\u003e3\u003c\/inf\u003e receptor ligands (I.J.P. de Esch \u003ci\u003eet al.\u003c\/i\u003e). Brain histamine in pathophysiological conditions and brain diseases (P. Panula \u003ci\u003eet al.\u003c\/i\u003e). Histamine H\u003cinf\u003e3\u003c\/inf\u003e antagonists as potential therapeutics in the CNS (K. Onodera, T. Watanabe). Clinical application of HA H\u003cinf\u003e3\u003c\/inf\u003e receptor antagonists in learning and memory disorders (C.E. Tedford).\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Neurosciences [\u003ca title=\"See our other books on Neurosciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Neurosciences%20%5BPSAN%5D%22\"\u003ePSAN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e], Neurology \u0026amp; clinical neurophysiology [\u003ca title=\"See our other books on Neurology \u0026amp; clinical neurophysiology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Neurology%20\u0026amp;%20clinical%20neurophysiology%20%5BMJN%5D%22\"\u003eMJN\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":46651525857560,"sku":"9780444829368","price":141.29,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444829368_3c334260-ad62-4774-8950-776baf433712.jpg?v=1694987419"},{"product_id":"trends-in-drug-research-ii-hardback-9780444826336","title":"Trends in Drug Research II (Hardback) 9780444826336","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eTrends in Drug Research II\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003eH. van der Goot (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9780444826336, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 16 January 1998\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e246 pages\u003cbr\u003e24.1 x 18.3 x 2.1 cm, 0.56 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eThis volume of Pharmacochemistry Library comprises the text of invited lectures presented at the 11th Noordwijkerhout-Camerino Symposium \u003ci\u003eTrends in Drug Research\u003c\/i\u003e, held in Noordwijkerhout, The Netherlands, from 11-15 May 1997.\u003c\/p\u003e  \u003cp\u003eIn the programme attention has been given to the generation of new biological target systems and the generation of new lead molecules, with presentations on e.g. combinatorial chemistry, compound libraries, database search, high throughput screening and molecular biology.\u003c\/p\u003e  \u003cp\u003eOther topics discussed were the perspectives for new medicines for the gastro-intestinal tract, the major developments in the search for effective anti-HIV drugs and new aspects in synthetic approaches. In a special session three topics which currently draw much attention were discussed: How to deal with the major problem of resistance against antimirobial agents? Can the apoptosis mechanism be used as a drug target? Is the newly observed phenomenon of inverse agonism a general principle and has it consequences for drug development (and use?)\u003c\/p\u003e\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eInsights into the structure and function of genetic disease genes from genome research and clues for drug therapy (P.L. Pearson). New Developments in synthetic medicinal chemistry (F. Gaultieri). New biocatalytic approaches for the synthesis of chiral drugs, intermediates, and substrates (K. Laumen \u003ci\u003eet al\u003c\/i\u003e.). Ligands for the 5-HT \u003ci\u003e2C\u003c\/i\u003e receptor as potential antidepressents and anxiolytics (D. Leysen, J. Kelder). 5-HT \u003ci\u003e1A\u003c\/i\u003e-affinity, activity and selectivity \u003ci\u003eversus\u003c\/i\u003e D\u003ci\u003e2\u003c\/i\u003e-receptors of flesinoxan and analogous (W. Kuipers). Pharmacokinetics and metabolism in drug development: current and future strategies (D.D. Breimer). Novel approaches towards anti-HIV chemotherapy (E. De Clercq). HBY 097 - a second-generation nonnucleoside inhibitor of the HIV-1 reverse transcriptase (J-P. Kleim). The HIV tat-TAR interaction, a novel target for drug discovery (J. Karn \u003ci\u003eet al\u003c\/i\u003e.). Diverse approaches to combinatorial library design (E.J. Martin \u003ci\u003eet al\u003c\/i\u003e.). Heterocyclic mixture- based combinatorial libraries: synthesis and analysis of composition (J.S. Kiely, Y. Pei). Chemistry and SAR of prokinetic motilides: non peptidic motilin receptor agonists (P.A. Lartey). Modulators of 5-HT functions in the treatment of gastrointestinal disorders (F.D. King \u003ci\u003eet al\u003c\/i\u003e.). The impact of robotics and novel assay technologies on lead discovery processes (J.G. Houston). Hot topics (P. Angeli). Inverse agonism at G protein-coupled receptors. Studies with wild type and mutated adrenergic and opioid receptors (G. Milligan). Antibiotic resistance - a view from the pharmaceutical industry (R. Bax).\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Genetics [\u003ca title=\"See our other books on Genetics\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Genetics%20%5Bnon-medical%5D%20%5BPSAK%5D%22\"\u003enon-medical PSAK\u003c\/a\u003e], Organic chemistry [\u003ca title=\"See our other books on Organic chemistry\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Organic%20chemistry%20%5BPNN%5D%22\"\u003ePNN\u003c\/a\u003e], Pharmacology [\u003ca title=\"See our other books on Pharmacology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmacology%20%5BMMG%5D%22\"\u003eMMG\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Elsevier Science","offers":[{"title":"Default Title","offer_id":46651535294744,"sku":"9780444826336","price":138.99,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9780444826336_2cb1709b-6608-400d-ad0e-a026cadba047.jpg?v=1694987409"},{"product_id":"from-plant-genomics-to-plant-biotechnology-hardback-9781907568299","title":"From Plant Genomics to Plant Biotechnology (Hardback) 9781907568299","description":"\u003cfont face=\"Georgia\"\u003e\r\n\u003cp\u003e\u003cfont size=\"6\"\u003eFrom Plant Genomics to Plant Biotechnology\u003c\/font\u003e\u003cbr\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003c\/p\u003e\n\u003cp\u003e\u003cfont size=\"4\"\u003ePalmiro Poltronieri (Edited by), Natalija Burbulis (Edited by), Corrado Fogher (Edited by)\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e9781907568299, Elsevier Science\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eHardback, published 31 August 2013\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e274 pages\u003cbr\u003e23.3 x 15.6 x 2.2 cm, 0.57 kg\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\r\n\r\n\r\n\u003cp align=\"justify\"\u003e\u003cstrong\u003e\u003cfont size=\"3\"\u003eWith the appearance of methods for the sequencing of genomes and less expensive next generation sequencing methods, we face rapid advancements of the -omics technologies and plant biology studies: reverse and forward genetics, functional genomics, transcriptomics, proteomics, metabolomics, the movement at distance of effectors and structural biology. From plant genomics to plant biotechnology reviews the recent advancements in the post-genomic era, discussing how different varieties respond to abiotic and biotic stresses, understanding the epigenetic control and epigenetic memory, the roles of non-coding RNAs, applicative uses of RNA silencing and RNA interference in plant physiology and in experimental transgenics and plants modified to specific aims. In the forthcoming years these advancements will support the production of plant varieties better suited to resist biotic and abiotic stresses, for food and non-food applications.\u003cbr\u003e\u003cbr\u003eThis book covers these issues, showing how such technologies are influencing the plant field in sectors such as the selection of plant varieties and plant breeding, selection of optimum agronomic traits, stress-resistant varieties, improvement of plant fitness, improving crop yield, and non-food applications in the knowledge based bio-economy.\u003c\/font\u003e\u003c\/strong\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003e\u003cp\u003eList of figures\u003c\/p\u003e \u003cp\u003eList of tables\u003c\/p\u003e \u003cp\u003eAbbreviations\u003c\/p\u003e \u003cp\u003eAbout the contributors\u003c\/p\u003e \u003cp\u003eIntroduction\u003c\/p\u003e \u003cp\u003eChapter 1: From plant genomics to -omics technologies\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e1.1 SuperSAGE\u003c\/p\u003e \u003cp\u003e1.2 CAGE – cap analysis of gene expression\u003c\/p\u003e \u003cp\u003e1.3 -Omics and new advances in plant functional genomics\u003c\/p\u003e \u003cp\u003eChapter 2: Plant microRNAs\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e2.1 Introduction\u003c\/p\u003e \u003cp\u003e2.2 Transcription of miRNA genes\u003c\/p\u003e \u003cp\u003e2.3 MicroRNA processing\u003c\/p\u003e \u003cp\u003e2.4 Modes of action\u003c\/p\u003e \u003cp\u003e2.5 Evolution of miRNA genes\u003c\/p\u003e \u003cp\u003e2.6 Differences from animal miRNAs\u003c\/p\u003e \u003cp\u003e2.7 miRNA functions\u003c\/p\u003e \u003cp\u003e2.8 The potential roles of microRNAs in crop improvement\u003c\/p\u003e \u003cp\u003eChapter 3: Epigenetic control by plant Polycomb proteins: new perspectives and emerging roles in stress response\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e3.1 Introduction\u003c\/p\u003e \u003cp\u003e3.2 Conserved multi-protein complexes with histone post-translational modifying activities\u003c\/p\u003e \u003cp\u003e3.3 Polycomb functions in plant development\u003c\/p\u003e \u003cp\u003e3.4 Non-coding RNAs as regulatory cofactors of Polycomb complexes\u003c\/p\u003e \u003cp\u003e3.5 Emerging roles of PcG and ncRNAs in responses to environmental stress\u003c\/p\u003e \u003cp\u003e3.6 PcG protein functions in three-dimensional nuclear organization\u003c\/p\u003e \u003cp\u003e3.7 Perspectives: the role of Polycomb in abiotic and biotic stress response\u003c\/p\u003e \u003cp\u003eChapter 4: Metabolite profiling for plant research\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e4.1 Introduction\u003c\/p\u003e \u003cp\u003e4.2 Methodological approach\u003c\/p\u003e \u003cp\u003e4.3 Metabolomic platform\u003c\/p\u003e \u003cp\u003e4.4 Metabolomics in plant science\u003c\/p\u003e \u003cp\u003e4.5 The future role of metabolomics in crop improvement\u003c\/p\u003e \u003cp\u003e4.6 Conclusion\u003c\/p\u003e \u003cp\u003eChapter 5: The uniqueness of conifers\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e5.1 Introduction\u003c\/p\u003e \u003cp\u003e5.2 Functional differentiation\u003c\/p\u003e \u003cp\u003e5.3 Genome structure and composition\u003c\/p\u003e \u003cp\u003e5.4 Genome function\u003c\/p\u003e \u003cp\u003e5.5 Chemical divergence\u003c\/p\u003e \u003cp\u003e5.6 Meeting the challenge: the system biology approach to unraveling the conifer genome\u003c\/p\u003e \u003cp\u003eChapter 6: Cryptochrome genes modulate global transcriptome of tomato\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e6.1 Introduction\u003c\/p\u003e \u003cp\u003e6.2 Cryptochrome functions\u003c\/p\u003e \u003cp\u003e6.3 Role of cryptochromes in mediating light-regulated gene expression in plants\u003c\/p\u003e \u003cp\u003e6.4 Cryptochromes influence the diurnal global transcription profiles in tomato\u003c\/p\u003e \u003cp\u003eChapter 7: Genomics of grapevine: from genomics research on model plants to crops and from science to grapevine breeding\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e7.1 Use of genetic and molecular markers for studies of genetic diversity and genome selection in grapevine\u003c\/p\u003e \u003cp\u003e7.2 Grapevine breeding\u003c\/p\u003e \u003cp\u003e7.3 Transgene silencing\u003c\/p\u003e \u003cp\u003e7.4 Identification and characterization of transgene insertion loci\u003c\/p\u003e \u003cp\u003e7.5 Integration of vector backbone\u003c\/p\u003e \u003cp\u003e7.6 Stability of inserted transgenes\u003c\/p\u003e \u003cp\u003e7.7 Conclusions\u003c\/p\u003e \u003cp\u003e7.8 Acknowledgement\u003c\/p\u003e \u003cp\u003eChapter 8: Grapevine genomics and phenotypic diversity of bud sports, varieties and wild relatives\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e8.1 Introduction\u003c\/p\u003e \u003cp\u003e8.2 Origin of Vitis vinifera, domestication, and early selection for fruit characters\u003c\/p\u003e \u003cp\u003e8.3 Sources of phenotypic variation in present-day grapevines\u003c\/p\u003e \u003cp\u003e8.4 Genomic tools in the genome sequencing era\u003c\/p\u003e \u003cp\u003e8.5 Current activities in grapevine genome analysis\u003c\/p\u003e \u003cp\u003e8.6 Bud organogenesis, somatic mutations, and DNA typing of somatic chimeras\u003c\/p\u003e \u003cp\u003e8.7 Phenotypically divergent clones and the underlying DNA variation\u003c\/p\u003e \u003cp\u003e8.8 Transposon insertion-site profiling using NGS\u003c\/p\u003e \u003cp\u003e8.9 Large structural variation using NGS\u003c\/p\u003e \u003cp\u003e8.10 Copy number variation, gene redundancy, and subtle specialisation in secondary metabolism\u003c\/p\u003e \u003cp\u003e8.11 Conclusions\u003c\/p\u003e \u003cp\u003eChapter 9: Peach ripening transcriptomics unveils new and unexpected targets for the improvement of drupe quality\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e9.1 Introduction\u003c\/p\u003e \u003cp\u003e9.2 The fruit\u003c\/p\u003e \u003cp\u003e9.3 Peach development and ripening\u003c\/p\u003e \u003cp\u003e9.4 Microarray Transcript Profiling in peach\u003c\/p\u003e \u003cp\u003e9.5 New players in the control of peach ripening\u003c\/p\u003e \u003cp\u003e9.6 Conclusions\u003c\/p\u003e \u003cp\u003e9.7 Acknowledgements\u003c\/p\u003e \u003cp\u003eChapter 10: Application of doubled haploid technology in breeding of Brassica napus\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e10.1 Introduction\u003c\/p\u003e \u003cp\u003e10.2 Technique of isolated microspore culture\u003c\/p\u003e \u003cp\u003e10.3 Doubled haploid method in breeding of Brassica napus\u003c\/p\u003e \u003cp\u003e10.4 In vitro mutagenesis\u003c\/p\u003e \u003cp\u003e10.5 Utilization of double haploidy in selection for resistance\u003c\/p\u003e \u003cp\u003e10.6 Selection for modified seed oil composition\u003c\/p\u003e \u003cp\u003e10.7 Selection for improved seed meal\u003c\/p\u003e \u003cp\u003e10.8 Selection for cold tolerance\u003c\/p\u003e \u003cp\u003e10.9 Concluding remarks\u003c\/p\u003e \u003cp\u003eChapter 11: Plant biodiversity and biotechnology\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e11.1 Biodiversity\u003c\/p\u003e \u003cp\u003e11.2 Biotechnology\u003c\/p\u003e \u003cp\u003e11.3 Heat stress tolerance in cereals\u003c\/p\u003e \u003cp\u003e11.4 Modern approaches in cereals for yield and food security under temperature stress\u003c\/p\u003e \u003cp\u003e11.5 Future perspectives\u003c\/p\u003e \u003cp\u003e11.6 Acknowledgment\u003c\/p\u003e \u003cp\u003eChapter 12: Natural resveratrol bioproduction\u003c\/p\u003e \u003cp\u003eAbstract:\u003c\/p\u003e \u003cp\u003e12.1 Stilbenes and resveratrol\u003c\/p\u003e \u003cp\u003e12.2 Health benefits of resveratrol\u003c\/p\u003e \u003cp\u003e12.3 trans-resveratrol production through plant cell cultures\u003c\/p\u003e \u003cp\u003e12.4 Introducing new pathway branches to crop plants: trans-resveratrol synthesis in tomato fruits\u003c\/p\u003e \u003cp\u003e12.5 Concluding remarks\u003c\/p\u003e \u003cp\u003eIndex\u003c\/p\u003e\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\u003cp\u003e\u003cfont size=\"3\"\u003eSubject Areas: Pharmaceutical technology [\u003ca title=\"See our other books on Pharmaceutical technology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Pharmaceutical%20technology%20%5BTDCW%5D%22\"\u003eTDCW\u003c\/a\u003e], Biotechnology [\u003ca title=\"See our other books on Biotechnology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Biotechnology%20%5BTCB%5D%22\"\u003eTCB\u003c\/a\u003e], Botany \u0026amp; plant sciences [\u003ca title=\"See our other books on Botany \u0026amp; plant sciences\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Botany%20\u0026amp;%20plant%20sciences%20%5BPST%5D%22\"\u003ePST\u003c\/a\u003e], Molecular biology [\u003ca title=\"See our other books on Molecular biology\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22Molecular%20biology%20%5BPSD%5D%22\"\u003ePSD\u003c\/a\u003e], DNA \u0026amp; Genome [\u003ca title=\"See our other books on DNA \u0026amp; Genome\" href=\"https:\/\/freshlyprintedbooks.co.uk\/search?q=%22DNA%20\u0026amp;%20Genome%20%5BPSAK1%5D%22\"\u003ePSAK1\u003c\/a\u003e]\u003c\/font\u003e\u003c\/p\u003e\r\n\r\n\r\n\u003c\/font\u003e","brand":"Woodhead Publishing","offers":[{"title":"Default Title","offer_id":46651786952984,"sku":"9781907568299","price":125.69,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0730\/2037\/5320\/products\/9781907568299_ede29456-188e-45ce-aa13-94c2dffd20f4.jpg?v=1696403889"}],"url":"https:\/\/freshlyprintedbooks.co.uk\/collections\/pharmaceutical-technology.oembed","provider":"Freshly Printed Books","version":"1.0","type":"link"}